Reversible Inactivation of the Higher Order Auditory Cortex during Fear Memory Consolidation Prevents Memory-Related Activity in the Basolateral Amygdala during Remote Memory Retrieval

Recent findings have shown that the auditory cortex, and specifically the higher order Te2 area, is necessary for the consolidation of long-term fearful memories and that it interacts with the amygdala during the retrieval of long-term fearful memories. Here, we tested whether the reversible blockad...
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Autor*in:	Marco Cambiaghi [verfasserIn] Annamaria Renna [verfasserIn] Luisella Milano [verfasserIn] Benedetto Sacchetti [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	auditory cortex amygdala memory consolidation memory storage and retrieval neuronal synchrony

Übergeordnetes Werk:	In: Frontiers in Behavioral Neuroscience - Frontiers Media S.A., 2008, 11(2017)
Übergeordnetes Werk:	volume:11 ; year:2017

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnbeh.2017.00138

Katalog-ID:	DOAJ040087069

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language	English
source	In Frontiers in Behavioral Neuroscience 11(2017) volume:11 year:2017
sourceStr	In Frontiers in Behavioral Neuroscience 11(2017) volume:11 year:2017
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	auditory cortex amygdala memory consolidation memory storage and retrieval neuronal synchrony Neurosciences. Biological psychiatry. Neuropsychiatry
isfreeaccess_bool	true
container_title	Frontiers in Behavioral Neuroscience
authorswithroles_txt_mv	Marco Cambiaghi @@aut@@ Annamaria Renna @@aut@@ Luisella Milano @@aut@@ Benedetto Sacchetti @@aut@@
publishDateDaySort_date	2017-01-01T00:00:00Z
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callnumber-first	R - Medicine
author	Marco Cambiaghi
spellingShingle	Marco Cambiaghi misc RC321-571 misc auditory cortex misc amygdala misc memory consolidation misc memory storage and retrieval misc neuronal synchrony misc Neurosciences. Biological psychiatry. Neuropsychiatry Reversible Inactivation of the Higher Order Auditory Cortex during Fear Memory Consolidation Prevents Memory-Related Activity in the Basolateral Amygdala during Remote Memory Retrieval
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topic_title	RC321-571 Reversible Inactivation of the Higher Order Auditory Cortex during Fear Memory Consolidation Prevents Memory-Related Activity in the Basolateral Amygdala during Remote Memory Retrieval auditory cortex amygdala memory consolidation memory storage and retrieval neuronal synchrony
topic	misc RC321-571 misc auditory cortex misc amygdala misc memory consolidation misc memory storage and retrieval misc neuronal synchrony misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc auditory cortex misc amygdala misc memory consolidation misc memory storage and retrieval misc neuronal synchrony misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Reversible Inactivation of the Higher Order Auditory Cortex during Fear Memory Consolidation Prevents Memory-Related Activity in the Basolateral Amygdala during Remote Memory Retrieval
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title_full	Reversible Inactivation of the Higher Order Auditory Cortex during Fear Memory Consolidation Prevents Memory-Related Activity in the Basolateral Amygdala during Remote Memory Retrieval
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title_sort	reversible inactivation of the higher order auditory cortex during fear memory consolidation prevents memory-related activity in the basolateral amygdala during remote memory retrieval
callnumber	RC321-571
title_auth	Reversible Inactivation of the Higher Order Auditory Cortex during Fear Memory Consolidation Prevents Memory-Related Activity in the Basolateral Amygdala during Remote Memory Retrieval
abstract	Recent findings have shown that the auditory cortex, and specifically the higher order Te2 area, is necessary for the consolidation of long-term fearful memories and that it interacts with the amygdala during the retrieval of long-term fearful memories. Here, we tested whether the reversible blockade of Te2 during memory consolidation may affect the activity changes occurring in the amygdala during the retrieval of fearful memories. To address this issue, we blocked Te2 in a reversible manner during memory consolidation processes. After 4 weeks, we assessed the activity of Te2 and individual nuclei of the amygdala during the retrieval of long-term memories. Rats in which Te2 was inactivated upon memory encoding showed a decreased freezing and failed to show Te2-to-basolateral amygdala (BLA) synchrony during memory retrieval. In addition, the expression of the immediate early gene zif268 in the lateral, basal and central amygdala nuclei did not show memory-related enhancement. As all sites were intact upon memory retrieval, we propose that the auditory cortex represents a key node in the consolidation of fear memories and it is essential for amygdala nuclei to support memory retrieval process.
abstractGer	Recent findings have shown that the auditory cortex, and specifically the higher order Te2 area, is necessary for the consolidation of long-term fearful memories and that it interacts with the amygdala during the retrieval of long-term fearful memories. Here, we tested whether the reversible blockade of Te2 during memory consolidation may affect the activity changes occurring in the amygdala during the retrieval of fearful memories. To address this issue, we blocked Te2 in a reversible manner during memory consolidation processes. After 4 weeks, we assessed the activity of Te2 and individual nuclei of the amygdala during the retrieval of long-term memories. Rats in which Te2 was inactivated upon memory encoding showed a decreased freezing and failed to show Te2-to-basolateral amygdala (BLA) synchrony during memory retrieval. In addition, the expression of the immediate early gene zif268 in the lateral, basal and central amygdala nuclei did not show memory-related enhancement. As all sites were intact upon memory retrieval, we propose that the auditory cortex represents a key node in the consolidation of fear memories and it is essential for amygdala nuclei to support memory retrieval process.
abstract_unstemmed	Recent findings have shown that the auditory cortex, and specifically the higher order Te2 area, is necessary for the consolidation of long-term fearful memories and that it interacts with the amygdala during the retrieval of long-term fearful memories. Here, we tested whether the reversible blockade of Te2 during memory consolidation may affect the activity changes occurring in the amygdala during the retrieval of fearful memories. To address this issue, we blocked Te2 in a reversible manner during memory consolidation processes. After 4 weeks, we assessed the activity of Te2 and individual nuclei of the amygdala during the retrieval of long-term memories. Rats in which Te2 was inactivated upon memory encoding showed a decreased freezing and failed to show Te2-to-basolateral amygdala (BLA) synchrony during memory retrieval. In addition, the expression of the immediate early gene zif268 in the lateral, basal and central amygdala nuclei did not show memory-related enhancement. As all sites were intact upon memory retrieval, we propose that the auditory cortex represents a key node in the consolidation of fear memories and it is essential for amygdala nuclei to support memory retrieval process.
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title_short	Reversible Inactivation of the Higher Order Auditory Cortex during Fear Memory Consolidation Prevents Memory-Related Activity in the Basolateral Amygdala during Remote Memory Retrieval
url	https://doi.org/10.3389/fnbeh.2017.00138 https://doaj.org/article/fd1c7d4b414148d4a8b5e5868faf6717 http://journal.frontiersin.org/article/10.3389/fnbeh.2017.00138/full https://doaj.org/toc/1662-5153
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Reversible Inactivation of the Higher Order Auditory Cortex during Fear Memory Consolidation Prevents Memory-Related Activity in the Basolateral Amygdala during Remote Memory Retrieval

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