Testis-Specific Isoform of Na<sup<+</sup<-K<sup<+</sup< ATPase and Regulation of Bull Fertility

An advanced understanding of sperm function is relevant for evidence-based male fertility prediction and addressing male infertility. A standard breeding soundness evaluation (BSE) merely identifies gross abnormalities in bulls, whereas selection based on single nucleotide polymorphisms and genomic...
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Gespeichert in:

Autor*in:	Saurabh Tiwari [verfasserIn] Gayathri Rajamanickam [verfasserIn] Veena Unnikrishnan [verfasserIn] Mina Ojaghi [verfasserIn] John P. Kastelic [verfasserIn] Jacob C. Thundathil [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	ATP1A4 capacitation male fertility signaling sperm

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 23(2022), 14, p 7936
Übergeordnetes Werk:	volume:23 ; year:2022 ; number:14, p 7936

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms23147936

Katalog-ID:	DOAJ040204928

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callnumber-first	Q - Science
author	Saurabh Tiwari
spellingShingle	Saurabh Tiwari misc QH301-705.5 misc QD1-999 misc ATP1A4 misc capacitation misc male fertility misc signaling misc sperm misc Biology (General) misc Chemistry Testis-Specific Isoform of Na<sup<+</sup<-K<sup<+</sup< ATPase and Regulation of Bull Fertility
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title	Testis-Specific Isoform of Na<sup<+</sup<-K<sup<+</sup< ATPase and Regulation of Bull Fertility
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title_auth	Testis-Specific Isoform of Na<sup<+</sup<-K<sup<+</sup< ATPase and Regulation of Bull Fertility
abstract	An advanced understanding of sperm function is relevant for evidence-based male fertility prediction and addressing male infertility. A standard breeding soundness evaluation (BSE) merely identifies gross abnormalities in bulls, whereas selection based on single nucleotide polymorphisms and genomic estimated breeding values overlooks sub-microscopic differences in sperm. Molecular tools are important for validating genomic selection and advancing knowledge on the regulation of male fertility at an interdisciplinary level. Therefore, research in this field is now focused on developing a combination of in vitro sperm function tests and identifying biomarkers such as sperm proteins with critical roles in fertility. The Na<sup<+</sup<-K<sup<+</sup< ATPase is a ubiquitous transmembrane protein and its α4 isoform (ATP1A4) is exclusively expressed in germ cells and sperm. Furthermore, ATP1A4 is essential for male fertility, as it interacts with signaling molecules in both raft and non-raft fractions of the sperm plasma membrane to regulate capacitation-associated signaling, hyperactivation, sperm-oocyte interactions, and activation. Interestingly, ATP1A4 activity and expression increase during capacitation, challenging the widely accepted dogma of sperm translational quiescence. This review discusses the literature on the role of ATP1A4 during capacitation and fertilization events and its prospective use in improving male fertility prediction.
abstractGer	An advanced understanding of sperm function is relevant for evidence-based male fertility prediction and addressing male infertility. A standard breeding soundness evaluation (BSE) merely identifies gross abnormalities in bulls, whereas selection based on single nucleotide polymorphisms and genomic estimated breeding values overlooks sub-microscopic differences in sperm. Molecular tools are important for validating genomic selection and advancing knowledge on the regulation of male fertility at an interdisciplinary level. Therefore, research in this field is now focused on developing a combination of in vitro sperm function tests and identifying biomarkers such as sperm proteins with critical roles in fertility. The Na<sup<+</sup<-K<sup<+</sup< ATPase is a ubiquitous transmembrane protein and its α4 isoform (ATP1A4) is exclusively expressed in germ cells and sperm. Furthermore, ATP1A4 is essential for male fertility, as it interacts with signaling molecules in both raft and non-raft fractions of the sperm plasma membrane to regulate capacitation-associated signaling, hyperactivation, sperm-oocyte interactions, and activation. Interestingly, ATP1A4 activity and expression increase during capacitation, challenging the widely accepted dogma of sperm translational quiescence. This review discusses the literature on the role of ATP1A4 during capacitation and fertilization events and its prospective use in improving male fertility prediction.
abstract_unstemmed	An advanced understanding of sperm function is relevant for evidence-based male fertility prediction and addressing male infertility. A standard breeding soundness evaluation (BSE) merely identifies gross abnormalities in bulls, whereas selection based on single nucleotide polymorphisms and genomic estimated breeding values overlooks sub-microscopic differences in sperm. Molecular tools are important for validating genomic selection and advancing knowledge on the regulation of male fertility at an interdisciplinary level. Therefore, research in this field is now focused on developing a combination of in vitro sperm function tests and identifying biomarkers such as sperm proteins with critical roles in fertility. The Na<sup<+</sup<-K<sup<+</sup< ATPase is a ubiquitous transmembrane protein and its α4 isoform (ATP1A4) is exclusively expressed in germ cells and sperm. Furthermore, ATP1A4 is essential for male fertility, as it interacts with signaling molecules in both raft and non-raft fractions of the sperm plasma membrane to regulate capacitation-associated signaling, hyperactivation, sperm-oocyte interactions, and activation. Interestingly, ATP1A4 activity and expression increase during capacitation, challenging the widely accepted dogma of sperm translational quiescence. This review discusses the literature on the role of ATP1A4 during capacitation and fertilization events and its prospective use in improving male fertility prediction.
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title_short	Testis-Specific Isoform of Na<sup<+</sup<-K<sup<+</sup< ATPase and Regulation of Bull Fertility
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up_date	2024-07-03T13:34:14.088Z
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Testis-Specific Isoform of Na<sup<+</sup<-K<sup<+</sup< ATPase and Regulation of Bull Fertility

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