Risk factors for necrotizing enterocolitis in neonates: a systematic review of prognostic studies

Abstract Background Necrotizing enterocolitis (NEC) is a severe multifactorial disease in preterm neonates associated with high morbidity and mortality. Better insight into prognostic values of the many reported factors associated with NEC is needed to enable identification of neonates at risk for N...
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Autor*in:	Noor Samuels [verfasserIn] Rob A. van de Graaf [verfasserIn] Rogier C. J. de Jonge [verfasserIn] Irwin K. M. Reiss [verfasserIn] Marijn J. Vermeulen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	necrotizing enterocolitis intestinal perforation preterm neonatal intensive care unit risk factors prognosis

Übergeordnetes Werk:	In: BMC Pediatrics - BMC, 2003, 17(2017), 1, Seite 9
Übergeordnetes Werk:	volume:17 ; year:2017 ; number:1 ; pages:9

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12887-017-0847-3

Katalog-ID:	DOAJ040281698

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520			\|a Abstract Background Necrotizing enterocolitis (NEC) is a severe multifactorial disease in preterm neonates associated with high morbidity and mortality. Better insight into prognostic values of the many reported factors associated with NEC is needed to enable identification of neonates at risk for NEC. The aim was to systematically review the literature to identify independent risk factors for NEC from the literature. Methods Medline, Cochrane, Embase, Pubmed and Google Scholar were searched systematically for cohort studies reporting prognostic factors for NEC in neonates using multivariable analysis. Studies were scored with the Quality In Prognosis Studies tool (QUIPS). Results From 5154 initial hits, 14 prognostic studies were included, with various designs. Study quality was rated high in three studies, moderate or low in the 11 others. Significant prognostic factors for NEC reported in at least two studies were: low birth weight, small for gestational age, low gestational age, assisted ventilation, premature rupture of membranes, black ethnicity, sepsis, outborn, hypotension (all increased risk), surfactant therapy (conflicting results) and cesarean section (lower risk). Meta-analysis was considered not feasible. Conclusion High quality studies on prognostic factors for NEC are rare. Several prognostic factors, that are not necessarily causal, are associated with NEC. High quality prognostic research is necessary to establish the predictive values of these factors.
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allfields	10.1186/s12887-017-0847-3 doi (DE-627)DOAJ040281698 (DE-599)DOAJ782f053e3e064b18a0be1e503d580d64 DE-627 ger DE-627 rakwb eng RJ1-570 Noor Samuels verfasserin aut Risk factors for necrotizing enterocolitis in neonates: a systematic review of prognostic studies 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Necrotizing enterocolitis (NEC) is a severe multifactorial disease in preterm neonates associated with high morbidity and mortality. Better insight into prognostic values of the many reported factors associated with NEC is needed to enable identification of neonates at risk for NEC. The aim was to systematically review the literature to identify independent risk factors for NEC from the literature. Methods Medline, Cochrane, Embase, Pubmed and Google Scholar were searched systematically for cohort studies reporting prognostic factors for NEC in neonates using multivariable analysis. Studies were scored with the Quality In Prognosis Studies tool (QUIPS). Results From 5154 initial hits, 14 prognostic studies were included, with various designs. Study quality was rated high in three studies, moderate or low in the 11 others. Significant prognostic factors for NEC reported in at least two studies were: low birth weight, small for gestational age, low gestational age, assisted ventilation, premature rupture of membranes, black ethnicity, sepsis, outborn, hypotension (all increased risk), surfactant therapy (conflicting results) and cesarean section (lower risk). Meta-analysis was considered not feasible. Conclusion High quality studies on prognostic factors for NEC are rare. Several prognostic factors, that are not necessarily causal, are associated with NEC. High quality prognostic research is necessary to establish the predictive values of these factors. necrotizing enterocolitis intestinal perforation preterm neonatal intensive care unit risk factors prognosis Pediatrics Rob A. van de Graaf verfasserin aut Rogier C. J. de Jonge verfasserin aut Irwin K. M. Reiss verfasserin aut Marijn J. Vermeulen verfasserin aut In BMC Pediatrics BMC, 2003 17(2017), 1, Seite 9 (DE-627)326643621 (DE-600)2041342-7 14712431 nnns volume:17 year:2017 number:1 pages:9 https://doi.org/10.1186/s12887-017-0847-3 kostenfrei https://doaj.org/article/782f053e3e064b18a0be1e503d580d64 kostenfrei http://link.springer.com/article/10.1186/s12887-017-0847-3 kostenfrei https://doaj.org/toc/1471-2431 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2017 1 9
spelling	10.1186/s12887-017-0847-3 doi (DE-627)DOAJ040281698 (DE-599)DOAJ782f053e3e064b18a0be1e503d580d64 DE-627 ger DE-627 rakwb eng RJ1-570 Noor Samuels verfasserin aut Risk factors for necrotizing enterocolitis in neonates: a systematic review of prognostic studies 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Necrotizing enterocolitis (NEC) is a severe multifactorial disease in preterm neonates associated with high morbidity and mortality. Better insight into prognostic values of the many reported factors associated with NEC is needed to enable identification of neonates at risk for NEC. The aim was to systematically review the literature to identify independent risk factors for NEC from the literature. Methods Medline, Cochrane, Embase, Pubmed and Google Scholar were searched systematically for cohort studies reporting prognostic factors for NEC in neonates using multivariable analysis. Studies were scored with the Quality In Prognosis Studies tool (QUIPS). Results From 5154 initial hits, 14 prognostic studies were included, with various designs. Study quality was rated high in three studies, moderate or low in the 11 others. Significant prognostic factors for NEC reported in at least two studies were: low birth weight, small for gestational age, low gestational age, assisted ventilation, premature rupture of membranes, black ethnicity, sepsis, outborn, hypotension (all increased risk), surfactant therapy (conflicting results) and cesarean section (lower risk). Meta-analysis was considered not feasible. Conclusion High quality studies on prognostic factors for NEC are rare. Several prognostic factors, that are not necessarily causal, are associated with NEC. High quality prognostic research is necessary to establish the predictive values of these factors. necrotizing enterocolitis intestinal perforation preterm neonatal intensive care unit risk factors prognosis Pediatrics Rob A. van de Graaf verfasserin aut Rogier C. J. de Jonge verfasserin aut Irwin K. M. Reiss verfasserin aut Marijn J. Vermeulen verfasserin aut In BMC Pediatrics BMC, 2003 17(2017), 1, Seite 9 (DE-627)326643621 (DE-600)2041342-7 14712431 nnns volume:17 year:2017 number:1 pages:9 https://doi.org/10.1186/s12887-017-0847-3 kostenfrei https://doaj.org/article/782f053e3e064b18a0be1e503d580d64 kostenfrei http://link.springer.com/article/10.1186/s12887-017-0847-3 kostenfrei https://doaj.org/toc/1471-2431 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2017 1 9
allfields_unstemmed	10.1186/s12887-017-0847-3 doi (DE-627)DOAJ040281698 (DE-599)DOAJ782f053e3e064b18a0be1e503d580d64 DE-627 ger DE-627 rakwb eng RJ1-570 Noor Samuels verfasserin aut Risk factors for necrotizing enterocolitis in neonates: a systematic review of prognostic studies 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Necrotizing enterocolitis (NEC) is a severe multifactorial disease in preterm neonates associated with high morbidity and mortality. Better insight into prognostic values of the many reported factors associated with NEC is needed to enable identification of neonates at risk for NEC. The aim was to systematically review the literature to identify independent risk factors for NEC from the literature. Methods Medline, Cochrane, Embase, Pubmed and Google Scholar were searched systematically for cohort studies reporting prognostic factors for NEC in neonates using multivariable analysis. Studies were scored with the Quality In Prognosis Studies tool (QUIPS). Results From 5154 initial hits, 14 prognostic studies were included, with various designs. Study quality was rated high in three studies, moderate or low in the 11 others. Significant prognostic factors for NEC reported in at least two studies were: low birth weight, small for gestational age, low gestational age, assisted ventilation, premature rupture of membranes, black ethnicity, sepsis, outborn, hypotension (all increased risk), surfactant therapy (conflicting results) and cesarean section (lower risk). Meta-analysis was considered not feasible. Conclusion High quality studies on prognostic factors for NEC are rare. Several prognostic factors, that are not necessarily causal, are associated with NEC. High quality prognostic research is necessary to establish the predictive values of these factors. necrotizing enterocolitis intestinal perforation preterm neonatal intensive care unit risk factors prognosis Pediatrics Rob A. van de Graaf verfasserin aut Rogier C. J. de Jonge verfasserin aut Irwin K. M. Reiss verfasserin aut Marijn J. Vermeulen verfasserin aut In BMC Pediatrics BMC, 2003 17(2017), 1, Seite 9 (DE-627)326643621 (DE-600)2041342-7 14712431 nnns volume:17 year:2017 number:1 pages:9 https://doi.org/10.1186/s12887-017-0847-3 kostenfrei https://doaj.org/article/782f053e3e064b18a0be1e503d580d64 kostenfrei http://link.springer.com/article/10.1186/s12887-017-0847-3 kostenfrei https://doaj.org/toc/1471-2431 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2017 1 9
allfieldsGer	10.1186/s12887-017-0847-3 doi (DE-627)DOAJ040281698 (DE-599)DOAJ782f053e3e064b18a0be1e503d580d64 DE-627 ger DE-627 rakwb eng RJ1-570 Noor Samuels verfasserin aut Risk factors for necrotizing enterocolitis in neonates: a systematic review of prognostic studies 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Necrotizing enterocolitis (NEC) is a severe multifactorial disease in preterm neonates associated with high morbidity and mortality. Better insight into prognostic values of the many reported factors associated with NEC is needed to enable identification of neonates at risk for NEC. The aim was to systematically review the literature to identify independent risk factors for NEC from the literature. Methods Medline, Cochrane, Embase, Pubmed and Google Scholar were searched systematically for cohort studies reporting prognostic factors for NEC in neonates using multivariable analysis. Studies were scored with the Quality In Prognosis Studies tool (QUIPS). Results From 5154 initial hits, 14 prognostic studies were included, with various designs. Study quality was rated high in three studies, moderate or low in the 11 others. Significant prognostic factors for NEC reported in at least two studies were: low birth weight, small for gestational age, low gestational age, assisted ventilation, premature rupture of membranes, black ethnicity, sepsis, outborn, hypotension (all increased risk), surfactant therapy (conflicting results) and cesarean section (lower risk). Meta-analysis was considered not feasible. Conclusion High quality studies on prognostic factors for NEC are rare. Several prognostic factors, that are not necessarily causal, are associated with NEC. High quality prognostic research is necessary to establish the predictive values of these factors. necrotizing enterocolitis intestinal perforation preterm neonatal intensive care unit risk factors prognosis Pediatrics Rob A. van de Graaf verfasserin aut Rogier C. J. de Jonge verfasserin aut Irwin K. M. Reiss verfasserin aut Marijn J. Vermeulen verfasserin aut In BMC Pediatrics BMC, 2003 17(2017), 1, Seite 9 (DE-627)326643621 (DE-600)2041342-7 14712431 nnns volume:17 year:2017 number:1 pages:9 https://doi.org/10.1186/s12887-017-0847-3 kostenfrei https://doaj.org/article/782f053e3e064b18a0be1e503d580d64 kostenfrei http://link.springer.com/article/10.1186/s12887-017-0847-3 kostenfrei https://doaj.org/toc/1471-2431 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2017 1 9
allfieldsSound	10.1186/s12887-017-0847-3 doi (DE-627)DOAJ040281698 (DE-599)DOAJ782f053e3e064b18a0be1e503d580d64 DE-627 ger DE-627 rakwb eng RJ1-570 Noor Samuels verfasserin aut Risk factors for necrotizing enterocolitis in neonates: a systematic review of prognostic studies 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Necrotizing enterocolitis (NEC) is a severe multifactorial disease in preterm neonates associated with high morbidity and mortality. Better insight into prognostic values of the many reported factors associated with NEC is needed to enable identification of neonates at risk for NEC. The aim was to systematically review the literature to identify independent risk factors for NEC from the literature. Methods Medline, Cochrane, Embase, Pubmed and Google Scholar were searched systematically for cohort studies reporting prognostic factors for NEC in neonates using multivariable analysis. Studies were scored with the Quality In Prognosis Studies tool (QUIPS). Results From 5154 initial hits, 14 prognostic studies were included, with various designs. Study quality was rated high in three studies, moderate or low in the 11 others. Significant prognostic factors for NEC reported in at least two studies were: low birth weight, small for gestational age, low gestational age, assisted ventilation, premature rupture of membranes, black ethnicity, sepsis, outborn, hypotension (all increased risk), surfactant therapy (conflicting results) and cesarean section (lower risk). Meta-analysis was considered not feasible. Conclusion High quality studies on prognostic factors for NEC are rare. Several prognostic factors, that are not necessarily causal, are associated with NEC. High quality prognostic research is necessary to establish the predictive values of these factors. necrotizing enterocolitis intestinal perforation preterm neonatal intensive care unit risk factors prognosis Pediatrics Rob A. van de Graaf verfasserin aut Rogier C. J. de Jonge verfasserin aut Irwin K. M. Reiss verfasserin aut Marijn J. Vermeulen verfasserin aut In BMC Pediatrics BMC, 2003 17(2017), 1, Seite 9 (DE-627)326643621 (DE-600)2041342-7 14712431 nnns volume:17 year:2017 number:1 pages:9 https://doi.org/10.1186/s12887-017-0847-3 kostenfrei https://doaj.org/article/782f053e3e064b18a0be1e503d580d64 kostenfrei http://link.springer.com/article/10.1186/s12887-017-0847-3 kostenfrei https://doaj.org/toc/1471-2431 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2017 1 9
language	English
source	In BMC Pediatrics 17(2017), 1, Seite 9 volume:17 year:2017 number:1 pages:9
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topic_facet	necrotizing enterocolitis intestinal perforation preterm neonatal intensive care unit risk factors prognosis Pediatrics
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authorswithroles_txt_mv	Noor Samuels @@aut@@ Rob A. van de Graaf @@aut@@ Rogier C. J. de Jonge @@aut@@ Irwin K. M. Reiss @@aut@@ Marijn J. Vermeulen @@aut@@
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Significant prognostic factors for NEC reported in at least two studies were: low birth weight, small for gestational age, low gestational age, assisted ventilation, premature rupture of membranes, black ethnicity, sepsis, outborn, hypotension (all increased risk), surfactant therapy (conflicting results) and cesarean section (lower risk). Meta-analysis was considered not feasible. Conclusion High quality studies on prognostic factors for NEC are rare. Several prognostic factors, that are not necessarily causal, are associated with NEC. 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callnumber-first	R - Medicine
author	Noor Samuels
spellingShingle	Noor Samuels misc RJ1-570 misc necrotizing enterocolitis misc intestinal perforation misc preterm misc neonatal intensive care unit misc risk factors misc prognosis misc Pediatrics Risk factors for necrotizing enterocolitis in neonates: a systematic review of prognostic studies
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topic_title	RJ1-570 Risk factors for necrotizing enterocolitis in neonates: a systematic review of prognostic studies necrotizing enterocolitis intestinal perforation preterm neonatal intensive care unit risk factors prognosis
topic	misc RJ1-570 misc necrotizing enterocolitis misc intestinal perforation misc preterm misc neonatal intensive care unit misc risk factors misc prognosis misc Pediatrics
topic_unstemmed	misc RJ1-570 misc necrotizing enterocolitis misc intestinal perforation misc preterm misc neonatal intensive care unit misc risk factors misc prognosis misc Pediatrics
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title	Risk factors for necrotizing enterocolitis in neonates: a systematic review of prognostic studies
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title_full	Risk factors for necrotizing enterocolitis in neonates: a systematic review of prognostic studies
author_sort	Noor Samuels
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author_browse	Noor Samuels Rob A. van de Graaf Rogier C. J. de Jonge Irwin K. M. Reiss Marijn J. Vermeulen
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title_sort	risk factors for necrotizing enterocolitis in neonates: a systematic review of prognostic studies
callnumber	RJ1-570
title_auth	Risk factors for necrotizing enterocolitis in neonates: a systematic review of prognostic studies
abstract	Abstract Background Necrotizing enterocolitis (NEC) is a severe multifactorial disease in preterm neonates associated with high morbidity and mortality. Better insight into prognostic values of the many reported factors associated with NEC is needed to enable identification of neonates at risk for NEC. The aim was to systematically review the literature to identify independent risk factors for NEC from the literature. Methods Medline, Cochrane, Embase, Pubmed and Google Scholar were searched systematically for cohort studies reporting prognostic factors for NEC in neonates using multivariable analysis. Studies were scored with the Quality In Prognosis Studies tool (QUIPS). Results From 5154 initial hits, 14 prognostic studies were included, with various designs. Study quality was rated high in three studies, moderate or low in the 11 others. Significant prognostic factors for NEC reported in at least two studies were: low birth weight, small for gestational age, low gestational age, assisted ventilation, premature rupture of membranes, black ethnicity, sepsis, outborn, hypotension (all increased risk), surfactant therapy (conflicting results) and cesarean section (lower risk). Meta-analysis was considered not feasible. Conclusion High quality studies on prognostic factors for NEC are rare. Several prognostic factors, that are not necessarily causal, are associated with NEC. High quality prognostic research is necessary to establish the predictive values of these factors.
abstractGer	Abstract Background Necrotizing enterocolitis (NEC) is a severe multifactorial disease in preterm neonates associated with high morbidity and mortality. Better insight into prognostic values of the many reported factors associated with NEC is needed to enable identification of neonates at risk for NEC. The aim was to systematically review the literature to identify independent risk factors for NEC from the literature. Methods Medline, Cochrane, Embase, Pubmed and Google Scholar were searched systematically for cohort studies reporting prognostic factors for NEC in neonates using multivariable analysis. Studies were scored with the Quality In Prognosis Studies tool (QUIPS). Results From 5154 initial hits, 14 prognostic studies were included, with various designs. Study quality was rated high in three studies, moderate or low in the 11 others. Significant prognostic factors for NEC reported in at least two studies were: low birth weight, small for gestational age, low gestational age, assisted ventilation, premature rupture of membranes, black ethnicity, sepsis, outborn, hypotension (all increased risk), surfactant therapy (conflicting results) and cesarean section (lower risk). Meta-analysis was considered not feasible. Conclusion High quality studies on prognostic factors for NEC are rare. Several prognostic factors, that are not necessarily causal, are associated with NEC. High quality prognostic research is necessary to establish the predictive values of these factors.
abstract_unstemmed	Abstract Background Necrotizing enterocolitis (NEC) is a severe multifactorial disease in preterm neonates associated with high morbidity and mortality. Better insight into prognostic values of the many reported factors associated with NEC is needed to enable identification of neonates at risk for NEC. The aim was to systematically review the literature to identify independent risk factors for NEC from the literature. Methods Medline, Cochrane, Embase, Pubmed and Google Scholar were searched systematically for cohort studies reporting prognostic factors for NEC in neonates using multivariable analysis. Studies were scored with the Quality In Prognosis Studies tool (QUIPS). Results From 5154 initial hits, 14 prognostic studies were included, with various designs. Study quality was rated high in three studies, moderate or low in the 11 others. Significant prognostic factors for NEC reported in at least two studies were: low birth weight, small for gestational age, low gestational age, assisted ventilation, premature rupture of membranes, black ethnicity, sepsis, outborn, hypotension (all increased risk), surfactant therapy (conflicting results) and cesarean section (lower risk). Meta-analysis was considered not feasible. Conclusion High quality studies on prognostic factors for NEC are rare. Several prognostic factors, that are not necessarily causal, are associated with NEC. High quality prognostic research is necessary to establish the predictive values of these factors.
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title_short	Risk factors for necrotizing enterocolitis in neonates: a systematic review of prognostic studies
url	https://doi.org/10.1186/s12887-017-0847-3 https://doaj.org/article/782f053e3e064b18a0be1e503d580d64 http://link.springer.com/article/10.1186/s12887-017-0847-3 https://doaj.org/toc/1471-2431
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author2	Rob A. van de Graaf Rogier C. J. de Jonge Irwin K. M. Reiss Marijn J. Vermeulen
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up_date	2024-07-03T13:59:06.569Z
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Risk factors for necrotizing enterocolitis in neonates: a systematic review of prognostic studies

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