Isolation and Identification of <i<Lactobacillus plantarum</i< HFY05 from Natural Fermented Yak Yogurt and Its Effect on Alcoholic Liver Injury in Mice
Yak yogurt is a type of naturally fermented dairy product prepared by herdsmen in the Qinghai-Tibet Plateau, which is rich in microorganisms. In this study, a strain of <i<Lactobacillus plantarum</i< was isolated and identified from yak yogurt in Hongyuan, Sichuan Province and named <...
Ausführliche Beschreibung
Autor*in: |
Ruokun Yi [verfasserIn] Fang Tan [verfasserIn] Wei Liao [verfasserIn] Qiang Wang [verfasserIn] Jianfei Mu [verfasserIn] Xianrong Zhou [verfasserIn] Zhennai Yang [verfasserIn] Xin Zhao [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2019 |
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Übergeordnetes Werk: |
In: Microorganisms - MDPI AG, 2013, 7(2019), 11, p 530 |
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Übergeordnetes Werk: |
volume:7 ; year:2019 ; number:11, p 530 |
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DOI / URN: |
10.3390/microorganisms7110530 |
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Katalog-ID: |
DOAJ040358836 |
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520 | |a Yak yogurt is a type of naturally fermented dairy product prepared by herdsmen in the Qinghai-Tibet Plateau, which is rich in microorganisms. In this study, a strain of <i<Lactobacillus plantarum</i< was isolated and identified from yak yogurt in Hongyuan, Sichuan Province and named <i<Lactobacillus plantarum</i< HFY05 (LP-HFY05). LP-HFY05 was compared with a common commercial strain of <i<Lactobacillus delbrueckii subsp</i<. <i<bulgaricus</i< (LDSB). LP-HFY05 showed better anti-artificial gastric acid and bile salt effects than LDSB in in vitro experiments, indicating its potential as a probiotic. In animal experiments, long-term alcohol gavage induced alcoholic liver injury. LP-HFY05 effectively reduced the liver index of mice with liver injury, downregulated the levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, triglyceride, total cholesterol, blood urea nitrogen, nitric oxide, and MDA and upregulated the levels of albumin, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase in the serum of liver-injured mice. LP-HFY05 also reduced the levels of interleukin (IL)-6, IL-12, tumor necrosis factor-alpha, and interferon-gamma in the serum of liver-injured mice. The pathological observations showed that LP-HFY05 reduced the damage to liver cells caused by alcohol. Quantitative polymerase chain reaction and Western blot assays further showed that LP-HFY05 upregulated neuronal nitric oxide synthase, endothelial nitric oxide synthase, manganese-SOD, cuprozinc-SOD, CAT, and inhibitor of κB-α mRNA and protein expression and downregulated the expression of nuclear factor-κB-p65 and inducible nitric oxide synthase in the livers of liver-injured mice. A fecal analysis revealed that LP-HFY05 regulated the microbial content in the intestinal tract of mice with liver injury, increased the content of beneficial bacteria, including <i<Bacteroides</i<, <i<Bifidobacterium</i<, and <i<Lactobacillus</i< and reduced the content of harmful bacteria, including <i<Firmicutes</i<, <i<Actinobacteria</i<, <i<Proteobacteria</i<, and <i<Enterobacteriaceae</i<, thus, regulating intestinal microorganisms to protect against liver injury. The effect of LP-HFY05 on liver-injured mice was better than that of LDSB, and the effect was similar to that of silymarin. LP-HFY05 is a high-quality microbial strain with a liver protective effect on experimental mice with alcoholic liver injury. | ||
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10.3390/microorganisms7110530 doi (DE-627)DOAJ040358836 (DE-599)DOAJ0b4d4e38bed342e7a7ffe3334f8d38ce DE-627 ger DE-627 rakwb eng QH301-705.5 Ruokun Yi verfasserin aut Isolation and Identification of <i<Lactobacillus plantarum</i< HFY05 from Natural Fermented Yak Yogurt and Its Effect on Alcoholic Liver Injury in Mice 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Yak yogurt is a type of naturally fermented dairy product prepared by herdsmen in the Qinghai-Tibet Plateau, which is rich in microorganisms. In this study, a strain of <i<Lactobacillus plantarum</i< was isolated and identified from yak yogurt in Hongyuan, Sichuan Province and named <i<Lactobacillus plantarum</i< HFY05 (LP-HFY05). LP-HFY05 was compared with a common commercial strain of <i<Lactobacillus delbrueckii subsp</i<. <i<bulgaricus</i< (LDSB). LP-HFY05 showed better anti-artificial gastric acid and bile salt effects than LDSB in in vitro experiments, indicating its potential as a probiotic. In animal experiments, long-term alcohol gavage induced alcoholic liver injury. LP-HFY05 effectively reduced the liver index of mice with liver injury, downregulated the levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, triglyceride, total cholesterol, blood urea nitrogen, nitric oxide, and MDA and upregulated the levels of albumin, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase in the serum of liver-injured mice. LP-HFY05 also reduced the levels of interleukin (IL)-6, IL-12, tumor necrosis factor-alpha, and interferon-gamma in the serum of liver-injured mice. The pathological observations showed that LP-HFY05 reduced the damage to liver cells caused by alcohol. Quantitative polymerase chain reaction and Western blot assays further showed that LP-HFY05 upregulated neuronal nitric oxide synthase, endothelial nitric oxide synthase, manganese-SOD, cuprozinc-SOD, CAT, and inhibitor of κB-α mRNA and protein expression and downregulated the expression of nuclear factor-κB-p65 and inducible nitric oxide synthase in the livers of liver-injured mice. A fecal analysis revealed that LP-HFY05 regulated the microbial content in the intestinal tract of mice with liver injury, increased the content of beneficial bacteria, including <i<Bacteroides</i<, <i<Bifidobacterium</i<, and <i<Lactobacillus</i< and reduced the content of harmful bacteria, including <i<Firmicutes</i<, <i<Actinobacteria</i<, <i<Proteobacteria</i<, and <i<Enterobacteriaceae</i<, thus, regulating intestinal microorganisms to protect against liver injury. The effect of LP-HFY05 on liver-injured mice was better than that of LDSB, and the effect was similar to that of silymarin. LP-HFY05 is a high-quality microbial strain with a liver protective effect on experimental mice with alcoholic liver injury. <i<lactobacillus plantarum</i< hfy05 yak yogurt alcoholic liver injury mice expression Biology (General) Fang Tan verfasserin aut Wei Liao verfasserin aut Qiang Wang verfasserin aut Jianfei Mu verfasserin aut Xianrong Zhou verfasserin aut Zhennai Yang verfasserin aut Xin Zhao verfasserin aut In Microorganisms MDPI AG, 2013 7(2019), 11, p 530 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:7 year:2019 number:11, p 530 https://doi.org/10.3390/microorganisms7110530 kostenfrei https://doaj.org/article/0b4d4e38bed342e7a7ffe3334f8d38ce kostenfrei https://www.mdpi.com/2076-2607/7/11/530 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2019 11, p 530 |
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10.3390/microorganisms7110530 doi (DE-627)DOAJ040358836 (DE-599)DOAJ0b4d4e38bed342e7a7ffe3334f8d38ce DE-627 ger DE-627 rakwb eng QH301-705.5 Ruokun Yi verfasserin aut Isolation and Identification of <i<Lactobacillus plantarum</i< HFY05 from Natural Fermented Yak Yogurt and Its Effect on Alcoholic Liver Injury in Mice 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Yak yogurt is a type of naturally fermented dairy product prepared by herdsmen in the Qinghai-Tibet Plateau, which is rich in microorganisms. In this study, a strain of <i<Lactobacillus plantarum</i< was isolated and identified from yak yogurt in Hongyuan, Sichuan Province and named <i<Lactobacillus plantarum</i< HFY05 (LP-HFY05). LP-HFY05 was compared with a common commercial strain of <i<Lactobacillus delbrueckii subsp</i<. <i<bulgaricus</i< (LDSB). LP-HFY05 showed better anti-artificial gastric acid and bile salt effects than LDSB in in vitro experiments, indicating its potential as a probiotic. In animal experiments, long-term alcohol gavage induced alcoholic liver injury. LP-HFY05 effectively reduced the liver index of mice with liver injury, downregulated the levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, triglyceride, total cholesterol, blood urea nitrogen, nitric oxide, and MDA and upregulated the levels of albumin, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase in the serum of liver-injured mice. LP-HFY05 also reduced the levels of interleukin (IL)-6, IL-12, tumor necrosis factor-alpha, and interferon-gamma in the serum of liver-injured mice. The pathological observations showed that LP-HFY05 reduced the damage to liver cells caused by alcohol. Quantitative polymerase chain reaction and Western blot assays further showed that LP-HFY05 upregulated neuronal nitric oxide synthase, endothelial nitric oxide synthase, manganese-SOD, cuprozinc-SOD, CAT, and inhibitor of κB-α mRNA and protein expression and downregulated the expression of nuclear factor-κB-p65 and inducible nitric oxide synthase in the livers of liver-injured mice. A fecal analysis revealed that LP-HFY05 regulated the microbial content in the intestinal tract of mice with liver injury, increased the content of beneficial bacteria, including <i<Bacteroides</i<, <i<Bifidobacterium</i<, and <i<Lactobacillus</i< and reduced the content of harmful bacteria, including <i<Firmicutes</i<, <i<Actinobacteria</i<, <i<Proteobacteria</i<, and <i<Enterobacteriaceae</i<, thus, regulating intestinal microorganisms to protect against liver injury. The effect of LP-HFY05 on liver-injured mice was better than that of LDSB, and the effect was similar to that of silymarin. LP-HFY05 is a high-quality microbial strain with a liver protective effect on experimental mice with alcoholic liver injury. <i<lactobacillus plantarum</i< hfy05 yak yogurt alcoholic liver injury mice expression Biology (General) Fang Tan verfasserin aut Wei Liao verfasserin aut Qiang Wang verfasserin aut Jianfei Mu verfasserin aut Xianrong Zhou verfasserin aut Zhennai Yang verfasserin aut Xin Zhao verfasserin aut In Microorganisms MDPI AG, 2013 7(2019), 11, p 530 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:7 year:2019 number:11, p 530 https://doi.org/10.3390/microorganisms7110530 kostenfrei https://doaj.org/article/0b4d4e38bed342e7a7ffe3334f8d38ce kostenfrei https://www.mdpi.com/2076-2607/7/11/530 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2019 11, p 530 |
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10.3390/microorganisms7110530 doi (DE-627)DOAJ040358836 (DE-599)DOAJ0b4d4e38bed342e7a7ffe3334f8d38ce DE-627 ger DE-627 rakwb eng QH301-705.5 Ruokun Yi verfasserin aut Isolation and Identification of <i<Lactobacillus plantarum</i< HFY05 from Natural Fermented Yak Yogurt and Its Effect on Alcoholic Liver Injury in Mice 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Yak yogurt is a type of naturally fermented dairy product prepared by herdsmen in the Qinghai-Tibet Plateau, which is rich in microorganisms. In this study, a strain of <i<Lactobacillus plantarum</i< was isolated and identified from yak yogurt in Hongyuan, Sichuan Province and named <i<Lactobacillus plantarum</i< HFY05 (LP-HFY05). LP-HFY05 was compared with a common commercial strain of <i<Lactobacillus delbrueckii subsp</i<. <i<bulgaricus</i< (LDSB). LP-HFY05 showed better anti-artificial gastric acid and bile salt effects than LDSB in in vitro experiments, indicating its potential as a probiotic. In animal experiments, long-term alcohol gavage induced alcoholic liver injury. LP-HFY05 effectively reduced the liver index of mice with liver injury, downregulated the levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, triglyceride, total cholesterol, blood urea nitrogen, nitric oxide, and MDA and upregulated the levels of albumin, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase in the serum of liver-injured mice. LP-HFY05 also reduced the levels of interleukin (IL)-6, IL-12, tumor necrosis factor-alpha, and interferon-gamma in the serum of liver-injured mice. The pathological observations showed that LP-HFY05 reduced the damage to liver cells caused by alcohol. Quantitative polymerase chain reaction and Western blot assays further showed that LP-HFY05 upregulated neuronal nitric oxide synthase, endothelial nitric oxide synthase, manganese-SOD, cuprozinc-SOD, CAT, and inhibitor of κB-α mRNA and protein expression and downregulated the expression of nuclear factor-κB-p65 and inducible nitric oxide synthase in the livers of liver-injured mice. A fecal analysis revealed that LP-HFY05 regulated the microbial content in the intestinal tract of mice with liver injury, increased the content of beneficial bacteria, including <i<Bacteroides</i<, <i<Bifidobacterium</i<, and <i<Lactobacillus</i< and reduced the content of harmful bacteria, including <i<Firmicutes</i<, <i<Actinobacteria</i<, <i<Proteobacteria</i<, and <i<Enterobacteriaceae</i<, thus, regulating intestinal microorganisms to protect against liver injury. The effect of LP-HFY05 on liver-injured mice was better than that of LDSB, and the effect was similar to that of silymarin. LP-HFY05 is a high-quality microbial strain with a liver protective effect on experimental mice with alcoholic liver injury. <i<lactobacillus plantarum</i< hfy05 yak yogurt alcoholic liver injury mice expression Biology (General) Fang Tan verfasserin aut Wei Liao verfasserin aut Qiang Wang verfasserin aut Jianfei Mu verfasserin aut Xianrong Zhou verfasserin aut Zhennai Yang verfasserin aut Xin Zhao verfasserin aut In Microorganisms MDPI AG, 2013 7(2019), 11, p 530 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:7 year:2019 number:11, p 530 https://doi.org/10.3390/microorganisms7110530 kostenfrei https://doaj.org/article/0b4d4e38bed342e7a7ffe3334f8d38ce kostenfrei https://www.mdpi.com/2076-2607/7/11/530 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2019 11, p 530 |
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10.3390/microorganisms7110530 doi (DE-627)DOAJ040358836 (DE-599)DOAJ0b4d4e38bed342e7a7ffe3334f8d38ce DE-627 ger DE-627 rakwb eng QH301-705.5 Ruokun Yi verfasserin aut Isolation and Identification of <i<Lactobacillus plantarum</i< HFY05 from Natural Fermented Yak Yogurt and Its Effect on Alcoholic Liver Injury in Mice 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Yak yogurt is a type of naturally fermented dairy product prepared by herdsmen in the Qinghai-Tibet Plateau, which is rich in microorganisms. In this study, a strain of <i<Lactobacillus plantarum</i< was isolated and identified from yak yogurt in Hongyuan, Sichuan Province and named <i<Lactobacillus plantarum</i< HFY05 (LP-HFY05). LP-HFY05 was compared with a common commercial strain of <i<Lactobacillus delbrueckii subsp</i<. <i<bulgaricus</i< (LDSB). LP-HFY05 showed better anti-artificial gastric acid and bile salt effects than LDSB in in vitro experiments, indicating its potential as a probiotic. In animal experiments, long-term alcohol gavage induced alcoholic liver injury. LP-HFY05 effectively reduced the liver index of mice with liver injury, downregulated the levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, triglyceride, total cholesterol, blood urea nitrogen, nitric oxide, and MDA and upregulated the levels of albumin, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase in the serum of liver-injured mice. LP-HFY05 also reduced the levels of interleukin (IL)-6, IL-12, tumor necrosis factor-alpha, and interferon-gamma in the serum of liver-injured mice. The pathological observations showed that LP-HFY05 reduced the damage to liver cells caused by alcohol. Quantitative polymerase chain reaction and Western blot assays further showed that LP-HFY05 upregulated neuronal nitric oxide synthase, endothelial nitric oxide synthase, manganese-SOD, cuprozinc-SOD, CAT, and inhibitor of κB-α mRNA and protein expression and downregulated the expression of nuclear factor-κB-p65 and inducible nitric oxide synthase in the livers of liver-injured mice. A fecal analysis revealed that LP-HFY05 regulated the microbial content in the intestinal tract of mice with liver injury, increased the content of beneficial bacteria, including <i<Bacteroides</i<, <i<Bifidobacterium</i<, and <i<Lactobacillus</i< and reduced the content of harmful bacteria, including <i<Firmicutes</i<, <i<Actinobacteria</i<, <i<Proteobacteria</i<, and <i<Enterobacteriaceae</i<, thus, regulating intestinal microorganisms to protect against liver injury. The effect of LP-HFY05 on liver-injured mice was better than that of LDSB, and the effect was similar to that of silymarin. LP-HFY05 is a high-quality microbial strain with a liver protective effect on experimental mice with alcoholic liver injury. <i<lactobacillus plantarum</i< hfy05 yak yogurt alcoholic liver injury mice expression Biology (General) Fang Tan verfasserin aut Wei Liao verfasserin aut Qiang Wang verfasserin aut Jianfei Mu verfasserin aut Xianrong Zhou verfasserin aut Zhennai Yang verfasserin aut Xin Zhao verfasserin aut In Microorganisms MDPI AG, 2013 7(2019), 11, p 530 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:7 year:2019 number:11, p 530 https://doi.org/10.3390/microorganisms7110530 kostenfrei https://doaj.org/article/0b4d4e38bed342e7a7ffe3334f8d38ce kostenfrei https://www.mdpi.com/2076-2607/7/11/530 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2019 11, p 530 |
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Isolation and Identification of <i<Lactobacillus plantarum</i< HFY05 from Natural Fermented Yak Yogurt and Its Effect on Alcoholic Liver Injury in Mice |
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Yak yogurt is a type of naturally fermented dairy product prepared by herdsmen in the Qinghai-Tibet Plateau, which is rich in microorganisms. In this study, a strain of <i<Lactobacillus plantarum</i< was isolated and identified from yak yogurt in Hongyuan, Sichuan Province and named <i<Lactobacillus plantarum</i< HFY05 (LP-HFY05). LP-HFY05 was compared with a common commercial strain of <i<Lactobacillus delbrueckii subsp</i<. <i<bulgaricus</i< (LDSB). LP-HFY05 showed better anti-artificial gastric acid and bile salt effects than LDSB in in vitro experiments, indicating its potential as a probiotic. In animal experiments, long-term alcohol gavage induced alcoholic liver injury. LP-HFY05 effectively reduced the liver index of mice with liver injury, downregulated the levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, triglyceride, total cholesterol, blood urea nitrogen, nitric oxide, and MDA and upregulated the levels of albumin, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase in the serum of liver-injured mice. LP-HFY05 also reduced the levels of interleukin (IL)-6, IL-12, tumor necrosis factor-alpha, and interferon-gamma in the serum of liver-injured mice. The pathological observations showed that LP-HFY05 reduced the damage to liver cells caused by alcohol. Quantitative polymerase chain reaction and Western blot assays further showed that LP-HFY05 upregulated neuronal nitric oxide synthase, endothelial nitric oxide synthase, manganese-SOD, cuprozinc-SOD, CAT, and inhibitor of κB-α mRNA and protein expression and downregulated the expression of nuclear factor-κB-p65 and inducible nitric oxide synthase in the livers of liver-injured mice. A fecal analysis revealed that LP-HFY05 regulated the microbial content in the intestinal tract of mice with liver injury, increased the content of beneficial bacteria, including <i<Bacteroides</i<, <i<Bifidobacterium</i<, and <i<Lactobacillus</i< and reduced the content of harmful bacteria, including <i<Firmicutes</i<, <i<Actinobacteria</i<, <i<Proteobacteria</i<, and <i<Enterobacteriaceae</i<, thus, regulating intestinal microorganisms to protect against liver injury. The effect of LP-HFY05 on liver-injured mice was better than that of LDSB, and the effect was similar to that of silymarin. LP-HFY05 is a high-quality microbial strain with a liver protective effect on experimental mice with alcoholic liver injury. |
abstractGer |
Yak yogurt is a type of naturally fermented dairy product prepared by herdsmen in the Qinghai-Tibet Plateau, which is rich in microorganisms. In this study, a strain of <i<Lactobacillus plantarum</i< was isolated and identified from yak yogurt in Hongyuan, Sichuan Province and named <i<Lactobacillus plantarum</i< HFY05 (LP-HFY05). LP-HFY05 was compared with a common commercial strain of <i<Lactobacillus delbrueckii subsp</i<. <i<bulgaricus</i< (LDSB). LP-HFY05 showed better anti-artificial gastric acid and bile salt effects than LDSB in in vitro experiments, indicating its potential as a probiotic. In animal experiments, long-term alcohol gavage induced alcoholic liver injury. LP-HFY05 effectively reduced the liver index of mice with liver injury, downregulated the levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, triglyceride, total cholesterol, blood urea nitrogen, nitric oxide, and MDA and upregulated the levels of albumin, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase in the serum of liver-injured mice. LP-HFY05 also reduced the levels of interleukin (IL)-6, IL-12, tumor necrosis factor-alpha, and interferon-gamma in the serum of liver-injured mice. The pathological observations showed that LP-HFY05 reduced the damage to liver cells caused by alcohol. Quantitative polymerase chain reaction and Western blot assays further showed that LP-HFY05 upregulated neuronal nitric oxide synthase, endothelial nitric oxide synthase, manganese-SOD, cuprozinc-SOD, CAT, and inhibitor of κB-α mRNA and protein expression and downregulated the expression of nuclear factor-κB-p65 and inducible nitric oxide synthase in the livers of liver-injured mice. A fecal analysis revealed that LP-HFY05 regulated the microbial content in the intestinal tract of mice with liver injury, increased the content of beneficial bacteria, including <i<Bacteroides</i<, <i<Bifidobacterium</i<, and <i<Lactobacillus</i< and reduced the content of harmful bacteria, including <i<Firmicutes</i<, <i<Actinobacteria</i<, <i<Proteobacteria</i<, and <i<Enterobacteriaceae</i<, thus, regulating intestinal microorganisms to protect against liver injury. The effect of LP-HFY05 on liver-injured mice was better than that of LDSB, and the effect was similar to that of silymarin. LP-HFY05 is a high-quality microbial strain with a liver protective effect on experimental mice with alcoholic liver injury. |
abstract_unstemmed |
Yak yogurt is a type of naturally fermented dairy product prepared by herdsmen in the Qinghai-Tibet Plateau, which is rich in microorganisms. In this study, a strain of <i<Lactobacillus plantarum</i< was isolated and identified from yak yogurt in Hongyuan, Sichuan Province and named <i<Lactobacillus plantarum</i< HFY05 (LP-HFY05). LP-HFY05 was compared with a common commercial strain of <i<Lactobacillus delbrueckii subsp</i<. <i<bulgaricus</i< (LDSB). LP-HFY05 showed better anti-artificial gastric acid and bile salt effects than LDSB in in vitro experiments, indicating its potential as a probiotic. In animal experiments, long-term alcohol gavage induced alcoholic liver injury. LP-HFY05 effectively reduced the liver index of mice with liver injury, downregulated the levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, triglyceride, total cholesterol, blood urea nitrogen, nitric oxide, and MDA and upregulated the levels of albumin, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase in the serum of liver-injured mice. LP-HFY05 also reduced the levels of interleukin (IL)-6, IL-12, tumor necrosis factor-alpha, and interferon-gamma in the serum of liver-injured mice. The pathological observations showed that LP-HFY05 reduced the damage to liver cells caused by alcohol. Quantitative polymerase chain reaction and Western blot assays further showed that LP-HFY05 upregulated neuronal nitric oxide synthase, endothelial nitric oxide synthase, manganese-SOD, cuprozinc-SOD, CAT, and inhibitor of κB-α mRNA and protein expression and downregulated the expression of nuclear factor-κB-p65 and inducible nitric oxide synthase in the livers of liver-injured mice. A fecal analysis revealed that LP-HFY05 regulated the microbial content in the intestinal tract of mice with liver injury, increased the content of beneficial bacteria, including <i<Bacteroides</i<, <i<Bifidobacterium</i<, and <i<Lactobacillus</i< and reduced the content of harmful bacteria, including <i<Firmicutes</i<, <i<Actinobacteria</i<, <i<Proteobacteria</i<, and <i<Enterobacteriaceae</i<, thus, regulating intestinal microorganisms to protect against liver injury. The effect of LP-HFY05 on liver-injured mice was better than that of LDSB, and the effect was similar to that of silymarin. LP-HFY05 is a high-quality microbial strain with a liver protective effect on experimental mice with alcoholic liver injury. |
collection_details |
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container_issue |
11, p 530 |
title_short |
Isolation and Identification of <i<Lactobacillus plantarum</i< HFY05 from Natural Fermented Yak Yogurt and Its Effect on Alcoholic Liver Injury in Mice |
url |
https://doi.org/10.3390/microorganisms7110530 https://doaj.org/article/0b4d4e38bed342e7a7ffe3334f8d38ce https://www.mdpi.com/2076-2607/7/11/530 https://doaj.org/toc/2076-2607 |
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Fang Tan Wei Liao Qiang Wang Jianfei Mu Xianrong Zhou Zhennai Yang Xin Zhao |
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up_date |
2024-07-03T14:24:35.975Z |
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