UP1306: A Composition Containing Standardized Extracts of <em<Acacia catechu</em< and <em<Morus alba</em< for Arthritis Management

Osteoarthritis (OA) is characterized by progressive articular cartilage degradation. Although there have been significant advances in OA management, to date, there are no effective treatment options to modify progression of the disease. We believe these unmet needs could be bridged by nutrients from...
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Gespeichert in:

Autor*in:	Mesfin Yimam [verfasserIn] Teresa Horm [verfasserIn] Laura Wright [verfasserIn] Ping Jiao [verfasserIn] Mei Hong [verfasserIn] Lidia Brownell [verfasserIn] Qi Jia [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	collagen induced arthritis UP1306

Übergeordnetes Werk:	In: Nutrients - MDPI AG, 2009, 11(2019), 2, p 272
Übergeordnetes Werk:	volume:11 ; year:2019 ; number:2, p 272

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/nu11020272

Katalog-ID:	DOAJ040572145

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allfields	10.3390/nu11020272 doi (DE-627)DOAJ040572145 (DE-599)DOAJ8e5028aa477c41c5afbd3b18c0b37f6b DE-627 ger DE-627 rakwb eng TX341-641 Mesfin Yimam verfasserin aut UP1306: A Composition Containing Standardized Extracts of <em<Acacia catechu</em< and <em<Morus alba</em< for Arthritis Management 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Osteoarthritis (OA) is characterized by progressive articular cartilage degradation. Although there have been significant advances in OA management, to date, there are no effective treatment options to modify progression of the disease. We believe these unmet needs could be bridged by nutrients from natural products. Collagen induced arthritis in rats was developed and utilized to evaluate anti-inflammatory and cartilage protection activity of orally administered botanical composition, UP1306 (50 mg/kg) and Methotrexate (75 µg/kg) daily for three weeks. Objective arthritis severity markers, urine, synovial lavage, and serum were collected. At necropsy, the hock joint from each rat was collected for histopathology analysis. Urinary cartilage degradation marker (CTX-II), pro-inflammatory cytokines (tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and IL-6), and proteases (Matrix Metallopeptidase 3 (MMP3) and 13) were measured. Rats treated with UP1306 showed statistically significant improvements in arthritis severity markers, including uCTX-II (91.4% vs. collagen-induced arthritis (CIA)), serum IL-1β, TNF-α, and IL-6 levels as well as synovial MMP-13. The histopathology data were also well aligned with the severity score of arthritis for both UP1306 and Methotrexate. UP1306, a botanical composition that contains a standardized blend of extracts from the heartwood of <i<Acacia catechu</i< and the root bark of <i<Morus alba</i<, could potentially be considered as a dietary supplement product for the management of arthritis. collagen induced arthritis <i<Acacia catechu</i< <i<Morus alba</i< UP1306 Nutrition. Foods and food supply Teresa Horm verfasserin aut Laura Wright verfasserin aut Ping Jiao verfasserin aut Mei Hong verfasserin aut Lidia Brownell verfasserin aut Qi Jia verfasserin aut In Nutrients MDPI AG, 2009 11(2019), 2, p 272 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:11 year:2019 number:2, p 272 https://doi.org/10.3390/nu11020272 kostenfrei https://doaj.org/article/8e5028aa477c41c5afbd3b18c0b37f6b kostenfrei https://www.mdpi.com/2072-6643/11/2/272 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2019 2, p 272
spelling	10.3390/nu11020272 doi (DE-627)DOAJ040572145 (DE-599)DOAJ8e5028aa477c41c5afbd3b18c0b37f6b DE-627 ger DE-627 rakwb eng TX341-641 Mesfin Yimam verfasserin aut UP1306: A Composition Containing Standardized Extracts of <em<Acacia catechu</em< and <em<Morus alba</em< for Arthritis Management 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Osteoarthritis (OA) is characterized by progressive articular cartilage degradation. Although there have been significant advances in OA management, to date, there are no effective treatment options to modify progression of the disease. We believe these unmet needs could be bridged by nutrients from natural products. Collagen induced arthritis in rats was developed and utilized to evaluate anti-inflammatory and cartilage protection activity of orally administered botanical composition, UP1306 (50 mg/kg) and Methotrexate (75 µg/kg) daily for three weeks. Objective arthritis severity markers, urine, synovial lavage, and serum were collected. At necropsy, the hock joint from each rat was collected for histopathology analysis. Urinary cartilage degradation marker (CTX-II), pro-inflammatory cytokines (tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and IL-6), and proteases (Matrix Metallopeptidase 3 (MMP3) and 13) were measured. Rats treated with UP1306 showed statistically significant improvements in arthritis severity markers, including uCTX-II (91.4% vs. collagen-induced arthritis (CIA)), serum IL-1β, TNF-α, and IL-6 levels as well as synovial MMP-13. The histopathology data were also well aligned with the severity score of arthritis for both UP1306 and Methotrexate. UP1306, a botanical composition that contains a standardized blend of extracts from the heartwood of <i<Acacia catechu</i< and the root bark of <i<Morus alba</i<, could potentially be considered as a dietary supplement product for the management of arthritis. collagen induced arthritis <i<Acacia catechu</i< <i<Morus alba</i< UP1306 Nutrition. Foods and food supply Teresa Horm verfasserin aut Laura Wright verfasserin aut Ping Jiao verfasserin aut Mei Hong verfasserin aut Lidia Brownell verfasserin aut Qi Jia verfasserin aut In Nutrients MDPI AG, 2009 11(2019), 2, p 272 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:11 year:2019 number:2, p 272 https://doi.org/10.3390/nu11020272 kostenfrei https://doaj.org/article/8e5028aa477c41c5afbd3b18c0b37f6b kostenfrei https://www.mdpi.com/2072-6643/11/2/272 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2019 2, p 272
allfields_unstemmed	10.3390/nu11020272 doi (DE-627)DOAJ040572145 (DE-599)DOAJ8e5028aa477c41c5afbd3b18c0b37f6b DE-627 ger DE-627 rakwb eng TX341-641 Mesfin Yimam verfasserin aut UP1306: A Composition Containing Standardized Extracts of <em<Acacia catechu</em< and <em<Morus alba</em< for Arthritis Management 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Osteoarthritis (OA) is characterized by progressive articular cartilage degradation. Although there have been significant advances in OA management, to date, there are no effective treatment options to modify progression of the disease. We believe these unmet needs could be bridged by nutrients from natural products. Collagen induced arthritis in rats was developed and utilized to evaluate anti-inflammatory and cartilage protection activity of orally administered botanical composition, UP1306 (50 mg/kg) and Methotrexate (75 µg/kg) daily for three weeks. Objective arthritis severity markers, urine, synovial lavage, and serum were collected. At necropsy, the hock joint from each rat was collected for histopathology analysis. Urinary cartilage degradation marker (CTX-II), pro-inflammatory cytokines (tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and IL-6), and proteases (Matrix Metallopeptidase 3 (MMP3) and 13) were measured. Rats treated with UP1306 showed statistically significant improvements in arthritis severity markers, including uCTX-II (91.4% vs. collagen-induced arthritis (CIA)), serum IL-1β, TNF-α, and IL-6 levels as well as synovial MMP-13. The histopathology data were also well aligned with the severity score of arthritis for both UP1306 and Methotrexate. UP1306, a botanical composition that contains a standardized blend of extracts from the heartwood of <i<Acacia catechu</i< and the root bark of <i<Morus alba</i<, could potentially be considered as a dietary supplement product for the management of arthritis. collagen induced arthritis <i<Acacia catechu</i< <i<Morus alba</i< UP1306 Nutrition. Foods and food supply Teresa Horm verfasserin aut Laura Wright verfasserin aut Ping Jiao verfasserin aut Mei Hong verfasserin aut Lidia Brownell verfasserin aut Qi Jia verfasserin aut In Nutrients MDPI AG, 2009 11(2019), 2, p 272 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:11 year:2019 number:2, p 272 https://doi.org/10.3390/nu11020272 kostenfrei https://doaj.org/article/8e5028aa477c41c5afbd3b18c0b37f6b kostenfrei https://www.mdpi.com/2072-6643/11/2/272 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2019 2, p 272
allfieldsGer	10.3390/nu11020272 doi (DE-627)DOAJ040572145 (DE-599)DOAJ8e5028aa477c41c5afbd3b18c0b37f6b DE-627 ger DE-627 rakwb eng TX341-641 Mesfin Yimam verfasserin aut UP1306: A Composition Containing Standardized Extracts of <em<Acacia catechu</em< and <em<Morus alba</em< for Arthritis Management 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Osteoarthritis (OA) is characterized by progressive articular cartilage degradation. Although there have been significant advances in OA management, to date, there are no effective treatment options to modify progression of the disease. We believe these unmet needs could be bridged by nutrients from natural products. Collagen induced arthritis in rats was developed and utilized to evaluate anti-inflammatory and cartilage protection activity of orally administered botanical composition, UP1306 (50 mg/kg) and Methotrexate (75 µg/kg) daily for three weeks. Objective arthritis severity markers, urine, synovial lavage, and serum were collected. At necropsy, the hock joint from each rat was collected for histopathology analysis. Urinary cartilage degradation marker (CTX-II), pro-inflammatory cytokines (tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and IL-6), and proteases (Matrix Metallopeptidase 3 (MMP3) and 13) were measured. Rats treated with UP1306 showed statistically significant improvements in arthritis severity markers, including uCTX-II (91.4% vs. collagen-induced arthritis (CIA)), serum IL-1β, TNF-α, and IL-6 levels as well as synovial MMP-13. The histopathology data were also well aligned with the severity score of arthritis for both UP1306 and Methotrexate. UP1306, a botanical composition that contains a standardized blend of extracts from the heartwood of <i<Acacia catechu</i< and the root bark of <i<Morus alba</i<, could potentially be considered as a dietary supplement product for the management of arthritis. collagen induced arthritis <i<Acacia catechu</i< <i<Morus alba</i< UP1306 Nutrition. Foods and food supply Teresa Horm verfasserin aut Laura Wright verfasserin aut Ping Jiao verfasserin aut Mei Hong verfasserin aut Lidia Brownell verfasserin aut Qi Jia verfasserin aut In Nutrients MDPI AG, 2009 11(2019), 2, p 272 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:11 year:2019 number:2, p 272 https://doi.org/10.3390/nu11020272 kostenfrei https://doaj.org/article/8e5028aa477c41c5afbd3b18c0b37f6b kostenfrei https://www.mdpi.com/2072-6643/11/2/272 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2019 2, p 272
allfieldsSound	10.3390/nu11020272 doi (DE-627)DOAJ040572145 (DE-599)DOAJ8e5028aa477c41c5afbd3b18c0b37f6b DE-627 ger DE-627 rakwb eng TX341-641 Mesfin Yimam verfasserin aut UP1306: A Composition Containing Standardized Extracts of <em<Acacia catechu</em< and <em<Morus alba</em< for Arthritis Management 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Osteoarthritis (OA) is characterized by progressive articular cartilage degradation. Although there have been significant advances in OA management, to date, there are no effective treatment options to modify progression of the disease. We believe these unmet needs could be bridged by nutrients from natural products. Collagen induced arthritis in rats was developed and utilized to evaluate anti-inflammatory and cartilage protection activity of orally administered botanical composition, UP1306 (50 mg/kg) and Methotrexate (75 µg/kg) daily for three weeks. Objective arthritis severity markers, urine, synovial lavage, and serum were collected. At necropsy, the hock joint from each rat was collected for histopathology analysis. Urinary cartilage degradation marker (CTX-II), pro-inflammatory cytokines (tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and IL-6), and proteases (Matrix Metallopeptidase 3 (MMP3) and 13) were measured. Rats treated with UP1306 showed statistically significant improvements in arthritis severity markers, including uCTX-II (91.4% vs. collagen-induced arthritis (CIA)), serum IL-1β, TNF-α, and IL-6 levels as well as synovial MMP-13. The histopathology data were also well aligned with the severity score of arthritis for both UP1306 and Methotrexate. UP1306, a botanical composition that contains a standardized blend of extracts from the heartwood of <i<Acacia catechu</i< and the root bark of <i<Morus alba</i<, could potentially be considered as a dietary supplement product for the management of arthritis. collagen induced arthritis <i<Acacia catechu</i< <i<Morus alba</i< UP1306 Nutrition. Foods and food supply Teresa Horm verfasserin aut Laura Wright verfasserin aut Ping Jiao verfasserin aut Mei Hong verfasserin aut Lidia Brownell verfasserin aut Qi Jia verfasserin aut In Nutrients MDPI AG, 2009 11(2019), 2, p 272 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:11 year:2019 number:2, p 272 https://doi.org/10.3390/nu11020272 kostenfrei https://doaj.org/article/8e5028aa477c41c5afbd3b18c0b37f6b kostenfrei https://www.mdpi.com/2072-6643/11/2/272 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2019 2, p 272
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topic_title	TX341-641 UP1306: A Composition Containing Standardized Extracts of <em<Acacia catechu</em< and <em<Morus alba</em< for Arthritis Management collagen induced arthritis <i<Acacia catechu</i< <i<Morus alba</i< UP1306
topic	misc TX341-641 misc collagen induced arthritis misc <i<Acacia catechu</i< misc <i<Morus alba</i< misc UP1306 misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc collagen induced arthritis misc <i<Acacia catechu</i< misc <i<Morus alba</i< misc UP1306 misc Nutrition. Foods and food supply
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title	UP1306: A Composition Containing Standardized Extracts of <em<Acacia catechu</em< and <em<Morus alba</em< for Arthritis Management
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title_full	UP1306: A Composition Containing Standardized Extracts of <em<Acacia catechu</em< and <em<Morus alba</em< for Arthritis Management
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title_sort	up1306: a composition containing standardized extracts of <em<acacia catechu</em< and <em<morus alba</em< for arthritis management
callnumber	TX341-641
title_auth	UP1306: A Composition Containing Standardized Extracts of <em<Acacia catechu</em< and <em<Morus alba</em< for Arthritis Management
abstract	Osteoarthritis (OA) is characterized by progressive articular cartilage degradation. Although there have been significant advances in OA management, to date, there are no effective treatment options to modify progression of the disease. We believe these unmet needs could be bridged by nutrients from natural products. Collagen induced arthritis in rats was developed and utilized to evaluate anti-inflammatory and cartilage protection activity of orally administered botanical composition, UP1306 (50 mg/kg) and Methotrexate (75 µg/kg) daily for three weeks. Objective arthritis severity markers, urine, synovial lavage, and serum were collected. At necropsy, the hock joint from each rat was collected for histopathology analysis. Urinary cartilage degradation marker (CTX-II), pro-inflammatory cytokines (tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and IL-6), and proteases (Matrix Metallopeptidase 3 (MMP3) and 13) were measured. Rats treated with UP1306 showed statistically significant improvements in arthritis severity markers, including uCTX-II (91.4% vs. collagen-induced arthritis (CIA)), serum IL-1β, TNF-α, and IL-6 levels as well as synovial MMP-13. The histopathology data were also well aligned with the severity score of arthritis for both UP1306 and Methotrexate. UP1306, a botanical composition that contains a standardized blend of extracts from the heartwood of <i<Acacia catechu</i< and the root bark of <i<Morus alba</i<, could potentially be considered as a dietary supplement product for the management of arthritis.
abstractGer	Osteoarthritis (OA) is characterized by progressive articular cartilage degradation. Although there have been significant advances in OA management, to date, there are no effective treatment options to modify progression of the disease. We believe these unmet needs could be bridged by nutrients from natural products. Collagen induced arthritis in rats was developed and utilized to evaluate anti-inflammatory and cartilage protection activity of orally administered botanical composition, UP1306 (50 mg/kg) and Methotrexate (75 µg/kg) daily for three weeks. Objective arthritis severity markers, urine, synovial lavage, and serum were collected. At necropsy, the hock joint from each rat was collected for histopathology analysis. Urinary cartilage degradation marker (CTX-II), pro-inflammatory cytokines (tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and IL-6), and proteases (Matrix Metallopeptidase 3 (MMP3) and 13) were measured. Rats treated with UP1306 showed statistically significant improvements in arthritis severity markers, including uCTX-II (91.4% vs. collagen-induced arthritis (CIA)), serum IL-1β, TNF-α, and IL-6 levels as well as synovial MMP-13. The histopathology data were also well aligned with the severity score of arthritis for both UP1306 and Methotrexate. UP1306, a botanical composition that contains a standardized blend of extracts from the heartwood of <i<Acacia catechu</i< and the root bark of <i<Morus alba</i<, could potentially be considered as a dietary supplement product for the management of arthritis.
abstract_unstemmed	Osteoarthritis (OA) is characterized by progressive articular cartilage degradation. Although there have been significant advances in OA management, to date, there are no effective treatment options to modify progression of the disease. We believe these unmet needs could be bridged by nutrients from natural products. Collagen induced arthritis in rats was developed and utilized to evaluate anti-inflammatory and cartilage protection activity of orally administered botanical composition, UP1306 (50 mg/kg) and Methotrexate (75 µg/kg) daily for three weeks. Objective arthritis severity markers, urine, synovial lavage, and serum were collected. At necropsy, the hock joint from each rat was collected for histopathology analysis. Urinary cartilage degradation marker (CTX-II), pro-inflammatory cytokines (tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and IL-6), and proteases (Matrix Metallopeptidase 3 (MMP3) and 13) were measured. Rats treated with UP1306 showed statistically significant improvements in arthritis severity markers, including uCTX-II (91.4% vs. collagen-induced arthritis (CIA)), serum IL-1β, TNF-α, and IL-6 levels as well as synovial MMP-13. The histopathology data were also well aligned with the severity score of arthritis for both UP1306 and Methotrexate. UP1306, a botanical composition that contains a standardized blend of extracts from the heartwood of <i<Acacia catechu</i< and the root bark of <i<Morus alba</i<, could potentially be considered as a dietary supplement product for the management of arthritis.
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title_short	UP1306: A Composition Containing Standardized Extracts of <em<Acacia catechu</em< and <em<Morus alba</em< for Arthritis Management
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Rats treated with UP1306 showed statistically significant improvements in arthritis severity markers, including uCTX-II (91.4% vs. collagen-induced arthritis (CIA)), serum IL-1β, TNF-α, and IL-6 levels as well as synovial MMP-13. The histopathology data were also well aligned with the severity score of arthritis for both UP1306 and Methotrexate. 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UP1306: A Composition Containing Standardized Extracts of <em<Acacia catechu</em< and <em<Morus alba</em< for Arthritis Management

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