New insights to the functional role of the T cell-Antigen Presenting Cell immunological synapse

Three innovative and complementary morphological approaches were employed to study the T cell/antigen presenting cell (APC) interaction: (i) high resolution three-dimensional confocal microscopy of the T cell-APC contact site; (ii) time lapse video recording in living T cells of [Ca2+]I and changes...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	MUSTAPHA FAROUDI [verfasserIn] ROSSANA ZARU [verfasserIn] BENOIT FAVIER [verfasserIn] SALVATORE VALITUTTI [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2002

Schlagwörter:	T cell antigen receptor Immunological synapse signal transduction

Übergeordnetes Werk:	In: Biological Research - BMC, 2018, 35(2002), 2, Seite 133-137
Übergeordnetes Werk:	volume:35 ; year:2002 ; number:2 ; pages:133-137

Links:	Link aufrufen Link aufrufen Journal toc Journal toc

Katalog-ID:	DOAJ040595560

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spelling	(DE-627)DOAJ040595560 (DE-599)DOAJ6513d88a5b3147ef824ea852411f1a54 DE-627 ger DE-627 rakwb eng QH301-705.5 MUSTAPHA FAROUDI verfasserin aut New insights to the functional role of the T cell-Antigen Presenting Cell immunological synapse 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Three innovative and complementary morphological approaches were employed to study the T cell/antigen presenting cell (APC) interaction: (i) high resolution three-dimensional confocal microscopy of the T cell-APC contact site; (ii) time lapse video recording in living T cells of [Ca2+]I and changes in distribution of various GFP fusion proteins with TCR/CD3-zetacomplex associated- and other signaling components; (iii) measurement of lateral TCR mobility and that of recruited signaling components using techniques based on fluorescence recovery after photo-bleaching. These approaches were combined with biochemical and functional experiments to investigate two principal issues: (A) Recruitment and the three-dimensional arrangement of receptors and signaling components at the contact site between human CD4+ T lymphocytes and APCs, (B) Structure of the immunological synapse formed at the contact site between cytotoxic T lymphocytes (CTLs) and target cells. We discuss evidence indicating that TCR engagement and triggering can occur in the absence of large-scale molecular segregation into the T cell-APC contact site. Taken together our results indicate that although not required for TCR engagement and triggering, formation of the IS is important to reinforce TCR-mediated signal transduction and achieve full T cell activation. T cell antigen receptor Immunological synapse signal transduction Biology (General) ROSSANA ZARU verfasserin aut BENOIT FAVIER verfasserin aut SALVATORE VALITUTTI verfasserin aut In Biological Research BMC, 2018 35(2002), 2, Seite 133-137 (DE-627)329975374 (DE-600)2048380-6 07176287 nnns volume:35 year:2002 number:2 pages:133-137 https://doaj.org/article/6513d88a5b3147ef824ea852411f1a54 kostenfrei http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200004 kostenfrei https://doaj.org/toc/0716-9760 Journal toc kostenfrei https://doaj.org/toc/0717-6287 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 35 2002 2 133-137
allfields_unstemmed	(DE-627)DOAJ040595560 (DE-599)DOAJ6513d88a5b3147ef824ea852411f1a54 DE-627 ger DE-627 rakwb eng QH301-705.5 MUSTAPHA FAROUDI verfasserin aut New insights to the functional role of the T cell-Antigen Presenting Cell immunological synapse 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Three innovative and complementary morphological approaches were employed to study the T cell/antigen presenting cell (APC) interaction: (i) high resolution three-dimensional confocal microscopy of the T cell-APC contact site; (ii) time lapse video recording in living T cells of [Ca2+]I and changes in distribution of various GFP fusion proteins with TCR/CD3-zetacomplex associated- and other signaling components; (iii) measurement of lateral TCR mobility and that of recruited signaling components using techniques based on fluorescence recovery after photo-bleaching. These approaches were combined with biochemical and functional experiments to investigate two principal issues: (A) Recruitment and the three-dimensional arrangement of receptors and signaling components at the contact site between human CD4+ T lymphocytes and APCs, (B) Structure of the immunological synapse formed at the contact site between cytotoxic T lymphocytes (CTLs) and target cells. We discuss evidence indicating that TCR engagement and triggering can occur in the absence of large-scale molecular segregation into the T cell-APC contact site. Taken together our results indicate that although not required for TCR engagement and triggering, formation of the IS is important to reinforce TCR-mediated signal transduction and achieve full T cell activation. T cell antigen receptor Immunological synapse signal transduction Biology (General) ROSSANA ZARU verfasserin aut BENOIT FAVIER verfasserin aut SALVATORE VALITUTTI verfasserin aut In Biological Research BMC, 2018 35(2002), 2, Seite 133-137 (DE-627)329975374 (DE-600)2048380-6 07176287 nnns volume:35 year:2002 number:2 pages:133-137 https://doaj.org/article/6513d88a5b3147ef824ea852411f1a54 kostenfrei http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200004 kostenfrei https://doaj.org/toc/0716-9760 Journal toc kostenfrei https://doaj.org/toc/0717-6287 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 35 2002 2 133-137
allfieldsGer	(DE-627)DOAJ040595560 (DE-599)DOAJ6513d88a5b3147ef824ea852411f1a54 DE-627 ger DE-627 rakwb eng QH301-705.5 MUSTAPHA FAROUDI verfasserin aut New insights to the functional role of the T cell-Antigen Presenting Cell immunological synapse 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Three innovative and complementary morphological approaches were employed to study the T cell/antigen presenting cell (APC) interaction: (i) high resolution three-dimensional confocal microscopy of the T cell-APC contact site; (ii) time lapse video recording in living T cells of [Ca2+]I and changes in distribution of various GFP fusion proteins with TCR/CD3-zetacomplex associated- and other signaling components; (iii) measurement of lateral TCR mobility and that of recruited signaling components using techniques based on fluorescence recovery after photo-bleaching. These approaches were combined with biochemical and functional experiments to investigate two principal issues: (A) Recruitment and the three-dimensional arrangement of receptors and signaling components at the contact site between human CD4+ T lymphocytes and APCs, (B) Structure of the immunological synapse formed at the contact site between cytotoxic T lymphocytes (CTLs) and target cells. We discuss evidence indicating that TCR engagement and triggering can occur in the absence of large-scale molecular segregation into the T cell-APC contact site. Taken together our results indicate that although not required for TCR engagement and triggering, formation of the IS is important to reinforce TCR-mediated signal transduction and achieve full T cell activation. T cell antigen receptor Immunological synapse signal transduction Biology (General) ROSSANA ZARU verfasserin aut BENOIT FAVIER verfasserin aut SALVATORE VALITUTTI verfasserin aut In Biological Research BMC, 2018 35(2002), 2, Seite 133-137 (DE-627)329975374 (DE-600)2048380-6 07176287 nnns volume:35 year:2002 number:2 pages:133-137 https://doaj.org/article/6513d88a5b3147ef824ea852411f1a54 kostenfrei http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200004 kostenfrei https://doaj.org/toc/0716-9760 Journal toc kostenfrei https://doaj.org/toc/0717-6287 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 35 2002 2 133-137
allfieldsSound	(DE-627)DOAJ040595560 (DE-599)DOAJ6513d88a5b3147ef824ea852411f1a54 DE-627 ger DE-627 rakwb eng QH301-705.5 MUSTAPHA FAROUDI verfasserin aut New insights to the functional role of the T cell-Antigen Presenting Cell immunological synapse 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Three innovative and complementary morphological approaches were employed to study the T cell/antigen presenting cell (APC) interaction: (i) high resolution three-dimensional confocal microscopy of the T cell-APC contact site; (ii) time lapse video recording in living T cells of [Ca2+]I and changes in distribution of various GFP fusion proteins with TCR/CD3-zetacomplex associated- and other signaling components; (iii) measurement of lateral TCR mobility and that of recruited signaling components using techniques based on fluorescence recovery after photo-bleaching. These approaches were combined with biochemical and functional experiments to investigate two principal issues: (A) Recruitment and the three-dimensional arrangement of receptors and signaling components at the contact site between human CD4+ T lymphocytes and APCs, (B) Structure of the immunological synapse formed at the contact site between cytotoxic T lymphocytes (CTLs) and target cells. We discuss evidence indicating that TCR engagement and triggering can occur in the absence of large-scale molecular segregation into the T cell-APC contact site. Taken together our results indicate that although not required for TCR engagement and triggering, formation of the IS is important to reinforce TCR-mediated signal transduction and achieve full T cell activation. T cell antigen receptor Immunological synapse signal transduction Biology (General) ROSSANA ZARU verfasserin aut BENOIT FAVIER verfasserin aut SALVATORE VALITUTTI verfasserin aut In Biological Research BMC, 2018 35(2002), 2, Seite 133-137 (DE-627)329975374 (DE-600)2048380-6 07176287 nnns volume:35 year:2002 number:2 pages:133-137 https://doaj.org/article/6513d88a5b3147ef824ea852411f1a54 kostenfrei http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200004 kostenfrei https://doaj.org/toc/0716-9760 Journal toc kostenfrei https://doaj.org/toc/0717-6287 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 35 2002 2 133-137
language	English
source	In Biological Research 35(2002), 2, Seite 133-137 volume:35 year:2002 number:2 pages:133-137
sourceStr	In Biological Research 35(2002), 2, Seite 133-137 volume:35 year:2002 number:2 pages:133-137
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topic_facet	T cell antigen receptor Immunological synapse signal transduction Biology (General)
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authorswithroles_txt_mv	MUSTAPHA FAROUDI @@aut@@ ROSSANA ZARU @@aut@@ BENOIT FAVIER @@aut@@ SALVATORE VALITUTTI @@aut@@
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author	MUSTAPHA FAROUDI
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topic_title	QH301-705.5 New insights to the functional role of the T cell-Antigen Presenting Cell immunological synapse T cell antigen receptor Immunological synapse signal transduction
topic	misc QH301-705.5 misc T cell antigen receptor misc Immunological synapse misc signal transduction misc Biology (General)
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title	New insights to the functional role of the T cell-Antigen Presenting Cell immunological synapse
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title_full	New insights to the functional role of the T cell-Antigen Presenting Cell immunological synapse
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title_sort	new insights to the functional role of the t cell-antigen presenting cell immunological synapse
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title_auth	New insights to the functional role of the T cell-Antigen Presenting Cell immunological synapse
abstract	Three innovative and complementary morphological approaches were employed to study the T cell/antigen presenting cell (APC) interaction: (i) high resolution three-dimensional confocal microscopy of the T cell-APC contact site; (ii) time lapse video recording in living T cells of [Ca2+]I and changes in distribution of various GFP fusion proteins with TCR/CD3-zetacomplex associated- and other signaling components; (iii) measurement of lateral TCR mobility and that of recruited signaling components using techniques based on fluorescence recovery after photo-bleaching. These approaches were combined with biochemical and functional experiments to investigate two principal issues: (A) Recruitment and the three-dimensional arrangement of receptors and signaling components at the contact site between human CD4+ T lymphocytes and APCs, (B) Structure of the immunological synapse formed at the contact site between cytotoxic T lymphocytes (CTLs) and target cells. We discuss evidence indicating that TCR engagement and triggering can occur in the absence of large-scale molecular segregation into the T cell-APC contact site. Taken together our results indicate that although not required for TCR engagement and triggering, formation of the IS is important to reinforce TCR-mediated signal transduction and achieve full T cell activation.
abstractGer	Three innovative and complementary morphological approaches were employed to study the T cell/antigen presenting cell (APC) interaction: (i) high resolution three-dimensional confocal microscopy of the T cell-APC contact site; (ii) time lapse video recording in living T cells of [Ca2+]I and changes in distribution of various GFP fusion proteins with TCR/CD3-zetacomplex associated- and other signaling components; (iii) measurement of lateral TCR mobility and that of recruited signaling components using techniques based on fluorescence recovery after photo-bleaching. These approaches were combined with biochemical and functional experiments to investigate two principal issues: (A) Recruitment and the three-dimensional arrangement of receptors and signaling components at the contact site between human CD4+ T lymphocytes and APCs, (B) Structure of the immunological synapse formed at the contact site between cytotoxic T lymphocytes (CTLs) and target cells. We discuss evidence indicating that TCR engagement and triggering can occur in the absence of large-scale molecular segregation into the T cell-APC contact site. Taken together our results indicate that although not required for TCR engagement and triggering, formation of the IS is important to reinforce TCR-mediated signal transduction and achieve full T cell activation.
abstract_unstemmed	Three innovative and complementary morphological approaches were employed to study the T cell/antigen presenting cell (APC) interaction: (i) high resolution three-dimensional confocal microscopy of the T cell-APC contact site; (ii) time lapse video recording in living T cells of [Ca2+]I and changes in distribution of various GFP fusion proteins with TCR/CD3-zetacomplex associated- and other signaling components; (iii) measurement of lateral TCR mobility and that of recruited signaling components using techniques based on fluorescence recovery after photo-bleaching. These approaches were combined with biochemical and functional experiments to investigate two principal issues: (A) Recruitment and the three-dimensional arrangement of receptors and signaling components at the contact site between human CD4+ T lymphocytes and APCs, (B) Structure of the immunological synapse formed at the contact site between cytotoxic T lymphocytes (CTLs) and target cells. We discuss evidence indicating that TCR engagement and triggering can occur in the absence of large-scale molecular segregation into the T cell-APC contact site. Taken together our results indicate that although not required for TCR engagement and triggering, formation of the IS is important to reinforce TCR-mediated signal transduction and achieve full T cell activation.
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title_short	New insights to the functional role of the T cell-Antigen Presenting Cell immunological synapse
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