A Mendelian Randomization Analysis to Expose the Causal Effect of IL-18 on Osteoporosis Based on Genome-Wide Association Study Data
Accumulating evidence showed that Interleukin (IL) level is associated with Osteoporosis. Whereas, most of these associations are based on observational studies. Thus, their causality was still unclear. Mendelian randomization (MR) is a widely used statistical framework that uses genetic instrumenta...
Ausführliche Beschreibung
Autor*in: |
Ni Kou [verfasserIn] Wenyang Zhou [verfasserIn] Yuzhu He [verfasserIn] Xiaoxia Ying [verfasserIn] Songling Chai [verfasserIn] Tao Fei [verfasserIn] Wenqi Fu [verfasserIn] Jiaqian Huang [verfasserIn] Huiying Liu [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2020 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Frontiers in Bioengineering and Biotechnology - Frontiers Media S.A., 2014, 8(2020) |
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Übergeordnetes Werk: |
volume:8 ; year:2020 |
Links: |
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DOI / URN: |
10.3389/fbioe.2020.00201 |
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Katalog-ID: |
DOAJ040660524 |
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10.3389/fbioe.2020.00201 doi (DE-627)DOAJ040660524 (DE-599)DOAJ2de099fcc38842c485d6667a31533a5c DE-627 ger DE-627 rakwb eng TP248.13-248.65 Ni Kou verfasserin aut A Mendelian Randomization Analysis to Expose the Causal Effect of IL-18 on Osteoporosis Based on Genome-Wide Association Study Data 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Accumulating evidence showed that Interleukin (IL) level is associated with Osteoporosis. Whereas, most of these associations are based on observational studies. Thus, their causality was still unclear. Mendelian randomization (MR) is a widely used statistical framework that uses genetic instrumental variables (IVs) to explore the causality of intermediate phenotype with disease. To classify their causality, we conducted a MR analysis to investigate the effect of IL-18 level on the risk of Osteoporosis. First, based on summarized genome-wide association study (GWAS) data, 8 independent IL-18 SNPs reaching genome-wide significance were deemed as IVs. Next, Simple median method was used to calculate the pooled odds ratio (OR) of these 8 SNPs for the assessment of IL-8 on the risk of Osteoporosis. Then, MR-Egger regression was utilized to detect potential bias due to the horizontal pleiotropy of these IVs. As a result of simple median method, we get the SE (−0.001; 95% CI−0.002 to 0; P = 0.042), which means low IL-18 level could increases the risk of the development of Osteoporosis. The low intercept (0; 95% CI −0.001 to 0; P = 0.59) shows there is no bias due to the horizontal pleiotropy of the IVs. genome-wide association studies Interleukin-18 Osteoporosis casual effect Mendelian randomization Biotechnology Wenyang Zhou verfasserin aut Yuzhu He verfasserin aut Xiaoxia Ying verfasserin aut Songling Chai verfasserin aut Tao Fei verfasserin aut Wenqi Fu verfasserin aut Jiaqian Huang verfasserin aut Huiying Liu verfasserin aut In Frontiers in Bioengineering and Biotechnology Frontiers Media S.A., 2014 8(2020) (DE-627)74950403X (DE-600)2719493-0 22964185 nnns volume:8 year:2020 https://doi.org/10.3389/fbioe.2020.00201 kostenfrei https://doaj.org/article/2de099fcc38842c485d6667a31533a5c kostenfrei https://www.frontiersin.org/article/10.3389/fbioe.2020.00201/full kostenfrei https://doaj.org/toc/2296-4185 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020 |
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10.3389/fbioe.2020.00201 doi (DE-627)DOAJ040660524 (DE-599)DOAJ2de099fcc38842c485d6667a31533a5c DE-627 ger DE-627 rakwb eng TP248.13-248.65 Ni Kou verfasserin aut A Mendelian Randomization Analysis to Expose the Causal Effect of IL-18 on Osteoporosis Based on Genome-Wide Association Study Data 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Accumulating evidence showed that Interleukin (IL) level is associated with Osteoporosis. Whereas, most of these associations are based on observational studies. Thus, their causality was still unclear. Mendelian randomization (MR) is a widely used statistical framework that uses genetic instrumental variables (IVs) to explore the causality of intermediate phenotype with disease. To classify their causality, we conducted a MR analysis to investigate the effect of IL-18 level on the risk of Osteoporosis. First, based on summarized genome-wide association study (GWAS) data, 8 independent IL-18 SNPs reaching genome-wide significance were deemed as IVs. Next, Simple median method was used to calculate the pooled odds ratio (OR) of these 8 SNPs for the assessment of IL-8 on the risk of Osteoporosis. Then, MR-Egger regression was utilized to detect potential bias due to the horizontal pleiotropy of these IVs. As a result of simple median method, we get the SE (−0.001; 95% CI−0.002 to 0; P = 0.042), which means low IL-18 level could increases the risk of the development of Osteoporosis. The low intercept (0; 95% CI −0.001 to 0; P = 0.59) shows there is no bias due to the horizontal pleiotropy of the IVs. genome-wide association studies Interleukin-18 Osteoporosis casual effect Mendelian randomization Biotechnology Wenyang Zhou verfasserin aut Yuzhu He verfasserin aut Xiaoxia Ying verfasserin aut Songling Chai verfasserin aut Tao Fei verfasserin aut Wenqi Fu verfasserin aut Jiaqian Huang verfasserin aut Huiying Liu verfasserin aut In Frontiers in Bioengineering and Biotechnology Frontiers Media S.A., 2014 8(2020) (DE-627)74950403X (DE-600)2719493-0 22964185 nnns volume:8 year:2020 https://doi.org/10.3389/fbioe.2020.00201 kostenfrei https://doaj.org/article/2de099fcc38842c485d6667a31533a5c kostenfrei https://www.frontiersin.org/article/10.3389/fbioe.2020.00201/full kostenfrei https://doaj.org/toc/2296-4185 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020 |
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10.3389/fbioe.2020.00201 doi (DE-627)DOAJ040660524 (DE-599)DOAJ2de099fcc38842c485d6667a31533a5c DE-627 ger DE-627 rakwb eng TP248.13-248.65 Ni Kou verfasserin aut A Mendelian Randomization Analysis to Expose the Causal Effect of IL-18 on Osteoporosis Based on Genome-Wide Association Study Data 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Accumulating evidence showed that Interleukin (IL) level is associated with Osteoporosis. Whereas, most of these associations are based on observational studies. Thus, their causality was still unclear. Mendelian randomization (MR) is a widely used statistical framework that uses genetic instrumental variables (IVs) to explore the causality of intermediate phenotype with disease. To classify their causality, we conducted a MR analysis to investigate the effect of IL-18 level on the risk of Osteoporosis. First, based on summarized genome-wide association study (GWAS) data, 8 independent IL-18 SNPs reaching genome-wide significance were deemed as IVs. Next, Simple median method was used to calculate the pooled odds ratio (OR) of these 8 SNPs for the assessment of IL-8 on the risk of Osteoporosis. Then, MR-Egger regression was utilized to detect potential bias due to the horizontal pleiotropy of these IVs. As a result of simple median method, we get the SE (−0.001; 95% CI−0.002 to 0; P = 0.042), which means low IL-18 level could increases the risk of the development of Osteoporosis. The low intercept (0; 95% CI −0.001 to 0; P = 0.59) shows there is no bias due to the horizontal pleiotropy of the IVs. genome-wide association studies Interleukin-18 Osteoporosis casual effect Mendelian randomization Biotechnology Wenyang Zhou verfasserin aut Yuzhu He verfasserin aut Xiaoxia Ying verfasserin aut Songling Chai verfasserin aut Tao Fei verfasserin aut Wenqi Fu verfasserin aut Jiaqian Huang verfasserin aut Huiying Liu verfasserin aut In Frontiers in Bioengineering and Biotechnology Frontiers Media S.A., 2014 8(2020) (DE-627)74950403X (DE-600)2719493-0 22964185 nnns volume:8 year:2020 https://doi.org/10.3389/fbioe.2020.00201 kostenfrei https://doaj.org/article/2de099fcc38842c485d6667a31533a5c kostenfrei https://www.frontiersin.org/article/10.3389/fbioe.2020.00201/full kostenfrei https://doaj.org/toc/2296-4185 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020 |
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10.3389/fbioe.2020.00201 doi (DE-627)DOAJ040660524 (DE-599)DOAJ2de099fcc38842c485d6667a31533a5c DE-627 ger DE-627 rakwb eng TP248.13-248.65 Ni Kou verfasserin aut A Mendelian Randomization Analysis to Expose the Causal Effect of IL-18 on Osteoporosis Based on Genome-Wide Association Study Data 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Accumulating evidence showed that Interleukin (IL) level is associated with Osteoporosis. Whereas, most of these associations are based on observational studies. Thus, their causality was still unclear. Mendelian randomization (MR) is a widely used statistical framework that uses genetic instrumental variables (IVs) to explore the causality of intermediate phenotype with disease. To classify their causality, we conducted a MR analysis to investigate the effect of IL-18 level on the risk of Osteoporosis. First, based on summarized genome-wide association study (GWAS) data, 8 independent IL-18 SNPs reaching genome-wide significance were deemed as IVs. Next, Simple median method was used to calculate the pooled odds ratio (OR) of these 8 SNPs for the assessment of IL-8 on the risk of Osteoporosis. Then, MR-Egger regression was utilized to detect potential bias due to the horizontal pleiotropy of these IVs. As a result of simple median method, we get the SE (−0.001; 95% CI−0.002 to 0; P = 0.042), which means low IL-18 level could increases the risk of the development of Osteoporosis. The low intercept (0; 95% CI −0.001 to 0; P = 0.59) shows there is no bias due to the horizontal pleiotropy of the IVs. genome-wide association studies Interleukin-18 Osteoporosis casual effect Mendelian randomization Biotechnology Wenyang Zhou verfasserin aut Yuzhu He verfasserin aut Xiaoxia Ying verfasserin aut Songling Chai verfasserin aut Tao Fei verfasserin aut Wenqi Fu verfasserin aut Jiaqian Huang verfasserin aut Huiying Liu verfasserin aut In Frontiers in Bioengineering and Biotechnology Frontiers Media S.A., 2014 8(2020) (DE-627)74950403X (DE-600)2719493-0 22964185 nnns volume:8 year:2020 https://doi.org/10.3389/fbioe.2020.00201 kostenfrei https://doaj.org/article/2de099fcc38842c485d6667a31533a5c kostenfrei https://www.frontiersin.org/article/10.3389/fbioe.2020.00201/full kostenfrei https://doaj.org/toc/2296-4185 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020 |
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10.3389/fbioe.2020.00201 doi (DE-627)DOAJ040660524 (DE-599)DOAJ2de099fcc38842c485d6667a31533a5c DE-627 ger DE-627 rakwb eng TP248.13-248.65 Ni Kou verfasserin aut A Mendelian Randomization Analysis to Expose the Causal Effect of IL-18 on Osteoporosis Based on Genome-Wide Association Study Data 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Accumulating evidence showed that Interleukin (IL) level is associated with Osteoporosis. Whereas, most of these associations are based on observational studies. Thus, their causality was still unclear. Mendelian randomization (MR) is a widely used statistical framework that uses genetic instrumental variables (IVs) to explore the causality of intermediate phenotype with disease. To classify their causality, we conducted a MR analysis to investigate the effect of IL-18 level on the risk of Osteoporosis. First, based on summarized genome-wide association study (GWAS) data, 8 independent IL-18 SNPs reaching genome-wide significance were deemed as IVs. Next, Simple median method was used to calculate the pooled odds ratio (OR) of these 8 SNPs for the assessment of IL-8 on the risk of Osteoporosis. Then, MR-Egger regression was utilized to detect potential bias due to the horizontal pleiotropy of these IVs. As a result of simple median method, we get the SE (−0.001; 95% CI−0.002 to 0; P = 0.042), which means low IL-18 level could increases the risk of the development of Osteoporosis. The low intercept (0; 95% CI −0.001 to 0; P = 0.59) shows there is no bias due to the horizontal pleiotropy of the IVs. genome-wide association studies Interleukin-18 Osteoporosis casual effect Mendelian randomization Biotechnology Wenyang Zhou verfasserin aut Yuzhu He verfasserin aut Xiaoxia Ying verfasserin aut Songling Chai verfasserin aut Tao Fei verfasserin aut Wenqi Fu verfasserin aut Jiaqian Huang verfasserin aut Huiying Liu verfasserin aut In Frontiers in Bioengineering and Biotechnology Frontiers Media S.A., 2014 8(2020) (DE-627)74950403X (DE-600)2719493-0 22964185 nnns volume:8 year:2020 https://doi.org/10.3389/fbioe.2020.00201 kostenfrei https://doaj.org/article/2de099fcc38842c485d6667a31533a5c kostenfrei https://www.frontiersin.org/article/10.3389/fbioe.2020.00201/full kostenfrei https://doaj.org/toc/2296-4185 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020 |
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TP248.13-248.65 A Mendelian Randomization Analysis to Expose the Causal Effect of IL-18 on Osteoporosis Based on Genome-Wide Association Study Data genome-wide association studies Interleukin-18 Osteoporosis casual effect Mendelian randomization |
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A Mendelian Randomization Analysis to Expose the Causal Effect of IL-18 on Osteoporosis Based on Genome-Wide Association Study Data |
abstract |
Accumulating evidence showed that Interleukin (IL) level is associated with Osteoporosis. Whereas, most of these associations are based on observational studies. Thus, their causality was still unclear. Mendelian randomization (MR) is a widely used statistical framework that uses genetic instrumental variables (IVs) to explore the causality of intermediate phenotype with disease. To classify their causality, we conducted a MR analysis to investigate the effect of IL-18 level on the risk of Osteoporosis. First, based on summarized genome-wide association study (GWAS) data, 8 independent IL-18 SNPs reaching genome-wide significance were deemed as IVs. Next, Simple median method was used to calculate the pooled odds ratio (OR) of these 8 SNPs for the assessment of IL-8 on the risk of Osteoporosis. Then, MR-Egger regression was utilized to detect potential bias due to the horizontal pleiotropy of these IVs. As a result of simple median method, we get the SE (−0.001; 95% CI−0.002 to 0; P = 0.042), which means low IL-18 level could increases the risk of the development of Osteoporosis. The low intercept (0; 95% CI −0.001 to 0; P = 0.59) shows there is no bias due to the horizontal pleiotropy of the IVs. |
abstractGer |
Accumulating evidence showed that Interleukin (IL) level is associated with Osteoporosis. Whereas, most of these associations are based on observational studies. Thus, their causality was still unclear. Mendelian randomization (MR) is a widely used statistical framework that uses genetic instrumental variables (IVs) to explore the causality of intermediate phenotype with disease. To classify their causality, we conducted a MR analysis to investigate the effect of IL-18 level on the risk of Osteoporosis. First, based on summarized genome-wide association study (GWAS) data, 8 independent IL-18 SNPs reaching genome-wide significance were deemed as IVs. Next, Simple median method was used to calculate the pooled odds ratio (OR) of these 8 SNPs for the assessment of IL-8 on the risk of Osteoporosis. Then, MR-Egger regression was utilized to detect potential bias due to the horizontal pleiotropy of these IVs. As a result of simple median method, we get the SE (−0.001; 95% CI−0.002 to 0; P = 0.042), which means low IL-18 level could increases the risk of the development of Osteoporosis. The low intercept (0; 95% CI −0.001 to 0; P = 0.59) shows there is no bias due to the horizontal pleiotropy of the IVs. |
abstract_unstemmed |
Accumulating evidence showed that Interleukin (IL) level is associated with Osteoporosis. Whereas, most of these associations are based on observational studies. Thus, their causality was still unclear. Mendelian randomization (MR) is a widely used statistical framework that uses genetic instrumental variables (IVs) to explore the causality of intermediate phenotype with disease. To classify their causality, we conducted a MR analysis to investigate the effect of IL-18 level on the risk of Osteoporosis. First, based on summarized genome-wide association study (GWAS) data, 8 independent IL-18 SNPs reaching genome-wide significance were deemed as IVs. Next, Simple median method was used to calculate the pooled odds ratio (OR) of these 8 SNPs for the assessment of IL-8 on the risk of Osteoporosis. Then, MR-Egger regression was utilized to detect potential bias due to the horizontal pleiotropy of these IVs. As a result of simple median method, we get the SE (−0.001; 95% CI−0.002 to 0; P = 0.042), which means low IL-18 level could increases the risk of the development of Osteoporosis. The low intercept (0; 95% CI −0.001 to 0; P = 0.59) shows there is no bias due to the horizontal pleiotropy of the IVs. |
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title_short |
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code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Frontiers in Bioengineering and Biotechnology</subfield><subfield code="d">Frontiers Media S.A., 2014</subfield><subfield code="g">8(2020)</subfield><subfield code="w">(DE-627)74950403X</subfield><subfield code="w">(DE-600)2719493-0</subfield><subfield code="x">22964185</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:8</subfield><subfield code="g">year:2020</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.3389/fbioe.2020.00201</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/2de099fcc38842c485d6667a31533a5c</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" 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