Hydrogels for Tissue Engineering: Addressing Key Design Needs Toward Clinical Translation

While the soft mechanics and tunable cell interactions facilitated by hydrogels have attracted significant interest in the development of functional hydrogel-based tissue engineering scaffolds, translating the many positive results observed in the lab into the clinic remains a slow process. In this...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Fei Xu [verfasserIn] Chloe Dawson [verfasserIn] Makenzie Lamb [verfasserIn] Eva Mueller [verfasserIn] Evan Stefanek [verfasserIn] Mohsen Akbari [verfasserIn] Todd Hoare [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Hydrogels Tissue Engineering Bioprinting Electrospinning Biomaterials

Übergeordnetes Werk:	In: Frontiers in Bioengineering and Biotechnology - Frontiers Media S.A., 2014, 10(2022)
Übergeordnetes Werk:	volume:10 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fbioe.2022.849831

Katalog-ID:	DOAJ041200063

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authorswithroles_txt_mv	Fei Xu @@aut@@ Chloe Dawson @@aut@@ Makenzie Lamb @@aut@@ Eva Mueller @@aut@@ Evan Stefanek @@aut@@ Mohsen Akbari @@aut@@ Todd Hoare @@aut@@
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callnumber-first	T - Technology
author	Fei Xu
spellingShingle	Fei Xu misc TP248.13-248.65 misc Hydrogels misc Tissue Engineering misc Bioprinting misc Electrospinning misc Biomaterials misc Biotechnology Hydrogels for Tissue Engineering: Addressing Key Design Needs Toward Clinical Translation
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topic_title	TP248.13-248.65 Hydrogels for Tissue Engineering: Addressing Key Design Needs Toward Clinical Translation Hydrogels Tissue Engineering Bioprinting Electrospinning Biomaterials
topic	misc TP248.13-248.65 misc Hydrogels misc Tissue Engineering misc Bioprinting misc Electrospinning misc Biomaterials misc Biotechnology
topic_unstemmed	misc TP248.13-248.65 misc Hydrogels misc Tissue Engineering misc Bioprinting misc Electrospinning misc Biomaterials misc Biotechnology
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title	Hydrogels for Tissue Engineering: Addressing Key Design Needs Toward Clinical Translation
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title_full	Hydrogels for Tissue Engineering: Addressing Key Design Needs Toward Clinical Translation
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title_sort	hydrogels for tissue engineering: addressing key design needs toward clinical translation
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title_auth	Hydrogels for Tissue Engineering: Addressing Key Design Needs Toward Clinical Translation
abstract	While the soft mechanics and tunable cell interactions facilitated by hydrogels have attracted significant interest in the development of functional hydrogel-based tissue engineering scaffolds, translating the many positive results observed in the lab into the clinic remains a slow process. In this review, we address the key design criteria in terms of the materials, crosslinkers, and fabrication techniques useful for fabricating translationally-relevant tissue engineering hydrogels, with particular attention to three emerging fabrication techniques that enable simultaneous scaffold fabrication and cell loading: 3D printing, in situ tissue engineering, and cell electrospinning. In particular, we emphasize strategies for manufacturing tissue engineering hydrogels in which both macroporous scaffold fabrication and cell loading can be conducted in a single manufacturing step – electrospinning, 3D printing, and in situ tissue engineering. We suggest that combining such integrated fabrication approaches with the lessons learned from previously successful translational experiences with other hydrogels represents a promising strategy to accelerate the implementation of hydrogels for tissue engineering in the clinic.
abstractGer	While the soft mechanics and tunable cell interactions facilitated by hydrogels have attracted significant interest in the development of functional hydrogel-based tissue engineering scaffolds, translating the many positive results observed in the lab into the clinic remains a slow process. In this review, we address the key design criteria in terms of the materials, crosslinkers, and fabrication techniques useful for fabricating translationally-relevant tissue engineering hydrogels, with particular attention to three emerging fabrication techniques that enable simultaneous scaffold fabrication and cell loading: 3D printing, in situ tissue engineering, and cell electrospinning. In particular, we emphasize strategies for manufacturing tissue engineering hydrogels in which both macroporous scaffold fabrication and cell loading can be conducted in a single manufacturing step – electrospinning, 3D printing, and in situ tissue engineering. We suggest that combining such integrated fabrication approaches with the lessons learned from previously successful translational experiences with other hydrogels represents a promising strategy to accelerate the implementation of hydrogels for tissue engineering in the clinic.
abstract_unstemmed	While the soft mechanics and tunable cell interactions facilitated by hydrogels have attracted significant interest in the development of functional hydrogel-based tissue engineering scaffolds, translating the many positive results observed in the lab into the clinic remains a slow process. In this review, we address the key design criteria in terms of the materials, crosslinkers, and fabrication techniques useful for fabricating translationally-relevant tissue engineering hydrogels, with particular attention to three emerging fabrication techniques that enable simultaneous scaffold fabrication and cell loading: 3D printing, in situ tissue engineering, and cell electrospinning. In particular, we emphasize strategies for manufacturing tissue engineering hydrogels in which both macroporous scaffold fabrication and cell loading can be conducted in a single manufacturing step – electrospinning, 3D printing, and in situ tissue engineering. We suggest that combining such integrated fabrication approaches with the lessons learned from previously successful translational experiences with other hydrogels represents a promising strategy to accelerate the implementation of hydrogels for tissue engineering in the clinic.
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title_short	Hydrogels for Tissue Engineering: Addressing Key Design Needs Toward Clinical Translation
url	https://doi.org/10.3389/fbioe.2022.849831 https://doaj.org/article/462c2e162a6b4887acb1cf133450437f https://www.frontiersin.org/articles/10.3389/fbioe.2022.849831/full https://doaj.org/toc/2296-4185
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