Relationship between ATOH1 and tumor microenvironment in colon adenocarcinoma patients with different microsatellite instability status

Abstract Background Colon adenocarcinoma (COAD) is one of the major varieties of malignant tumors threatening human health today. Immune checkpoint inhibitors (ICIs) have recently begun to emerge as an effective option for the treatment of COAD patients, but not all patients can benefit from ICI tre...
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Autor*in:	Weiming Mou [verfasserIn] Lingxuan Zhu [verfasserIn] Tao Yang [verfasserIn] Anqi Lin [verfasserIn] Qiong Lyu [verfasserIn] Linlang Guo [verfasserIn] Zaoqu Liu [verfasserIn] Quan Cheng [verfasserIn] Jian Zhang [verfasserIn] Peng Luo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Chromatin accessibility Colon adenocarcinoma Microsatellite instability Tumor microenvironment Immune checkpoint inhibitors ATOH1

Übergeordnetes Werk:	In: Cancer Cell International - BMC, 2003, 22(2022), 1, Seite 17
Übergeordnetes Werk:	volume:22 ; year:2022 ; number:1 ; pages:17

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12935-022-02651-6

Katalog-ID:	DOAJ041353897

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520			\|a Abstract Background Colon adenocarcinoma (COAD) is one of the major varieties of malignant tumors threatening human health today. Immune checkpoint inhibitors (ICIs) have recently begun to emerge as an effective option for the treatment of COAD patients, but not all patients can benefit from ICI treatment. Previous studies have suggested that ICIs boast significant clinical effects on patients with microsatellite instability-high (MSI-H), while conversely patients with microsatellite-stable/microsatellite instability-low (MSS/MSI-L) have shown limited response. Methods We used ATAC-seq, RNA-seq, and mutation data from The Cancer Genome Atlas Colon adenocarcinoma (TCGA-COAD) cohort to perform multi-omics differential analysis on COAD samples with different MSI statuses, then further screened genes by additionally combining these results with survival analysis. We analyzed the effects of the screened genes on the tumor microenvironment and immunogenicity of COAD patients, and subsequently determined their influence on the efficacy of ICIs in COAD patients using a series of predictive indexes. Results Twelve genes were screened in the TCGA-COAD cohort, and after the combined survival analysis, we identified ATOH1 as having significant effects. ATOH1 is characterized by high chromatin accessibility, high expression, and high mutation in COAD patients in the MSI-H group. COAD patients with high ATOH1 expression are associated with a better prognosis, unique immune microenvironment, and higher efficacy in ICI treatment. Enrichment analysis showed that COAD patients with high ATOH1 expression displayed significant upregulation in their humoral immunity and other related pathways. Conclusions We speculate that ATOH1 may influence the efficacy of ICIs therapy in patients with COAD by affecting the immune microenvironment and immunogenicity of the tumor.
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653		0	\|a Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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allfields	10.1186/s12935-022-02651-6 doi (DE-627)DOAJ041353897 (DE-599)DOAJd96ae038a375463f8fea51c74c36e91d DE-627 ger DE-627 rakwb eng RC254-282 QH573-671 Weiming Mou verfasserin aut Relationship between ATOH1 and tumor microenvironment in colon adenocarcinoma patients with different microsatellite instability status 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Colon adenocarcinoma (COAD) is one of the major varieties of malignant tumors threatening human health today. Immune checkpoint inhibitors (ICIs) have recently begun to emerge as an effective option for the treatment of COAD patients, but not all patients can benefit from ICI treatment. Previous studies have suggested that ICIs boast significant clinical effects on patients with microsatellite instability-high (MSI-H), while conversely patients with microsatellite-stable/microsatellite instability-low (MSS/MSI-L) have shown limited response. Methods We used ATAC-seq, RNA-seq, and mutation data from The Cancer Genome Atlas Colon adenocarcinoma (TCGA-COAD) cohort to perform multi-omics differential analysis on COAD samples with different MSI statuses, then further screened genes by additionally combining these results with survival analysis. We analyzed the effects of the screened genes on the tumor microenvironment and immunogenicity of COAD patients, and subsequently determined their influence on the efficacy of ICIs in COAD patients using a series of predictive indexes. Results Twelve genes were screened in the TCGA-COAD cohort, and after the combined survival analysis, we identified ATOH1 as having significant effects. ATOH1 is characterized by high chromatin accessibility, high expression, and high mutation in COAD patients in the MSI-H group. COAD patients with high ATOH1 expression are associated with a better prognosis, unique immune microenvironment, and higher efficacy in ICI treatment. Enrichment analysis showed that COAD patients with high ATOH1 expression displayed significant upregulation in their humoral immunity and other related pathways. Conclusions We speculate that ATOH1 may influence the efficacy of ICIs therapy in patients with COAD by affecting the immune microenvironment and immunogenicity of the tumor. Chromatin accessibility Colon adenocarcinoma Microsatellite instability Tumor microenvironment Immune checkpoint inhibitors ATOH1 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cytology Lingxuan Zhu verfasserin aut Tao Yang verfasserin aut Anqi Lin verfasserin aut Qiong Lyu verfasserin aut Linlang Guo verfasserin aut Zaoqu Liu verfasserin aut Quan Cheng verfasserin aut Jian Zhang verfasserin aut Peng Luo verfasserin aut In Cancer Cell International BMC, 2003 22(2022), 1, Seite 17 (DE-627)355989204 (DE-600)2091573-1 14752867 nnns volume:22 year:2022 number:1 pages:17 https://doi.org/10.1186/s12935-022-02651-6 kostenfrei https://doaj.org/article/d96ae038a375463f8fea51c74c36e91d kostenfrei https://doi.org/10.1186/s12935-022-02651-6 kostenfrei https://doaj.org/toc/1475-2867 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 17
spelling	10.1186/s12935-022-02651-6 doi (DE-627)DOAJ041353897 (DE-599)DOAJd96ae038a375463f8fea51c74c36e91d DE-627 ger DE-627 rakwb eng RC254-282 QH573-671 Weiming Mou verfasserin aut Relationship between ATOH1 and tumor microenvironment in colon adenocarcinoma patients with different microsatellite instability status 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Colon adenocarcinoma (COAD) is one of the major varieties of malignant tumors threatening human health today. Immune checkpoint inhibitors (ICIs) have recently begun to emerge as an effective option for the treatment of COAD patients, but not all patients can benefit from ICI treatment. Previous studies have suggested that ICIs boast significant clinical effects on patients with microsatellite instability-high (MSI-H), while conversely patients with microsatellite-stable/microsatellite instability-low (MSS/MSI-L) have shown limited response. Methods We used ATAC-seq, RNA-seq, and mutation data from The Cancer Genome Atlas Colon adenocarcinoma (TCGA-COAD) cohort to perform multi-omics differential analysis on COAD samples with different MSI statuses, then further screened genes by additionally combining these results with survival analysis. We analyzed the effects of the screened genes on the tumor microenvironment and immunogenicity of COAD patients, and subsequently determined their influence on the efficacy of ICIs in COAD patients using a series of predictive indexes. Results Twelve genes were screened in the TCGA-COAD cohort, and after the combined survival analysis, we identified ATOH1 as having significant effects. ATOH1 is characterized by high chromatin accessibility, high expression, and high mutation in COAD patients in the MSI-H group. COAD patients with high ATOH1 expression are associated with a better prognosis, unique immune microenvironment, and higher efficacy in ICI treatment. Enrichment analysis showed that COAD patients with high ATOH1 expression displayed significant upregulation in their humoral immunity and other related pathways. Conclusions We speculate that ATOH1 may influence the efficacy of ICIs therapy in patients with COAD by affecting the immune microenvironment and immunogenicity of the tumor. Chromatin accessibility Colon adenocarcinoma Microsatellite instability Tumor microenvironment Immune checkpoint inhibitors ATOH1 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cytology Lingxuan Zhu verfasserin aut Tao Yang verfasserin aut Anqi Lin verfasserin aut Qiong Lyu verfasserin aut Linlang Guo verfasserin aut Zaoqu Liu verfasserin aut Quan Cheng verfasserin aut Jian Zhang verfasserin aut Peng Luo verfasserin aut In Cancer Cell International BMC, 2003 22(2022), 1, Seite 17 (DE-627)355989204 (DE-600)2091573-1 14752867 nnns volume:22 year:2022 number:1 pages:17 https://doi.org/10.1186/s12935-022-02651-6 kostenfrei https://doaj.org/article/d96ae038a375463f8fea51c74c36e91d kostenfrei https://doi.org/10.1186/s12935-022-02651-6 kostenfrei https://doaj.org/toc/1475-2867 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 17
allfields_unstemmed	10.1186/s12935-022-02651-6 doi (DE-627)DOAJ041353897 (DE-599)DOAJd96ae038a375463f8fea51c74c36e91d DE-627 ger DE-627 rakwb eng RC254-282 QH573-671 Weiming Mou verfasserin aut Relationship between ATOH1 and tumor microenvironment in colon adenocarcinoma patients with different microsatellite instability status 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Colon adenocarcinoma (COAD) is one of the major varieties of malignant tumors threatening human health today. Immune checkpoint inhibitors (ICIs) have recently begun to emerge as an effective option for the treatment of COAD patients, but not all patients can benefit from ICI treatment. Previous studies have suggested that ICIs boast significant clinical effects on patients with microsatellite instability-high (MSI-H), while conversely patients with microsatellite-stable/microsatellite instability-low (MSS/MSI-L) have shown limited response. Methods We used ATAC-seq, RNA-seq, and mutation data from The Cancer Genome Atlas Colon adenocarcinoma (TCGA-COAD) cohort to perform multi-omics differential analysis on COAD samples with different MSI statuses, then further screened genes by additionally combining these results with survival analysis. We analyzed the effects of the screened genes on the tumor microenvironment and immunogenicity of COAD patients, and subsequently determined their influence on the efficacy of ICIs in COAD patients using a series of predictive indexes. Results Twelve genes were screened in the TCGA-COAD cohort, and after the combined survival analysis, we identified ATOH1 as having significant effects. ATOH1 is characterized by high chromatin accessibility, high expression, and high mutation in COAD patients in the MSI-H group. COAD patients with high ATOH1 expression are associated with a better prognosis, unique immune microenvironment, and higher efficacy in ICI treatment. Enrichment analysis showed that COAD patients with high ATOH1 expression displayed significant upregulation in their humoral immunity and other related pathways. Conclusions We speculate that ATOH1 may influence the efficacy of ICIs therapy in patients with COAD by affecting the immune microenvironment and immunogenicity of the tumor. Chromatin accessibility Colon adenocarcinoma Microsatellite instability Tumor microenvironment Immune checkpoint inhibitors ATOH1 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cytology Lingxuan Zhu verfasserin aut Tao Yang verfasserin aut Anqi Lin verfasserin aut Qiong Lyu verfasserin aut Linlang Guo verfasserin aut Zaoqu Liu verfasserin aut Quan Cheng verfasserin aut Jian Zhang verfasserin aut Peng Luo verfasserin aut In Cancer Cell International BMC, 2003 22(2022), 1, Seite 17 (DE-627)355989204 (DE-600)2091573-1 14752867 nnns volume:22 year:2022 number:1 pages:17 https://doi.org/10.1186/s12935-022-02651-6 kostenfrei https://doaj.org/article/d96ae038a375463f8fea51c74c36e91d kostenfrei https://doi.org/10.1186/s12935-022-02651-6 kostenfrei https://doaj.org/toc/1475-2867 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 17
allfieldsGer	10.1186/s12935-022-02651-6 doi (DE-627)DOAJ041353897 (DE-599)DOAJd96ae038a375463f8fea51c74c36e91d DE-627 ger DE-627 rakwb eng RC254-282 QH573-671 Weiming Mou verfasserin aut Relationship between ATOH1 and tumor microenvironment in colon adenocarcinoma patients with different microsatellite instability status 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Colon adenocarcinoma (COAD) is one of the major varieties of malignant tumors threatening human health today. Immune checkpoint inhibitors (ICIs) have recently begun to emerge as an effective option for the treatment of COAD patients, but not all patients can benefit from ICI treatment. Previous studies have suggested that ICIs boast significant clinical effects on patients with microsatellite instability-high (MSI-H), while conversely patients with microsatellite-stable/microsatellite instability-low (MSS/MSI-L) have shown limited response. Methods We used ATAC-seq, RNA-seq, and mutation data from The Cancer Genome Atlas Colon adenocarcinoma (TCGA-COAD) cohort to perform multi-omics differential analysis on COAD samples with different MSI statuses, then further screened genes by additionally combining these results with survival analysis. We analyzed the effects of the screened genes on the tumor microenvironment and immunogenicity of COAD patients, and subsequently determined their influence on the efficacy of ICIs in COAD patients using a series of predictive indexes. Results Twelve genes were screened in the TCGA-COAD cohort, and after the combined survival analysis, we identified ATOH1 as having significant effects. ATOH1 is characterized by high chromatin accessibility, high expression, and high mutation in COAD patients in the MSI-H group. COAD patients with high ATOH1 expression are associated with a better prognosis, unique immune microenvironment, and higher efficacy in ICI treatment. Enrichment analysis showed that COAD patients with high ATOH1 expression displayed significant upregulation in their humoral immunity and other related pathways. Conclusions We speculate that ATOH1 may influence the efficacy of ICIs therapy in patients with COAD by affecting the immune microenvironment and immunogenicity of the tumor. Chromatin accessibility Colon adenocarcinoma Microsatellite instability Tumor microenvironment Immune checkpoint inhibitors ATOH1 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cytology Lingxuan Zhu verfasserin aut Tao Yang verfasserin aut Anqi Lin verfasserin aut Qiong Lyu verfasserin aut Linlang Guo verfasserin aut Zaoqu Liu verfasserin aut Quan Cheng verfasserin aut Jian Zhang verfasserin aut Peng Luo verfasserin aut In Cancer Cell International BMC, 2003 22(2022), 1, Seite 17 (DE-627)355989204 (DE-600)2091573-1 14752867 nnns volume:22 year:2022 number:1 pages:17 https://doi.org/10.1186/s12935-022-02651-6 kostenfrei https://doaj.org/article/d96ae038a375463f8fea51c74c36e91d kostenfrei https://doi.org/10.1186/s12935-022-02651-6 kostenfrei https://doaj.org/toc/1475-2867 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 17
allfieldsSound	10.1186/s12935-022-02651-6 doi (DE-627)DOAJ041353897 (DE-599)DOAJd96ae038a375463f8fea51c74c36e91d DE-627 ger DE-627 rakwb eng RC254-282 QH573-671 Weiming Mou verfasserin aut Relationship between ATOH1 and tumor microenvironment in colon adenocarcinoma patients with different microsatellite instability status 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Colon adenocarcinoma (COAD) is one of the major varieties of malignant tumors threatening human health today. Immune checkpoint inhibitors (ICIs) have recently begun to emerge as an effective option for the treatment of COAD patients, but not all patients can benefit from ICI treatment. Previous studies have suggested that ICIs boast significant clinical effects on patients with microsatellite instability-high (MSI-H), while conversely patients with microsatellite-stable/microsatellite instability-low (MSS/MSI-L) have shown limited response. Methods We used ATAC-seq, RNA-seq, and mutation data from The Cancer Genome Atlas Colon adenocarcinoma (TCGA-COAD) cohort to perform multi-omics differential analysis on COAD samples with different MSI statuses, then further screened genes by additionally combining these results with survival analysis. We analyzed the effects of the screened genes on the tumor microenvironment and immunogenicity of COAD patients, and subsequently determined their influence on the efficacy of ICIs in COAD patients using a series of predictive indexes. Results Twelve genes were screened in the TCGA-COAD cohort, and after the combined survival analysis, we identified ATOH1 as having significant effects. ATOH1 is characterized by high chromatin accessibility, high expression, and high mutation in COAD patients in the MSI-H group. COAD patients with high ATOH1 expression are associated with a better prognosis, unique immune microenvironment, and higher efficacy in ICI treatment. Enrichment analysis showed that COAD patients with high ATOH1 expression displayed significant upregulation in their humoral immunity and other related pathways. Conclusions We speculate that ATOH1 may influence the efficacy of ICIs therapy in patients with COAD by affecting the immune microenvironment and immunogenicity of the tumor. Chromatin accessibility Colon adenocarcinoma Microsatellite instability Tumor microenvironment Immune checkpoint inhibitors ATOH1 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cytology Lingxuan Zhu verfasserin aut Tao Yang verfasserin aut Anqi Lin verfasserin aut Qiong Lyu verfasserin aut Linlang Guo verfasserin aut Zaoqu Liu verfasserin aut Quan Cheng verfasserin aut Jian Zhang verfasserin aut Peng Luo verfasserin aut In Cancer Cell International BMC, 2003 22(2022), 1, Seite 17 (DE-627)355989204 (DE-600)2091573-1 14752867 nnns volume:22 year:2022 number:1 pages:17 https://doi.org/10.1186/s12935-022-02651-6 kostenfrei https://doaj.org/article/d96ae038a375463f8fea51c74c36e91d kostenfrei https://doi.org/10.1186/s12935-022-02651-6 kostenfrei https://doaj.org/toc/1475-2867 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 17
language	English
source	In Cancer Cell International 22(2022), 1, Seite 17 volume:22 year:2022 number:1 pages:17
sourceStr	In Cancer Cell International 22(2022), 1, Seite 17 volume:22 year:2022 number:1 pages:17
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Chromatin accessibility Colon adenocarcinoma Microsatellite instability Tumor microenvironment Immune checkpoint inhibitors ATOH1 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cytology
isfreeaccess_bool	true
container_title	Cancer Cell International
authorswithroles_txt_mv	Weiming Mou @@aut@@ Lingxuan Zhu @@aut@@ Tao Yang @@aut@@ Anqi Lin @@aut@@ Qiong Lyu @@aut@@ Linlang Guo @@aut@@ Zaoqu Liu @@aut@@ Quan Cheng @@aut@@ Jian Zhang @@aut@@ Peng Luo @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	355989204
id	DOAJ041353897
language_de	englisch
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callnumber-first	R - Medicine
author	Weiming Mou
spellingShingle	Weiming Mou misc RC254-282 misc QH573-671 misc Chromatin accessibility misc Colon adenocarcinoma misc Microsatellite instability misc Tumor microenvironment misc Immune checkpoint inhibitors misc ATOH1 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens misc Cytology Relationship between ATOH1 and tumor microenvironment in colon adenocarcinoma patients with different microsatellite instability status
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topic_title	RC254-282 QH573-671 Relationship between ATOH1 and tumor microenvironment in colon adenocarcinoma patients with different microsatellite instability status Chromatin accessibility Colon adenocarcinoma Microsatellite instability Tumor microenvironment Immune checkpoint inhibitors ATOH1
topic	misc RC254-282 misc QH573-671 misc Chromatin accessibility misc Colon adenocarcinoma misc Microsatellite instability misc Tumor microenvironment misc Immune checkpoint inhibitors misc ATOH1 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens misc Cytology
topic_unstemmed	misc RC254-282 misc QH573-671 misc Chromatin accessibility misc Colon adenocarcinoma misc Microsatellite instability misc Tumor microenvironment misc Immune checkpoint inhibitors misc ATOH1 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens misc Cytology
topic_browse	misc RC254-282 misc QH573-671 misc Chromatin accessibility misc Colon adenocarcinoma misc Microsatellite instability misc Tumor microenvironment misc Immune checkpoint inhibitors misc ATOH1 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens misc Cytology
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title	Relationship between ATOH1 and tumor microenvironment in colon adenocarcinoma patients with different microsatellite instability status
ctrlnum	(DE-627)DOAJ041353897 (DE-599)DOAJd96ae038a375463f8fea51c74c36e91d
title_full	Relationship between ATOH1 and tumor microenvironment in colon adenocarcinoma patients with different microsatellite instability status
author_sort	Weiming Mou
journal	Cancer Cell International
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author_browse	Weiming Mou Lingxuan Zhu Tao Yang Anqi Lin Qiong Lyu Linlang Guo Zaoqu Liu Quan Cheng Jian Zhang Peng Luo
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title_sort	relationship between atoh1 and tumor microenvironment in colon adenocarcinoma patients with different microsatellite instability status
callnumber	RC254-282
title_auth	Relationship between ATOH1 and tumor microenvironment in colon adenocarcinoma patients with different microsatellite instability status
abstract	Abstract Background Colon adenocarcinoma (COAD) is one of the major varieties of malignant tumors threatening human health today. Immune checkpoint inhibitors (ICIs) have recently begun to emerge as an effective option for the treatment of COAD patients, but not all patients can benefit from ICI treatment. Previous studies have suggested that ICIs boast significant clinical effects on patients with microsatellite instability-high (MSI-H), while conversely patients with microsatellite-stable/microsatellite instability-low (MSS/MSI-L) have shown limited response. Methods We used ATAC-seq, RNA-seq, and mutation data from The Cancer Genome Atlas Colon adenocarcinoma (TCGA-COAD) cohort to perform multi-omics differential analysis on COAD samples with different MSI statuses, then further screened genes by additionally combining these results with survival analysis. We analyzed the effects of the screened genes on the tumor microenvironment and immunogenicity of COAD patients, and subsequently determined their influence on the efficacy of ICIs in COAD patients using a series of predictive indexes. Results Twelve genes were screened in the TCGA-COAD cohort, and after the combined survival analysis, we identified ATOH1 as having significant effects. ATOH1 is characterized by high chromatin accessibility, high expression, and high mutation in COAD patients in the MSI-H group. COAD patients with high ATOH1 expression are associated with a better prognosis, unique immune microenvironment, and higher efficacy in ICI treatment. Enrichment analysis showed that COAD patients with high ATOH1 expression displayed significant upregulation in their humoral immunity and other related pathways. Conclusions We speculate that ATOH1 may influence the efficacy of ICIs therapy in patients with COAD by affecting the immune microenvironment and immunogenicity of the tumor.
abstractGer	Abstract Background Colon adenocarcinoma (COAD) is one of the major varieties of malignant tumors threatening human health today. Immune checkpoint inhibitors (ICIs) have recently begun to emerge as an effective option for the treatment of COAD patients, but not all patients can benefit from ICI treatment. Previous studies have suggested that ICIs boast significant clinical effects on patients with microsatellite instability-high (MSI-H), while conversely patients with microsatellite-stable/microsatellite instability-low (MSS/MSI-L) have shown limited response. Methods We used ATAC-seq, RNA-seq, and mutation data from The Cancer Genome Atlas Colon adenocarcinoma (TCGA-COAD) cohort to perform multi-omics differential analysis on COAD samples with different MSI statuses, then further screened genes by additionally combining these results with survival analysis. We analyzed the effects of the screened genes on the tumor microenvironment and immunogenicity of COAD patients, and subsequently determined their influence on the efficacy of ICIs in COAD patients using a series of predictive indexes. Results Twelve genes were screened in the TCGA-COAD cohort, and after the combined survival analysis, we identified ATOH1 as having significant effects. ATOH1 is characterized by high chromatin accessibility, high expression, and high mutation in COAD patients in the MSI-H group. COAD patients with high ATOH1 expression are associated with a better prognosis, unique immune microenvironment, and higher efficacy in ICI treatment. Enrichment analysis showed that COAD patients with high ATOH1 expression displayed significant upregulation in their humoral immunity and other related pathways. Conclusions We speculate that ATOH1 may influence the efficacy of ICIs therapy in patients with COAD by affecting the immune microenvironment and immunogenicity of the tumor.
abstract_unstemmed	Abstract Background Colon adenocarcinoma (COAD) is one of the major varieties of malignant tumors threatening human health today. Immune checkpoint inhibitors (ICIs) have recently begun to emerge as an effective option for the treatment of COAD patients, but not all patients can benefit from ICI treatment. Previous studies have suggested that ICIs boast significant clinical effects on patients with microsatellite instability-high (MSI-H), while conversely patients with microsatellite-stable/microsatellite instability-low (MSS/MSI-L) have shown limited response. Methods We used ATAC-seq, RNA-seq, and mutation data from The Cancer Genome Atlas Colon adenocarcinoma (TCGA-COAD) cohort to perform multi-omics differential analysis on COAD samples with different MSI statuses, then further screened genes by additionally combining these results with survival analysis. We analyzed the effects of the screened genes on the tumor microenvironment and immunogenicity of COAD patients, and subsequently determined their influence on the efficacy of ICIs in COAD patients using a series of predictive indexes. Results Twelve genes were screened in the TCGA-COAD cohort, and after the combined survival analysis, we identified ATOH1 as having significant effects. ATOH1 is characterized by high chromatin accessibility, high expression, and high mutation in COAD patients in the MSI-H group. COAD patients with high ATOH1 expression are associated with a better prognosis, unique immune microenvironment, and higher efficacy in ICI treatment. Enrichment analysis showed that COAD patients with high ATOH1 expression displayed significant upregulation in their humoral immunity and other related pathways. Conclusions We speculate that ATOH1 may influence the efficacy of ICIs therapy in patients with COAD by affecting the immune microenvironment and immunogenicity of the tumor.
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title_short	Relationship between ATOH1 and tumor microenvironment in colon adenocarcinoma patients with different microsatellite instability status
url	https://doi.org/10.1186/s12935-022-02651-6 https://doaj.org/article/d96ae038a375463f8fea51c74c36e91d https://doaj.org/toc/1475-2867
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