Functional Diversity of Non-Histone Chromosomal Protein HmgB1

The functioning of DNA in the cell nucleus is ensured by a multitude of proteins, whose interactions with DNA as well as with other proteins lead to the formation of a complicated, organized, and quite dynamic system known as chromatin. This review is devoted to the description of properties and str...
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Autor*in:	Elena Chikhirzhina [verfasserIn] Tatyana Starkova [verfasserIn] Anton Beljajev [verfasserIn] Alexander Polyanichko [verfasserIn] Alexey Tomilin [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	protein HmgB1 DNA-protein protein–protein interactions nuclear extranuclear functions of HmgB1

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 21(2020), 21, p 7948
Übergeordnetes Werk:	volume:21 ; year:2020 ; number:21, p 7948

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms21217948

Katalog-ID:	DOAJ041393546

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allfields	10.3390/ijms21217948 doi (DE-627)DOAJ041393546 (DE-599)DOAJ70b1c885d74a45719d55f20baa701aa7 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Elena Chikhirzhina verfasserin aut Functional Diversity of Non-Histone Chromosomal Protein HmgB1 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The functioning of DNA in the cell nucleus is ensured by a multitude of proteins, whose interactions with DNA as well as with other proteins lead to the formation of a complicated, organized, and quite dynamic system known as chromatin. This review is devoted to the description of properties and structure of the progenitors of the most abundant non-histone protein of the HMGB family—the HmgB1 protein. The proteins of the HMGB family are also known as “architectural factors” of chromatin, which play an important role in gene expression, transcription, DNA replication, and repair. However, as soon as HmgB1 goes outside the nucleus, it acquires completely different functions, post-translational modifications, and change of its redox state. Despite a lot of evidence of the functional activity of HmgB1, there are still many issues to be solved related to the mechanisms of the influence of HmgB1 on the development and treatment of different diseases—from oncological and cardiovascular diseases to pathologies during pregnancy and childbirth. Here, we describe molecular structure of the HmgB1 protein and discuss general mechanisms of its interactions with other proteins and DNA in cell. protein HmgB1 DNA-protein protein–protein interactions nuclear extranuclear functions of HmgB1 Biology (General) Chemistry Tatyana Starkova verfasserin aut Anton Beljajev verfasserin aut Alexander Polyanichko verfasserin aut Alexey Tomilin verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 21(2020), 21, p 7948 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:21 year:2020 number:21, p 7948 https://doi.org/10.3390/ijms21217948 kostenfrei https://doaj.org/article/70b1c885d74a45719d55f20baa701aa7 kostenfrei https://www.mdpi.com/1422-0067/21/21/7948 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 21, p 7948
spelling	10.3390/ijms21217948 doi (DE-627)DOAJ041393546 (DE-599)DOAJ70b1c885d74a45719d55f20baa701aa7 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Elena Chikhirzhina verfasserin aut Functional Diversity of Non-Histone Chromosomal Protein HmgB1 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The functioning of DNA in the cell nucleus is ensured by a multitude of proteins, whose interactions with DNA as well as with other proteins lead to the formation of a complicated, organized, and quite dynamic system known as chromatin. This review is devoted to the description of properties and structure of the progenitors of the most abundant non-histone protein of the HMGB family—the HmgB1 protein. The proteins of the HMGB family are also known as “architectural factors” of chromatin, which play an important role in gene expression, transcription, DNA replication, and repair. However, as soon as HmgB1 goes outside the nucleus, it acquires completely different functions, post-translational modifications, and change of its redox state. Despite a lot of evidence of the functional activity of HmgB1, there are still many issues to be solved related to the mechanisms of the influence of HmgB1 on the development and treatment of different diseases—from oncological and cardiovascular diseases to pathologies during pregnancy and childbirth. Here, we describe molecular structure of the HmgB1 protein and discuss general mechanisms of its interactions with other proteins and DNA in cell. protein HmgB1 DNA-protein protein–protein interactions nuclear extranuclear functions of HmgB1 Biology (General) Chemistry Tatyana Starkova verfasserin aut Anton Beljajev verfasserin aut Alexander Polyanichko verfasserin aut Alexey Tomilin verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 21(2020), 21, p 7948 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:21 year:2020 number:21, p 7948 https://doi.org/10.3390/ijms21217948 kostenfrei https://doaj.org/article/70b1c885d74a45719d55f20baa701aa7 kostenfrei https://www.mdpi.com/1422-0067/21/21/7948 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 21, p 7948
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allfieldsSound	10.3390/ijms21217948 doi (DE-627)DOAJ041393546 (DE-599)DOAJ70b1c885d74a45719d55f20baa701aa7 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Elena Chikhirzhina verfasserin aut Functional Diversity of Non-Histone Chromosomal Protein HmgB1 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The functioning of DNA in the cell nucleus is ensured by a multitude of proteins, whose interactions with DNA as well as with other proteins lead to the formation of a complicated, organized, and quite dynamic system known as chromatin. This review is devoted to the description of properties and structure of the progenitors of the most abundant non-histone protein of the HMGB family—the HmgB1 protein. The proteins of the HMGB family are also known as “architectural factors” of chromatin, which play an important role in gene expression, transcription, DNA replication, and repair. However, as soon as HmgB1 goes outside the nucleus, it acquires completely different functions, post-translational modifications, and change of its redox state. Despite a lot of evidence of the functional activity of HmgB1, there are still many issues to be solved related to the mechanisms of the influence of HmgB1 on the development and treatment of different diseases—from oncological and cardiovascular diseases to pathologies during pregnancy and childbirth. Here, we describe molecular structure of the HmgB1 protein and discuss general mechanisms of its interactions with other proteins and DNA in cell. protein HmgB1 DNA-protein protein–protein interactions nuclear extranuclear functions of HmgB1 Biology (General) Chemistry Tatyana Starkova verfasserin aut Anton Beljajev verfasserin aut Alexander Polyanichko verfasserin aut Alexey Tomilin verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 21(2020), 21, p 7948 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:21 year:2020 number:21, p 7948 https://doi.org/10.3390/ijms21217948 kostenfrei https://doaj.org/article/70b1c885d74a45719d55f20baa701aa7 kostenfrei https://www.mdpi.com/1422-0067/21/21/7948 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 21, p 7948
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callnumber-first	Q - Science
author	Elena Chikhirzhina
spellingShingle	Elena Chikhirzhina misc QH301-705.5 misc QD1-999 misc protein HmgB1 misc DNA-protein misc protein–protein interactions misc nuclear misc extranuclear functions of HmgB1 misc Biology (General) misc Chemistry Functional Diversity of Non-Histone Chromosomal Protein HmgB1
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topic_title	QH301-705.5 QD1-999 Functional Diversity of Non-Histone Chromosomal Protein HmgB1 protein HmgB1 DNA-protein protein–protein interactions nuclear extranuclear functions of HmgB1
topic	misc QH301-705.5 misc QD1-999 misc protein HmgB1 misc DNA-protein misc protein–protein interactions misc nuclear misc extranuclear functions of HmgB1 misc Biology (General) misc Chemistry
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title	Functional Diversity of Non-Histone Chromosomal Protein HmgB1
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title_full	Functional Diversity of Non-Histone Chromosomal Protein HmgB1
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title_sort	functional diversity of non-histone chromosomal protein hmgb1
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title_auth	Functional Diversity of Non-Histone Chromosomal Protein HmgB1
abstract	The functioning of DNA in the cell nucleus is ensured by a multitude of proteins, whose interactions with DNA as well as with other proteins lead to the formation of a complicated, organized, and quite dynamic system known as chromatin. This review is devoted to the description of properties and structure of the progenitors of the most abundant non-histone protein of the HMGB family—the HmgB1 protein. The proteins of the HMGB family are also known as “architectural factors” of chromatin, which play an important role in gene expression, transcription, DNA replication, and repair. However, as soon as HmgB1 goes outside the nucleus, it acquires completely different functions, post-translational modifications, and change of its redox state. Despite a lot of evidence of the functional activity of HmgB1, there are still many issues to be solved related to the mechanisms of the influence of HmgB1 on the development and treatment of different diseases—from oncological and cardiovascular diseases to pathologies during pregnancy and childbirth. Here, we describe molecular structure of the HmgB1 protein and discuss general mechanisms of its interactions with other proteins and DNA in cell.
abstractGer	The functioning of DNA in the cell nucleus is ensured by a multitude of proteins, whose interactions with DNA as well as with other proteins lead to the formation of a complicated, organized, and quite dynamic system known as chromatin. This review is devoted to the description of properties and structure of the progenitors of the most abundant non-histone protein of the HMGB family—the HmgB1 protein. The proteins of the HMGB family are also known as “architectural factors” of chromatin, which play an important role in gene expression, transcription, DNA replication, and repair. However, as soon as HmgB1 goes outside the nucleus, it acquires completely different functions, post-translational modifications, and change of its redox state. Despite a lot of evidence of the functional activity of HmgB1, there are still many issues to be solved related to the mechanisms of the influence of HmgB1 on the development and treatment of different diseases—from oncological and cardiovascular diseases to pathologies during pregnancy and childbirth. Here, we describe molecular structure of the HmgB1 protein and discuss general mechanisms of its interactions with other proteins and DNA in cell.
abstract_unstemmed	The functioning of DNA in the cell nucleus is ensured by a multitude of proteins, whose interactions with DNA as well as with other proteins lead to the formation of a complicated, organized, and quite dynamic system known as chromatin. This review is devoted to the description of properties and structure of the progenitors of the most abundant non-histone protein of the HMGB family—the HmgB1 protein. The proteins of the HMGB family are also known as “architectural factors” of chromatin, which play an important role in gene expression, transcription, DNA replication, and repair. However, as soon as HmgB1 goes outside the nucleus, it acquires completely different functions, post-translational modifications, and change of its redox state. Despite a lot of evidence of the functional activity of HmgB1, there are still many issues to be solved related to the mechanisms of the influence of HmgB1 on the development and treatment of different diseases—from oncological and cardiovascular diseases to pathologies during pregnancy and childbirth. Here, we describe molecular structure of the HmgB1 protein and discuss general mechanisms of its interactions with other proteins and DNA in cell.
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title_short	Functional Diversity of Non-Histone Chromosomal Protein HmgB1
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Functional Diversity of Non-Histone Chromosomal Protein HmgB1

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