Multiple Genes Related to Muscle Identified through a Joint Analysis of a Two-stage Genome-wide Association Study for Racing Performance of 1,156 Thoroughbreds

Thoroughbred, a relatively recent horse breed, is best known for its use in horse racing. Although myostatin (MSTN) variants have been reported to be highly associated with horse racing performance, the trait is more likely to be polygenic in nature. The purpose of this study was to identify genetic...
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Autor*in:	Dong-Hyun Shin [verfasserIn] Jin Woo Lee [verfasserIn] Jong-Eun Park [verfasserIn] Ik-Young Choi [verfasserIn] Hee-Seok Oh [verfasserIn] Hyeon Jeong Kim [verfasserIn] Heebal Kim [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Genome-wide Association Studies [GWAS] Thoroughbred Racing Performance Single Nucleotide Polymorphism Estimated Breeding Value

Übergeordnetes Werk:	In: Asian-Australasian Journal of Animal Sciences - Asian-Australasian Association of Animal Production Societies, 2017, 28(2015), 6, Seite 771-781
Übergeordnetes Werk:	volume:28 ; year:2015 ; number:6 ; pages:771-781

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.5713/ajas.14.0008

Katalog-ID:	DOAJ041506049

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spelling	10.5713/ajas.14.0008 doi (DE-627)DOAJ041506049 (DE-599)DOAJ1b05c2a54867436fae0b533c660e7d2b DE-627 ger DE-627 rakwb eng SF1-1100 QP501-801 Dong-Hyun Shin verfasserin aut Multiple Genes Related to Muscle Identified through a Joint Analysis of a Two-stage Genome-wide Association Study for Racing Performance of 1,156 Thoroughbreds 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Thoroughbred, a relatively recent horse breed, is best known for its use in horse racing. Although myostatin (MSTN) variants have been reported to be highly associated with horse racing performance, the trait is more likely to be polygenic in nature. The purpose of this study was to identify genetic variants strongly associated with racing performance by using estimated breeding value (EBV) for race time as a phenotype. We conducted a two-stage genome-wide association study to search for genetic variants associated with the EBV. In the first stage of genome-wide association study, a relatively large number of markers (~54,000 single-nucleotide polymorphisms, SNPs) were evaluated in a small number of samples (240 horses). In the second stage, a relatively small number of markers identified to have large effects (170 SNPs) were evaluated in a much larger number of samples (1,156 horses). We also validated the SNPs related to MSTN known to have large effects on racing performance and found significant associations in the stage two analysis, but not in stage one. We identified 28 significant SNPs related to 17 genes. Among these, six genes have a function related to myogenesis and five genes are involved in muscle maintenance. To our knowledge, these genes are newly reported for the genetic association with racing performance of Thoroughbreds. It complements a recent horse genome-wide association studies of racing performance that identified other SNPs and genes as the most significant variants. These results will help to expand our knowledge of the polygenic nature of racing performance in Thoroughbreds. Genome-wide Association Studies [GWAS] Thoroughbred Racing Performance Single Nucleotide Polymorphism Estimated Breeding Value Animal culture Animal biochemistry Jin Woo Lee verfasserin aut Jong-Eun Park verfasserin aut Ik-Young Choi verfasserin aut Hee-Seok Oh verfasserin aut Hyeon Jeong Kim verfasserin aut Heebal Kim verfasserin aut In Asian-Australasian Journal of Animal Sciences Asian-Australasian Association of Animal Production Societies, 2017 28(2015), 6, Seite 771-781 (DE-627)756825873 (DE-600)2727534-6 19765517 nnns volume:28 year:2015 number:6 pages:771-781 https://doi.org/10.5713/ajas.14.0008 kostenfrei https://doaj.org/article/1b05c2a54867436fae0b533c660e7d2b kostenfrei http://www.ajas.info/upload/pdf/ajas-28-6-771.pdf kostenfrei https://doaj.org/toc/1011-2367 Journal toc kostenfrei https://doaj.org/toc/1976-5517 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2015 6 771-781
allfields_unstemmed	10.5713/ajas.14.0008 doi (DE-627)DOAJ041506049 (DE-599)DOAJ1b05c2a54867436fae0b533c660e7d2b DE-627 ger DE-627 rakwb eng SF1-1100 QP501-801 Dong-Hyun Shin verfasserin aut Multiple Genes Related to Muscle Identified through a Joint Analysis of a Two-stage Genome-wide Association Study for Racing Performance of 1,156 Thoroughbreds 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Thoroughbred, a relatively recent horse breed, is best known for its use in horse racing. Although myostatin (MSTN) variants have been reported to be highly associated with horse racing performance, the trait is more likely to be polygenic in nature. The purpose of this study was to identify genetic variants strongly associated with racing performance by using estimated breeding value (EBV) for race time as a phenotype. We conducted a two-stage genome-wide association study to search for genetic variants associated with the EBV. In the first stage of genome-wide association study, a relatively large number of markers (~54,000 single-nucleotide polymorphisms, SNPs) were evaluated in a small number of samples (240 horses). In the second stage, a relatively small number of markers identified to have large effects (170 SNPs) were evaluated in a much larger number of samples (1,156 horses). We also validated the SNPs related to MSTN known to have large effects on racing performance and found significant associations in the stage two analysis, but not in stage one. We identified 28 significant SNPs related to 17 genes. Among these, six genes have a function related to myogenesis and five genes are involved in muscle maintenance. To our knowledge, these genes are newly reported for the genetic association with racing performance of Thoroughbreds. It complements a recent horse genome-wide association studies of racing performance that identified other SNPs and genes as the most significant variants. These results will help to expand our knowledge of the polygenic nature of racing performance in Thoroughbreds. Genome-wide Association Studies [GWAS] Thoroughbred Racing Performance Single Nucleotide Polymorphism Estimated Breeding Value Animal culture Animal biochemistry Jin Woo Lee verfasserin aut Jong-Eun Park verfasserin aut Ik-Young Choi verfasserin aut Hee-Seok Oh verfasserin aut Hyeon Jeong Kim verfasserin aut Heebal Kim verfasserin aut In Asian-Australasian Journal of Animal Sciences Asian-Australasian Association of Animal Production Societies, 2017 28(2015), 6, Seite 771-781 (DE-627)756825873 (DE-600)2727534-6 19765517 nnns volume:28 year:2015 number:6 pages:771-781 https://doi.org/10.5713/ajas.14.0008 kostenfrei https://doaj.org/article/1b05c2a54867436fae0b533c660e7d2b kostenfrei http://www.ajas.info/upload/pdf/ajas-28-6-771.pdf kostenfrei https://doaj.org/toc/1011-2367 Journal toc kostenfrei https://doaj.org/toc/1976-5517 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2015 6 771-781
allfieldsGer	10.5713/ajas.14.0008 doi (DE-627)DOAJ041506049 (DE-599)DOAJ1b05c2a54867436fae0b533c660e7d2b DE-627 ger DE-627 rakwb eng SF1-1100 QP501-801 Dong-Hyun Shin verfasserin aut Multiple Genes Related to Muscle Identified through a Joint Analysis of a Two-stage Genome-wide Association Study for Racing Performance of 1,156 Thoroughbreds 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Thoroughbred, a relatively recent horse breed, is best known for its use in horse racing. Although myostatin (MSTN) variants have been reported to be highly associated with horse racing performance, the trait is more likely to be polygenic in nature. The purpose of this study was to identify genetic variants strongly associated with racing performance by using estimated breeding value (EBV) for race time as a phenotype. We conducted a two-stage genome-wide association study to search for genetic variants associated with the EBV. In the first stage of genome-wide association study, a relatively large number of markers (~54,000 single-nucleotide polymorphisms, SNPs) were evaluated in a small number of samples (240 horses). In the second stage, a relatively small number of markers identified to have large effects (170 SNPs) were evaluated in a much larger number of samples (1,156 horses). We also validated the SNPs related to MSTN known to have large effects on racing performance and found significant associations in the stage two analysis, but not in stage one. We identified 28 significant SNPs related to 17 genes. Among these, six genes have a function related to myogenesis and five genes are involved in muscle maintenance. To our knowledge, these genes are newly reported for the genetic association with racing performance of Thoroughbreds. It complements a recent horse genome-wide association studies of racing performance that identified other SNPs and genes as the most significant variants. These results will help to expand our knowledge of the polygenic nature of racing performance in Thoroughbreds. Genome-wide Association Studies [GWAS] Thoroughbred Racing Performance Single Nucleotide Polymorphism Estimated Breeding Value Animal culture Animal biochemistry Jin Woo Lee verfasserin aut Jong-Eun Park verfasserin aut Ik-Young Choi verfasserin aut Hee-Seok Oh verfasserin aut Hyeon Jeong Kim verfasserin aut Heebal Kim verfasserin aut In Asian-Australasian Journal of Animal Sciences Asian-Australasian Association of Animal Production Societies, 2017 28(2015), 6, Seite 771-781 (DE-627)756825873 (DE-600)2727534-6 19765517 nnns volume:28 year:2015 number:6 pages:771-781 https://doi.org/10.5713/ajas.14.0008 kostenfrei https://doaj.org/article/1b05c2a54867436fae0b533c660e7d2b kostenfrei http://www.ajas.info/upload/pdf/ajas-28-6-771.pdf kostenfrei https://doaj.org/toc/1011-2367 Journal toc kostenfrei https://doaj.org/toc/1976-5517 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2015 6 771-781
allfieldsSound	10.5713/ajas.14.0008 doi (DE-627)DOAJ041506049 (DE-599)DOAJ1b05c2a54867436fae0b533c660e7d2b DE-627 ger DE-627 rakwb eng SF1-1100 QP501-801 Dong-Hyun Shin verfasserin aut Multiple Genes Related to Muscle Identified through a Joint Analysis of a Two-stage Genome-wide Association Study for Racing Performance of 1,156 Thoroughbreds 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Thoroughbred, a relatively recent horse breed, is best known for its use in horse racing. Although myostatin (MSTN) variants have been reported to be highly associated with horse racing performance, the trait is more likely to be polygenic in nature. The purpose of this study was to identify genetic variants strongly associated with racing performance by using estimated breeding value (EBV) for race time as a phenotype. We conducted a two-stage genome-wide association study to search for genetic variants associated with the EBV. In the first stage of genome-wide association study, a relatively large number of markers (~54,000 single-nucleotide polymorphisms, SNPs) were evaluated in a small number of samples (240 horses). In the second stage, a relatively small number of markers identified to have large effects (170 SNPs) were evaluated in a much larger number of samples (1,156 horses). We also validated the SNPs related to MSTN known to have large effects on racing performance and found significant associations in the stage two analysis, but not in stage one. We identified 28 significant SNPs related to 17 genes. Among these, six genes have a function related to myogenesis and five genes are involved in muscle maintenance. To our knowledge, these genes are newly reported for the genetic association with racing performance of Thoroughbreds. It complements a recent horse genome-wide association studies of racing performance that identified other SNPs and genes as the most significant variants. These results will help to expand our knowledge of the polygenic nature of racing performance in Thoroughbreds. Genome-wide Association Studies [GWAS] Thoroughbred Racing Performance Single Nucleotide Polymorphism Estimated Breeding Value Animal culture Animal biochemistry Jin Woo Lee verfasserin aut Jong-Eun Park verfasserin aut Ik-Young Choi verfasserin aut Hee-Seok Oh verfasserin aut Hyeon Jeong Kim verfasserin aut Heebal Kim verfasserin aut In Asian-Australasian Journal of Animal Sciences Asian-Australasian Association of Animal Production Societies, 2017 28(2015), 6, Seite 771-781 (DE-627)756825873 (DE-600)2727534-6 19765517 nnns volume:28 year:2015 number:6 pages:771-781 https://doi.org/10.5713/ajas.14.0008 kostenfrei https://doaj.org/article/1b05c2a54867436fae0b533c660e7d2b kostenfrei http://www.ajas.info/upload/pdf/ajas-28-6-771.pdf kostenfrei https://doaj.org/toc/1011-2367 Journal toc kostenfrei https://doaj.org/toc/1976-5517 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2015 6 771-781
language	English
source	In Asian-Australasian Journal of Animal Sciences 28(2015), 6, Seite 771-781 volume:28 year:2015 number:6 pages:771-781
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topic_title	SF1-1100 QP501-801 Multiple Genes Related to Muscle Identified through a Joint Analysis of a Two-stage Genome-wide Association Study for Racing Performance of 1,156 Thoroughbreds Genome-wide Association Studies [GWAS] Thoroughbred Racing Performance Single Nucleotide Polymorphism Estimated Breeding Value
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title	Multiple Genes Related to Muscle Identified through a Joint Analysis of a Two-stage Genome-wide Association Study for Racing Performance of 1,156 Thoroughbreds
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title_auth	Multiple Genes Related to Muscle Identified through a Joint Analysis of a Two-stage Genome-wide Association Study for Racing Performance of 1,156 Thoroughbreds
abstract	Thoroughbred, a relatively recent horse breed, is best known for its use in horse racing. Although myostatin (MSTN) variants have been reported to be highly associated with horse racing performance, the trait is more likely to be polygenic in nature. The purpose of this study was to identify genetic variants strongly associated with racing performance by using estimated breeding value (EBV) for race time as a phenotype. We conducted a two-stage genome-wide association study to search for genetic variants associated with the EBV. In the first stage of genome-wide association study, a relatively large number of markers (~54,000 single-nucleotide polymorphisms, SNPs) were evaluated in a small number of samples (240 horses). In the second stage, a relatively small number of markers identified to have large effects (170 SNPs) were evaluated in a much larger number of samples (1,156 horses). We also validated the SNPs related to MSTN known to have large effects on racing performance and found significant associations in the stage two analysis, but not in stage one. We identified 28 significant SNPs related to 17 genes. Among these, six genes have a function related to myogenesis and five genes are involved in muscle maintenance. To our knowledge, these genes are newly reported for the genetic association with racing performance of Thoroughbreds. It complements a recent horse genome-wide association studies of racing performance that identified other SNPs and genes as the most significant variants. These results will help to expand our knowledge of the polygenic nature of racing performance in Thoroughbreds.
abstractGer	Thoroughbred, a relatively recent horse breed, is best known for its use in horse racing. Although myostatin (MSTN) variants have been reported to be highly associated with horse racing performance, the trait is more likely to be polygenic in nature. The purpose of this study was to identify genetic variants strongly associated with racing performance by using estimated breeding value (EBV) for race time as a phenotype. We conducted a two-stage genome-wide association study to search for genetic variants associated with the EBV. In the first stage of genome-wide association study, a relatively large number of markers (~54,000 single-nucleotide polymorphisms, SNPs) were evaluated in a small number of samples (240 horses). In the second stage, a relatively small number of markers identified to have large effects (170 SNPs) were evaluated in a much larger number of samples (1,156 horses). We also validated the SNPs related to MSTN known to have large effects on racing performance and found significant associations in the stage two analysis, but not in stage one. We identified 28 significant SNPs related to 17 genes. Among these, six genes have a function related to myogenesis and five genes are involved in muscle maintenance. To our knowledge, these genes are newly reported for the genetic association with racing performance of Thoroughbreds. It complements a recent horse genome-wide association studies of racing performance that identified other SNPs and genes as the most significant variants. These results will help to expand our knowledge of the polygenic nature of racing performance in Thoroughbreds.
abstract_unstemmed	Thoroughbred, a relatively recent horse breed, is best known for its use in horse racing. Although myostatin (MSTN) variants have been reported to be highly associated with horse racing performance, the trait is more likely to be polygenic in nature. The purpose of this study was to identify genetic variants strongly associated with racing performance by using estimated breeding value (EBV) for race time as a phenotype. We conducted a two-stage genome-wide association study to search for genetic variants associated with the EBV. In the first stage of genome-wide association study, a relatively large number of markers (~54,000 single-nucleotide polymorphisms, SNPs) were evaluated in a small number of samples (240 horses). In the second stage, a relatively small number of markers identified to have large effects (170 SNPs) were evaluated in a much larger number of samples (1,156 horses). We also validated the SNPs related to MSTN known to have large effects on racing performance and found significant associations in the stage two analysis, but not in stage one. We identified 28 significant SNPs related to 17 genes. Among these, six genes have a function related to myogenesis and five genes are involved in muscle maintenance. To our knowledge, these genes are newly reported for the genetic association with racing performance of Thoroughbreds. It complements a recent horse genome-wide association studies of racing performance that identified other SNPs and genes as the most significant variants. These results will help to expand our knowledge of the polygenic nature of racing performance in Thoroughbreds.
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title_short	Multiple Genes Related to Muscle Identified through a Joint Analysis of a Two-stage Genome-wide Association Study for Racing Performance of 1,156 Thoroughbreds
url	https://doi.org/10.5713/ajas.14.0008 https://doaj.org/article/1b05c2a54867436fae0b533c660e7d2b http://www.ajas.info/upload/pdf/ajas-28-6-771.pdf https://doaj.org/toc/1011-2367 https://doaj.org/toc/1976-5517
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Multiple Genes Related to Muscle Identified through a Joint Analysis of a Two-stage Genome-wide Association Study for Racing Performance of 1,156 Thoroughbreds

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