Nintedanib in NSCLC: evidence to date and place in therapy

The treatment of advanced non-small cell lung cancer (NSCLC) is currently driven by the detection of targetable oncogenic drivers, i.e. epidermal growth factor receptor, echinoderm microtubule-associated protein-like 4–anaplastic lymphoma kinase, etc. Those patients who are wildtype for known and va...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Giuseppe Bronte [verfasserIn] Francesco Passiglia [verfasserIn] Antonio Galvano [verfasserIn] Nadia Barraco [verfasserIn] Angela Listì [verfasserIn] Marta Castiglia [verfasserIn] Sergio Rizzo [verfasserIn] Eugenio Fiorentino [verfasserIn] Viviana Bazan [verfasserIn] Antonio Russo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Übergeordnetes Werk:	In: Therapeutic Advances in Medical Oncology - SAGE Publishing, 2018, 8(2016)
Übergeordnetes Werk:	volume:8 ; year:2016

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1177/1758834016630976

Katalog-ID:	DOAJ041521072

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allfields	10.1177/1758834016630976 doi (DE-627)DOAJ041521072 (DE-599)DOAJ4c6e47a884db480ea22ab7072270a2e2 DE-627 ger DE-627 rakwb eng RC254-282 Giuseppe Bronte verfasserin aut Nintedanib in NSCLC: evidence to date and place in therapy 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The treatment of advanced non-small cell lung cancer (NSCLC) is currently driven by the detection of targetable oncogenic drivers, i.e. epidermal growth factor receptor, echinoderm microtubule-associated protein-like 4–anaplastic lymphoma kinase, etc. Those patients who are wildtype for known and valuable oncogenes can receive standard chemotherapy as first-line treatment, with the possibility of adding bevacizumab. With regard to second-line treatment, nintedanib can improve the efficacy of docetaxel. Nintedanib is a tyrosine kinase inhibitor targeting three angiogenesis-related transmembrane receptors. The usefulness of nintedanib as an anticancer agent for NSCLC has been proved by both preclinical and clinical phase I and II trials; however, its approval for the use in clinical practice has been possible because of the positive results of the LUME-Lung 1 trial (nintedanib + docetaxel versus docetaxel alone) in terms of progression-free survival and overall survival, and a manageable tolerability profile. Therefore, the good results seen in the clinical trials with nintedanib in the second-line setting for NSCLC patients with adenocarcinoma subtype are encouraging enough to recommend it in clinical practice. Neoplasms. Tumors. Oncology. Including cancer and carcinogens Francesco Passiglia verfasserin aut Antonio Galvano verfasserin aut Nadia Barraco verfasserin aut Angela Listì verfasserin aut Marta Castiglia verfasserin aut Sergio Rizzo verfasserin aut Eugenio Fiorentino verfasserin aut Viviana Bazan verfasserin aut Antonio Russo verfasserin aut In Therapeutic Advances in Medical Oncology SAGE Publishing, 2018 8(2016) (DE-627)604082282 (DE-600)2503443-1 17588359 nnns volume:8 year:2016 https://doi.org/10.1177/1758834016630976 kostenfrei https://doaj.org/article/4c6e47a884db480ea22ab7072270a2e2 kostenfrei https://doi.org/10.1177/1758834016630976 kostenfrei https://doaj.org/toc/1758-8359 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_121 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2014 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2889 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2016
spelling	10.1177/1758834016630976 doi (DE-627)DOAJ041521072 (DE-599)DOAJ4c6e47a884db480ea22ab7072270a2e2 DE-627 ger DE-627 rakwb eng RC254-282 Giuseppe Bronte verfasserin aut Nintedanib in NSCLC: evidence to date and place in therapy 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The treatment of advanced non-small cell lung cancer (NSCLC) is currently driven by the detection of targetable oncogenic drivers, i.e. epidermal growth factor receptor, echinoderm microtubule-associated protein-like 4–anaplastic lymphoma kinase, etc. Those patients who are wildtype for known and valuable oncogenes can receive standard chemotherapy as first-line treatment, with the possibility of adding bevacizumab. With regard to second-line treatment, nintedanib can improve the efficacy of docetaxel. Nintedanib is a tyrosine kinase inhibitor targeting three angiogenesis-related transmembrane receptors. The usefulness of nintedanib as an anticancer agent for NSCLC has been proved by both preclinical and clinical phase I and II trials; however, its approval for the use in clinical practice has been possible because of the positive results of the LUME-Lung 1 trial (nintedanib + docetaxel versus docetaxel alone) in terms of progression-free survival and overall survival, and a manageable tolerability profile. Therefore, the good results seen in the clinical trials with nintedanib in the second-line setting for NSCLC patients with adenocarcinoma subtype are encouraging enough to recommend it in clinical practice. Neoplasms. Tumors. Oncology. Including cancer and carcinogens Francesco Passiglia verfasserin aut Antonio Galvano verfasserin aut Nadia Barraco verfasserin aut Angela Listì verfasserin aut Marta Castiglia verfasserin aut Sergio Rizzo verfasserin aut Eugenio Fiorentino verfasserin aut Viviana Bazan verfasserin aut Antonio Russo verfasserin aut In Therapeutic Advances in Medical Oncology SAGE Publishing, 2018 8(2016) (DE-627)604082282 (DE-600)2503443-1 17588359 nnns volume:8 year:2016 https://doi.org/10.1177/1758834016630976 kostenfrei https://doaj.org/article/4c6e47a884db480ea22ab7072270a2e2 kostenfrei https://doi.org/10.1177/1758834016630976 kostenfrei https://doaj.org/toc/1758-8359 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_121 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2014 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2889 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2016
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allfieldsGer	10.1177/1758834016630976 doi (DE-627)DOAJ041521072 (DE-599)DOAJ4c6e47a884db480ea22ab7072270a2e2 DE-627 ger DE-627 rakwb eng RC254-282 Giuseppe Bronte verfasserin aut Nintedanib in NSCLC: evidence to date and place in therapy 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The treatment of advanced non-small cell lung cancer (NSCLC) is currently driven by the detection of targetable oncogenic drivers, i.e. epidermal growth factor receptor, echinoderm microtubule-associated protein-like 4–anaplastic lymphoma kinase, etc. Those patients who are wildtype for known and valuable oncogenes can receive standard chemotherapy as first-line treatment, with the possibility of adding bevacizumab. With regard to second-line treatment, nintedanib can improve the efficacy of docetaxel. Nintedanib is a tyrosine kinase inhibitor targeting three angiogenesis-related transmembrane receptors. The usefulness of nintedanib as an anticancer agent for NSCLC has been proved by both preclinical and clinical phase I and II trials; however, its approval for the use in clinical practice has been possible because of the positive results of the LUME-Lung 1 trial (nintedanib + docetaxel versus docetaxel alone) in terms of progression-free survival and overall survival, and a manageable tolerability profile. Therefore, the good results seen in the clinical trials with nintedanib in the second-line setting for NSCLC patients with adenocarcinoma subtype are encouraging enough to recommend it in clinical practice. Neoplasms. Tumors. Oncology. Including cancer and carcinogens Francesco Passiglia verfasserin aut Antonio Galvano verfasserin aut Nadia Barraco verfasserin aut Angela Listì verfasserin aut Marta Castiglia verfasserin aut Sergio Rizzo verfasserin aut Eugenio Fiorentino verfasserin aut Viviana Bazan verfasserin aut Antonio Russo verfasserin aut In Therapeutic Advances in Medical Oncology SAGE Publishing, 2018 8(2016) (DE-627)604082282 (DE-600)2503443-1 17588359 nnns volume:8 year:2016 https://doi.org/10.1177/1758834016630976 kostenfrei https://doaj.org/article/4c6e47a884db480ea22ab7072270a2e2 kostenfrei https://doi.org/10.1177/1758834016630976 kostenfrei https://doaj.org/toc/1758-8359 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_121 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2014 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2889 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2016
allfieldsSound	10.1177/1758834016630976 doi (DE-627)DOAJ041521072 (DE-599)DOAJ4c6e47a884db480ea22ab7072270a2e2 DE-627 ger DE-627 rakwb eng RC254-282 Giuseppe Bronte verfasserin aut Nintedanib in NSCLC: evidence to date and place in therapy 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The treatment of advanced non-small cell lung cancer (NSCLC) is currently driven by the detection of targetable oncogenic drivers, i.e. epidermal growth factor receptor, echinoderm microtubule-associated protein-like 4–anaplastic lymphoma kinase, etc. Those patients who are wildtype for known and valuable oncogenes can receive standard chemotherapy as first-line treatment, with the possibility of adding bevacizumab. With regard to second-line treatment, nintedanib can improve the efficacy of docetaxel. Nintedanib is a tyrosine kinase inhibitor targeting three angiogenesis-related transmembrane receptors. The usefulness of nintedanib as an anticancer agent for NSCLC has been proved by both preclinical and clinical phase I and II trials; however, its approval for the use in clinical practice has been possible because of the positive results of the LUME-Lung 1 trial (nintedanib + docetaxel versus docetaxel alone) in terms of progression-free survival and overall survival, and a manageable tolerability profile. Therefore, the good results seen in the clinical trials with nintedanib in the second-line setting for NSCLC patients with adenocarcinoma subtype are encouraging enough to recommend it in clinical practice. Neoplasms. Tumors. Oncology. Including cancer and carcinogens Francesco Passiglia verfasserin aut Antonio Galvano verfasserin aut Nadia Barraco verfasserin aut Angela Listì verfasserin aut Marta Castiglia verfasserin aut Sergio Rizzo verfasserin aut Eugenio Fiorentino verfasserin aut Viviana Bazan verfasserin aut Antonio Russo verfasserin aut In Therapeutic Advances in Medical Oncology SAGE Publishing, 2018 8(2016) (DE-627)604082282 (DE-600)2503443-1 17588359 nnns volume:8 year:2016 https://doi.org/10.1177/1758834016630976 kostenfrei https://doaj.org/article/4c6e47a884db480ea22ab7072270a2e2 kostenfrei https://doi.org/10.1177/1758834016630976 kostenfrei https://doaj.org/toc/1758-8359 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_121 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2014 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2889 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2016
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source	In Therapeutic Advances in Medical Oncology 8(2016) volume:8 year:2016
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container_title	Therapeutic Advances in Medical Oncology
authorswithroles_txt_mv	Giuseppe Bronte @@aut@@ Francesco Passiglia @@aut@@ Antonio Galvano @@aut@@ Nadia Barraco @@aut@@ Angela Listì @@aut@@ Marta Castiglia @@aut@@ Sergio Rizzo @@aut@@ Eugenio Fiorentino @@aut@@ Viviana Bazan @@aut@@ Antonio Russo @@aut@@
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author	Giuseppe Bronte
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topic_title	RC254-282 Nintedanib in NSCLC: evidence to date and place in therapy
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title	Nintedanib in NSCLC: evidence to date and place in therapy
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title_full	Nintedanib in NSCLC: evidence to date and place in therapy
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title_sort	nintedanib in nsclc: evidence to date and place in therapy
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title_auth	Nintedanib in NSCLC: evidence to date and place in therapy
abstract	The treatment of advanced non-small cell lung cancer (NSCLC) is currently driven by the detection of targetable oncogenic drivers, i.e. epidermal growth factor receptor, echinoderm microtubule-associated protein-like 4–anaplastic lymphoma kinase, etc. Those patients who are wildtype for known and valuable oncogenes can receive standard chemotherapy as first-line treatment, with the possibility of adding bevacizumab. With regard to second-line treatment, nintedanib can improve the efficacy of docetaxel. Nintedanib is a tyrosine kinase inhibitor targeting three angiogenesis-related transmembrane receptors. The usefulness of nintedanib as an anticancer agent for NSCLC has been proved by both preclinical and clinical phase I and II trials; however, its approval for the use in clinical practice has been possible because of the positive results of the LUME-Lung 1 trial (nintedanib + docetaxel versus docetaxel alone) in terms of progression-free survival and overall survival, and a manageable tolerability profile. Therefore, the good results seen in the clinical trials with nintedanib in the second-line setting for NSCLC patients with adenocarcinoma subtype are encouraging enough to recommend it in clinical practice.
abstractGer	The treatment of advanced non-small cell lung cancer (NSCLC) is currently driven by the detection of targetable oncogenic drivers, i.e. epidermal growth factor receptor, echinoderm microtubule-associated protein-like 4–anaplastic lymphoma kinase, etc. Those patients who are wildtype for known and valuable oncogenes can receive standard chemotherapy as first-line treatment, with the possibility of adding bevacizumab. With regard to second-line treatment, nintedanib can improve the efficacy of docetaxel. Nintedanib is a tyrosine kinase inhibitor targeting three angiogenesis-related transmembrane receptors. The usefulness of nintedanib as an anticancer agent for NSCLC has been proved by both preclinical and clinical phase I and II trials; however, its approval for the use in clinical practice has been possible because of the positive results of the LUME-Lung 1 trial (nintedanib + docetaxel versus docetaxel alone) in terms of progression-free survival and overall survival, and a manageable tolerability profile. Therefore, the good results seen in the clinical trials with nintedanib in the second-line setting for NSCLC patients with adenocarcinoma subtype are encouraging enough to recommend it in clinical practice.
abstract_unstemmed	The treatment of advanced non-small cell lung cancer (NSCLC) is currently driven by the detection of targetable oncogenic drivers, i.e. epidermal growth factor receptor, echinoderm microtubule-associated protein-like 4–anaplastic lymphoma kinase, etc. Those patients who are wildtype for known and valuable oncogenes can receive standard chemotherapy as first-line treatment, with the possibility of adding bevacizumab. With regard to second-line treatment, nintedanib can improve the efficacy of docetaxel. Nintedanib is a tyrosine kinase inhibitor targeting three angiogenesis-related transmembrane receptors. The usefulness of nintedanib as an anticancer agent for NSCLC has been proved by both preclinical and clinical phase I and II trials; however, its approval for the use in clinical practice has been possible because of the positive results of the LUME-Lung 1 trial (nintedanib + docetaxel versus docetaxel alone) in terms of progression-free survival and overall survival, and a manageable tolerability profile. Therefore, the good results seen in the clinical trials with nintedanib in the second-line setting for NSCLC patients with adenocarcinoma subtype are encouraging enough to recommend it in clinical practice.
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title_short	Nintedanib in NSCLC: evidence to date and place in therapy
url	https://doi.org/10.1177/1758834016630976 https://doaj.org/article/4c6e47a884db480ea22ab7072270a2e2 https://doaj.org/toc/1758-8359
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up_date	2024-07-03T20:41:43.526Z
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