Effects of a New Multicomponent Nutritional Supplement on Muscle Mass and Physical Performance in Adult and Old Patients Recovered from COVID-19: A Pilot Observational Case–Control Study

Objective: The purpose of the present study was to assess the effect of a specific oral nutritional supplement among patients recovered from COVID-19 but suffering symptoms of fatigue. Methods: This is an observational case–control study involving a sample of 66 COVID-19 survivors divided in two groups, 33 subjects in the intervention group who received the nutritional supplement and 33 subjects in the control group. The nutritional supplement received by subjects in the active group was based on amino acids; vitamin B6 and B1; and malic, succinic and citric acids. After an 8-week follow-up, the main outcomes considered were skeletal muscle index (measured by bioelectrical impedance analysis), physical performance measures (handgrip strength, one-minute chair–stand test, six-minute walking test), and quality of life (using EuroQol visual analogue scale). Results: All the considered areas increased significantly in the subjects receiving the active treatment with oral nutritional supplement in comparison with the baseline values. After adjusting for age, gender, and baseline values, skeletal muscle index, handgrip strength test, the one-minute chair–stand test, and six-minute walking test values were higher among participants in the treatment group compared with subjects in control group. The oral nutritional supplement significantly improved the handgrip strength; similarly, participants in the active group showed a higher improvement in skeletal muscle index, the one-minute chair–stand test, the six-minute walking test, and in quality of life. Conclusion: The nutritional supplement containing nine essential amino acids plus cysteine; vitamin B6 and B1; and malic, succinic and citric acids had a positive effect on nutritional status, functional recovery, and quality of life in COVID-19 survivors still suffering from fatigue. Additional controlled clinical trials are required to corroborate these results. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Francesco Landi [verfasserIn] Anna Maria Martone [verfasserIn] Francesca Ciciarello [verfasserIn] Vincenzo Galluzzo [verfasserIn] Giulia Savera [verfasserIn] Riccardo Calvani [verfasserIn] Anna Picca [verfasserIn] Emanuele Marzetti [verfasserIn] Matteo Tosato [verfasserIn] On behalf of Gemelli Against COVID-19 Post-Acute Care Team [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	COVID-19 personalized medicine frailty geriatric syndrome

Übergeordnetes Werk:	In: Nutrients - MDPI AG, 2009, 14(2022), 11, p 2316
Übergeordnetes Werk:	volume:14 ; year:2022 ; number:11, p 2316

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/nu14112316

Katalog-ID:	DOAJ041535103

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allfields_unstemmed	10.3390/nu14112316 doi (DE-627)DOAJ041535103 (DE-599)DOAJca351aabb0f94d9d80dc5f5b9c9cf3a1 DE-627 ger DE-627 rakwb eng TX341-641 Francesco Landi verfasserin aut Effects of a New Multicomponent Nutritional Supplement on Muscle Mass and Physical Performance in Adult and Old Patients Recovered from COVID-19: A Pilot Observational Case–Control Study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: The purpose of the present study was to assess the effect of a specific oral nutritional supplement among patients recovered from COVID-19 but suffering symptoms of fatigue. Methods: This is an observational case–control study involving a sample of 66 COVID-19 survivors divided in two groups, 33 subjects in the intervention group who received the nutritional supplement and 33 subjects in the control group. The nutritional supplement received by subjects in the active group was based on amino acids; vitamin B6 and B1; and malic, succinic and citric acids. After an 8-week follow-up, the main outcomes considered were skeletal muscle index (measured by bioelectrical impedance analysis), physical performance measures (handgrip strength, one-minute chair–stand test, six-minute walking test), and quality of life (using EuroQol visual analogue scale). Results: All the considered areas increased significantly in the subjects receiving the active treatment with oral nutritional supplement in comparison with the baseline values. After adjusting for age, gender, and baseline values, skeletal muscle index, handgrip strength test, the one-minute chair–stand test, and six-minute walking test values were higher among participants in the treatment group compared with subjects in control group. The oral nutritional supplement significantly improved the handgrip strength; similarly, participants in the active group showed a higher improvement in skeletal muscle index, the one-minute chair–stand test, the six-minute walking test, and in quality of life. Conclusion: The nutritional supplement containing nine essential amino acids plus cysteine; vitamin B6 and B1; and malic, succinic and citric acids had a positive effect on nutritional status, functional recovery, and quality of life in COVID-19 survivors still suffering from fatigue. Additional controlled clinical trials are required to corroborate these results. COVID-19 personalized medicine frailty geriatric syndrome Nutrition. Foods and food supply Anna Maria Martone verfasserin aut Francesca Ciciarello verfasserin aut Vincenzo Galluzzo verfasserin aut Giulia Savera verfasserin aut Riccardo Calvani verfasserin aut Anna Picca verfasserin aut Emanuele Marzetti verfasserin aut Matteo Tosato verfasserin aut On behalf of Gemelli Against COVID-19 Post-Acute Care Team verfasserin aut In Nutrients MDPI AG, 2009 14(2022), 11, p 2316 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:14 year:2022 number:11, p 2316 https://doi.org/10.3390/nu14112316 kostenfrei https://doaj.org/article/ca351aabb0f94d9d80dc5f5b9c9cf3a1 kostenfrei https://www.mdpi.com/2072-6643/14/11/2316 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 11, p 2316
allfieldsGer	10.3390/nu14112316 doi (DE-627)DOAJ041535103 (DE-599)DOAJca351aabb0f94d9d80dc5f5b9c9cf3a1 DE-627 ger DE-627 rakwb eng TX341-641 Francesco Landi verfasserin aut Effects of a New Multicomponent Nutritional Supplement on Muscle Mass and Physical Performance in Adult and Old Patients Recovered from COVID-19: A Pilot Observational Case–Control Study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: The purpose of the present study was to assess the effect of a specific oral nutritional supplement among patients recovered from COVID-19 but suffering symptoms of fatigue. Methods: This is an observational case–control study involving a sample of 66 COVID-19 survivors divided in two groups, 33 subjects in the intervention group who received the nutritional supplement and 33 subjects in the control group. The nutritional supplement received by subjects in the active group was based on amino acids; vitamin B6 and B1; and malic, succinic and citric acids. After an 8-week follow-up, the main outcomes considered were skeletal muscle index (measured by bioelectrical impedance analysis), physical performance measures (handgrip strength, one-minute chair–stand test, six-minute walking test), and quality of life (using EuroQol visual analogue scale). Results: All the considered areas increased significantly in the subjects receiving the active treatment with oral nutritional supplement in comparison with the baseline values. After adjusting for age, gender, and baseline values, skeletal muscle index, handgrip strength test, the one-minute chair–stand test, and six-minute walking test values were higher among participants in the treatment group compared with subjects in control group. The oral nutritional supplement significantly improved the handgrip strength; similarly, participants in the active group showed a higher improvement in skeletal muscle index, the one-minute chair–stand test, the six-minute walking test, and in quality of life. Conclusion: The nutritional supplement containing nine essential amino acids plus cysteine; vitamin B6 and B1; and malic, succinic and citric acids had a positive effect on nutritional status, functional recovery, and quality of life in COVID-19 survivors still suffering from fatigue. Additional controlled clinical trials are required to corroborate these results. COVID-19 personalized medicine frailty geriatric syndrome Nutrition. Foods and food supply Anna Maria Martone verfasserin aut Francesca Ciciarello verfasserin aut Vincenzo Galluzzo verfasserin aut Giulia Savera verfasserin aut Riccardo Calvani verfasserin aut Anna Picca verfasserin aut Emanuele Marzetti verfasserin aut Matteo Tosato verfasserin aut On behalf of Gemelli Against COVID-19 Post-Acute Care Team verfasserin aut In Nutrients MDPI AG, 2009 14(2022), 11, p 2316 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:14 year:2022 number:11, p 2316 https://doi.org/10.3390/nu14112316 kostenfrei https://doaj.org/article/ca351aabb0f94d9d80dc5f5b9c9cf3a1 kostenfrei https://www.mdpi.com/2072-6643/14/11/2316 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 11, p 2316
allfieldsSound	10.3390/nu14112316 doi (DE-627)DOAJ041535103 (DE-599)DOAJca351aabb0f94d9d80dc5f5b9c9cf3a1 DE-627 ger DE-627 rakwb eng TX341-641 Francesco Landi verfasserin aut Effects of a New Multicomponent Nutritional Supplement on Muscle Mass and Physical Performance in Adult and Old Patients Recovered from COVID-19: A Pilot Observational Case–Control Study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: The purpose of the present study was to assess the effect of a specific oral nutritional supplement among patients recovered from COVID-19 but suffering symptoms of fatigue. Methods: This is an observational case–control study involving a sample of 66 COVID-19 survivors divided in two groups, 33 subjects in the intervention group who received the nutritional supplement and 33 subjects in the control group. The nutritional supplement received by subjects in the active group was based on amino acids; vitamin B6 and B1; and malic, succinic and citric acids. After an 8-week follow-up, the main outcomes considered were skeletal muscle index (measured by bioelectrical impedance analysis), physical performance measures (handgrip strength, one-minute chair–stand test, six-minute walking test), and quality of life (using EuroQol visual analogue scale). Results: All the considered areas increased significantly in the subjects receiving the active treatment with oral nutritional supplement in comparison with the baseline values. After adjusting for age, gender, and baseline values, skeletal muscle index, handgrip strength test, the one-minute chair–stand test, and six-minute walking test values were higher among participants in the treatment group compared with subjects in control group. The oral nutritional supplement significantly improved the handgrip strength; similarly, participants in the active group showed a higher improvement in skeletal muscle index, the one-minute chair–stand test, the six-minute walking test, and in quality of life. Conclusion: The nutritional supplement containing nine essential amino acids plus cysteine; vitamin B6 and B1; and malic, succinic and citric acids had a positive effect on nutritional status, functional recovery, and quality of life in COVID-19 survivors still suffering from fatigue. Additional controlled clinical trials are required to corroborate these results. COVID-19 personalized medicine frailty geriatric syndrome Nutrition. Foods and food supply Anna Maria Martone verfasserin aut Francesca Ciciarello verfasserin aut Vincenzo Galluzzo verfasserin aut Giulia Savera verfasserin aut Riccardo Calvani verfasserin aut Anna Picca verfasserin aut Emanuele Marzetti verfasserin aut Matteo Tosato verfasserin aut On behalf of Gemelli Against COVID-19 Post-Acute Care Team verfasserin aut In Nutrients MDPI AG, 2009 14(2022), 11, p 2316 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:14 year:2022 number:11, p 2316 https://doi.org/10.3390/nu14112316 kostenfrei https://doaj.org/article/ca351aabb0f94d9d80dc5f5b9c9cf3a1 kostenfrei https://www.mdpi.com/2072-6643/14/11/2316 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 11, p 2316
language	English
source	In Nutrients 14(2022), 11, p 2316 volume:14 year:2022 number:11, p 2316
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topic_facet	COVID-19 personalized medicine frailty geriatric syndrome Nutrition. Foods and food supply
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container_title	Nutrients
authorswithroles_txt_mv	Francesco Landi @@aut@@ Anna Maria Martone @@aut@@ Francesca Ciciarello @@aut@@ Vincenzo Galluzzo @@aut@@ Giulia Savera @@aut@@ Riccardo Calvani @@aut@@ Anna Picca @@aut@@ Emanuele Marzetti @@aut@@ Matteo Tosato @@aut@@ On behalf of Gemelli Against COVID-19 Post-Acute Care Team @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
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author	Francesco Landi
spellingShingle	Francesco Landi misc TX341-641 misc COVID-19 misc personalized medicine misc frailty misc geriatric syndrome misc Nutrition. Foods and food supply Effects of a New Multicomponent Nutritional Supplement on Muscle Mass and Physical Performance in Adult and Old Patients Recovered from COVID-19: A Pilot Observational Case–Control Study
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topic_title	TX341-641 Effects of a New Multicomponent Nutritional Supplement on Muscle Mass and Physical Performance in Adult and Old Patients Recovered from COVID-19: A Pilot Observational Case–Control Study COVID-19 personalized medicine frailty geriatric syndrome
topic	misc TX341-641 misc COVID-19 misc personalized medicine misc frailty misc geriatric syndrome misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc COVID-19 misc personalized medicine misc frailty misc geriatric syndrome misc Nutrition. Foods and food supply
topic_browse	misc TX341-641 misc COVID-19 misc personalized medicine misc frailty misc geriatric syndrome misc Nutrition. Foods and food supply
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title	Effects of a New Multicomponent Nutritional Supplement on Muscle Mass and Physical Performance in Adult and Old Patients Recovered from COVID-19: A Pilot Observational Case–Control Study
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title_full	Effects of a New Multicomponent Nutritional Supplement on Muscle Mass and Physical Performance in Adult and Old Patients Recovered from COVID-19: A Pilot Observational Case–Control Study
author_sort	Francesco Landi
journal	Nutrients
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author_browse	Francesco Landi Anna Maria Martone Francesca Ciciarello Vincenzo Galluzzo Giulia Savera Riccardo Calvani Anna Picca Emanuele Marzetti Matteo Tosato On behalf of Gemelli Against COVID-19 Post-Acute Care Team
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author-letter	Francesco Landi
doi_str_mv	10.3390/nu14112316
author2-role	verfasserin
title_sort	effects of a new multicomponent nutritional supplement on muscle mass and physical performance in adult and old patients recovered from covid-19: a pilot observational case–control study
callnumber	TX341-641
title_auth	Effects of a New Multicomponent Nutritional Supplement on Muscle Mass and Physical Performance in Adult and Old Patients Recovered from COVID-19: A Pilot Observational Case–Control Study
abstract	Objective: The purpose of the present study was to assess the effect of a specific oral nutritional supplement among patients recovered from COVID-19 but suffering symptoms of fatigue. Methods: This is an observational case–control study involving a sample of 66 COVID-19 survivors divided in two groups, 33 subjects in the intervention group who received the nutritional supplement and 33 subjects in the control group. The nutritional supplement received by subjects in the active group was based on amino acids; vitamin B6 and B1; and malic, succinic and citric acids. After an 8-week follow-up, the main outcomes considered were skeletal muscle index (measured by bioelectrical impedance analysis), physical performance measures (handgrip strength, one-minute chair–stand test, six-minute walking test), and quality of life (using EuroQol visual analogue scale). Results: All the considered areas increased significantly in the subjects receiving the active treatment with oral nutritional supplement in comparison with the baseline values. After adjusting for age, gender, and baseline values, skeletal muscle index, handgrip strength test, the one-minute chair–stand test, and six-minute walking test values were higher among participants in the treatment group compared with subjects in control group. The oral nutritional supplement significantly improved the handgrip strength; similarly, participants in the active group showed a higher improvement in skeletal muscle index, the one-minute chair–stand test, the six-minute walking test, and in quality of life. Conclusion: The nutritional supplement containing nine essential amino acids plus cysteine; vitamin B6 and B1; and malic, succinic and citric acids had a positive effect on nutritional status, functional recovery, and quality of life in COVID-19 survivors still suffering from fatigue. Additional controlled clinical trials are required to corroborate these results.
abstractGer	Objective: The purpose of the present study was to assess the effect of a specific oral nutritional supplement among patients recovered from COVID-19 but suffering symptoms of fatigue. Methods: This is an observational case–control study involving a sample of 66 COVID-19 survivors divided in two groups, 33 subjects in the intervention group who received the nutritional supplement and 33 subjects in the control group. The nutritional supplement received by subjects in the active group was based on amino acids; vitamin B6 and B1; and malic, succinic and citric acids. After an 8-week follow-up, the main outcomes considered were skeletal muscle index (measured by bioelectrical impedance analysis), physical performance measures (handgrip strength, one-minute chair–stand test, six-minute walking test), and quality of life (using EuroQol visual analogue scale). Results: All the considered areas increased significantly in the subjects receiving the active treatment with oral nutritional supplement in comparison with the baseline values. After adjusting for age, gender, and baseline values, skeletal muscle index, handgrip strength test, the one-minute chair–stand test, and six-minute walking test values were higher among participants in the treatment group compared with subjects in control group. The oral nutritional supplement significantly improved the handgrip strength; similarly, participants in the active group showed a higher improvement in skeletal muscle index, the one-minute chair–stand test, the six-minute walking test, and in quality of life. Conclusion: The nutritional supplement containing nine essential amino acids plus cysteine; vitamin B6 and B1; and malic, succinic and citric acids had a positive effect on nutritional status, functional recovery, and quality of life in COVID-19 survivors still suffering from fatigue. Additional controlled clinical trials are required to corroborate these results.
abstract_unstemmed	Objective: The purpose of the present study was to assess the effect of a specific oral nutritional supplement among patients recovered from COVID-19 but suffering symptoms of fatigue. Methods: This is an observational case–control study involving a sample of 66 COVID-19 survivors divided in two groups, 33 subjects in the intervention group who received the nutritional supplement and 33 subjects in the control group. The nutritional supplement received by subjects in the active group was based on amino acids; vitamin B6 and B1; and malic, succinic and citric acids. After an 8-week follow-up, the main outcomes considered were skeletal muscle index (measured by bioelectrical impedance analysis), physical performance measures (handgrip strength, one-minute chair–stand test, six-minute walking test), and quality of life (using EuroQol visual analogue scale). Results: All the considered areas increased significantly in the subjects receiving the active treatment with oral nutritional supplement in comparison with the baseline values. After adjusting for age, gender, and baseline values, skeletal muscle index, handgrip strength test, the one-minute chair–stand test, and six-minute walking test values were higher among participants in the treatment group compared with subjects in control group. The oral nutritional supplement significantly improved the handgrip strength; similarly, participants in the active group showed a higher improvement in skeletal muscle index, the one-minute chair–stand test, the six-minute walking test, and in quality of life. Conclusion: The nutritional supplement containing nine essential amino acids plus cysteine; vitamin B6 and B1; and malic, succinic and citric acids had a positive effect on nutritional status, functional recovery, and quality of life in COVID-19 survivors still suffering from fatigue. Additional controlled clinical trials are required to corroborate these results.
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container_issue	11, p 2316
title_short	Effects of a New Multicomponent Nutritional Supplement on Muscle Mass and Physical Performance in Adult and Old Patients Recovered from COVID-19: A Pilot Observational Case–Control Study
url	https://doi.org/10.3390/nu14112316 https://doaj.org/article/ca351aabb0f94d9d80dc5f5b9c9cf3a1 https://www.mdpi.com/2072-6643/14/11/2316 https://doaj.org/toc/2072-6643
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author2	Anna Maria Martone Francesca Ciciarello Vincenzo Galluzzo Giulia Savera Riccardo Calvani Anna Picca Emanuele Marzetti Matteo Tosato On behalf of Gemelli Against COVID-19 Post-Acute Care Team
author2Str	Anna Maria Martone Francesca Ciciarello Vincenzo Galluzzo Giulia Savera Riccardo Calvani Anna Picca Emanuele Marzetti Matteo Tosato On behalf of Gemelli Against COVID-19 Post-Acute Care Team
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up_date	2024-07-03T20:46:17.521Z
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