Genetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: a case-control study

Abstract Background Human papillomavirus (HPV) is the most common sexually transmitted virus in women worldwide. The persistence of the virus may cause warts that are considered benign lesions and low or high grade intraepithelial lesions (LSIL/HSIL). Immunological system plays an important role in...
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Autor*in:	Nádia Calvo Martins Okuyama [verfasserIn] Fernando Cezar-dos-Santos [verfasserIn] Érica Romão Pereira [verfasserIn] Kleber Paiva Trugilo [verfasserIn] Guilherme Cesar Martelossi Cebinelli [verfasserIn] Michelle Mota Sena [verfasserIn] Ana Paula Lombardi Pereira [verfasserIn] Adriano Martin Felis Aranome [verfasserIn] Luis Fernando Lasaro Mangieri [verfasserIn] Rodolfo Sanches Ferreira [verfasserIn] Maria Angelica Ehara Watanabe [verfasserIn] Karen Brajão de Oliveira [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	CXCL12 rs1801157 polymorphism HPV infection Cervical lesion

Übergeordnetes Werk:	In: Journal of Biomedical Science - BMC, 2002, 25(2018), 1, Seite 10
Übergeordnetes Werk:	volume:25 ; year:2018 ; number:1 ; pages:10

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12929-018-0472-y

Katalog-ID:	DOAJ041548868

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520			\|a Abstract Background Human papillomavirus (HPV) is the most common sexually transmitted virus in women worldwide. The persistence of the virus may cause warts that are considered benign lesions and low or high grade intraepithelial lesions (LSIL/HSIL). Immunological system plays an important role in the resolution of infections. In this context, we highlight the chemokines, which are important regulators in the development of viral infections and inflammation. Among which CXCL12 stands out, due to its pro-inflammatory features, acting as chemoattractant recruiting immune cells. Several polymorphisms were identified in CXCL12 gene including rs1801157 in the 3′-untranslated region, which is characterized by a substitution of a guanine for an adenine. Methods In this study, 195 women were classified as HPV non-infected and 169 as HPV-infected. HPV-DNA was detected by polymerase chain reaction (PCR) and the polymorphism was assessed in blood cells through restriction fragment length polymorphism analysis. Results HPV infection was more incident in women who had more than 4 sexual partners during lifetime (p = 0.007), among those who presented lower number of pregnancies (p = 0.017). HPV was more prevalent among allele A carriers confirmed by logistic regression analysis adjusted for several confounding factors [ORADJ = 4.985; CI95% (2.85–8.72), p < 0.001]. An association between allele A carriers and HSIL development (p = 0.003) was also observed. Conclusions In the present study, we demonstrated that CXCL12 rs1801157 is independently associated with HPV infection and exerts influence in HSIL development, suggesting it as a promising susceptibility biomarker for HPV infection and lesions development.
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650		4	\|a rs1801157 polymorphism
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700	0		\|a Fernando Cezar-dos-Santos \|e verfasserin \|4 aut
700	0		\|a Érica Romão Pereira \|e verfasserin \|4 aut
700	0		\|a Kleber Paiva Trugilo \|e verfasserin \|4 aut
700	0		\|a Guilherme Cesar Martelossi Cebinelli \|e verfasserin \|4 aut
700	0		\|a Michelle Mota Sena \|e verfasserin \|4 aut
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700	0		\|a Adriano Martin Felis Aranome \|e verfasserin \|4 aut
700	0		\|a Luis Fernando Lasaro Mangieri \|e verfasserin \|4 aut
700	0		\|a Rodolfo Sanches Ferreira \|e verfasserin \|4 aut
700	0		\|a Maria Angelica Ehara Watanabe \|e verfasserin \|4 aut
700	0		\|a Karen Brajão de Oliveira \|e verfasserin \|4 aut
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Indexfelder

author_variant	n c m o ncmo f c d fcd é r p érp k p t kpt g c m c gcmc m m s mms a p l p aplp a m f a amfa l f l m lflm r s f rsf m a e w maew k b d o kbdo
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allfields	10.1186/s12929-018-0472-y doi (DE-627)DOAJ041548868 (DE-599)DOAJ7ce36585c3b74b67bc9839f60b7e270c DE-627 ger DE-627 rakwb eng Nádia Calvo Martins Okuyama verfasserin aut Genetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: a case-control study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Human papillomavirus (HPV) is the most common sexually transmitted virus in women worldwide. The persistence of the virus may cause warts that are considered benign lesions and low or high grade intraepithelial lesions (LSIL/HSIL). Immunological system plays an important role in the resolution of infections. In this context, we highlight the chemokines, which are important regulators in the development of viral infections and inflammation. Among which CXCL12 stands out, due to its pro-inflammatory features, acting as chemoattractant recruiting immune cells. Several polymorphisms were identified in CXCL12 gene including rs1801157 in the 3′-untranslated region, which is characterized by a substitution of a guanine for an adenine. Methods In this study, 195 women were classified as HPV non-infected and 169 as HPV-infected. HPV-DNA was detected by polymerase chain reaction (PCR) and the polymorphism was assessed in blood cells through restriction fragment length polymorphism analysis. Results HPV infection was more incident in women who had more than 4 sexual partners during lifetime (p = 0.007), among those who presented lower number of pregnancies (p = 0.017). HPV was more prevalent among allele A carriers confirmed by logistic regression analysis adjusted for several confounding factors [ORADJ = 4.985; CI95% (2.85–8.72), p < 0.001]. An association between allele A carriers and HSIL development (p = 0.003) was also observed. Conclusions In the present study, we demonstrated that CXCL12 rs1801157 is independently associated with HPV infection and exerts influence in HSIL development, suggesting it as a promising susceptibility biomarker for HPV infection and lesions development. CXCL12 rs1801157 polymorphism HPV infection Cervical lesion Medicine R Fernando Cezar-dos-Santos verfasserin aut Érica Romão Pereira verfasserin aut Kleber Paiva Trugilo verfasserin aut Guilherme Cesar Martelossi Cebinelli verfasserin aut Michelle Mota Sena verfasserin aut Ana Paula Lombardi Pereira verfasserin aut Adriano Martin Felis Aranome verfasserin aut Luis Fernando Lasaro Mangieri verfasserin aut Rodolfo Sanches Ferreira verfasserin aut Maria Angelica Ehara Watanabe verfasserin aut Karen Brajão de Oliveira verfasserin aut In Journal of Biomedical Science BMC, 2002 25(2018), 1, Seite 10 (DE-627)300593724 (DE-600)1482918-6 14230127 nnns volume:25 year:2018 number:1 pages:10 https://doi.org/10.1186/s12929-018-0472-y kostenfrei https://doaj.org/article/7ce36585c3b74b67bc9839f60b7e270c kostenfrei http://link.springer.com/article/10.1186/s12929-018-0472-y kostenfrei https://doaj.org/toc/1423-0127 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4328 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2018 1 10
spelling	10.1186/s12929-018-0472-y doi (DE-627)DOAJ041548868 (DE-599)DOAJ7ce36585c3b74b67bc9839f60b7e270c DE-627 ger DE-627 rakwb eng Nádia Calvo Martins Okuyama verfasserin aut Genetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: a case-control study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Human papillomavirus (HPV) is the most common sexually transmitted virus in women worldwide. The persistence of the virus may cause warts that are considered benign lesions and low or high grade intraepithelial lesions (LSIL/HSIL). Immunological system plays an important role in the resolution of infections. In this context, we highlight the chemokines, which are important regulators in the development of viral infections and inflammation. Among which CXCL12 stands out, due to its pro-inflammatory features, acting as chemoattractant recruiting immune cells. Several polymorphisms were identified in CXCL12 gene including rs1801157 in the 3′-untranslated region, which is characterized by a substitution of a guanine for an adenine. Methods In this study, 195 women were classified as HPV non-infected and 169 as HPV-infected. HPV-DNA was detected by polymerase chain reaction (PCR) and the polymorphism was assessed in blood cells through restriction fragment length polymorphism analysis. Results HPV infection was more incident in women who had more than 4 sexual partners during lifetime (p = 0.007), among those who presented lower number of pregnancies (p = 0.017). HPV was more prevalent among allele A carriers confirmed by logistic regression analysis adjusted for several confounding factors [ORADJ = 4.985; CI95% (2.85–8.72), p < 0.001]. An association between allele A carriers and HSIL development (p = 0.003) was also observed. Conclusions In the present study, we demonstrated that CXCL12 rs1801157 is independently associated with HPV infection and exerts influence in HSIL development, suggesting it as a promising susceptibility biomarker for HPV infection and lesions development. CXCL12 rs1801157 polymorphism HPV infection Cervical lesion Medicine R Fernando Cezar-dos-Santos verfasserin aut Érica Romão Pereira verfasserin aut Kleber Paiva Trugilo verfasserin aut Guilherme Cesar Martelossi Cebinelli verfasserin aut Michelle Mota Sena verfasserin aut Ana Paula Lombardi Pereira verfasserin aut Adriano Martin Felis Aranome verfasserin aut Luis Fernando Lasaro Mangieri verfasserin aut Rodolfo Sanches Ferreira verfasserin aut Maria Angelica Ehara Watanabe verfasserin aut Karen Brajão de Oliveira verfasserin aut In Journal of Biomedical Science BMC, 2002 25(2018), 1, Seite 10 (DE-627)300593724 (DE-600)1482918-6 14230127 nnns volume:25 year:2018 number:1 pages:10 https://doi.org/10.1186/s12929-018-0472-y kostenfrei https://doaj.org/article/7ce36585c3b74b67bc9839f60b7e270c kostenfrei http://link.springer.com/article/10.1186/s12929-018-0472-y kostenfrei https://doaj.org/toc/1423-0127 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4328 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2018 1 10
allfields_unstemmed	10.1186/s12929-018-0472-y doi (DE-627)DOAJ041548868 (DE-599)DOAJ7ce36585c3b74b67bc9839f60b7e270c DE-627 ger DE-627 rakwb eng Nádia Calvo Martins Okuyama verfasserin aut Genetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: a case-control study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Human papillomavirus (HPV) is the most common sexually transmitted virus in women worldwide. The persistence of the virus may cause warts that are considered benign lesions and low or high grade intraepithelial lesions (LSIL/HSIL). Immunological system plays an important role in the resolution of infections. In this context, we highlight the chemokines, which are important regulators in the development of viral infections and inflammation. Among which CXCL12 stands out, due to its pro-inflammatory features, acting as chemoattractant recruiting immune cells. Several polymorphisms were identified in CXCL12 gene including rs1801157 in the 3′-untranslated region, which is characterized by a substitution of a guanine for an adenine. Methods In this study, 195 women were classified as HPV non-infected and 169 as HPV-infected. HPV-DNA was detected by polymerase chain reaction (PCR) and the polymorphism was assessed in blood cells through restriction fragment length polymorphism analysis. Results HPV infection was more incident in women who had more than 4 sexual partners during lifetime (p = 0.007), among those who presented lower number of pregnancies (p = 0.017). HPV was more prevalent among allele A carriers confirmed by logistic regression analysis adjusted for several confounding factors [ORADJ = 4.985; CI95% (2.85–8.72), p < 0.001]. An association between allele A carriers and HSIL development (p = 0.003) was also observed. Conclusions In the present study, we demonstrated that CXCL12 rs1801157 is independently associated with HPV infection and exerts influence in HSIL development, suggesting it as a promising susceptibility biomarker for HPV infection and lesions development. CXCL12 rs1801157 polymorphism HPV infection Cervical lesion Medicine R Fernando Cezar-dos-Santos verfasserin aut Érica Romão Pereira verfasserin aut Kleber Paiva Trugilo verfasserin aut Guilherme Cesar Martelossi Cebinelli verfasserin aut Michelle Mota Sena verfasserin aut Ana Paula Lombardi Pereira verfasserin aut Adriano Martin Felis Aranome verfasserin aut Luis Fernando Lasaro Mangieri verfasserin aut Rodolfo Sanches Ferreira verfasserin aut Maria Angelica Ehara Watanabe verfasserin aut Karen Brajão de Oliveira verfasserin aut In Journal of Biomedical Science BMC, 2002 25(2018), 1, Seite 10 (DE-627)300593724 (DE-600)1482918-6 14230127 nnns volume:25 year:2018 number:1 pages:10 https://doi.org/10.1186/s12929-018-0472-y kostenfrei https://doaj.org/article/7ce36585c3b74b67bc9839f60b7e270c kostenfrei http://link.springer.com/article/10.1186/s12929-018-0472-y kostenfrei https://doaj.org/toc/1423-0127 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4328 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2018 1 10
allfieldsGer	10.1186/s12929-018-0472-y doi (DE-627)DOAJ041548868 (DE-599)DOAJ7ce36585c3b74b67bc9839f60b7e270c DE-627 ger DE-627 rakwb eng Nádia Calvo Martins Okuyama verfasserin aut Genetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: a case-control study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Human papillomavirus (HPV) is the most common sexually transmitted virus in women worldwide. The persistence of the virus may cause warts that are considered benign lesions and low or high grade intraepithelial lesions (LSIL/HSIL). Immunological system plays an important role in the resolution of infections. In this context, we highlight the chemokines, which are important regulators in the development of viral infections and inflammation. Among which CXCL12 stands out, due to its pro-inflammatory features, acting as chemoattractant recruiting immune cells. Several polymorphisms were identified in CXCL12 gene including rs1801157 in the 3′-untranslated region, which is characterized by a substitution of a guanine for an adenine. Methods In this study, 195 women were classified as HPV non-infected and 169 as HPV-infected. HPV-DNA was detected by polymerase chain reaction (PCR) and the polymorphism was assessed in blood cells through restriction fragment length polymorphism analysis. Results HPV infection was more incident in women who had more than 4 sexual partners during lifetime (p = 0.007), among those who presented lower number of pregnancies (p = 0.017). HPV was more prevalent among allele A carriers confirmed by logistic regression analysis adjusted for several confounding factors [ORADJ = 4.985; CI95% (2.85–8.72), p < 0.001]. An association between allele A carriers and HSIL development (p = 0.003) was also observed. Conclusions In the present study, we demonstrated that CXCL12 rs1801157 is independently associated with HPV infection and exerts influence in HSIL development, suggesting it as a promising susceptibility biomarker for HPV infection and lesions development. CXCL12 rs1801157 polymorphism HPV infection Cervical lesion Medicine R Fernando Cezar-dos-Santos verfasserin aut Érica Romão Pereira verfasserin aut Kleber Paiva Trugilo verfasserin aut Guilherme Cesar Martelossi Cebinelli verfasserin aut Michelle Mota Sena verfasserin aut Ana Paula Lombardi Pereira verfasserin aut Adriano Martin Felis Aranome verfasserin aut Luis Fernando Lasaro Mangieri verfasserin aut Rodolfo Sanches Ferreira verfasserin aut Maria Angelica Ehara Watanabe verfasserin aut Karen Brajão de Oliveira verfasserin aut In Journal of Biomedical Science BMC, 2002 25(2018), 1, Seite 10 (DE-627)300593724 (DE-600)1482918-6 14230127 nnns volume:25 year:2018 number:1 pages:10 https://doi.org/10.1186/s12929-018-0472-y kostenfrei https://doaj.org/article/7ce36585c3b74b67bc9839f60b7e270c kostenfrei http://link.springer.com/article/10.1186/s12929-018-0472-y kostenfrei https://doaj.org/toc/1423-0127 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4328 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2018 1 10
allfieldsSound	10.1186/s12929-018-0472-y doi (DE-627)DOAJ041548868 (DE-599)DOAJ7ce36585c3b74b67bc9839f60b7e270c DE-627 ger DE-627 rakwb eng Nádia Calvo Martins Okuyama verfasserin aut Genetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: a case-control study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Human papillomavirus (HPV) is the most common sexually transmitted virus in women worldwide. The persistence of the virus may cause warts that are considered benign lesions and low or high grade intraepithelial lesions (LSIL/HSIL). Immunological system plays an important role in the resolution of infections. In this context, we highlight the chemokines, which are important regulators in the development of viral infections and inflammation. Among which CXCL12 stands out, due to its pro-inflammatory features, acting as chemoattractant recruiting immune cells. Several polymorphisms were identified in CXCL12 gene including rs1801157 in the 3′-untranslated region, which is characterized by a substitution of a guanine for an adenine. Methods In this study, 195 women were classified as HPV non-infected and 169 as HPV-infected. HPV-DNA was detected by polymerase chain reaction (PCR) and the polymorphism was assessed in blood cells through restriction fragment length polymorphism analysis. Results HPV infection was more incident in women who had more than 4 sexual partners during lifetime (p = 0.007), among those who presented lower number of pregnancies (p = 0.017). HPV was more prevalent among allele A carriers confirmed by logistic regression analysis adjusted for several confounding factors [ORADJ = 4.985; CI95% (2.85–8.72), p < 0.001]. An association between allele A carriers and HSIL development (p = 0.003) was also observed. Conclusions In the present study, we demonstrated that CXCL12 rs1801157 is independently associated with HPV infection and exerts influence in HSIL development, suggesting it as a promising susceptibility biomarker for HPV infection and lesions development. CXCL12 rs1801157 polymorphism HPV infection Cervical lesion Medicine R Fernando Cezar-dos-Santos verfasserin aut Érica Romão Pereira verfasserin aut Kleber Paiva Trugilo verfasserin aut Guilherme Cesar Martelossi Cebinelli verfasserin aut Michelle Mota Sena verfasserin aut Ana Paula Lombardi Pereira verfasserin aut Adriano Martin Felis Aranome verfasserin aut Luis Fernando Lasaro Mangieri verfasserin aut Rodolfo Sanches Ferreira verfasserin aut Maria Angelica Ehara Watanabe verfasserin aut Karen Brajão de Oliveira verfasserin aut In Journal of Biomedical Science BMC, 2002 25(2018), 1, Seite 10 (DE-627)300593724 (DE-600)1482918-6 14230127 nnns volume:25 year:2018 number:1 pages:10 https://doi.org/10.1186/s12929-018-0472-y kostenfrei https://doaj.org/article/7ce36585c3b74b67bc9839f60b7e270c kostenfrei http://link.springer.com/article/10.1186/s12929-018-0472-y kostenfrei https://doaj.org/toc/1423-0127 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4328 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2018 1 10
language	English
source	In Journal of Biomedical Science 25(2018), 1, Seite 10 volume:25 year:2018 number:1 pages:10
sourceStr	In Journal of Biomedical Science 25(2018), 1, Seite 10 volume:25 year:2018 number:1 pages:10
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	CXCL12 rs1801157 polymorphism HPV infection Cervical lesion Medicine R
isfreeaccess_bool	true
container_title	Journal of Biomedical Science
authorswithroles_txt_mv	Nádia Calvo Martins Okuyama @@aut@@ Fernando Cezar-dos-Santos @@aut@@ Érica Romão Pereira @@aut@@ Kleber Paiva Trugilo @@aut@@ Guilherme Cesar Martelossi Cebinelli @@aut@@ Michelle Mota Sena @@aut@@ Ana Paula Lombardi Pereira @@aut@@ Adriano Martin Felis Aranome @@aut@@ Luis Fernando Lasaro Mangieri @@aut@@ Rodolfo Sanches Ferreira @@aut@@ Maria Angelica Ehara Watanabe @@aut@@ Karen Brajão de Oliveira @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	300593724
id	DOAJ041548868
language_de	englisch
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The persistence of the virus may cause warts that are considered benign lesions and low or high grade intraepithelial lesions (LSIL/HSIL). Immunological system plays an important role in the resolution of infections. In this context, we highlight the chemokines, which are important regulators in the development of viral infections and inflammation. Among which CXCL12 stands out, due to its pro-inflammatory features, acting as chemoattractant recruiting immune cells. Several polymorphisms were identified in CXCL12 gene including rs1801157 in the 3′-untranslated region, which is characterized by a substitution of a guanine for an adenine. Methods In this study, 195 women were classified as HPV non-infected and 169 as HPV-infected. HPV-DNA was detected by polymerase chain reaction (PCR) and the polymorphism was assessed in blood cells through restriction fragment length polymorphism analysis. Results HPV infection was more incident in women who had more than 4 sexual partners during lifetime (p = 0.007), among those who presented lower number of pregnancies (p = 0.017). HPV was more prevalent among allele A carriers confirmed by logistic regression analysis adjusted for several confounding factors [ORADJ = 4.985; CI95% (2.85–8.72), p < 0.001]. An association between allele A carriers and HSIL development (p = 0.003) was also observed. 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author	Nádia Calvo Martins Okuyama
spellingShingle	Nádia Calvo Martins Okuyama misc CXCL12 misc rs1801157 polymorphism misc HPV infection misc Cervical lesion misc Medicine misc R Genetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: a case-control study
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topic_title	Genetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: a case-control study CXCL12 rs1801157 polymorphism HPV infection Cervical lesion
topic	misc CXCL12 misc rs1801157 polymorphism misc HPV infection misc Cervical lesion misc Medicine misc R
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title	Genetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: a case-control study
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title_full	Genetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: a case-control study
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author_browse	Nádia Calvo Martins Okuyama Fernando Cezar-dos-Santos Érica Romão Pereira Kleber Paiva Trugilo Guilherme Cesar Martelossi Cebinelli Michelle Mota Sena Ana Paula Lombardi Pereira Adriano Martin Felis Aranome Luis Fernando Lasaro Mangieri Rodolfo Sanches Ferreira Maria Angelica Ehara Watanabe Karen Brajão de Oliveira
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title_sort	genetic variant in cxcl12 gene raises susceptibility to hpv infection and squamous intraepithelial lesions development: a case-control study
title_auth	Genetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: a case-control study
abstract	Abstract Background Human papillomavirus (HPV) is the most common sexually transmitted virus in women worldwide. The persistence of the virus may cause warts that are considered benign lesions and low or high grade intraepithelial lesions (LSIL/HSIL). Immunological system plays an important role in the resolution of infections. In this context, we highlight the chemokines, which are important regulators in the development of viral infections and inflammation. Among which CXCL12 stands out, due to its pro-inflammatory features, acting as chemoattractant recruiting immune cells. Several polymorphisms were identified in CXCL12 gene including rs1801157 in the 3′-untranslated region, which is characterized by a substitution of a guanine for an adenine. Methods In this study, 195 women were classified as HPV non-infected and 169 as HPV-infected. HPV-DNA was detected by polymerase chain reaction (PCR) and the polymorphism was assessed in blood cells through restriction fragment length polymorphism analysis. Results HPV infection was more incident in women who had more than 4 sexual partners during lifetime (p = 0.007), among those who presented lower number of pregnancies (p = 0.017). HPV was more prevalent among allele A carriers confirmed by logistic regression analysis adjusted for several confounding factors [ORADJ = 4.985; CI95% (2.85–8.72), p < 0.001]. An association between allele A carriers and HSIL development (p = 0.003) was also observed. Conclusions In the present study, we demonstrated that CXCL12 rs1801157 is independently associated with HPV infection and exerts influence in HSIL development, suggesting it as a promising susceptibility biomarker for HPV infection and lesions development.
abstractGer	Abstract Background Human papillomavirus (HPV) is the most common sexually transmitted virus in women worldwide. The persistence of the virus may cause warts that are considered benign lesions and low or high grade intraepithelial lesions (LSIL/HSIL). Immunological system plays an important role in the resolution of infections. In this context, we highlight the chemokines, which are important regulators in the development of viral infections and inflammation. Among which CXCL12 stands out, due to its pro-inflammatory features, acting as chemoattractant recruiting immune cells. Several polymorphisms were identified in CXCL12 gene including rs1801157 in the 3′-untranslated region, which is characterized by a substitution of a guanine for an adenine. Methods In this study, 195 women were classified as HPV non-infected and 169 as HPV-infected. HPV-DNA was detected by polymerase chain reaction (PCR) and the polymorphism was assessed in blood cells through restriction fragment length polymorphism analysis. Results HPV infection was more incident in women who had more than 4 sexual partners during lifetime (p = 0.007), among those who presented lower number of pregnancies (p = 0.017). HPV was more prevalent among allele A carriers confirmed by logistic regression analysis adjusted for several confounding factors [ORADJ = 4.985; CI95% (2.85–8.72), p < 0.001]. An association between allele A carriers and HSIL development (p = 0.003) was also observed. Conclusions In the present study, we demonstrated that CXCL12 rs1801157 is independently associated with HPV infection and exerts influence in HSIL development, suggesting it as a promising susceptibility biomarker for HPV infection and lesions development.
abstract_unstemmed	Abstract Background Human papillomavirus (HPV) is the most common sexually transmitted virus in women worldwide. The persistence of the virus may cause warts that are considered benign lesions and low or high grade intraepithelial lesions (LSIL/HSIL). Immunological system plays an important role in the resolution of infections. In this context, we highlight the chemokines, which are important regulators in the development of viral infections and inflammation. Among which CXCL12 stands out, due to its pro-inflammatory features, acting as chemoattractant recruiting immune cells. Several polymorphisms were identified in CXCL12 gene including rs1801157 in the 3′-untranslated region, which is characterized by a substitution of a guanine for an adenine. Methods In this study, 195 women were classified as HPV non-infected and 169 as HPV-infected. HPV-DNA was detected by polymerase chain reaction (PCR) and the polymorphism was assessed in blood cells through restriction fragment length polymorphism analysis. Results HPV infection was more incident in women who had more than 4 sexual partners during lifetime (p = 0.007), among those who presented lower number of pregnancies (p = 0.017). HPV was more prevalent among allele A carriers confirmed by logistic regression analysis adjusted for several confounding factors [ORADJ = 4.985; CI95% (2.85–8.72), p < 0.001]. An association between allele A carriers and HSIL development (p = 0.003) was also observed. Conclusions In the present study, we demonstrated that CXCL12 rs1801157 is independently associated with HPV infection and exerts influence in HSIL development, suggesting it as a promising susceptibility biomarker for HPV infection and lesions development.
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title_short	Genetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: a case-control study
url	https://doi.org/10.1186/s12929-018-0472-y https://doaj.org/article/7ce36585c3b74b67bc9839f60b7e270c http://link.springer.com/article/10.1186/s12929-018-0472-y https://doaj.org/toc/1423-0127
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author2	Fernando Cezar-dos-Santos Érica Romão Pereira Kleber Paiva Trugilo Guilherme Cesar Martelossi Cebinelli Michelle Mota Sena Ana Paula Lombardi Pereira Adriano Martin Felis Aranome Luis Fernando Lasaro Mangieri Rodolfo Sanches Ferreira Maria Angelica Ehara Watanabe Karen Brajão de Oliveira
author2Str	Fernando Cezar-dos-Santos Érica Romão Pereira Kleber Paiva Trugilo Guilherme Cesar Martelossi Cebinelli Michelle Mota Sena Ana Paula Lombardi Pereira Adriano Martin Felis Aranome Luis Fernando Lasaro Mangieri Rodolfo Sanches Ferreira Maria Angelica Ehara Watanabe Karen Brajão de Oliveira
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Genetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: a case-control study

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