Tryptophan Catabolism and Response to Therapy in Locally Advanced Rectal Cancer (LARC) Patients

In locally advanced rectal cancer patients (LARC), preoperative chemoradiation improves local control and sphincter preservation. The response rate to treatment varies substantially between 20 and 30%, and it is an important prognostic factor. Indeed, nonresponsive patients are subjected to higher r...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Sara Crotti [verfasserIn] Alessandra Fraccaro [verfasserIn] Chiara Bedin [verfasserIn] Antonella Bertazzo [verfasserIn] Valerio Di Marco [verfasserIn] Salvatore Pucciarelli [verfasserIn] Marco Agostini [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	tryptophan rectal cancer IDO1 TDO2 TPH1 kynurenine pathway

Übergeordnetes Werk:	In: Frontiers in Oncology - Frontiers Media S.A., 2012, 10(2020)
Übergeordnetes Werk:	volume:10 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fonc.2020.583228

Katalog-ID:	DOAJ041668448

Internformat


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allfields	10.3389/fonc.2020.583228 doi (DE-627)DOAJ041668448 (DE-599)DOAJ7a613e561dbf4d09864b97f2ae8c2cab DE-627 ger DE-627 rakwb eng RC254-282 Sara Crotti verfasserin aut Tryptophan Catabolism and Response to Therapy in Locally Advanced Rectal Cancer (LARC) Patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In locally advanced rectal cancer patients (LARC), preoperative chemoradiation improves local control and sphincter preservation. The response rate to treatment varies substantially between 20 and 30%, and it is an important prognostic factor. Indeed, nonresponsive patients are subjected to higher rates of local and distant metastases, and worse survival compared to patients with complete response. In the search of predictive biomarkers for response prediction to therapy in LARC patients, we found increased plasma tryptophan levels in nonresponsive patients. On the basis of plasma levels of 5-hydroxy-tryptophan and kynurenine, the activities of tryptophan 5-hydroxylase 1 (TPH1) and indoleamine-2,3-dioxygenases 1 (IDO1)/tryptophan-2,3-dioxygenase (TDO2) have been obtained and data have been correlated with gene expression profiles. We demonstrated that TDO2 overexpression in nonresponsive patients correlates with kynurenine plasma levels. Finally, through the gene expression and targeted metabolomic analysis in paired healthy mucosa-rectal cancer tumor samples, we evaluated the impact of tryptophan catabolism at tissue level in responsive and nonresponsive patients. tryptophan rectal cancer IDO1 TDO2 TPH1 kynurenine pathway Neoplasms. Tumors. Oncology. Including cancer and carcinogens Alessandra Fraccaro verfasserin aut Chiara Bedin verfasserin aut Antonella Bertazzo verfasserin aut Valerio Di Marco verfasserin aut Salvatore Pucciarelli verfasserin aut Marco Agostini verfasserin aut Marco Agostini verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 10(2020) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:10 year:2020 https://doi.org/10.3389/fonc.2020.583228 kostenfrei https://doaj.org/article/7a613e561dbf4d09864b97f2ae8c2cab kostenfrei https://www.frontiersin.org/article/10.3389/fonc.2020.583228/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020
spelling	10.3389/fonc.2020.583228 doi (DE-627)DOAJ041668448 (DE-599)DOAJ7a613e561dbf4d09864b97f2ae8c2cab DE-627 ger DE-627 rakwb eng RC254-282 Sara Crotti verfasserin aut Tryptophan Catabolism and Response to Therapy in Locally Advanced Rectal Cancer (LARC) Patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In locally advanced rectal cancer patients (LARC), preoperative chemoradiation improves local control and sphincter preservation. The response rate to treatment varies substantially between 20 and 30%, and it is an important prognostic factor. Indeed, nonresponsive patients are subjected to higher rates of local and distant metastases, and worse survival compared to patients with complete response. In the search of predictive biomarkers for response prediction to therapy in LARC patients, we found increased plasma tryptophan levels in nonresponsive patients. On the basis of plasma levels of 5-hydroxy-tryptophan and kynurenine, the activities of tryptophan 5-hydroxylase 1 (TPH1) and indoleamine-2,3-dioxygenases 1 (IDO1)/tryptophan-2,3-dioxygenase (TDO2) have been obtained and data have been correlated with gene expression profiles. We demonstrated that TDO2 overexpression in nonresponsive patients correlates with kynurenine plasma levels. Finally, through the gene expression and targeted metabolomic analysis in paired healthy mucosa-rectal cancer tumor samples, we evaluated the impact of tryptophan catabolism at tissue level in responsive and nonresponsive patients. tryptophan rectal cancer IDO1 TDO2 TPH1 kynurenine pathway Neoplasms. Tumors. Oncology. Including cancer and carcinogens Alessandra Fraccaro verfasserin aut Chiara Bedin verfasserin aut Antonella Bertazzo verfasserin aut Valerio Di Marco verfasserin aut Salvatore Pucciarelli verfasserin aut Marco Agostini verfasserin aut Marco Agostini verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 10(2020) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:10 year:2020 https://doi.org/10.3389/fonc.2020.583228 kostenfrei https://doaj.org/article/7a613e561dbf4d09864b97f2ae8c2cab kostenfrei https://www.frontiersin.org/article/10.3389/fonc.2020.583228/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020
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allfieldsGer	10.3389/fonc.2020.583228 doi (DE-627)DOAJ041668448 (DE-599)DOAJ7a613e561dbf4d09864b97f2ae8c2cab DE-627 ger DE-627 rakwb eng RC254-282 Sara Crotti verfasserin aut Tryptophan Catabolism and Response to Therapy in Locally Advanced Rectal Cancer (LARC) Patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In locally advanced rectal cancer patients (LARC), preoperative chemoradiation improves local control and sphincter preservation. The response rate to treatment varies substantially between 20 and 30%, and it is an important prognostic factor. Indeed, nonresponsive patients are subjected to higher rates of local and distant metastases, and worse survival compared to patients with complete response. In the search of predictive biomarkers for response prediction to therapy in LARC patients, we found increased plasma tryptophan levels in nonresponsive patients. On the basis of plasma levels of 5-hydroxy-tryptophan and kynurenine, the activities of tryptophan 5-hydroxylase 1 (TPH1) and indoleamine-2,3-dioxygenases 1 (IDO1)/tryptophan-2,3-dioxygenase (TDO2) have been obtained and data have been correlated with gene expression profiles. We demonstrated that TDO2 overexpression in nonresponsive patients correlates with kynurenine plasma levels. Finally, through the gene expression and targeted metabolomic analysis in paired healthy mucosa-rectal cancer tumor samples, we evaluated the impact of tryptophan catabolism at tissue level in responsive and nonresponsive patients. tryptophan rectal cancer IDO1 TDO2 TPH1 kynurenine pathway Neoplasms. Tumors. Oncology. Including cancer and carcinogens Alessandra Fraccaro verfasserin aut Chiara Bedin verfasserin aut Antonella Bertazzo verfasserin aut Valerio Di Marco verfasserin aut Salvatore Pucciarelli verfasserin aut Marco Agostini verfasserin aut Marco Agostini verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 10(2020) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:10 year:2020 https://doi.org/10.3389/fonc.2020.583228 kostenfrei https://doaj.org/article/7a613e561dbf4d09864b97f2ae8c2cab kostenfrei https://www.frontiersin.org/article/10.3389/fonc.2020.583228/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020
allfieldsSound	10.3389/fonc.2020.583228 doi (DE-627)DOAJ041668448 (DE-599)DOAJ7a613e561dbf4d09864b97f2ae8c2cab DE-627 ger DE-627 rakwb eng RC254-282 Sara Crotti verfasserin aut Tryptophan Catabolism and Response to Therapy in Locally Advanced Rectal Cancer (LARC) Patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In locally advanced rectal cancer patients (LARC), preoperative chemoradiation improves local control and sphincter preservation. The response rate to treatment varies substantially between 20 and 30%, and it is an important prognostic factor. Indeed, nonresponsive patients are subjected to higher rates of local and distant metastases, and worse survival compared to patients with complete response. In the search of predictive biomarkers for response prediction to therapy in LARC patients, we found increased plasma tryptophan levels in nonresponsive patients. On the basis of plasma levels of 5-hydroxy-tryptophan and kynurenine, the activities of tryptophan 5-hydroxylase 1 (TPH1) and indoleamine-2,3-dioxygenases 1 (IDO1)/tryptophan-2,3-dioxygenase (TDO2) have been obtained and data have been correlated with gene expression profiles. We demonstrated that TDO2 overexpression in nonresponsive patients correlates with kynurenine plasma levels. Finally, through the gene expression and targeted metabolomic analysis in paired healthy mucosa-rectal cancer tumor samples, we evaluated the impact of tryptophan catabolism at tissue level in responsive and nonresponsive patients. tryptophan rectal cancer IDO1 TDO2 TPH1 kynurenine pathway Neoplasms. Tumors. Oncology. Including cancer and carcinogens Alessandra Fraccaro verfasserin aut Chiara Bedin verfasserin aut Antonella Bertazzo verfasserin aut Valerio Di Marco verfasserin aut Salvatore Pucciarelli verfasserin aut Marco Agostini verfasserin aut Marco Agostini verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 10(2020) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:10 year:2020 https://doi.org/10.3389/fonc.2020.583228 kostenfrei https://doaj.org/article/7a613e561dbf4d09864b97f2ae8c2cab kostenfrei https://www.frontiersin.org/article/10.3389/fonc.2020.583228/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020
language	English
source	In Frontiers in Oncology 10(2020) volume:10 year:2020
sourceStr	In Frontiers in Oncology 10(2020) volume:10 year:2020
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topic_facet	tryptophan rectal cancer IDO1 TDO2 TPH1 kynurenine pathway Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	Frontiers in Oncology
authorswithroles_txt_mv	Sara Crotti @@aut@@ Alessandra Fraccaro @@aut@@ Chiara Bedin @@aut@@ Antonella Bertazzo @@aut@@ Valerio Di Marco @@aut@@ Salvatore Pucciarelli @@aut@@ Marco Agostini @@aut@@
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callnumber-first	R - Medicine
author	Sara Crotti
spellingShingle	Sara Crotti misc RC254-282 misc tryptophan misc rectal cancer misc IDO1 misc TDO2 misc TPH1 misc kynurenine pathway misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Tryptophan Catabolism and Response to Therapy in Locally Advanced Rectal Cancer (LARC) Patients
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topic_title	RC254-282 Tryptophan Catabolism and Response to Therapy in Locally Advanced Rectal Cancer (LARC) Patients tryptophan rectal cancer IDO1 TDO2 TPH1 kynurenine pathway
topic	misc RC254-282 misc tryptophan misc rectal cancer misc IDO1 misc TDO2 misc TPH1 misc kynurenine pathway misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc tryptophan misc rectal cancer misc IDO1 misc TDO2 misc TPH1 misc kynurenine pathway misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc tryptophan misc rectal cancer misc IDO1 misc TDO2 misc TPH1 misc kynurenine pathway misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Tryptophan Catabolism and Response to Therapy in Locally Advanced Rectal Cancer (LARC) Patients
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title_full	Tryptophan Catabolism and Response to Therapy in Locally Advanced Rectal Cancer (LARC) Patients
author_sort	Sara Crotti
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author_browse	Sara Crotti Alessandra Fraccaro Chiara Bedin Antonella Bertazzo Valerio Di Marco Salvatore Pucciarelli Marco Agostini
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title_sort	tryptophan catabolism and response to therapy in locally advanced rectal cancer (larc) patients
callnumber	RC254-282
title_auth	Tryptophan Catabolism and Response to Therapy in Locally Advanced Rectal Cancer (LARC) Patients
abstract	In locally advanced rectal cancer patients (LARC), preoperative chemoradiation improves local control and sphincter preservation. The response rate to treatment varies substantially between 20 and 30%, and it is an important prognostic factor. Indeed, nonresponsive patients are subjected to higher rates of local and distant metastases, and worse survival compared to patients with complete response. In the search of predictive biomarkers for response prediction to therapy in LARC patients, we found increased plasma tryptophan levels in nonresponsive patients. On the basis of plasma levels of 5-hydroxy-tryptophan and kynurenine, the activities of tryptophan 5-hydroxylase 1 (TPH1) and indoleamine-2,3-dioxygenases 1 (IDO1)/tryptophan-2,3-dioxygenase (TDO2) have been obtained and data have been correlated with gene expression profiles. We demonstrated that TDO2 overexpression in nonresponsive patients correlates with kynurenine plasma levels. Finally, through the gene expression and targeted metabolomic analysis in paired healthy mucosa-rectal cancer tumor samples, we evaluated the impact of tryptophan catabolism at tissue level in responsive and nonresponsive patients.
abstractGer	In locally advanced rectal cancer patients (LARC), preoperative chemoradiation improves local control and sphincter preservation. The response rate to treatment varies substantially between 20 and 30%, and it is an important prognostic factor. Indeed, nonresponsive patients are subjected to higher rates of local and distant metastases, and worse survival compared to patients with complete response. In the search of predictive biomarkers for response prediction to therapy in LARC patients, we found increased plasma tryptophan levels in nonresponsive patients. On the basis of plasma levels of 5-hydroxy-tryptophan and kynurenine, the activities of tryptophan 5-hydroxylase 1 (TPH1) and indoleamine-2,3-dioxygenases 1 (IDO1)/tryptophan-2,3-dioxygenase (TDO2) have been obtained and data have been correlated with gene expression profiles. We demonstrated that TDO2 overexpression in nonresponsive patients correlates with kynurenine plasma levels. Finally, through the gene expression and targeted metabolomic analysis in paired healthy mucosa-rectal cancer tumor samples, we evaluated the impact of tryptophan catabolism at tissue level in responsive and nonresponsive patients.
abstract_unstemmed	In locally advanced rectal cancer patients (LARC), preoperative chemoradiation improves local control and sphincter preservation. The response rate to treatment varies substantially between 20 and 30%, and it is an important prognostic factor. Indeed, nonresponsive patients are subjected to higher rates of local and distant metastases, and worse survival compared to patients with complete response. In the search of predictive biomarkers for response prediction to therapy in LARC patients, we found increased plasma tryptophan levels in nonresponsive patients. On the basis of plasma levels of 5-hydroxy-tryptophan and kynurenine, the activities of tryptophan 5-hydroxylase 1 (TPH1) and indoleamine-2,3-dioxygenases 1 (IDO1)/tryptophan-2,3-dioxygenase (TDO2) have been obtained and data have been correlated with gene expression profiles. We demonstrated that TDO2 overexpression in nonresponsive patients correlates with kynurenine plasma levels. Finally, through the gene expression and targeted metabolomic analysis in paired healthy mucosa-rectal cancer tumor samples, we evaluated the impact of tryptophan catabolism at tissue level in responsive and nonresponsive patients.
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title_short	Tryptophan Catabolism and Response to Therapy in Locally Advanced Rectal Cancer (LARC) Patients
url	https://doi.org/10.3389/fonc.2020.583228 https://doaj.org/article/7a613e561dbf4d09864b97f2ae8c2cab https://www.frontiersin.org/article/10.3389/fonc.2020.583228/full https://doaj.org/toc/2234-943X
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up_date	2024-07-03T21:30:20.118Z
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