Diagnostic value of MR spectroscopy in suspicious breast lesions

Background: MRI has an essential role in breast imaging, along with mammography and ultrasonography. DCE- MRI is not 100% accurate in discriminating benign from malignant lesions. In attempt to improve the specificity of DCE-MRI, multiparametric MRI (mp-MRI) with additional functional parameters had...
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Autor*in:	Nahla Mohamed Ali Hasan * [verfasserIn] Mohamed Mamdouh Noaman Hussein [verfasserIn] Naglaa Mohamed Abdelrazek [verfasserIn] Mohamed Tharwat Mahmoud Soliman [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	breast lesions; mp-mri; mr spectroscopy

Übergeordnetes Werk:	In: SVU - International Journal of Medical Sciences - South Valley University, Faculty of Medicine, 2021, 5(2022), 2, Seite 115-135
Übergeordnetes Werk:	volume:5 ; year:2022 ; number:2 ; pages:115-135

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

Katalog-ID:	DOAJ041673174

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520			\|a Background: MRI has an essential role in breast imaging, along with mammography and ultrasonography. DCE- MRI is not 100% accurate in discriminating benign from malignant lesions. In attempt to improve the specificity of DCE-MRI, multiparametric MRI (mp-MRI) with additional functional parameters had been introduced. Objectives: To assess the added diagnostic value of MR spectroscopy in evaluation of suspicious breast lesions. Patients and methods: This prospective study included 60 females, their mean age was 42.1 ± 12 SD with 75 breast lesions categorized as BI-RADS 3 or BI-RADS 4 based on sonomamography. They were subjected to multiparametric breast MRI (T2WI, dynamic contrast-enhanced MR imaging, diffusion-weighted images, and MR spectroscopy). ROC-analysis was employed for comparison between the diagnostic accuracy of mp-MRI and mp-MRI combined with MRS to predict the malignant lesions using the histopathological results as a standard of reference. Results: 33 (55 %) patients had histopathologically diagnosed 43 (58%) benign breast lesions and 27 (45%) patients had 32 (42%) malignant lesions. Using mp-MRI (dynamic contrast-enhanced MR imaging, T2-weighted images and diffusion-weighted images) had 98% accuracy of with 97.8%, sensitivity and 98.6%, specificity in differentiating malignant from benign lesions. A higher diagnostic 99.2% accuracy was obtained from combined mp-MRI and MRS with 99.5% sensitivity, 98.6% specificity. Conclusion: Despite of its limitations, MRS is a promising functional MRI technique thus improves the diagnostic accuracy of MRI for characterization of suspicious breast lesions when combined to mp-MRI to avoid unnecessary biopsy.
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allfields	(DE-627)DOAJ041673174 (DE-599)DOAJ481e74a9fa53404483835dda2d9272b4 DE-627 ger DE-627 rakwb eng Nahla Mohamed Ali Hasan * verfasserin aut Diagnostic value of MR spectroscopy in suspicious breast lesions 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: MRI has an essential role in breast imaging, along with mammography and ultrasonography. DCE- MRI is not 100% accurate in discriminating benign from malignant lesions. In attempt to improve the specificity of DCE-MRI, multiparametric MRI (mp-MRI) with additional functional parameters had been introduced. Objectives: To assess the added diagnostic value of MR spectroscopy in evaluation of suspicious breast lesions. Patients and methods: This prospective study included 60 females, their mean age was 42.1 ± 12 SD with 75 breast lesions categorized as BI-RADS 3 or BI-RADS 4 based on sonomamography. They were subjected to multiparametric breast MRI (T2WI, dynamic contrast-enhanced MR imaging, diffusion-weighted images, and MR spectroscopy). ROC-analysis was employed for comparison between the diagnostic accuracy of mp-MRI and mp-MRI combined with MRS to predict the malignant lesions using the histopathological results as a standard of reference. Results: 33 (55 %) patients had histopathologically diagnosed 43 (58%) benign breast lesions and 27 (45%) patients had 32 (42%) malignant lesions. Using mp-MRI (dynamic contrast-enhanced MR imaging, T2-weighted images and diffusion-weighted images) had 98% accuracy of with 97.8%, sensitivity and 98.6%, specificity in differentiating malignant from benign lesions. A higher diagnostic 99.2% accuracy was obtained from combined mp-MRI and MRS with 99.5% sensitivity, 98.6% specificity. Conclusion: Despite of its limitations, MRS is a promising functional MRI technique thus improves the diagnostic accuracy of MRI for characterization of suspicious breast lesions when combined to mp-MRI to avoid unnecessary biopsy. breast lesions; mp-mri; mr spectroscopy Medicine R Mohamed Mamdouh Noaman Hussein verfasserin aut Naglaa Mohamed Abdelrazek verfasserin aut Mohamed Tharwat Mahmoud Soliman verfasserin aut In SVU - International Journal of Medical Sciences South Valley University, Faculty of Medicine, 2021 5(2022), 2, Seite 115-135 (DE-627)1761094386 26363402 nnns volume:5 year:2022 number:2 pages:115-135 https://dx.doi.org/10.21608/svuijm.2022.125320.1289 kostenfrei https://doaj.org/article/481e74a9fa53404483835dda2d9272b4 kostenfrei https://svuijm.journals.ekb.eg/article_227308.html kostenfrei https://doaj.org/toc/2735-427X Journal toc kostenfrei https://doaj.org/toc/2636-3402 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2022 2 115-135
spelling	(DE-627)DOAJ041673174 (DE-599)DOAJ481e74a9fa53404483835dda2d9272b4 DE-627 ger DE-627 rakwb eng Nahla Mohamed Ali Hasan * verfasserin aut Diagnostic value of MR spectroscopy in suspicious breast lesions 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: MRI has an essential role in breast imaging, along with mammography and ultrasonography. DCE- MRI is not 100% accurate in discriminating benign from malignant lesions. In attempt to improve the specificity of DCE-MRI, multiparametric MRI (mp-MRI) with additional functional parameters had been introduced. Objectives: To assess the added diagnostic value of MR spectroscopy in evaluation of suspicious breast lesions. Patients and methods: This prospective study included 60 females, their mean age was 42.1 ± 12 SD with 75 breast lesions categorized as BI-RADS 3 or BI-RADS 4 based on sonomamography. They were subjected to multiparametric breast MRI (T2WI, dynamic contrast-enhanced MR imaging, diffusion-weighted images, and MR spectroscopy). ROC-analysis was employed for comparison between the diagnostic accuracy of mp-MRI and mp-MRI combined with MRS to predict the malignant lesions using the histopathological results as a standard of reference. Results: 33 (55 %) patients had histopathologically diagnosed 43 (58%) benign breast lesions and 27 (45%) patients had 32 (42%) malignant lesions. Using mp-MRI (dynamic contrast-enhanced MR imaging, T2-weighted images and diffusion-weighted images) had 98% accuracy of with 97.8%, sensitivity and 98.6%, specificity in differentiating malignant from benign lesions. A higher diagnostic 99.2% accuracy was obtained from combined mp-MRI and MRS with 99.5% sensitivity, 98.6% specificity. Conclusion: Despite of its limitations, MRS is a promising functional MRI technique thus improves the diagnostic accuracy of MRI for characterization of suspicious breast lesions when combined to mp-MRI to avoid unnecessary biopsy. breast lesions; mp-mri; mr spectroscopy Medicine R Mohamed Mamdouh Noaman Hussein verfasserin aut Naglaa Mohamed Abdelrazek verfasserin aut Mohamed Tharwat Mahmoud Soliman verfasserin aut In SVU - International Journal of Medical Sciences South Valley University, Faculty of Medicine, 2021 5(2022), 2, Seite 115-135 (DE-627)1761094386 26363402 nnns volume:5 year:2022 number:2 pages:115-135 https://dx.doi.org/10.21608/svuijm.2022.125320.1289 kostenfrei https://doaj.org/article/481e74a9fa53404483835dda2d9272b4 kostenfrei https://svuijm.journals.ekb.eg/article_227308.html kostenfrei https://doaj.org/toc/2735-427X Journal toc kostenfrei https://doaj.org/toc/2636-3402 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2022 2 115-135
allfields_unstemmed	(DE-627)DOAJ041673174 (DE-599)DOAJ481e74a9fa53404483835dda2d9272b4 DE-627 ger DE-627 rakwb eng Nahla Mohamed Ali Hasan * verfasserin aut Diagnostic value of MR spectroscopy in suspicious breast lesions 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: MRI has an essential role in breast imaging, along with mammography and ultrasonography. DCE- MRI is not 100% accurate in discriminating benign from malignant lesions. In attempt to improve the specificity of DCE-MRI, multiparametric MRI (mp-MRI) with additional functional parameters had been introduced. Objectives: To assess the added diagnostic value of MR spectroscopy in evaluation of suspicious breast lesions. Patients and methods: This prospective study included 60 females, their mean age was 42.1 ± 12 SD with 75 breast lesions categorized as BI-RADS 3 or BI-RADS 4 based on sonomamography. They were subjected to multiparametric breast MRI (T2WI, dynamic contrast-enhanced MR imaging, diffusion-weighted images, and MR spectroscopy). ROC-analysis was employed for comparison between the diagnostic accuracy of mp-MRI and mp-MRI combined with MRS to predict the malignant lesions using the histopathological results as a standard of reference. Results: 33 (55 %) patients had histopathologically diagnosed 43 (58%) benign breast lesions and 27 (45%) patients had 32 (42%) malignant lesions. Using mp-MRI (dynamic contrast-enhanced MR imaging, T2-weighted images and diffusion-weighted images) had 98% accuracy of with 97.8%, sensitivity and 98.6%, specificity in differentiating malignant from benign lesions. A higher diagnostic 99.2% accuracy was obtained from combined mp-MRI and MRS with 99.5% sensitivity, 98.6% specificity. Conclusion: Despite of its limitations, MRS is a promising functional MRI technique thus improves the diagnostic accuracy of MRI for characterization of suspicious breast lesions when combined to mp-MRI to avoid unnecessary biopsy. breast lesions; mp-mri; mr spectroscopy Medicine R Mohamed Mamdouh Noaman Hussein verfasserin aut Naglaa Mohamed Abdelrazek verfasserin aut Mohamed Tharwat Mahmoud Soliman verfasserin aut In SVU - International Journal of Medical Sciences South Valley University, Faculty of Medicine, 2021 5(2022), 2, Seite 115-135 (DE-627)1761094386 26363402 nnns volume:5 year:2022 number:2 pages:115-135 https://dx.doi.org/10.21608/svuijm.2022.125320.1289 kostenfrei https://doaj.org/article/481e74a9fa53404483835dda2d9272b4 kostenfrei https://svuijm.journals.ekb.eg/article_227308.html kostenfrei https://doaj.org/toc/2735-427X Journal toc kostenfrei https://doaj.org/toc/2636-3402 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2022 2 115-135
allfieldsGer	(DE-627)DOAJ041673174 (DE-599)DOAJ481e74a9fa53404483835dda2d9272b4 DE-627 ger DE-627 rakwb eng Nahla Mohamed Ali Hasan * verfasserin aut Diagnostic value of MR spectroscopy in suspicious breast lesions 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: MRI has an essential role in breast imaging, along with mammography and ultrasonography. DCE- MRI is not 100% accurate in discriminating benign from malignant lesions. In attempt to improve the specificity of DCE-MRI, multiparametric MRI (mp-MRI) with additional functional parameters had been introduced. Objectives: To assess the added diagnostic value of MR spectroscopy in evaluation of suspicious breast lesions. Patients and methods: This prospective study included 60 females, their mean age was 42.1 ± 12 SD with 75 breast lesions categorized as BI-RADS 3 or BI-RADS 4 based on sonomamography. They were subjected to multiparametric breast MRI (T2WI, dynamic contrast-enhanced MR imaging, diffusion-weighted images, and MR spectroscopy). ROC-analysis was employed for comparison between the diagnostic accuracy of mp-MRI and mp-MRI combined with MRS to predict the malignant lesions using the histopathological results as a standard of reference. Results: 33 (55 %) patients had histopathologically diagnosed 43 (58%) benign breast lesions and 27 (45%) patients had 32 (42%) malignant lesions. Using mp-MRI (dynamic contrast-enhanced MR imaging, T2-weighted images and diffusion-weighted images) had 98% accuracy of with 97.8%, sensitivity and 98.6%, specificity in differentiating malignant from benign lesions. A higher diagnostic 99.2% accuracy was obtained from combined mp-MRI and MRS with 99.5% sensitivity, 98.6% specificity. Conclusion: Despite of its limitations, MRS is a promising functional MRI technique thus improves the diagnostic accuracy of MRI for characterization of suspicious breast lesions when combined to mp-MRI to avoid unnecessary biopsy. breast lesions; mp-mri; mr spectroscopy Medicine R Mohamed Mamdouh Noaman Hussein verfasserin aut Naglaa Mohamed Abdelrazek verfasserin aut Mohamed Tharwat Mahmoud Soliman verfasserin aut In SVU - International Journal of Medical Sciences South Valley University, Faculty of Medicine, 2021 5(2022), 2, Seite 115-135 (DE-627)1761094386 26363402 nnns volume:5 year:2022 number:2 pages:115-135 https://dx.doi.org/10.21608/svuijm.2022.125320.1289 kostenfrei https://doaj.org/article/481e74a9fa53404483835dda2d9272b4 kostenfrei https://svuijm.journals.ekb.eg/article_227308.html kostenfrei https://doaj.org/toc/2735-427X Journal toc kostenfrei https://doaj.org/toc/2636-3402 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2022 2 115-135
allfieldsSound	(DE-627)DOAJ041673174 (DE-599)DOAJ481e74a9fa53404483835dda2d9272b4 DE-627 ger DE-627 rakwb eng Nahla Mohamed Ali Hasan * verfasserin aut Diagnostic value of MR spectroscopy in suspicious breast lesions 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: MRI has an essential role in breast imaging, along with mammography and ultrasonography. DCE- MRI is not 100% accurate in discriminating benign from malignant lesions. In attempt to improve the specificity of DCE-MRI, multiparametric MRI (mp-MRI) with additional functional parameters had been introduced. Objectives: To assess the added diagnostic value of MR spectroscopy in evaluation of suspicious breast lesions. Patients and methods: This prospective study included 60 females, their mean age was 42.1 ± 12 SD with 75 breast lesions categorized as BI-RADS 3 or BI-RADS 4 based on sonomamography. They were subjected to multiparametric breast MRI (T2WI, dynamic contrast-enhanced MR imaging, diffusion-weighted images, and MR spectroscopy). ROC-analysis was employed for comparison between the diagnostic accuracy of mp-MRI and mp-MRI combined with MRS to predict the malignant lesions using the histopathological results as a standard of reference. Results: 33 (55 %) patients had histopathologically diagnosed 43 (58%) benign breast lesions and 27 (45%) patients had 32 (42%) malignant lesions. Using mp-MRI (dynamic contrast-enhanced MR imaging, T2-weighted images and diffusion-weighted images) had 98% accuracy of with 97.8%, sensitivity and 98.6%, specificity in differentiating malignant from benign lesions. A higher diagnostic 99.2% accuracy was obtained from combined mp-MRI and MRS with 99.5% sensitivity, 98.6% specificity. Conclusion: Despite of its limitations, MRS is a promising functional MRI technique thus improves the diagnostic accuracy of MRI for characterization of suspicious breast lesions when combined to mp-MRI to avoid unnecessary biopsy. breast lesions; mp-mri; mr spectroscopy Medicine R Mohamed Mamdouh Noaman Hussein verfasserin aut Naglaa Mohamed Abdelrazek verfasserin aut Mohamed Tharwat Mahmoud Soliman verfasserin aut In SVU - International Journal of Medical Sciences South Valley University, Faculty of Medicine, 2021 5(2022), 2, Seite 115-135 (DE-627)1761094386 26363402 nnns volume:5 year:2022 number:2 pages:115-135 https://dx.doi.org/10.21608/svuijm.2022.125320.1289 kostenfrei https://doaj.org/article/481e74a9fa53404483835dda2d9272b4 kostenfrei https://svuijm.journals.ekb.eg/article_227308.html kostenfrei https://doaj.org/toc/2735-427X Journal toc kostenfrei https://doaj.org/toc/2636-3402 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2022 2 115-135
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DCE- MRI is not 100% accurate in discriminating benign from malignant lesions. In attempt to improve the specificity of DCE-MRI, multiparametric MRI (mp-MRI) with additional functional parameters had been introduced. Objectives: To assess the added diagnostic value of MR spectroscopy in evaluation of suspicious breast lesions. Patients and methods: This prospective study included 60 females, their mean age was 42.1 ± 12 SD with 75 breast lesions categorized as BI-RADS 3 or BI-RADS 4 based on sonomamography. They were subjected to multiparametric breast MRI (T2WI, dynamic contrast-enhanced MR imaging, diffusion-weighted images, and MR spectroscopy). ROC-analysis was employed for comparison between the diagnostic accuracy of mp-MRI and mp-MRI combined with MRS to predict the malignant lesions using the histopathological results as a standard of reference. Results: 33 (55 %) patients had histopathologically diagnosed 43 (58%) benign breast lesions and 27 (45%) patients had 32 (42%) malignant lesions. Using mp-MRI (dynamic contrast-enhanced MR imaging, T2-weighted images and diffusion-weighted images) had 98% accuracy of with 97.8%, sensitivity and 98.6%, specificity in differentiating malignant from benign lesions. A higher diagnostic 99.2% accuracy was obtained from combined mp-MRI and MRS with 99.5% sensitivity, 98.6% specificity. 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author	Nahla Mohamed Ali Hasan *
spellingShingle	Nahla Mohamed Ali Hasan * misc breast lesions; mp-mri; mr spectroscopy misc Medicine misc R Diagnostic value of MR spectroscopy in suspicious breast lesions
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topic_title	Diagnostic value of MR spectroscopy in suspicious breast lesions breast lesions; mp-mri; mr spectroscopy
topic	misc breast lesions; mp-mri; mr spectroscopy misc Medicine misc R
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title	Diagnostic value of MR spectroscopy in suspicious breast lesions
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title_full	Diagnostic value of MR spectroscopy in suspicious breast lesions
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author_browse	Nahla Mohamed Ali Hasan * Mohamed Mamdouh Noaman Hussein Naglaa Mohamed Abdelrazek Mohamed Tharwat Mahmoud Soliman
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title_sort	diagnostic value of mr spectroscopy in suspicious breast lesions
title_auth	Diagnostic value of MR spectroscopy in suspicious breast lesions
abstract	Background: MRI has an essential role in breast imaging, along with mammography and ultrasonography. DCE- MRI is not 100% accurate in discriminating benign from malignant lesions. In attempt to improve the specificity of DCE-MRI, multiparametric MRI (mp-MRI) with additional functional parameters had been introduced. Objectives: To assess the added diagnostic value of MR spectroscopy in evaluation of suspicious breast lesions. Patients and methods: This prospective study included 60 females, their mean age was 42.1 ± 12 SD with 75 breast lesions categorized as BI-RADS 3 or BI-RADS 4 based on sonomamography. They were subjected to multiparametric breast MRI (T2WI, dynamic contrast-enhanced MR imaging, diffusion-weighted images, and MR spectroscopy). ROC-analysis was employed for comparison between the diagnostic accuracy of mp-MRI and mp-MRI combined with MRS to predict the malignant lesions using the histopathological results as a standard of reference. Results: 33 (55 %) patients had histopathologically diagnosed 43 (58%) benign breast lesions and 27 (45%) patients had 32 (42%) malignant lesions. Using mp-MRI (dynamic contrast-enhanced MR imaging, T2-weighted images and diffusion-weighted images) had 98% accuracy of with 97.8%, sensitivity and 98.6%, specificity in differentiating malignant from benign lesions. A higher diagnostic 99.2% accuracy was obtained from combined mp-MRI and MRS with 99.5% sensitivity, 98.6% specificity. Conclusion: Despite of its limitations, MRS is a promising functional MRI technique thus improves the diagnostic accuracy of MRI for characterization of suspicious breast lesions when combined to mp-MRI to avoid unnecessary biopsy.
abstractGer	Background: MRI has an essential role in breast imaging, along with mammography and ultrasonography. DCE- MRI is not 100% accurate in discriminating benign from malignant lesions. In attempt to improve the specificity of DCE-MRI, multiparametric MRI (mp-MRI) with additional functional parameters had been introduced. Objectives: To assess the added diagnostic value of MR spectroscopy in evaluation of suspicious breast lesions. Patients and methods: This prospective study included 60 females, their mean age was 42.1 ± 12 SD with 75 breast lesions categorized as BI-RADS 3 or BI-RADS 4 based on sonomamography. They were subjected to multiparametric breast MRI (T2WI, dynamic contrast-enhanced MR imaging, diffusion-weighted images, and MR spectroscopy). ROC-analysis was employed for comparison between the diagnostic accuracy of mp-MRI and mp-MRI combined with MRS to predict the malignant lesions using the histopathological results as a standard of reference. Results: 33 (55 %) patients had histopathologically diagnosed 43 (58%) benign breast lesions and 27 (45%) patients had 32 (42%) malignant lesions. Using mp-MRI (dynamic contrast-enhanced MR imaging, T2-weighted images and diffusion-weighted images) had 98% accuracy of with 97.8%, sensitivity and 98.6%, specificity in differentiating malignant from benign lesions. A higher diagnostic 99.2% accuracy was obtained from combined mp-MRI and MRS with 99.5% sensitivity, 98.6% specificity. Conclusion: Despite of its limitations, MRS is a promising functional MRI technique thus improves the diagnostic accuracy of MRI for characterization of suspicious breast lesions when combined to mp-MRI to avoid unnecessary biopsy.
abstract_unstemmed	Background: MRI has an essential role in breast imaging, along with mammography and ultrasonography. DCE- MRI is not 100% accurate in discriminating benign from malignant lesions. In attempt to improve the specificity of DCE-MRI, multiparametric MRI (mp-MRI) with additional functional parameters had been introduced. Objectives: To assess the added diagnostic value of MR spectroscopy in evaluation of suspicious breast lesions. Patients and methods: This prospective study included 60 females, their mean age was 42.1 ± 12 SD with 75 breast lesions categorized as BI-RADS 3 or BI-RADS 4 based on sonomamography. They were subjected to multiparametric breast MRI (T2WI, dynamic contrast-enhanced MR imaging, diffusion-weighted images, and MR spectroscopy). ROC-analysis was employed for comparison between the diagnostic accuracy of mp-MRI and mp-MRI combined with MRS to predict the malignant lesions using the histopathological results as a standard of reference. Results: 33 (55 %) patients had histopathologically diagnosed 43 (58%) benign breast lesions and 27 (45%) patients had 32 (42%) malignant lesions. Using mp-MRI (dynamic contrast-enhanced MR imaging, T2-weighted images and diffusion-weighted images) had 98% accuracy of with 97.8%, sensitivity and 98.6%, specificity in differentiating malignant from benign lesions. A higher diagnostic 99.2% accuracy was obtained from combined mp-MRI and MRS with 99.5% sensitivity, 98.6% specificity. Conclusion: Despite of its limitations, MRS is a promising functional MRI technique thus improves the diagnostic accuracy of MRI for characterization of suspicious breast lesions when combined to mp-MRI to avoid unnecessary biopsy.
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title_short	Diagnostic value of MR spectroscopy in suspicious breast lesions
url	https://dx.doi.org/10.21608/svuijm.2022.125320.1289 https://doaj.org/article/481e74a9fa53404483835dda2d9272b4 https://svuijm.journals.ekb.eg/article_227308.html https://doaj.org/toc/2735-427X https://doaj.org/toc/2636-3402
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author2	Mohamed Mamdouh Noaman Hussein Naglaa Mohamed Abdelrazek Mohamed Tharwat Mahmoud Soliman
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