OPTIMIZATION OF SECOND-LINE TARGETED THERAPY FOR METASTATIC RENAL CELL CARCINOMA CANCER AFTER USE OF VEGF RECEPTOR – TYROSINE KINASE INHIBITORS (LITERATURE REVIEW)

<p<<em<Sequential targeted therapy is now the standard of treatment for metastatic renal cell carcinoma (mRCC). A switch into a different mechanism of action of mTOR inhibitor after vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKI) in second-line therap...
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Autor*in:	R. V. Savkov [verfasserIn]

Format:	E-Artikel
Sprache:	Russisch

Erschienen:	2014

Schlagwörter:	sequential targeted therapy second-line therapy everolimus

Übergeordnetes Werk:	In: Onkourologiâ - ABV-press, 2015, 8(2014), 4, Seite 22-26
Übergeordnetes Werk:	volume:8 ; year:2014 ; number:4 ; pages:22-26

Links:	Link aufrufen Link aufrufen Journal toc Journal toc

Katalog-ID:	DOAJ041844041

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spelling	(DE-627)DOAJ041844041 (DE-599)DOAJd772e4426f0a4b12be2dcabb94c73b6c DE-627 ger DE-627 rakwb rus R. V. Savkov verfasserin aut OPTIMIZATION OF SECOND-LINE TARGETED THERAPY FOR METASTATIC RENAL CELL CARCINOMA CANCER AFTER USE OF VEGF RECEPTOR – TYROSINE KINASE INHIBITORS (LITERATURE REVIEW) 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<<em<Sequential targeted therapy is now the standard of treatment for metastatic renal cell carcinoma (mRCC). A switch into a different mechanism of action of mTOR inhibitor after vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKI) in second-line therapy helps to elude cumulative toxicity and cross-resistance, which may occur in the sequential use of different anti-VEGFR agents through the overlapping mechanisms of action. After VEGFR TKI therapy failure, treatment with the mTOR inhibitor everolimus in second-line therapy is recognized to be effective and safe, substantially increasing progression-free survival, without worsening its quality. Everolimus is recommended as second-line targeted treatment for patients with progressive mRCC after primary VEGFR TKI use. Switching to everolimus is warranted especially in patients who have a poor response to or a high toxicity of first-line antiangiogenic therapy.</em<</p< sequential targeted therapy second-line therapy everolimus Medicine R In Onkourologiâ ABV-press, 2015 8(2014), 4, Seite 22-26 (DE-627)1736705067 17269776 nnns volume:8 year:2014 number:4 pages:22-26 https://doaj.org/article/d772e4426f0a4b12be2dcabb94c73b6c kostenfrei http://oncourology.abvpress.ru/index.php/oncur/article/view/351 kostenfrei https://doaj.org/toc/1726-9776 Journal toc kostenfrei https://doaj.org/toc/1996-1812 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2014 4 22-26
allfields_unstemmed	(DE-627)DOAJ041844041 (DE-599)DOAJd772e4426f0a4b12be2dcabb94c73b6c DE-627 ger DE-627 rakwb rus R. V. Savkov verfasserin aut OPTIMIZATION OF SECOND-LINE TARGETED THERAPY FOR METASTATIC RENAL CELL CARCINOMA CANCER AFTER USE OF VEGF RECEPTOR – TYROSINE KINASE INHIBITORS (LITERATURE REVIEW) 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<<em<Sequential targeted therapy is now the standard of treatment for metastatic renal cell carcinoma (mRCC). A switch into a different mechanism of action of mTOR inhibitor after vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKI) in second-line therapy helps to elude cumulative toxicity and cross-resistance, which may occur in the sequential use of different anti-VEGFR agents through the overlapping mechanisms of action. After VEGFR TKI therapy failure, treatment with the mTOR inhibitor everolimus in second-line therapy is recognized to be effective and safe, substantially increasing progression-free survival, without worsening its quality. Everolimus is recommended as second-line targeted treatment for patients with progressive mRCC after primary VEGFR TKI use. Switching to everolimus is warranted especially in patients who have a poor response to or a high toxicity of first-line antiangiogenic therapy.</em<</p< sequential targeted therapy second-line therapy everolimus Medicine R In Onkourologiâ ABV-press, 2015 8(2014), 4, Seite 22-26 (DE-627)1736705067 17269776 nnns volume:8 year:2014 number:4 pages:22-26 https://doaj.org/article/d772e4426f0a4b12be2dcabb94c73b6c kostenfrei http://oncourology.abvpress.ru/index.php/oncur/article/view/351 kostenfrei https://doaj.org/toc/1726-9776 Journal toc kostenfrei https://doaj.org/toc/1996-1812 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2014 4 22-26
allfieldsGer	(DE-627)DOAJ041844041 (DE-599)DOAJd772e4426f0a4b12be2dcabb94c73b6c DE-627 ger DE-627 rakwb rus R. V. Savkov verfasserin aut OPTIMIZATION OF SECOND-LINE TARGETED THERAPY FOR METASTATIC RENAL CELL CARCINOMA CANCER AFTER USE OF VEGF RECEPTOR – TYROSINE KINASE INHIBITORS (LITERATURE REVIEW) 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<<em<Sequential targeted therapy is now the standard of treatment for metastatic renal cell carcinoma (mRCC). A switch into a different mechanism of action of mTOR inhibitor after vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKI) in second-line therapy helps to elude cumulative toxicity and cross-resistance, which may occur in the sequential use of different anti-VEGFR agents through the overlapping mechanisms of action. After VEGFR TKI therapy failure, treatment with the mTOR inhibitor everolimus in second-line therapy is recognized to be effective and safe, substantially increasing progression-free survival, without worsening its quality. Everolimus is recommended as second-line targeted treatment for patients with progressive mRCC after primary VEGFR TKI use. Switching to everolimus is warranted especially in patients who have a poor response to or a high toxicity of first-line antiangiogenic therapy.</em<</p< sequential targeted therapy second-line therapy everolimus Medicine R In Onkourologiâ ABV-press, 2015 8(2014), 4, Seite 22-26 (DE-627)1736705067 17269776 nnns volume:8 year:2014 number:4 pages:22-26 https://doaj.org/article/d772e4426f0a4b12be2dcabb94c73b6c kostenfrei http://oncourology.abvpress.ru/index.php/oncur/article/view/351 kostenfrei https://doaj.org/toc/1726-9776 Journal toc kostenfrei https://doaj.org/toc/1996-1812 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2014 4 22-26
allfieldsSound	(DE-627)DOAJ041844041 (DE-599)DOAJd772e4426f0a4b12be2dcabb94c73b6c DE-627 ger DE-627 rakwb rus R. V. Savkov verfasserin aut OPTIMIZATION OF SECOND-LINE TARGETED THERAPY FOR METASTATIC RENAL CELL CARCINOMA CANCER AFTER USE OF VEGF RECEPTOR – TYROSINE KINASE INHIBITORS (LITERATURE REVIEW) 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<<em<Sequential targeted therapy is now the standard of treatment for metastatic renal cell carcinoma (mRCC). A switch into a different mechanism of action of mTOR inhibitor after vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKI) in second-line therapy helps to elude cumulative toxicity and cross-resistance, which may occur in the sequential use of different anti-VEGFR agents through the overlapping mechanisms of action. After VEGFR TKI therapy failure, treatment with the mTOR inhibitor everolimus in second-line therapy is recognized to be effective and safe, substantially increasing progression-free survival, without worsening its quality. Everolimus is recommended as second-line targeted treatment for patients with progressive mRCC after primary VEGFR TKI use. Switching to everolimus is warranted especially in patients who have a poor response to or a high toxicity of first-line antiangiogenic therapy.</em<</p< sequential targeted therapy second-line therapy everolimus Medicine R In Onkourologiâ ABV-press, 2015 8(2014), 4, Seite 22-26 (DE-627)1736705067 17269776 nnns volume:8 year:2014 number:4 pages:22-26 https://doaj.org/article/d772e4426f0a4b12be2dcabb94c73b6c kostenfrei http://oncourology.abvpress.ru/index.php/oncur/article/view/351 kostenfrei https://doaj.org/toc/1726-9776 Journal toc kostenfrei https://doaj.org/toc/1996-1812 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2014 4 22-26
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spellingShingle	R. V. Savkov misc sequential targeted therapy misc second-line therapy misc everolimus misc Medicine misc R OPTIMIZATION OF SECOND-LINE TARGETED THERAPY FOR METASTATIC RENAL CELL CARCINOMA CANCER AFTER USE OF VEGF RECEPTOR – TYROSINE KINASE INHIBITORS (LITERATURE REVIEW)
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topic_title	OPTIMIZATION OF SECOND-LINE TARGETED THERAPY FOR METASTATIC RENAL CELL CARCINOMA CANCER AFTER USE OF VEGF RECEPTOR – TYROSINE KINASE INHIBITORS (LITERATURE REVIEW) sequential targeted therapy second-line therapy everolimus
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title	OPTIMIZATION OF SECOND-LINE TARGETED THERAPY FOR METASTATIC RENAL CELL CARCINOMA CANCER AFTER USE OF VEGF RECEPTOR – TYROSINE KINASE INHIBITORS (LITERATURE REVIEW)
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title_full	OPTIMIZATION OF SECOND-LINE TARGETED THERAPY FOR METASTATIC RENAL CELL CARCINOMA CANCER AFTER USE OF VEGF RECEPTOR – TYROSINE KINASE INHIBITORS (LITERATURE REVIEW)
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title_sort	optimization of second-line targeted therapy for metastatic renal cell carcinoma cancer after use of vegf receptor – tyrosine kinase inhibitors (literature review)
title_auth	OPTIMIZATION OF SECOND-LINE TARGETED THERAPY FOR METASTATIC RENAL CELL CARCINOMA CANCER AFTER USE OF VEGF RECEPTOR – TYROSINE KINASE INHIBITORS (LITERATURE REVIEW)
abstract	<p<<em<Sequential targeted therapy is now the standard of treatment for metastatic renal cell carcinoma (mRCC). A switch into a different mechanism of action of mTOR inhibitor after vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKI) in second-line therapy helps to elude cumulative toxicity and cross-resistance, which may occur in the sequential use of different anti-VEGFR agents through the overlapping mechanisms of action. After VEGFR TKI therapy failure, treatment with the mTOR inhibitor everolimus in second-line therapy is recognized to be effective and safe, substantially increasing progression-free survival, without worsening its quality. Everolimus is recommended as second-line targeted treatment for patients with progressive mRCC after primary VEGFR TKI use. Switching to everolimus is warranted especially in patients who have a poor response to or a high toxicity of first-line antiangiogenic therapy.</em<</p<
abstractGer	<p<<em<Sequential targeted therapy is now the standard of treatment for metastatic renal cell carcinoma (mRCC). A switch into a different mechanism of action of mTOR inhibitor after vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKI) in second-line therapy helps to elude cumulative toxicity and cross-resistance, which may occur in the sequential use of different anti-VEGFR agents through the overlapping mechanisms of action. After VEGFR TKI therapy failure, treatment with the mTOR inhibitor everolimus in second-line therapy is recognized to be effective and safe, substantially increasing progression-free survival, without worsening its quality. Everolimus is recommended as second-line targeted treatment for patients with progressive mRCC after primary VEGFR TKI use. Switching to everolimus is warranted especially in patients who have a poor response to or a high toxicity of first-line antiangiogenic therapy.</em<</p<
abstract_unstemmed	<p<<em<Sequential targeted therapy is now the standard of treatment for metastatic renal cell carcinoma (mRCC). A switch into a different mechanism of action of mTOR inhibitor after vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKI) in second-line therapy helps to elude cumulative toxicity and cross-resistance, which may occur in the sequential use of different anti-VEGFR agents through the overlapping mechanisms of action. After VEGFR TKI therapy failure, treatment with the mTOR inhibitor everolimus in second-line therapy is recognized to be effective and safe, substantially increasing progression-free survival, without worsening its quality. Everolimus is recommended as second-line targeted treatment for patients with progressive mRCC after primary VEGFR TKI use. Switching to everolimus is warranted especially in patients who have a poor response to or a high toxicity of first-line antiangiogenic therapy.</em<</p<
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title_short	OPTIMIZATION OF SECOND-LINE TARGETED THERAPY FOR METASTATIC RENAL CELL CARCINOMA CANCER AFTER USE OF VEGF RECEPTOR – TYROSINE KINASE INHIBITORS (LITERATURE REVIEW)
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