Anti-tumor synergistic activity of nano-chlorophyll with sonophotodynamic on Ehrlich ascites carcinoma in mice
Background and objective: Cancer is a major health problem that threatens the life of many people with an increasing need for anticancer therapy. The present work aimed to investigate the effectiveness of using sonophotodynamic modality (exposure of infra-red laser as photodynamic) and to the ultras...
Ausführliche Beschreibung
Autor*in: |
Jubran Mohammed Abdulrahman [verfasserIn] Gihan Hosny AbdElsamie [verfasserIn] Rafal Abdulrazaq A. Al-rawi [verfasserIn] Samir Ali Abd El- kaream [verfasserIn] |
---|
Format: |
E-Artikel |
---|---|
Sprache: |
Englisch |
Erschienen: |
2020 |
---|
Schlagwörter: |
---|
Übergeordnetes Werk: |
In: Zanco Journal of Medical Sciences - Hawler Medical University, 2017, 24(2020), 1, Seite 132-142 |
---|---|
Übergeordnetes Werk: |
volume:24 ; year:2020 ; number:1 ; pages:132-142 |
Links: |
Link aufrufen |
---|
DOI / URN: |
10.15218/zjms.2020.016 |
---|
Katalog-ID: |
DOAJ041859367 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | DOAJ041859367 | ||
003 | DE-627 | ||
005 | 20230308052954.0 | ||
007 | cr uuu---uuuuu | ||
008 | 230227s2020 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.15218/zjms.2020.016 |2 doi | |
035 | |a (DE-627)DOAJ041859367 | ||
035 | |a (DE-599)DOAJ6ee747416e0b41e4bd084d77d84e90f6 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 0 | |a Jubran Mohammed Abdulrahman |e verfasserin |4 aut | |
245 | 1 | 0 | |a Anti-tumor synergistic activity of nano-chlorophyll with sonophotodynamic on Ehrlich ascites carcinoma in mice |
264 | 1 | |c 2020 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
520 | |a Background and objective: Cancer is a major health problem that threatens the life of many people with an increasing need for anticancer therapy. The present work aimed to investigate the effectiveness of using sonophotodynamic modality (exposure of infra-red laser as photodynamic) and to the ultrasound as sonodynamic modality in combination with nano-chlorophyll, for cancer therapy through histopathological assessment in Ehrlich ascites carcinoma cell implanted to mice as experimental animals. Methods: A total of 120 male mice were randomly assigned to 12 treatment groups. Ehrlich ascites carcinoma cell was inoculated subcutaneously in all the experimental mice. When the tumor had grown to about 10 mm in diameter at day 10 after inoculation, treatments were started. Experimental groups were investigated histopathologically two weeks after treatments. Results: The histological evaluation revealed that tumors from various treated groups of mice bearing the tumor showed different percentages of necrosis and tumor proliferation based on the type of treatment. Tumor excised from mice receiving sonophotodynamic with nano-Chlorophyll treatment showed a significant increase of necrosis about 15 – 25% compared to other groups without nano-chlorophyll as a sensitizer. The group of mice subjected to the combination of photodynamic and sonodynamic therapy in the presence of nano-Chlorophyll, showed large foci distinct necrosis areas 95% of large distinct foci of necrosis in the tumor and no tumor proliferation. Conclusion: The anti-tumor activity of nano-chlorophyll in combination with sonophotodynamic therapy for Ehrlich ascites carcinoma in mice was effective. | ||
650 | 4 | |a sonodynamic therapy | |
650 | 4 | |a photodynamic therapy | |
650 | 4 | |a sonophotodynamic therapy | |
650 | 4 | |a nano-chlorophyll | |
650 | 4 | |a histopathology | |
653 | 0 | |a Medicine | |
653 | 0 | |a R | |
700 | 0 | |a Gihan Hosny AbdElsamie |e verfasserin |4 aut | |
700 | 0 | |a Rafal Abdulrazaq A. Al-rawi |e verfasserin |4 aut | |
700 | 0 | |a Samir Ali Abd El- kaream |e verfasserin |4 aut | |
773 | 0 | 8 | |i In |t Zanco Journal of Medical Sciences |d Hawler Medical University, 2017 |g 24(2020), 1, Seite 132-142 |w (DE-627)1760589705 |x 19955596 |7 nnns |
773 | 1 | 8 | |g volume:24 |g year:2020 |g number:1 |g pages:132-142 |
856 | 4 | 0 | |u https://doi.org/10.15218/zjms.2020.016 |z kostenfrei |
856 | 4 | 0 | |u https://doaj.org/article/6ee747416e0b41e4bd084d77d84e90f6 |z kostenfrei |
856 | 4 | 0 | |u https://zjms.hmu.edu.krd/index.php/zjms/article/view/726/624 |z kostenfrei |
856 | 4 | 2 | |u https://doaj.org/toc/1995-5588 |y Journal toc |z kostenfrei |
856 | 4 | 2 | |u https://doaj.org/toc/1995-5596 |y Journal toc |z kostenfrei |
912 | |a GBV_USEFLAG_A | ||
912 | |a SYSFLAG_A | ||
912 | |a GBV_DOAJ | ||
951 | |a AR | ||
952 | |d 24 |j 2020 |e 1 |h 132-142 |
matchkey_str |
article:19955596:2020----::niuosnritcciiyfaohoohlwtsnpooyaioeri |
---|---|
hierarchy_sort_str |
2020 |
publishDate |
2020 |
allfields |
10.15218/zjms.2020.016 doi (DE-627)DOAJ041859367 (DE-599)DOAJ6ee747416e0b41e4bd084d77d84e90f6 DE-627 ger DE-627 rakwb eng Jubran Mohammed Abdulrahman verfasserin aut Anti-tumor synergistic activity of nano-chlorophyll with sonophotodynamic on Ehrlich ascites carcinoma in mice 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and objective: Cancer is a major health problem that threatens the life of many people with an increasing need for anticancer therapy. The present work aimed to investigate the effectiveness of using sonophotodynamic modality (exposure of infra-red laser as photodynamic) and to the ultrasound as sonodynamic modality in combination with nano-chlorophyll, for cancer therapy through histopathological assessment in Ehrlich ascites carcinoma cell implanted to mice as experimental animals. Methods: A total of 120 male mice were randomly assigned to 12 treatment groups. Ehrlich ascites carcinoma cell was inoculated subcutaneously in all the experimental mice. When the tumor had grown to about 10 mm in diameter at day 10 after inoculation, treatments were started. Experimental groups were investigated histopathologically two weeks after treatments. Results: The histological evaluation revealed that tumors from various treated groups of mice bearing the tumor showed different percentages of necrosis and tumor proliferation based on the type of treatment. Tumor excised from mice receiving sonophotodynamic with nano-Chlorophyll treatment showed a significant increase of necrosis about 15 – 25% compared to other groups without nano-chlorophyll as a sensitizer. The group of mice subjected to the combination of photodynamic and sonodynamic therapy in the presence of nano-Chlorophyll, showed large foci distinct necrosis areas 95% of large distinct foci of necrosis in the tumor and no tumor proliferation. Conclusion: The anti-tumor activity of nano-chlorophyll in combination with sonophotodynamic therapy for Ehrlich ascites carcinoma in mice was effective. sonodynamic therapy photodynamic therapy sonophotodynamic therapy nano-chlorophyll histopathology Medicine R Gihan Hosny AbdElsamie verfasserin aut Rafal Abdulrazaq A. Al-rawi verfasserin aut Samir Ali Abd El- kaream verfasserin aut In Zanco Journal of Medical Sciences Hawler Medical University, 2017 24(2020), 1, Seite 132-142 (DE-627)1760589705 19955596 nnns volume:24 year:2020 number:1 pages:132-142 https://doi.org/10.15218/zjms.2020.016 kostenfrei https://doaj.org/article/6ee747416e0b41e4bd084d77d84e90f6 kostenfrei https://zjms.hmu.edu.krd/index.php/zjms/article/view/726/624 kostenfrei https://doaj.org/toc/1995-5588 Journal toc kostenfrei https://doaj.org/toc/1995-5596 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 24 2020 1 132-142 |
spelling |
10.15218/zjms.2020.016 doi (DE-627)DOAJ041859367 (DE-599)DOAJ6ee747416e0b41e4bd084d77d84e90f6 DE-627 ger DE-627 rakwb eng Jubran Mohammed Abdulrahman verfasserin aut Anti-tumor synergistic activity of nano-chlorophyll with sonophotodynamic on Ehrlich ascites carcinoma in mice 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and objective: Cancer is a major health problem that threatens the life of many people with an increasing need for anticancer therapy. The present work aimed to investigate the effectiveness of using sonophotodynamic modality (exposure of infra-red laser as photodynamic) and to the ultrasound as sonodynamic modality in combination with nano-chlorophyll, for cancer therapy through histopathological assessment in Ehrlich ascites carcinoma cell implanted to mice as experimental animals. Methods: A total of 120 male mice were randomly assigned to 12 treatment groups. Ehrlich ascites carcinoma cell was inoculated subcutaneously in all the experimental mice. When the tumor had grown to about 10 mm in diameter at day 10 after inoculation, treatments were started. Experimental groups were investigated histopathologically two weeks after treatments. Results: The histological evaluation revealed that tumors from various treated groups of mice bearing the tumor showed different percentages of necrosis and tumor proliferation based on the type of treatment. Tumor excised from mice receiving sonophotodynamic with nano-Chlorophyll treatment showed a significant increase of necrosis about 15 – 25% compared to other groups without nano-chlorophyll as a sensitizer. The group of mice subjected to the combination of photodynamic and sonodynamic therapy in the presence of nano-Chlorophyll, showed large foci distinct necrosis areas 95% of large distinct foci of necrosis in the tumor and no tumor proliferation. Conclusion: The anti-tumor activity of nano-chlorophyll in combination with sonophotodynamic therapy for Ehrlich ascites carcinoma in mice was effective. sonodynamic therapy photodynamic therapy sonophotodynamic therapy nano-chlorophyll histopathology Medicine R Gihan Hosny AbdElsamie verfasserin aut Rafal Abdulrazaq A. Al-rawi verfasserin aut Samir Ali Abd El- kaream verfasserin aut In Zanco Journal of Medical Sciences Hawler Medical University, 2017 24(2020), 1, Seite 132-142 (DE-627)1760589705 19955596 nnns volume:24 year:2020 number:1 pages:132-142 https://doi.org/10.15218/zjms.2020.016 kostenfrei https://doaj.org/article/6ee747416e0b41e4bd084d77d84e90f6 kostenfrei https://zjms.hmu.edu.krd/index.php/zjms/article/view/726/624 kostenfrei https://doaj.org/toc/1995-5588 Journal toc kostenfrei https://doaj.org/toc/1995-5596 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 24 2020 1 132-142 |
allfields_unstemmed |
10.15218/zjms.2020.016 doi (DE-627)DOAJ041859367 (DE-599)DOAJ6ee747416e0b41e4bd084d77d84e90f6 DE-627 ger DE-627 rakwb eng Jubran Mohammed Abdulrahman verfasserin aut Anti-tumor synergistic activity of nano-chlorophyll with sonophotodynamic on Ehrlich ascites carcinoma in mice 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and objective: Cancer is a major health problem that threatens the life of many people with an increasing need for anticancer therapy. The present work aimed to investigate the effectiveness of using sonophotodynamic modality (exposure of infra-red laser as photodynamic) and to the ultrasound as sonodynamic modality in combination with nano-chlorophyll, for cancer therapy through histopathological assessment in Ehrlich ascites carcinoma cell implanted to mice as experimental animals. Methods: A total of 120 male mice were randomly assigned to 12 treatment groups. Ehrlich ascites carcinoma cell was inoculated subcutaneously in all the experimental mice. When the tumor had grown to about 10 mm in diameter at day 10 after inoculation, treatments were started. Experimental groups were investigated histopathologically two weeks after treatments. Results: The histological evaluation revealed that tumors from various treated groups of mice bearing the tumor showed different percentages of necrosis and tumor proliferation based on the type of treatment. Tumor excised from mice receiving sonophotodynamic with nano-Chlorophyll treatment showed a significant increase of necrosis about 15 – 25% compared to other groups without nano-chlorophyll as a sensitizer. The group of mice subjected to the combination of photodynamic and sonodynamic therapy in the presence of nano-Chlorophyll, showed large foci distinct necrosis areas 95% of large distinct foci of necrosis in the tumor and no tumor proliferation. Conclusion: The anti-tumor activity of nano-chlorophyll in combination with sonophotodynamic therapy for Ehrlich ascites carcinoma in mice was effective. sonodynamic therapy photodynamic therapy sonophotodynamic therapy nano-chlorophyll histopathology Medicine R Gihan Hosny AbdElsamie verfasserin aut Rafal Abdulrazaq A. Al-rawi verfasserin aut Samir Ali Abd El- kaream verfasserin aut In Zanco Journal of Medical Sciences Hawler Medical University, 2017 24(2020), 1, Seite 132-142 (DE-627)1760589705 19955596 nnns volume:24 year:2020 number:1 pages:132-142 https://doi.org/10.15218/zjms.2020.016 kostenfrei https://doaj.org/article/6ee747416e0b41e4bd084d77d84e90f6 kostenfrei https://zjms.hmu.edu.krd/index.php/zjms/article/view/726/624 kostenfrei https://doaj.org/toc/1995-5588 Journal toc kostenfrei https://doaj.org/toc/1995-5596 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 24 2020 1 132-142 |
allfieldsGer |
10.15218/zjms.2020.016 doi (DE-627)DOAJ041859367 (DE-599)DOAJ6ee747416e0b41e4bd084d77d84e90f6 DE-627 ger DE-627 rakwb eng Jubran Mohammed Abdulrahman verfasserin aut Anti-tumor synergistic activity of nano-chlorophyll with sonophotodynamic on Ehrlich ascites carcinoma in mice 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and objective: Cancer is a major health problem that threatens the life of many people with an increasing need for anticancer therapy. The present work aimed to investigate the effectiveness of using sonophotodynamic modality (exposure of infra-red laser as photodynamic) and to the ultrasound as sonodynamic modality in combination with nano-chlorophyll, for cancer therapy through histopathological assessment in Ehrlich ascites carcinoma cell implanted to mice as experimental animals. Methods: A total of 120 male mice were randomly assigned to 12 treatment groups. Ehrlich ascites carcinoma cell was inoculated subcutaneously in all the experimental mice. When the tumor had grown to about 10 mm in diameter at day 10 after inoculation, treatments were started. Experimental groups were investigated histopathologically two weeks after treatments. Results: The histological evaluation revealed that tumors from various treated groups of mice bearing the tumor showed different percentages of necrosis and tumor proliferation based on the type of treatment. Tumor excised from mice receiving sonophotodynamic with nano-Chlorophyll treatment showed a significant increase of necrosis about 15 – 25% compared to other groups without nano-chlorophyll as a sensitizer. The group of mice subjected to the combination of photodynamic and sonodynamic therapy in the presence of nano-Chlorophyll, showed large foci distinct necrosis areas 95% of large distinct foci of necrosis in the tumor and no tumor proliferation. Conclusion: The anti-tumor activity of nano-chlorophyll in combination with sonophotodynamic therapy for Ehrlich ascites carcinoma in mice was effective. sonodynamic therapy photodynamic therapy sonophotodynamic therapy nano-chlorophyll histopathology Medicine R Gihan Hosny AbdElsamie verfasserin aut Rafal Abdulrazaq A. Al-rawi verfasserin aut Samir Ali Abd El- kaream verfasserin aut In Zanco Journal of Medical Sciences Hawler Medical University, 2017 24(2020), 1, Seite 132-142 (DE-627)1760589705 19955596 nnns volume:24 year:2020 number:1 pages:132-142 https://doi.org/10.15218/zjms.2020.016 kostenfrei https://doaj.org/article/6ee747416e0b41e4bd084d77d84e90f6 kostenfrei https://zjms.hmu.edu.krd/index.php/zjms/article/view/726/624 kostenfrei https://doaj.org/toc/1995-5588 Journal toc kostenfrei https://doaj.org/toc/1995-5596 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 24 2020 1 132-142 |
allfieldsSound |
10.15218/zjms.2020.016 doi (DE-627)DOAJ041859367 (DE-599)DOAJ6ee747416e0b41e4bd084d77d84e90f6 DE-627 ger DE-627 rakwb eng Jubran Mohammed Abdulrahman verfasserin aut Anti-tumor synergistic activity of nano-chlorophyll with sonophotodynamic on Ehrlich ascites carcinoma in mice 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and objective: Cancer is a major health problem that threatens the life of many people with an increasing need for anticancer therapy. The present work aimed to investigate the effectiveness of using sonophotodynamic modality (exposure of infra-red laser as photodynamic) and to the ultrasound as sonodynamic modality in combination with nano-chlorophyll, for cancer therapy through histopathological assessment in Ehrlich ascites carcinoma cell implanted to mice as experimental animals. Methods: A total of 120 male mice were randomly assigned to 12 treatment groups. Ehrlich ascites carcinoma cell was inoculated subcutaneously in all the experimental mice. When the tumor had grown to about 10 mm in diameter at day 10 after inoculation, treatments were started. Experimental groups were investigated histopathologically two weeks after treatments. Results: The histological evaluation revealed that tumors from various treated groups of mice bearing the tumor showed different percentages of necrosis and tumor proliferation based on the type of treatment. Tumor excised from mice receiving sonophotodynamic with nano-Chlorophyll treatment showed a significant increase of necrosis about 15 – 25% compared to other groups without nano-chlorophyll as a sensitizer. The group of mice subjected to the combination of photodynamic and sonodynamic therapy in the presence of nano-Chlorophyll, showed large foci distinct necrosis areas 95% of large distinct foci of necrosis in the tumor and no tumor proliferation. Conclusion: The anti-tumor activity of nano-chlorophyll in combination with sonophotodynamic therapy for Ehrlich ascites carcinoma in mice was effective. sonodynamic therapy photodynamic therapy sonophotodynamic therapy nano-chlorophyll histopathology Medicine R Gihan Hosny AbdElsamie verfasserin aut Rafal Abdulrazaq A. Al-rawi verfasserin aut Samir Ali Abd El- kaream verfasserin aut In Zanco Journal of Medical Sciences Hawler Medical University, 2017 24(2020), 1, Seite 132-142 (DE-627)1760589705 19955596 nnns volume:24 year:2020 number:1 pages:132-142 https://doi.org/10.15218/zjms.2020.016 kostenfrei https://doaj.org/article/6ee747416e0b41e4bd084d77d84e90f6 kostenfrei https://zjms.hmu.edu.krd/index.php/zjms/article/view/726/624 kostenfrei https://doaj.org/toc/1995-5588 Journal toc kostenfrei https://doaj.org/toc/1995-5596 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 24 2020 1 132-142 |
language |
English |
source |
In Zanco Journal of Medical Sciences 24(2020), 1, Seite 132-142 volume:24 year:2020 number:1 pages:132-142 |
sourceStr |
In Zanco Journal of Medical Sciences 24(2020), 1, Seite 132-142 volume:24 year:2020 number:1 pages:132-142 |
format_phy_str_mv |
Article |
institution |
findex.gbv.de |
topic_facet |
sonodynamic therapy photodynamic therapy sonophotodynamic therapy nano-chlorophyll histopathology Medicine R |
isfreeaccess_bool |
true |
container_title |
Zanco Journal of Medical Sciences |
authorswithroles_txt_mv |
Jubran Mohammed Abdulrahman @@aut@@ Gihan Hosny AbdElsamie @@aut@@ Rafal Abdulrazaq A. Al-rawi @@aut@@ Samir Ali Abd El- kaream @@aut@@ |
publishDateDaySort_date |
2020-01-01T00:00:00Z |
hierarchy_top_id |
1760589705 |
id |
DOAJ041859367 |
language_de |
englisch |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ041859367</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230308052954.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2020 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.15218/zjms.2020.016</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ041859367</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ6ee747416e0b41e4bd084d77d84e90f6</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Jubran Mohammed Abdulrahman</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Anti-tumor synergistic activity of nano-chlorophyll with sonophotodynamic on Ehrlich ascites carcinoma in mice</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background and objective: Cancer is a major health problem that threatens the life of many people with an increasing need for anticancer therapy. The present work aimed to investigate the effectiveness of using sonophotodynamic modality (exposure of infra-red laser as photodynamic) and to the ultrasound as sonodynamic modality in combination with nano-chlorophyll, for cancer therapy through histopathological assessment in Ehrlich ascites carcinoma cell implanted to mice as experimental animals. Methods: A total of 120 male mice were randomly assigned to 12 treatment groups. Ehrlich ascites carcinoma cell was inoculated subcutaneously in all the experimental mice. When the tumor had grown to about 10 mm in diameter at day 10 after inoculation, treatments were started. Experimental groups were investigated histopathologically two weeks after treatments. Results: The histological evaluation revealed that tumors from various treated groups of mice bearing the tumor showed different percentages of necrosis and tumor proliferation based on the type of treatment. Tumor excised from mice receiving sonophotodynamic with nano-Chlorophyll treatment showed a significant increase of necrosis about 15 – 25% compared to other groups without nano-chlorophyll as a sensitizer. The group of mice subjected to the combination of photodynamic and sonodynamic therapy in the presence of nano-Chlorophyll, showed large foci distinct necrosis areas 95% of large distinct foci of necrosis in the tumor and no tumor proliferation. Conclusion: The anti-tumor activity of nano-chlorophyll in combination with sonophotodynamic therapy for Ehrlich ascites carcinoma in mice was effective.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">sonodynamic therapy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">photodynamic therapy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">sonophotodynamic therapy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">nano-chlorophyll</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">histopathology</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">R</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gihan Hosny AbdElsamie</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rafal Abdulrazaq A. Al-rawi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Samir Ali Abd El- kaream</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Zanco Journal of Medical Sciences</subfield><subfield code="d">Hawler Medical University, 2017</subfield><subfield code="g">24(2020), 1, Seite 132-142</subfield><subfield code="w">(DE-627)1760589705</subfield><subfield code="x">19955596</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:24</subfield><subfield code="g">year:2020</subfield><subfield code="g">number:1</subfield><subfield code="g">pages:132-142</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.15218/zjms.2020.016</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/6ee747416e0b41e4bd084d77d84e90f6</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://zjms.hmu.edu.krd/index.php/zjms/article/view/726/624</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/1995-5588</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/1995-5596</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">24</subfield><subfield code="j">2020</subfield><subfield code="e">1</subfield><subfield code="h">132-142</subfield></datafield></record></collection>
|
author |
Jubran Mohammed Abdulrahman |
spellingShingle |
Jubran Mohammed Abdulrahman misc sonodynamic therapy misc photodynamic therapy misc sonophotodynamic therapy misc nano-chlorophyll misc histopathology misc Medicine misc R Anti-tumor synergistic activity of nano-chlorophyll with sonophotodynamic on Ehrlich ascites carcinoma in mice |
authorStr |
Jubran Mohammed Abdulrahman |
ppnlink_with_tag_str_mv |
@@773@@(DE-627)1760589705 |
format |
electronic Article |
delete_txt_mv |
keep |
author_role |
aut aut aut aut |
collection |
DOAJ |
remote_str |
true |
illustrated |
Not Illustrated |
issn |
19955596 |
topic_title |
Anti-tumor synergistic activity of nano-chlorophyll with sonophotodynamic on Ehrlich ascites carcinoma in mice sonodynamic therapy photodynamic therapy sonophotodynamic therapy nano-chlorophyll histopathology |
topic |
misc sonodynamic therapy misc photodynamic therapy misc sonophotodynamic therapy misc nano-chlorophyll misc histopathology misc Medicine misc R |
topic_unstemmed |
misc sonodynamic therapy misc photodynamic therapy misc sonophotodynamic therapy misc nano-chlorophyll misc histopathology misc Medicine misc R |
topic_browse |
misc sonodynamic therapy misc photodynamic therapy misc sonophotodynamic therapy misc nano-chlorophyll misc histopathology misc Medicine misc R |
format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
format_main_str_mv |
Text Zeitschrift/Artikel |
carriertype_str_mv |
cr |
hierarchy_parent_title |
Zanco Journal of Medical Sciences |
hierarchy_parent_id |
1760589705 |
hierarchy_top_title |
Zanco Journal of Medical Sciences |
isfreeaccess_txt |
true |
familylinks_str_mv |
(DE-627)1760589705 |
title |
Anti-tumor synergistic activity of nano-chlorophyll with sonophotodynamic on Ehrlich ascites carcinoma in mice |
ctrlnum |
(DE-627)DOAJ041859367 (DE-599)DOAJ6ee747416e0b41e4bd084d77d84e90f6 |
title_full |
Anti-tumor synergistic activity of nano-chlorophyll with sonophotodynamic on Ehrlich ascites carcinoma in mice |
author_sort |
Jubran Mohammed Abdulrahman |
journal |
Zanco Journal of Medical Sciences |
journalStr |
Zanco Journal of Medical Sciences |
lang_code |
eng |
isOA_bool |
true |
recordtype |
marc |
publishDateSort |
2020 |
contenttype_str_mv |
txt |
container_start_page |
132 |
author_browse |
Jubran Mohammed Abdulrahman Gihan Hosny AbdElsamie Rafal Abdulrazaq A. Al-rawi Samir Ali Abd El- kaream |
container_volume |
24 |
format_se |
Elektronische Aufsätze |
author-letter |
Jubran Mohammed Abdulrahman |
doi_str_mv |
10.15218/zjms.2020.016 |
author2-role |
verfasserin |
title_sort |
anti-tumor synergistic activity of nano-chlorophyll with sonophotodynamic on ehrlich ascites carcinoma in mice |
title_auth |
Anti-tumor synergistic activity of nano-chlorophyll with sonophotodynamic on Ehrlich ascites carcinoma in mice |
abstract |
Background and objective: Cancer is a major health problem that threatens the life of many people with an increasing need for anticancer therapy. The present work aimed to investigate the effectiveness of using sonophotodynamic modality (exposure of infra-red laser as photodynamic) and to the ultrasound as sonodynamic modality in combination with nano-chlorophyll, for cancer therapy through histopathological assessment in Ehrlich ascites carcinoma cell implanted to mice as experimental animals. Methods: A total of 120 male mice were randomly assigned to 12 treatment groups. Ehrlich ascites carcinoma cell was inoculated subcutaneously in all the experimental mice. When the tumor had grown to about 10 mm in diameter at day 10 after inoculation, treatments were started. Experimental groups were investigated histopathologically two weeks after treatments. Results: The histological evaluation revealed that tumors from various treated groups of mice bearing the tumor showed different percentages of necrosis and tumor proliferation based on the type of treatment. Tumor excised from mice receiving sonophotodynamic with nano-Chlorophyll treatment showed a significant increase of necrosis about 15 – 25% compared to other groups without nano-chlorophyll as a sensitizer. The group of mice subjected to the combination of photodynamic and sonodynamic therapy in the presence of nano-Chlorophyll, showed large foci distinct necrosis areas 95% of large distinct foci of necrosis in the tumor and no tumor proliferation. Conclusion: The anti-tumor activity of nano-chlorophyll in combination with sonophotodynamic therapy for Ehrlich ascites carcinoma in mice was effective. |
abstractGer |
Background and objective: Cancer is a major health problem that threatens the life of many people with an increasing need for anticancer therapy. The present work aimed to investigate the effectiveness of using sonophotodynamic modality (exposure of infra-red laser as photodynamic) and to the ultrasound as sonodynamic modality in combination with nano-chlorophyll, for cancer therapy through histopathological assessment in Ehrlich ascites carcinoma cell implanted to mice as experimental animals. Methods: A total of 120 male mice were randomly assigned to 12 treatment groups. Ehrlich ascites carcinoma cell was inoculated subcutaneously in all the experimental mice. When the tumor had grown to about 10 mm in diameter at day 10 after inoculation, treatments were started. Experimental groups were investigated histopathologically two weeks after treatments. Results: The histological evaluation revealed that tumors from various treated groups of mice bearing the tumor showed different percentages of necrosis and tumor proliferation based on the type of treatment. Tumor excised from mice receiving sonophotodynamic with nano-Chlorophyll treatment showed a significant increase of necrosis about 15 – 25% compared to other groups without nano-chlorophyll as a sensitizer. The group of mice subjected to the combination of photodynamic and sonodynamic therapy in the presence of nano-Chlorophyll, showed large foci distinct necrosis areas 95% of large distinct foci of necrosis in the tumor and no tumor proliferation. Conclusion: The anti-tumor activity of nano-chlorophyll in combination with sonophotodynamic therapy for Ehrlich ascites carcinoma in mice was effective. |
abstract_unstemmed |
Background and objective: Cancer is a major health problem that threatens the life of many people with an increasing need for anticancer therapy. The present work aimed to investigate the effectiveness of using sonophotodynamic modality (exposure of infra-red laser as photodynamic) and to the ultrasound as sonodynamic modality in combination with nano-chlorophyll, for cancer therapy through histopathological assessment in Ehrlich ascites carcinoma cell implanted to mice as experimental animals. Methods: A total of 120 male mice were randomly assigned to 12 treatment groups. Ehrlich ascites carcinoma cell was inoculated subcutaneously in all the experimental mice. When the tumor had grown to about 10 mm in diameter at day 10 after inoculation, treatments were started. Experimental groups were investigated histopathologically two weeks after treatments. Results: The histological evaluation revealed that tumors from various treated groups of mice bearing the tumor showed different percentages of necrosis and tumor proliferation based on the type of treatment. Tumor excised from mice receiving sonophotodynamic with nano-Chlorophyll treatment showed a significant increase of necrosis about 15 – 25% compared to other groups without nano-chlorophyll as a sensitizer. The group of mice subjected to the combination of photodynamic and sonodynamic therapy in the presence of nano-Chlorophyll, showed large foci distinct necrosis areas 95% of large distinct foci of necrosis in the tumor and no tumor proliferation. Conclusion: The anti-tumor activity of nano-chlorophyll in combination with sonophotodynamic therapy for Ehrlich ascites carcinoma in mice was effective. |
collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ |
container_issue |
1 |
title_short |
Anti-tumor synergistic activity of nano-chlorophyll with sonophotodynamic on Ehrlich ascites carcinoma in mice |
url |
https://doi.org/10.15218/zjms.2020.016 https://doaj.org/article/6ee747416e0b41e4bd084d77d84e90f6 https://zjms.hmu.edu.krd/index.php/zjms/article/view/726/624 https://doaj.org/toc/1995-5588 https://doaj.org/toc/1995-5596 |
remote_bool |
true |
author2 |
Gihan Hosny AbdElsamie Rafal Abdulrazaq A. Al-rawi Samir Ali Abd El- kaream |
author2Str |
Gihan Hosny AbdElsamie Rafal Abdulrazaq A. Al-rawi Samir Ali Abd El- kaream |
ppnlink |
1760589705 |
mediatype_str_mv |
c |
isOA_txt |
true |
hochschulschrift_bool |
false |
doi_str |
10.15218/zjms.2020.016 |
up_date |
2024-07-03T22:29:59.932Z |
_version_ |
1803598744722079744 |
fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ041859367</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230308052954.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2020 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.15218/zjms.2020.016</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ041859367</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ6ee747416e0b41e4bd084d77d84e90f6</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Jubran Mohammed Abdulrahman</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Anti-tumor synergistic activity of nano-chlorophyll with sonophotodynamic on Ehrlich ascites carcinoma in mice</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background and objective: Cancer is a major health problem that threatens the life of many people with an increasing need for anticancer therapy. The present work aimed to investigate the effectiveness of using sonophotodynamic modality (exposure of infra-red laser as photodynamic) and to the ultrasound as sonodynamic modality in combination with nano-chlorophyll, for cancer therapy through histopathological assessment in Ehrlich ascites carcinoma cell implanted to mice as experimental animals. Methods: A total of 120 male mice were randomly assigned to 12 treatment groups. Ehrlich ascites carcinoma cell was inoculated subcutaneously in all the experimental mice. When the tumor had grown to about 10 mm in diameter at day 10 after inoculation, treatments were started. Experimental groups were investigated histopathologically two weeks after treatments. Results: The histological evaluation revealed that tumors from various treated groups of mice bearing the tumor showed different percentages of necrosis and tumor proliferation based on the type of treatment. Tumor excised from mice receiving sonophotodynamic with nano-Chlorophyll treatment showed a significant increase of necrosis about 15 – 25% compared to other groups without nano-chlorophyll as a sensitizer. The group of mice subjected to the combination of photodynamic and sonodynamic therapy in the presence of nano-Chlorophyll, showed large foci distinct necrosis areas 95% of large distinct foci of necrosis in the tumor and no tumor proliferation. Conclusion: The anti-tumor activity of nano-chlorophyll in combination with sonophotodynamic therapy for Ehrlich ascites carcinoma in mice was effective.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">sonodynamic therapy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">photodynamic therapy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">sonophotodynamic therapy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">nano-chlorophyll</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">histopathology</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">R</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gihan Hosny AbdElsamie</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rafal Abdulrazaq A. Al-rawi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Samir Ali Abd El- kaream</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Zanco Journal of Medical Sciences</subfield><subfield code="d">Hawler Medical University, 2017</subfield><subfield code="g">24(2020), 1, Seite 132-142</subfield><subfield code="w">(DE-627)1760589705</subfield><subfield code="x">19955596</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:24</subfield><subfield code="g">year:2020</subfield><subfield code="g">number:1</subfield><subfield code="g">pages:132-142</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.15218/zjms.2020.016</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/6ee747416e0b41e4bd084d77d84e90f6</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://zjms.hmu.edu.krd/index.php/zjms/article/view/726/624</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/1995-5588</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/1995-5596</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">24</subfield><subfield code="j">2020</subfield><subfield code="e">1</subfield><subfield code="h">132-142</subfield></datafield></record></collection>
|
score |
7.400339 |