Serum levels of anti-PF4 IgG after AZD1222 (ChAdOx1 nCoV-19) vaccination

Abstract Rare cases of thrombosis with thrombocytopenia syndrome (TTS) have been reported after AZD1222. Anti-platelet factor-4 (PF4) antibodies were observed in patients following presentation of TTS, however it is unclear if AZD1222 was responsible for inducing production of anti-PF4. Paired sampl...
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Autor*in:	Taylor S. Cohen [verfasserIn] Elizabeth J. Kelly [verfasserIn] Sven Nylander [verfasserIn] Himanshu Bansal [verfasserIn] Brett M. Jepson [verfasserIn] Prakash Bhuyan [verfasserIn] Magdalena E. Sobieszczyk [verfasserIn] Ann R. Falsey [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Übergeordnetes Werk:	In: Scientific Reports - Nature Portfolio, 2011, 12(2022), 1, Seite 5
Übergeordnetes Werk:	volume:12 ; year:2022 ; number:1 ; pages:5

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41598-022-11623-9

Katalog-ID:	DOAJ042000548

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520			\|a Abstract Rare cases of thrombosis with thrombocytopenia syndrome (TTS) have been reported after AZD1222. Anti-platelet factor-4 (PF4) antibodies were observed in patients following presentation of TTS, however it is unclear if AZD1222 was responsible for inducing production of anti-PF4. Paired samples (baseline and day-15) from a phase 3 trial of AZD1222 vs placebo were analyzed for anti-PF4 levels; 19/1727 (1.1%, AZD1222) vs 7/857 (0.8%, placebo) participants were anti-PF4-IgG-negative at baseline but had moderate Day-15 levels (P = 0.676) and 0/35 and 1/20 (5.0%) had moderate levels at baseline but high Day-15 levels. These data indicate that AZD1222 does not induce a clinically relevant general increase in anti-PF4 IgG.
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allfields	10.1038/s41598-022-11623-9 doi (DE-627)DOAJ042000548 (DE-599)DOAJ557651084084447887ce8ffd65240554 DE-627 ger DE-627 rakwb eng Taylor S. Cohen verfasserin aut Serum levels of anti-PF4 IgG after AZD1222 (ChAdOx1 nCoV-19) vaccination 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Rare cases of thrombosis with thrombocytopenia syndrome (TTS) have been reported after AZD1222. Anti-platelet factor-4 (PF4) antibodies were observed in patients following presentation of TTS, however it is unclear if AZD1222 was responsible for inducing production of anti-PF4. Paired samples (baseline and day-15) from a phase 3 trial of AZD1222 vs placebo were analyzed for anti-PF4 levels; 19/1727 (1.1%, AZD1222) vs 7/857 (0.8%, placebo) participants were anti-PF4-IgG-negative at baseline but had moderate Day-15 levels (P = 0.676) and 0/35 and 1/20 (5.0%) had moderate levels at baseline but high Day-15 levels. These data indicate that AZD1222 does not induce a clinically relevant general increase in anti-PF4 IgG. Medicine R Science Q Elizabeth J. Kelly verfasserin aut Sven Nylander verfasserin aut Himanshu Bansal verfasserin aut Brett M. Jepson verfasserin aut Prakash Bhuyan verfasserin aut Magdalena E. Sobieszczyk verfasserin aut Ann R. Falsey verfasserin aut In Scientific Reports Nature Portfolio, 2011 12(2022), 1, Seite 5 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:12 year:2022 number:1 pages:5 https://doi.org/10.1038/s41598-022-11623-9 kostenfrei https://doaj.org/article/557651084084447887ce8ffd65240554 kostenfrei https://doi.org/10.1038/s41598-022-11623-9 kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 1 5
spelling	10.1038/s41598-022-11623-9 doi (DE-627)DOAJ042000548 (DE-599)DOAJ557651084084447887ce8ffd65240554 DE-627 ger DE-627 rakwb eng Taylor S. Cohen verfasserin aut Serum levels of anti-PF4 IgG after AZD1222 (ChAdOx1 nCoV-19) vaccination 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Rare cases of thrombosis with thrombocytopenia syndrome (TTS) have been reported after AZD1222. Anti-platelet factor-4 (PF4) antibodies were observed in patients following presentation of TTS, however it is unclear if AZD1222 was responsible for inducing production of anti-PF4. Paired samples (baseline and day-15) from a phase 3 trial of AZD1222 vs placebo were analyzed for anti-PF4 levels; 19/1727 (1.1%, AZD1222) vs 7/857 (0.8%, placebo) participants were anti-PF4-IgG-negative at baseline but had moderate Day-15 levels (P = 0.676) and 0/35 and 1/20 (5.0%) had moderate levels at baseline but high Day-15 levels. These data indicate that AZD1222 does not induce a clinically relevant general increase in anti-PF4 IgG. Medicine R Science Q Elizabeth J. Kelly verfasserin aut Sven Nylander verfasserin aut Himanshu Bansal verfasserin aut Brett M. Jepson verfasserin aut Prakash Bhuyan verfasserin aut Magdalena E. Sobieszczyk verfasserin aut Ann R. Falsey verfasserin aut In Scientific Reports Nature Portfolio, 2011 12(2022), 1, Seite 5 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:12 year:2022 number:1 pages:5 https://doi.org/10.1038/s41598-022-11623-9 kostenfrei https://doaj.org/article/557651084084447887ce8ffd65240554 kostenfrei https://doi.org/10.1038/s41598-022-11623-9 kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 1 5
allfields_unstemmed	10.1038/s41598-022-11623-9 doi (DE-627)DOAJ042000548 (DE-599)DOAJ557651084084447887ce8ffd65240554 DE-627 ger DE-627 rakwb eng Taylor S. Cohen verfasserin aut Serum levels of anti-PF4 IgG after AZD1222 (ChAdOx1 nCoV-19) vaccination 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Rare cases of thrombosis with thrombocytopenia syndrome (TTS) have been reported after AZD1222. Anti-platelet factor-4 (PF4) antibodies were observed in patients following presentation of TTS, however it is unclear if AZD1222 was responsible for inducing production of anti-PF4. Paired samples (baseline and day-15) from a phase 3 trial of AZD1222 vs placebo were analyzed for anti-PF4 levels; 19/1727 (1.1%, AZD1222) vs 7/857 (0.8%, placebo) participants were anti-PF4-IgG-negative at baseline but had moderate Day-15 levels (P = 0.676) and 0/35 and 1/20 (5.0%) had moderate levels at baseline but high Day-15 levels. These data indicate that AZD1222 does not induce a clinically relevant general increase in anti-PF4 IgG. Medicine R Science Q Elizabeth J. Kelly verfasserin aut Sven Nylander verfasserin aut Himanshu Bansal verfasserin aut Brett M. Jepson verfasserin aut Prakash Bhuyan verfasserin aut Magdalena E. Sobieszczyk verfasserin aut Ann R. Falsey verfasserin aut In Scientific Reports Nature Portfolio, 2011 12(2022), 1, Seite 5 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:12 year:2022 number:1 pages:5 https://doi.org/10.1038/s41598-022-11623-9 kostenfrei https://doaj.org/article/557651084084447887ce8ffd65240554 kostenfrei https://doi.org/10.1038/s41598-022-11623-9 kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 1 5
allfieldsGer	10.1038/s41598-022-11623-9 doi (DE-627)DOAJ042000548 (DE-599)DOAJ557651084084447887ce8ffd65240554 DE-627 ger DE-627 rakwb eng Taylor S. Cohen verfasserin aut Serum levels of anti-PF4 IgG after AZD1222 (ChAdOx1 nCoV-19) vaccination 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Rare cases of thrombosis with thrombocytopenia syndrome (TTS) have been reported after AZD1222. Anti-platelet factor-4 (PF4) antibodies were observed in patients following presentation of TTS, however it is unclear if AZD1222 was responsible for inducing production of anti-PF4. Paired samples (baseline and day-15) from a phase 3 trial of AZD1222 vs placebo were analyzed for anti-PF4 levels; 19/1727 (1.1%, AZD1222) vs 7/857 (0.8%, placebo) participants were anti-PF4-IgG-negative at baseline but had moderate Day-15 levels (P = 0.676) and 0/35 and 1/20 (5.0%) had moderate levels at baseline but high Day-15 levels. These data indicate that AZD1222 does not induce a clinically relevant general increase in anti-PF4 IgG. Medicine R Science Q Elizabeth J. Kelly verfasserin aut Sven Nylander verfasserin aut Himanshu Bansal verfasserin aut Brett M. Jepson verfasserin aut Prakash Bhuyan verfasserin aut Magdalena E. Sobieszczyk verfasserin aut Ann R. Falsey verfasserin aut In Scientific Reports Nature Portfolio, 2011 12(2022), 1, Seite 5 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:12 year:2022 number:1 pages:5 https://doi.org/10.1038/s41598-022-11623-9 kostenfrei https://doaj.org/article/557651084084447887ce8ffd65240554 kostenfrei https://doi.org/10.1038/s41598-022-11623-9 kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 1 5
allfieldsSound	10.1038/s41598-022-11623-9 doi (DE-627)DOAJ042000548 (DE-599)DOAJ557651084084447887ce8ffd65240554 DE-627 ger DE-627 rakwb eng Taylor S. Cohen verfasserin aut Serum levels of anti-PF4 IgG after AZD1222 (ChAdOx1 nCoV-19) vaccination 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Rare cases of thrombosis with thrombocytopenia syndrome (TTS) have been reported after AZD1222. Anti-platelet factor-4 (PF4) antibodies were observed in patients following presentation of TTS, however it is unclear if AZD1222 was responsible for inducing production of anti-PF4. Paired samples (baseline and day-15) from a phase 3 trial of AZD1222 vs placebo were analyzed for anti-PF4 levels; 19/1727 (1.1%, AZD1222) vs 7/857 (0.8%, placebo) participants were anti-PF4-IgG-negative at baseline but had moderate Day-15 levels (P = 0.676) and 0/35 and 1/20 (5.0%) had moderate levels at baseline but high Day-15 levels. These data indicate that AZD1222 does not induce a clinically relevant general increase in anti-PF4 IgG. Medicine R Science Q Elizabeth J. Kelly verfasserin aut Sven Nylander verfasserin aut Himanshu Bansal verfasserin aut Brett M. Jepson verfasserin aut Prakash Bhuyan verfasserin aut Magdalena E. Sobieszczyk verfasserin aut Ann R. Falsey verfasserin aut In Scientific Reports Nature Portfolio, 2011 12(2022), 1, Seite 5 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:12 year:2022 number:1 pages:5 https://doi.org/10.1038/s41598-022-11623-9 kostenfrei https://doaj.org/article/557651084084447887ce8ffd65240554 kostenfrei https://doi.org/10.1038/s41598-022-11623-9 kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 1 5
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author	Taylor S. Cohen
spellingShingle	Taylor S. Cohen misc Medicine misc R misc Science misc Q Serum levels of anti-PF4 IgG after AZD1222 (ChAdOx1 nCoV-19) vaccination
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topic_title	Serum levels of anti-PF4 IgG after AZD1222 (ChAdOx1 nCoV-19) vaccination
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title	Serum levels of anti-PF4 IgG after AZD1222 (ChAdOx1 nCoV-19) vaccination
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title_full	Serum levels of anti-PF4 IgG after AZD1222 (ChAdOx1 nCoV-19) vaccination
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author_browse	Taylor S. Cohen Elizabeth J. Kelly Sven Nylander Himanshu Bansal Brett M. Jepson Prakash Bhuyan Magdalena E. Sobieszczyk Ann R. Falsey
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title_sort	serum levels of anti-pf4 igg after azd1222 (chadox1 ncov-19) vaccination
title_auth	Serum levels of anti-PF4 IgG after AZD1222 (ChAdOx1 nCoV-19) vaccination
abstract	Abstract Rare cases of thrombosis with thrombocytopenia syndrome (TTS) have been reported after AZD1222. Anti-platelet factor-4 (PF4) antibodies were observed in patients following presentation of TTS, however it is unclear if AZD1222 was responsible for inducing production of anti-PF4. Paired samples (baseline and day-15) from a phase 3 trial of AZD1222 vs placebo were analyzed for anti-PF4 levels; 19/1727 (1.1%, AZD1222) vs 7/857 (0.8%, placebo) participants were anti-PF4-IgG-negative at baseline but had moderate Day-15 levels (P = 0.676) and 0/35 and 1/20 (5.0%) had moderate levels at baseline but high Day-15 levels. These data indicate that AZD1222 does not induce a clinically relevant general increase in anti-PF4 IgG.
abstractGer	Abstract Rare cases of thrombosis with thrombocytopenia syndrome (TTS) have been reported after AZD1222. Anti-platelet factor-4 (PF4) antibodies were observed in patients following presentation of TTS, however it is unclear if AZD1222 was responsible for inducing production of anti-PF4. Paired samples (baseline and day-15) from a phase 3 trial of AZD1222 vs placebo were analyzed for anti-PF4 levels; 19/1727 (1.1%, AZD1222) vs 7/857 (0.8%, placebo) participants were anti-PF4-IgG-negative at baseline but had moderate Day-15 levels (P = 0.676) and 0/35 and 1/20 (5.0%) had moderate levels at baseline but high Day-15 levels. These data indicate that AZD1222 does not induce a clinically relevant general increase in anti-PF4 IgG.
abstract_unstemmed	Abstract Rare cases of thrombosis with thrombocytopenia syndrome (TTS) have been reported after AZD1222. Anti-platelet factor-4 (PF4) antibodies were observed in patients following presentation of TTS, however it is unclear if AZD1222 was responsible for inducing production of anti-PF4. Paired samples (baseline and day-15) from a phase 3 trial of AZD1222 vs placebo were analyzed for anti-PF4 levels; 19/1727 (1.1%, AZD1222) vs 7/857 (0.8%, placebo) participants were anti-PF4-IgG-negative at baseline but had moderate Day-15 levels (P = 0.676) and 0/35 and 1/20 (5.0%) had moderate levels at baseline but high Day-15 levels. These data indicate that AZD1222 does not induce a clinically relevant general increase in anti-PF4 IgG.
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title_short	Serum levels of anti-PF4 IgG after AZD1222 (ChAdOx1 nCoV-19) vaccination
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