Evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (SIBO) - A pilot study
Background & objectives: Small intestinal bacterial overgrowth (SIBO) leads to several gastrointestinal (GI) problems and complications leading to malabsorption. The effectiveness of probiotics in the treatment of SIBO syndrome has not been well studied. This pilot study was aimed to assess the...
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| Autor*in: |
A R Khalighi [verfasserIn] M R Khalighi [verfasserIn] R Behdani [verfasserIn] J Jamali [verfasserIn] A Khosravi [verfasserIn] Sh. Kouhestani [verfasserIn] H Radmanesh [verfasserIn] S Esmaeelzadeh [verfasserIn] N Khalighi [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
Hydrogen breath test (HBT) - lactol - small intestinal bacterial overgrowth (SIBO) syndrome |
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| Übergeordnetes Werk: |
In: Indian Journal of Medical Research - Wolters Kluwer Medknow Publications, 2005, 140(2014), 5, Seite 604-608 |
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| Übergeordnetes Werk: |
volume:140 ; year:2014 ; number:5 ; pages:604-608 |
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DOAJ042203120 |
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| 520 | |a Background & objectives: Small intestinal bacterial overgrowth (SIBO) leads to several gastrointestinal (GI) problems and complications leading to malabsorption. The effectiveness of probiotics in the treatment of SIBO syndrome has not been well studied. This pilot study was aimed to assess the efficacy of a probiotic consisting of lactobacilli in the treatment of SIBO. Methods: In this study, 30 cases suffering from chronic abdominal pain or diarrhoea and with a positive hydrogen breath test were randomized in a double-blind manner into two groups: probiotic drug user and control group. After an initial 3-week aggressive therapy with broad-spectrum antibiotics, a 15-day maintenance antibiotic therapy with lactol was administered for the study group and the same regimen without lactol for the control group. After six months the HBT result and the GI symptoms were analyzed and compared between the two groups. Results: The result of hydrogen breath test and the clinical symptoms in patients receiving the maintenance regimen with lactol probiotic showed a better response. The hydrogen breath test turned negative in 93.3 per cent of those receiving lactol compared to 66.7 per cent of the controls. In all the cases receiving lactol, the abdominal pain disappeared completely ( p =0.002). In addition, other GI problems including flatulence, belching and diarrhoea significantly improved in the study group ( p <0.05). Interpretation & conclusions: Based on the preliminary data it seems that adding lactol probiotic to the maintenance therapy of small intestinal bacterial overgrowth patients on routine antibiotic therapy will be beneficial in preventing the complications of this syndrome. | ||
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(DE-627)DOAJ042203120 (DE-599)DOAJe87415bb3dd54e498fe094d55c8ff046 DE-627 ger DE-627 rakwb eng A R Khalighi verfasserin aut Evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (SIBO) - A pilot study 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background & objectives: Small intestinal bacterial overgrowth (SIBO) leads to several gastrointestinal (GI) problems and complications leading to malabsorption. The effectiveness of probiotics in the treatment of SIBO syndrome has not been well studied. This pilot study was aimed to assess the efficacy of a probiotic consisting of lactobacilli in the treatment of SIBO. Methods: In this study, 30 cases suffering from chronic abdominal pain or diarrhoea and with a positive hydrogen breath test were randomized in a double-blind manner into two groups: probiotic drug user and control group. After an initial 3-week aggressive therapy with broad-spectrum antibiotics, a 15-day maintenance antibiotic therapy with lactol was administered for the study group and the same regimen without lactol for the control group. After six months the HBT result and the GI symptoms were analyzed and compared between the two groups. Results: The result of hydrogen breath test and the clinical symptoms in patients receiving the maintenance regimen with lactol probiotic showed a better response. The hydrogen breath test turned negative in 93.3 per cent of those receiving lactol compared to 66.7 per cent of the controls. In all the cases receiving lactol, the abdominal pain disappeared completely ( p =0.002). In addition, other GI problems including flatulence, belching and diarrhoea significantly improved in the study group ( p <0.05). Interpretation & conclusions: Based on the preliminary data it seems that adding lactol probiotic to the maintenance therapy of small intestinal bacterial overgrowth patients on routine antibiotic therapy will be beneficial in preventing the complications of this syndrome. Hydrogen breath test (HBT) - lactol - small intestinal bacterial overgrowth (SIBO) syndrome Medicine R M R Khalighi verfasserin aut R Behdani verfasserin aut J Jamali verfasserin aut A Khosravi verfasserin aut Sh. Kouhestani verfasserin aut H Radmanesh verfasserin aut S Esmaeelzadeh verfasserin aut N Khalighi verfasserin aut In Indian Journal of Medical Research Wolters Kluwer Medknow Publications, 2005 140(2014), 5, Seite 604-608 (DE-627)DOAJ000026956 09715916 nnns volume:140 year:2014 number:5 pages:604-608 https://doaj.org/article/e87415bb3dd54e498fe094d55c8ff046 kostenfrei http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2014;volume=140;issue=5;spage=604;epage=608;aulast=Khalighi kostenfrei https://doaj.org/toc/0971-5916 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 140 2014 5 604-608 |
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(DE-627)DOAJ042203120 (DE-599)DOAJe87415bb3dd54e498fe094d55c8ff046 DE-627 ger DE-627 rakwb eng A R Khalighi verfasserin aut Evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (SIBO) - A pilot study 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background & objectives: Small intestinal bacterial overgrowth (SIBO) leads to several gastrointestinal (GI) problems and complications leading to malabsorption. The effectiveness of probiotics in the treatment of SIBO syndrome has not been well studied. This pilot study was aimed to assess the efficacy of a probiotic consisting of lactobacilli in the treatment of SIBO. Methods: In this study, 30 cases suffering from chronic abdominal pain or diarrhoea and with a positive hydrogen breath test were randomized in a double-blind manner into two groups: probiotic drug user and control group. After an initial 3-week aggressive therapy with broad-spectrum antibiotics, a 15-day maintenance antibiotic therapy with lactol was administered for the study group and the same regimen without lactol for the control group. After six months the HBT result and the GI symptoms were analyzed and compared between the two groups. Results: The result of hydrogen breath test and the clinical symptoms in patients receiving the maintenance regimen with lactol probiotic showed a better response. The hydrogen breath test turned negative in 93.3 per cent of those receiving lactol compared to 66.7 per cent of the controls. In all the cases receiving lactol, the abdominal pain disappeared completely ( p =0.002). In addition, other GI problems including flatulence, belching and diarrhoea significantly improved in the study group ( p <0.05). Interpretation & conclusions: Based on the preliminary data it seems that adding lactol probiotic to the maintenance therapy of small intestinal bacterial overgrowth patients on routine antibiotic therapy will be beneficial in preventing the complications of this syndrome. Hydrogen breath test (HBT) - lactol - small intestinal bacterial overgrowth (SIBO) syndrome Medicine R M R Khalighi verfasserin aut R Behdani verfasserin aut J Jamali verfasserin aut A Khosravi verfasserin aut Sh. Kouhestani verfasserin aut H Radmanesh verfasserin aut S Esmaeelzadeh verfasserin aut N Khalighi verfasserin aut In Indian Journal of Medical Research Wolters Kluwer Medknow Publications, 2005 140(2014), 5, Seite 604-608 (DE-627)DOAJ000026956 09715916 nnns volume:140 year:2014 number:5 pages:604-608 https://doaj.org/article/e87415bb3dd54e498fe094d55c8ff046 kostenfrei http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2014;volume=140;issue=5;spage=604;epage=608;aulast=Khalighi kostenfrei https://doaj.org/toc/0971-5916 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 140 2014 5 604-608 |
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(DE-627)DOAJ042203120 (DE-599)DOAJe87415bb3dd54e498fe094d55c8ff046 DE-627 ger DE-627 rakwb eng A R Khalighi verfasserin aut Evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (SIBO) - A pilot study 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background & objectives: Small intestinal bacterial overgrowth (SIBO) leads to several gastrointestinal (GI) problems and complications leading to malabsorption. The effectiveness of probiotics in the treatment of SIBO syndrome has not been well studied. This pilot study was aimed to assess the efficacy of a probiotic consisting of lactobacilli in the treatment of SIBO. Methods: In this study, 30 cases suffering from chronic abdominal pain or diarrhoea and with a positive hydrogen breath test were randomized in a double-blind manner into two groups: probiotic drug user and control group. After an initial 3-week aggressive therapy with broad-spectrum antibiotics, a 15-day maintenance antibiotic therapy with lactol was administered for the study group and the same regimen without lactol for the control group. After six months the HBT result and the GI symptoms were analyzed and compared between the two groups. Results: The result of hydrogen breath test and the clinical symptoms in patients receiving the maintenance regimen with lactol probiotic showed a better response. The hydrogen breath test turned negative in 93.3 per cent of those receiving lactol compared to 66.7 per cent of the controls. In all the cases receiving lactol, the abdominal pain disappeared completely ( p =0.002). In addition, other GI problems including flatulence, belching and diarrhoea significantly improved in the study group ( p <0.05). Interpretation & conclusions: Based on the preliminary data it seems that adding lactol probiotic to the maintenance therapy of small intestinal bacterial overgrowth patients on routine antibiotic therapy will be beneficial in preventing the complications of this syndrome. Hydrogen breath test (HBT) - lactol - small intestinal bacterial overgrowth (SIBO) syndrome Medicine R M R Khalighi verfasserin aut R Behdani verfasserin aut J Jamali verfasserin aut A Khosravi verfasserin aut Sh. Kouhestani verfasserin aut H Radmanesh verfasserin aut S Esmaeelzadeh verfasserin aut N Khalighi verfasserin aut In Indian Journal of Medical Research Wolters Kluwer Medknow Publications, 2005 140(2014), 5, Seite 604-608 (DE-627)DOAJ000026956 09715916 nnns volume:140 year:2014 number:5 pages:604-608 https://doaj.org/article/e87415bb3dd54e498fe094d55c8ff046 kostenfrei http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2014;volume=140;issue=5;spage=604;epage=608;aulast=Khalighi kostenfrei https://doaj.org/toc/0971-5916 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 140 2014 5 604-608 |
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(DE-627)DOAJ042203120 (DE-599)DOAJe87415bb3dd54e498fe094d55c8ff046 DE-627 ger DE-627 rakwb eng A R Khalighi verfasserin aut Evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (SIBO) - A pilot study 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background & objectives: Small intestinal bacterial overgrowth (SIBO) leads to several gastrointestinal (GI) problems and complications leading to malabsorption. The effectiveness of probiotics in the treatment of SIBO syndrome has not been well studied. This pilot study was aimed to assess the efficacy of a probiotic consisting of lactobacilli in the treatment of SIBO. Methods: In this study, 30 cases suffering from chronic abdominal pain or diarrhoea and with a positive hydrogen breath test were randomized in a double-blind manner into two groups: probiotic drug user and control group. After an initial 3-week aggressive therapy with broad-spectrum antibiotics, a 15-day maintenance antibiotic therapy with lactol was administered for the study group and the same regimen without lactol for the control group. After six months the HBT result and the GI symptoms were analyzed and compared between the two groups. Results: The result of hydrogen breath test and the clinical symptoms in patients receiving the maintenance regimen with lactol probiotic showed a better response. The hydrogen breath test turned negative in 93.3 per cent of those receiving lactol compared to 66.7 per cent of the controls. In all the cases receiving lactol, the abdominal pain disappeared completely ( p =0.002). In addition, other GI problems including flatulence, belching and diarrhoea significantly improved in the study group ( p <0.05). Interpretation & conclusions: Based on the preliminary data it seems that adding lactol probiotic to the maintenance therapy of small intestinal bacterial overgrowth patients on routine antibiotic therapy will be beneficial in preventing the complications of this syndrome. Hydrogen breath test (HBT) - lactol - small intestinal bacterial overgrowth (SIBO) syndrome Medicine R M R Khalighi verfasserin aut R Behdani verfasserin aut J Jamali verfasserin aut A Khosravi verfasserin aut Sh. Kouhestani verfasserin aut H Radmanesh verfasserin aut S Esmaeelzadeh verfasserin aut N Khalighi verfasserin aut In Indian Journal of Medical Research Wolters Kluwer Medknow Publications, 2005 140(2014), 5, Seite 604-608 (DE-627)DOAJ000026956 09715916 nnns volume:140 year:2014 number:5 pages:604-608 https://doaj.org/article/e87415bb3dd54e498fe094d55c8ff046 kostenfrei http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2014;volume=140;issue=5;spage=604;epage=608;aulast=Khalighi kostenfrei https://doaj.org/toc/0971-5916 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 140 2014 5 604-608 |
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(DE-627)DOAJ042203120 (DE-599)DOAJe87415bb3dd54e498fe094d55c8ff046 DE-627 ger DE-627 rakwb eng A R Khalighi verfasserin aut Evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (SIBO) - A pilot study 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background & objectives: Small intestinal bacterial overgrowth (SIBO) leads to several gastrointestinal (GI) problems and complications leading to malabsorption. The effectiveness of probiotics in the treatment of SIBO syndrome has not been well studied. This pilot study was aimed to assess the efficacy of a probiotic consisting of lactobacilli in the treatment of SIBO. Methods: In this study, 30 cases suffering from chronic abdominal pain or diarrhoea and with a positive hydrogen breath test were randomized in a double-blind manner into two groups: probiotic drug user and control group. After an initial 3-week aggressive therapy with broad-spectrum antibiotics, a 15-day maintenance antibiotic therapy with lactol was administered for the study group and the same regimen without lactol for the control group. After six months the HBT result and the GI symptoms were analyzed and compared between the two groups. Results: The result of hydrogen breath test and the clinical symptoms in patients receiving the maintenance regimen with lactol probiotic showed a better response. The hydrogen breath test turned negative in 93.3 per cent of those receiving lactol compared to 66.7 per cent of the controls. In all the cases receiving lactol, the abdominal pain disappeared completely ( p =0.002). In addition, other GI problems including flatulence, belching and diarrhoea significantly improved in the study group ( p <0.05). Interpretation & conclusions: Based on the preliminary data it seems that adding lactol probiotic to the maintenance therapy of small intestinal bacterial overgrowth patients on routine antibiotic therapy will be beneficial in preventing the complications of this syndrome. Hydrogen breath test (HBT) - lactol - small intestinal bacterial overgrowth (SIBO) syndrome Medicine R M R Khalighi verfasserin aut R Behdani verfasserin aut J Jamali verfasserin aut A Khosravi verfasserin aut Sh. Kouhestani verfasserin aut H Radmanesh verfasserin aut S Esmaeelzadeh verfasserin aut N Khalighi verfasserin aut In Indian Journal of Medical Research Wolters Kluwer Medknow Publications, 2005 140(2014), 5, Seite 604-608 (DE-627)DOAJ000026956 09715916 nnns volume:140 year:2014 number:5 pages:604-608 https://doaj.org/article/e87415bb3dd54e498fe094d55c8ff046 kostenfrei http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2014;volume=140;issue=5;spage=604;epage=608;aulast=Khalighi kostenfrei https://doaj.org/toc/0971-5916 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 140 2014 5 604-608 |
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A R Khalighi |
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Evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (SIBO) - A pilot study Hydrogen breath test (HBT) - lactol - small intestinal bacterial overgrowth (SIBO) syndrome |
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Evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (SIBO) - A pilot study |
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Evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (SIBO) - A pilot study |
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A R Khalighi M R Khalighi R Behdani J Jamali A Khosravi Sh. Kouhestani H Radmanesh S Esmaeelzadeh N Khalighi |
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evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (sibo) - a pilot study |
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Evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (SIBO) - A pilot study |
| abstract |
Background & objectives: Small intestinal bacterial overgrowth (SIBO) leads to several gastrointestinal (GI) problems and complications leading to malabsorption. The effectiveness of probiotics in the treatment of SIBO syndrome has not been well studied. This pilot study was aimed to assess the efficacy of a probiotic consisting of lactobacilli in the treatment of SIBO. Methods: In this study, 30 cases suffering from chronic abdominal pain or diarrhoea and with a positive hydrogen breath test were randomized in a double-blind manner into two groups: probiotic drug user and control group. After an initial 3-week aggressive therapy with broad-spectrum antibiotics, a 15-day maintenance antibiotic therapy with lactol was administered for the study group and the same regimen without lactol for the control group. After six months the HBT result and the GI symptoms were analyzed and compared between the two groups. Results: The result of hydrogen breath test and the clinical symptoms in patients receiving the maintenance regimen with lactol probiotic showed a better response. The hydrogen breath test turned negative in 93.3 per cent of those receiving lactol compared to 66.7 per cent of the controls. In all the cases receiving lactol, the abdominal pain disappeared completely ( p =0.002). In addition, other GI problems including flatulence, belching and diarrhoea significantly improved in the study group ( p <0.05). Interpretation & conclusions: Based on the preliminary data it seems that adding lactol probiotic to the maintenance therapy of small intestinal bacterial overgrowth patients on routine antibiotic therapy will be beneficial in preventing the complications of this syndrome. |
| abstractGer |
Background & objectives: Small intestinal bacterial overgrowth (SIBO) leads to several gastrointestinal (GI) problems and complications leading to malabsorption. The effectiveness of probiotics in the treatment of SIBO syndrome has not been well studied. This pilot study was aimed to assess the efficacy of a probiotic consisting of lactobacilli in the treatment of SIBO. Methods: In this study, 30 cases suffering from chronic abdominal pain or diarrhoea and with a positive hydrogen breath test were randomized in a double-blind manner into two groups: probiotic drug user and control group. After an initial 3-week aggressive therapy with broad-spectrum antibiotics, a 15-day maintenance antibiotic therapy with lactol was administered for the study group and the same regimen without lactol for the control group. After six months the HBT result and the GI symptoms were analyzed and compared between the two groups. Results: The result of hydrogen breath test and the clinical symptoms in patients receiving the maintenance regimen with lactol probiotic showed a better response. The hydrogen breath test turned negative in 93.3 per cent of those receiving lactol compared to 66.7 per cent of the controls. In all the cases receiving lactol, the abdominal pain disappeared completely ( p =0.002). In addition, other GI problems including flatulence, belching and diarrhoea significantly improved in the study group ( p <0.05). Interpretation & conclusions: Based on the preliminary data it seems that adding lactol probiotic to the maintenance therapy of small intestinal bacterial overgrowth patients on routine antibiotic therapy will be beneficial in preventing the complications of this syndrome. |
| abstract_unstemmed |
Background & objectives: Small intestinal bacterial overgrowth (SIBO) leads to several gastrointestinal (GI) problems and complications leading to malabsorption. The effectiveness of probiotics in the treatment of SIBO syndrome has not been well studied. This pilot study was aimed to assess the efficacy of a probiotic consisting of lactobacilli in the treatment of SIBO. Methods: In this study, 30 cases suffering from chronic abdominal pain or diarrhoea and with a positive hydrogen breath test were randomized in a double-blind manner into two groups: probiotic drug user and control group. After an initial 3-week aggressive therapy with broad-spectrum antibiotics, a 15-day maintenance antibiotic therapy with lactol was administered for the study group and the same regimen without lactol for the control group. After six months the HBT result and the GI symptoms were analyzed and compared between the two groups. Results: The result of hydrogen breath test and the clinical symptoms in patients receiving the maintenance regimen with lactol probiotic showed a better response. The hydrogen breath test turned negative in 93.3 per cent of those receiving lactol compared to 66.7 per cent of the controls. In all the cases receiving lactol, the abdominal pain disappeared completely ( p =0.002). In addition, other GI problems including flatulence, belching and diarrhoea significantly improved in the study group ( p <0.05). Interpretation & conclusions: Based on the preliminary data it seems that adding lactol probiotic to the maintenance therapy of small intestinal bacterial overgrowth patients on routine antibiotic therapy will be beneficial in preventing the complications of this syndrome. |
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