Lignans and Their Derivatives from Plants as Antivirals

Lignans are widely produced by various plant species; they are a class of natural products that share structural similarity. They usually contain a core scaffold that is formed by two or more phenylpropanoid units. Lignans possess diverse pharmacological properties, including their antiviral activit...
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Autor*in:	Qinghua Cui [verfasserIn] Ruikun Du [verfasserIn] Miaomiao Liu [verfasserIn] Lijun Rong [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	lignans antivirals mechanism drug development

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 25(2020), 1, p 183
Übergeordnetes Werk:	volume:25 ; year:2020 ; number:1, p 183

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules25010183

Katalog-ID:	DOAJ042214300

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allfields	10.3390/molecules25010183 doi (DE-627)DOAJ042214300 (DE-599)DOAJ8c6665c950ea4b93ace6f81af9282867 DE-627 ger DE-627 rakwb eng QD241-441 Qinghua Cui verfasserin aut Lignans and Their Derivatives from Plants as Antivirals 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Lignans are widely produced by various plant species; they are a class of natural products that share structural similarity. They usually contain a core scaffold that is formed by two or more phenylpropanoid units. Lignans possess diverse pharmacological properties, including their antiviral activities that have been reported in recent years. This review discusses the distribution of lignans in nature according to their structural classification, and it provides a comprehensive summary of their antiviral activities. Among them, two types of antiviral lignans—podophyllotoxin and bicyclol, which are used to treat venereal warts and chronic hepatitis B (CHB) in clinical, serve as examples of using lignans for antivirals—are discussed in some detail. Prospects of lignans in antiviral drug discovery are also discussed. lignans antivirals mechanism drug development Organic chemistry Ruikun Du verfasserin aut Miaomiao Liu verfasserin aut Lijun Rong verfasserin aut In Molecules MDPI AG, 2003 25(2020), 1, p 183 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:25 year:2020 number:1, p 183 https://doi.org/10.3390/molecules25010183 kostenfrei https://doaj.org/article/8c6665c950ea4b93ace6f81af9282867 kostenfrei https://www.mdpi.com/1420-3049/25/1/183 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2020 1, p 183
spelling	10.3390/molecules25010183 doi (DE-627)DOAJ042214300 (DE-599)DOAJ8c6665c950ea4b93ace6f81af9282867 DE-627 ger DE-627 rakwb eng QD241-441 Qinghua Cui verfasserin aut Lignans and Their Derivatives from Plants as Antivirals 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Lignans are widely produced by various plant species; they are a class of natural products that share structural similarity. They usually contain a core scaffold that is formed by two or more phenylpropanoid units. Lignans possess diverse pharmacological properties, including their antiviral activities that have been reported in recent years. This review discusses the distribution of lignans in nature according to their structural classification, and it provides a comprehensive summary of their antiviral activities. Among them, two types of antiviral lignans—podophyllotoxin and bicyclol, which are used to treat venereal warts and chronic hepatitis B (CHB) in clinical, serve as examples of using lignans for antivirals—are discussed in some detail. Prospects of lignans in antiviral drug discovery are also discussed. lignans antivirals mechanism drug development Organic chemistry Ruikun Du verfasserin aut Miaomiao Liu verfasserin aut Lijun Rong verfasserin aut In Molecules MDPI AG, 2003 25(2020), 1, p 183 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:25 year:2020 number:1, p 183 https://doi.org/10.3390/molecules25010183 kostenfrei https://doaj.org/article/8c6665c950ea4b93ace6f81af9282867 kostenfrei https://www.mdpi.com/1420-3049/25/1/183 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2020 1, p 183
allfields_unstemmed	10.3390/molecules25010183 doi (DE-627)DOAJ042214300 (DE-599)DOAJ8c6665c950ea4b93ace6f81af9282867 DE-627 ger DE-627 rakwb eng QD241-441 Qinghua Cui verfasserin aut Lignans and Their Derivatives from Plants as Antivirals 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Lignans are widely produced by various plant species; they are a class of natural products that share structural similarity. They usually contain a core scaffold that is formed by two or more phenylpropanoid units. Lignans possess diverse pharmacological properties, including their antiviral activities that have been reported in recent years. This review discusses the distribution of lignans in nature according to their structural classification, and it provides a comprehensive summary of their antiviral activities. Among them, two types of antiviral lignans—podophyllotoxin and bicyclol, which are used to treat venereal warts and chronic hepatitis B (CHB) in clinical, serve as examples of using lignans for antivirals—are discussed in some detail. Prospects of lignans in antiviral drug discovery are also discussed. lignans antivirals mechanism drug development Organic chemistry Ruikun Du verfasserin aut Miaomiao Liu verfasserin aut Lijun Rong verfasserin aut In Molecules MDPI AG, 2003 25(2020), 1, p 183 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:25 year:2020 number:1, p 183 https://doi.org/10.3390/molecules25010183 kostenfrei https://doaj.org/article/8c6665c950ea4b93ace6f81af9282867 kostenfrei https://www.mdpi.com/1420-3049/25/1/183 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2020 1, p 183
allfieldsGer	10.3390/molecules25010183 doi (DE-627)DOAJ042214300 (DE-599)DOAJ8c6665c950ea4b93ace6f81af9282867 DE-627 ger DE-627 rakwb eng QD241-441 Qinghua Cui verfasserin aut Lignans and Their Derivatives from Plants as Antivirals 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Lignans are widely produced by various plant species; they are a class of natural products that share structural similarity. They usually contain a core scaffold that is formed by two or more phenylpropanoid units. Lignans possess diverse pharmacological properties, including their antiviral activities that have been reported in recent years. This review discusses the distribution of lignans in nature according to their structural classification, and it provides a comprehensive summary of their antiviral activities. Among them, two types of antiviral lignans—podophyllotoxin and bicyclol, which are used to treat venereal warts and chronic hepatitis B (CHB) in clinical, serve as examples of using lignans for antivirals—are discussed in some detail. Prospects of lignans in antiviral drug discovery are also discussed. lignans antivirals mechanism drug development Organic chemistry Ruikun Du verfasserin aut Miaomiao Liu verfasserin aut Lijun Rong verfasserin aut In Molecules MDPI AG, 2003 25(2020), 1, p 183 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:25 year:2020 number:1, p 183 https://doi.org/10.3390/molecules25010183 kostenfrei https://doaj.org/article/8c6665c950ea4b93ace6f81af9282867 kostenfrei https://www.mdpi.com/1420-3049/25/1/183 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2020 1, p 183
allfieldsSound	10.3390/molecules25010183 doi (DE-627)DOAJ042214300 (DE-599)DOAJ8c6665c950ea4b93ace6f81af9282867 DE-627 ger DE-627 rakwb eng QD241-441 Qinghua Cui verfasserin aut Lignans and Their Derivatives from Plants as Antivirals 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Lignans are widely produced by various plant species; they are a class of natural products that share structural similarity. They usually contain a core scaffold that is formed by two or more phenylpropanoid units. Lignans possess diverse pharmacological properties, including their antiviral activities that have been reported in recent years. This review discusses the distribution of lignans in nature according to their structural classification, and it provides a comprehensive summary of their antiviral activities. Among them, two types of antiviral lignans—podophyllotoxin and bicyclol, which are used to treat venereal warts and chronic hepatitis B (CHB) in clinical, serve as examples of using lignans for antivirals—are discussed in some detail. Prospects of lignans in antiviral drug discovery are also discussed. lignans antivirals mechanism drug development Organic chemistry Ruikun Du verfasserin aut Miaomiao Liu verfasserin aut Lijun Rong verfasserin aut In Molecules MDPI AG, 2003 25(2020), 1, p 183 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:25 year:2020 number:1, p 183 https://doi.org/10.3390/molecules25010183 kostenfrei https://doaj.org/article/8c6665c950ea4b93ace6f81af9282867 kostenfrei https://www.mdpi.com/1420-3049/25/1/183 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2020 1, p 183
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source	In Molecules 25(2020), 1, p 183 volume:25 year:2020 number:1, p 183
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callnumber-first	Q - Science
author	Qinghua Cui
spellingShingle	Qinghua Cui misc QD241-441 misc lignans misc antivirals misc mechanism misc drug development misc Organic chemistry Lignans and Their Derivatives from Plants as Antivirals
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topic_title	QD241-441 Lignans and Their Derivatives from Plants as Antivirals lignans antivirals mechanism drug development
topic	misc QD241-441 misc lignans misc antivirals misc mechanism misc drug development misc Organic chemistry
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title	Lignans and Their Derivatives from Plants as Antivirals
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title_full	Lignans and Their Derivatives from Plants as Antivirals
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title_sort	lignans and their derivatives from plants as antivirals
callnumber	QD241-441
title_auth	Lignans and Their Derivatives from Plants as Antivirals
abstract	Lignans are widely produced by various plant species; they are a class of natural products that share structural similarity. They usually contain a core scaffold that is formed by two or more phenylpropanoid units. Lignans possess diverse pharmacological properties, including their antiviral activities that have been reported in recent years. This review discusses the distribution of lignans in nature according to their structural classification, and it provides a comprehensive summary of their antiviral activities. Among them, two types of antiviral lignans—podophyllotoxin and bicyclol, which are used to treat venereal warts and chronic hepatitis B (CHB) in clinical, serve as examples of using lignans for antivirals—are discussed in some detail. Prospects of lignans in antiviral drug discovery are also discussed.
abstractGer	Lignans are widely produced by various plant species; they are a class of natural products that share structural similarity. They usually contain a core scaffold that is formed by two or more phenylpropanoid units. Lignans possess diverse pharmacological properties, including their antiviral activities that have been reported in recent years. This review discusses the distribution of lignans in nature according to their structural classification, and it provides a comprehensive summary of their antiviral activities. Among them, two types of antiviral lignans—podophyllotoxin and bicyclol, which are used to treat venereal warts and chronic hepatitis B (CHB) in clinical, serve as examples of using lignans for antivirals—are discussed in some detail. Prospects of lignans in antiviral drug discovery are also discussed.
abstract_unstemmed	Lignans are widely produced by various plant species; they are a class of natural products that share structural similarity. They usually contain a core scaffold that is formed by two or more phenylpropanoid units. Lignans possess diverse pharmacological properties, including their antiviral activities that have been reported in recent years. This review discusses the distribution of lignans in nature according to their structural classification, and it provides a comprehensive summary of their antiviral activities. Among them, two types of antiviral lignans—podophyllotoxin and bicyclol, which are used to treat venereal warts and chronic hepatitis B (CHB) in clinical, serve as examples of using lignans for antivirals—are discussed in some detail. Prospects of lignans in antiviral drug discovery are also discussed.
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container_issue	1, p 183
title_short	Lignans and Their Derivatives from Plants as Antivirals
url	https://doi.org/10.3390/molecules25010183 https://doaj.org/article/8c6665c950ea4b93ace6f81af9282867 https://www.mdpi.com/1420-3049/25/1/183 https://doaj.org/toc/1420-3049
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