P119 LDL CHOLESTEROL IS ASSOCIATED WITH SYSTEMIC VASCULAR RESISTANCE AND WAVE REFLECTION IN SUBJECTS NOT USING MEDICATIONS WITH HAEMODYNAMIC INFLUENCES

Background and Aim: Low density lipoprotein cholesterol (LDL-C) is a primary risk factor for atherosclerosis, but it is also associated with elevated blood pressure (BP) and future development of hypertension. We examined the relationship between LDL-C and haemodynamic variables in normotensive and...
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Autor*in:	Manoj kumar Choudhary [verfasserIn] Arttu Eräranta [verfasserIn] Antti J. Tikkakoski [verfasserIn] Jenni Koskela [verfasserIn] Elina Hautaniemi [verfasserIn] Mika Kähönen [verfasserIn] Jukka Mustonen [verfasserIn] Ilkka Pörsti [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Übergeordnetes Werk:	In: Artery Research - BMC, 2020, 24(2018)
Übergeordnetes Werk:	volume:24 ; year:2018

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.artres.2018.10.172

Katalog-ID:	DOAJ042267501

Internformat


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520			\|a Background and Aim: Low density lipoprotein cholesterol (LDL-C) is a primary risk factor for atherosclerosis, but it is also associated with elevated blood pressure (BP) and future development of hypertension. We examined the relationship between LDL-C and haemodynamic variables in normotensive and never-treated hypertensive subjects. Methods: Altogether 615 volunteers (19–72 years) without lipid- and BP-lowering medication were recruited. Supine haemodynamics were recorded using continuous radial pulse wave analysis, whole-body impedance cardiography, and single channel electrocardiogram. The haemodynamic relations of LDL-C were examined using linear regression analyses with age, sex, body mass index (BMI) (or height and weight as appropriate), smoking status, alcohol use, and plasma C-reactive protein, sodium, uric acid, high density lipoprotein cholesterol (HDL-C), triglycerides, estimated glomerular filtration rate, and quantitative insulin sensitivity check index as the other included variables. Results: The mean (SD) characteristics of the subjects were: age 45 (12) years, BMI 27 (4) kg/m2, office BP 141/89 (21/13) mmHg, creatinine 74 (14) μmol/l, total cholesterol 5.2 (1.0), LDL-C 3.1 (0.6), triglycerides 1.2 (0.8), and HDL-C 1.6 (0.4) mmol/l. LDL-C was an independent explanatory factor for aortic systolic and diastolic BP, aortic pulse pressure, augmentation index, pulse wave velocity (PWV), and systemic vascular resistance index (p ≤ 0.013 for all). When central BP was included in the model for PWV, LDL-C was no more an explanatory factor for PWV. Conclusions: LDL-C is independently associated with BP via systemic vascular resistance and wave reflection. These results suggest that LDL-C may play a role in the pathogenesis of primary hypertension.
653		0	\|a Specialties of internal medicine
653		0	\|a Diseases of the circulatory (Cardiovascular) system
700	0		\|a Arttu Eräranta \|e verfasserin \|4 aut
700	0		\|a Antti J. Tikkakoski \|e verfasserin \|4 aut
700	0		\|a Jenni Koskela \|e verfasserin \|4 aut
700	0		\|a Elina Hautaniemi \|e verfasserin \|4 aut
700	0		\|a Mika Kähönen \|e verfasserin \|4 aut
700	0		\|a Jukka Mustonen \|e verfasserin \|4 aut
700	0		\|a Ilkka Pörsti \|e verfasserin \|4 aut
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allfields	10.1016/j.artres.2018.10.172 doi (DE-627)DOAJ042267501 (DE-599)DOAJ269d039f0a5243d2be79734631772b3f DE-627 ger DE-627 rakwb eng RC581-951 RC666-701 Manoj kumar Choudhary verfasserin aut P119 LDL CHOLESTEROL IS ASSOCIATED WITH SYSTEMIC VASCULAR RESISTANCE AND WAVE REFLECTION IN SUBJECTS NOT USING MEDICATIONS WITH HAEMODYNAMIC INFLUENCES 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Aim: Low density lipoprotein cholesterol (LDL-C) is a primary risk factor for atherosclerosis, but it is also associated with elevated blood pressure (BP) and future development of hypertension. We examined the relationship between LDL-C and haemodynamic variables in normotensive and never-treated hypertensive subjects. Methods: Altogether 615 volunteers (19–72 years) without lipid- and BP-lowering medication were recruited. Supine haemodynamics were recorded using continuous radial pulse wave analysis, whole-body impedance cardiography, and single channel electrocardiogram. The haemodynamic relations of LDL-C were examined using linear regression analyses with age, sex, body mass index (BMI) (or height and weight as appropriate), smoking status, alcohol use, and plasma C-reactive protein, sodium, uric acid, high density lipoprotein cholesterol (HDL-C), triglycerides, estimated glomerular filtration rate, and quantitative insulin sensitivity check index as the other included variables. Results: The mean (SD) characteristics of the subjects were: age 45 (12) years, BMI 27 (4) kg/m2, office BP 141/89 (21/13) mmHg, creatinine 74 (14) μmol/l, total cholesterol 5.2 (1.0), LDL-C 3.1 (0.6), triglycerides 1.2 (0.8), and HDL-C 1.6 (0.4) mmol/l. LDL-C was an independent explanatory factor for aortic systolic and diastolic BP, aortic pulse pressure, augmentation index, pulse wave velocity (PWV), and systemic vascular resistance index (p ≤ 0.013 for all). When central BP was included in the model for PWV, LDL-C was no more an explanatory factor for PWV. Conclusions: LDL-C is independently associated with BP via systemic vascular resistance and wave reflection. These results suggest that LDL-C may play a role in the pathogenesis of primary hypertension. Specialties of internal medicine Diseases of the circulatory (Cardiovascular) system Arttu Eräranta verfasserin aut Antti J. Tikkakoski verfasserin aut Jenni Koskela verfasserin aut Elina Hautaniemi verfasserin aut Mika Kähönen verfasserin aut Jukka Mustonen verfasserin aut Ilkka Pörsti verfasserin aut In Artery Research BMC, 2020 24(2018) (DE-627)534057489 (DE-600)2364789-9 18764401 nnns volume:24 year:2018 https://doi.org/10.1016/j.artres.2018.10.172 kostenfrei https://doaj.org/article/269d039f0a5243d2be79734631772b3f kostenfrei https://www.atlantis-press.com/article/125930120/view kostenfrei https://doaj.org/toc/1876-4401 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2018
spelling	10.1016/j.artres.2018.10.172 doi (DE-627)DOAJ042267501 (DE-599)DOAJ269d039f0a5243d2be79734631772b3f DE-627 ger DE-627 rakwb eng RC581-951 RC666-701 Manoj kumar Choudhary verfasserin aut P119 LDL CHOLESTEROL IS ASSOCIATED WITH SYSTEMIC VASCULAR RESISTANCE AND WAVE REFLECTION IN SUBJECTS NOT USING MEDICATIONS WITH HAEMODYNAMIC INFLUENCES 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Aim: Low density lipoprotein cholesterol (LDL-C) is a primary risk factor for atherosclerosis, but it is also associated with elevated blood pressure (BP) and future development of hypertension. We examined the relationship between LDL-C and haemodynamic variables in normotensive and never-treated hypertensive subjects. Methods: Altogether 615 volunteers (19–72 years) without lipid- and BP-lowering medication were recruited. Supine haemodynamics were recorded using continuous radial pulse wave analysis, whole-body impedance cardiography, and single channel electrocardiogram. The haemodynamic relations of LDL-C were examined using linear regression analyses with age, sex, body mass index (BMI) (or height and weight as appropriate), smoking status, alcohol use, and plasma C-reactive protein, sodium, uric acid, high density lipoprotein cholesterol (HDL-C), triglycerides, estimated glomerular filtration rate, and quantitative insulin sensitivity check index as the other included variables. Results: The mean (SD) characteristics of the subjects were: age 45 (12) years, BMI 27 (4) kg/m2, office BP 141/89 (21/13) mmHg, creatinine 74 (14) μmol/l, total cholesterol 5.2 (1.0), LDL-C 3.1 (0.6), triglycerides 1.2 (0.8), and HDL-C 1.6 (0.4) mmol/l. LDL-C was an independent explanatory factor for aortic systolic and diastolic BP, aortic pulse pressure, augmentation index, pulse wave velocity (PWV), and systemic vascular resistance index (p ≤ 0.013 for all). When central BP was included in the model for PWV, LDL-C was no more an explanatory factor for PWV. Conclusions: LDL-C is independently associated with BP via systemic vascular resistance and wave reflection. These results suggest that LDL-C may play a role in the pathogenesis of primary hypertension. Specialties of internal medicine Diseases of the circulatory (Cardiovascular) system Arttu Eräranta verfasserin aut Antti J. Tikkakoski verfasserin aut Jenni Koskela verfasserin aut Elina Hautaniemi verfasserin aut Mika Kähönen verfasserin aut Jukka Mustonen verfasserin aut Ilkka Pörsti verfasserin aut In Artery Research BMC, 2020 24(2018) (DE-627)534057489 (DE-600)2364789-9 18764401 nnns volume:24 year:2018 https://doi.org/10.1016/j.artres.2018.10.172 kostenfrei https://doaj.org/article/269d039f0a5243d2be79734631772b3f kostenfrei https://www.atlantis-press.com/article/125930120/view kostenfrei https://doaj.org/toc/1876-4401 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2018
allfields_unstemmed	10.1016/j.artres.2018.10.172 doi (DE-627)DOAJ042267501 (DE-599)DOAJ269d039f0a5243d2be79734631772b3f DE-627 ger DE-627 rakwb eng RC581-951 RC666-701 Manoj kumar Choudhary verfasserin aut P119 LDL CHOLESTEROL IS ASSOCIATED WITH SYSTEMIC VASCULAR RESISTANCE AND WAVE REFLECTION IN SUBJECTS NOT USING MEDICATIONS WITH HAEMODYNAMIC INFLUENCES 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Aim: Low density lipoprotein cholesterol (LDL-C) is a primary risk factor for atherosclerosis, but it is also associated with elevated blood pressure (BP) and future development of hypertension. We examined the relationship between LDL-C and haemodynamic variables in normotensive and never-treated hypertensive subjects. Methods: Altogether 615 volunteers (19–72 years) without lipid- and BP-lowering medication were recruited. Supine haemodynamics were recorded using continuous radial pulse wave analysis, whole-body impedance cardiography, and single channel electrocardiogram. The haemodynamic relations of LDL-C were examined using linear regression analyses with age, sex, body mass index (BMI) (or height and weight as appropriate), smoking status, alcohol use, and plasma C-reactive protein, sodium, uric acid, high density lipoprotein cholesterol (HDL-C), triglycerides, estimated glomerular filtration rate, and quantitative insulin sensitivity check index as the other included variables. Results: The mean (SD) characteristics of the subjects were: age 45 (12) years, BMI 27 (4) kg/m2, office BP 141/89 (21/13) mmHg, creatinine 74 (14) μmol/l, total cholesterol 5.2 (1.0), LDL-C 3.1 (0.6), triglycerides 1.2 (0.8), and HDL-C 1.6 (0.4) mmol/l. LDL-C was an independent explanatory factor for aortic systolic and diastolic BP, aortic pulse pressure, augmentation index, pulse wave velocity (PWV), and systemic vascular resistance index (p ≤ 0.013 for all). When central BP was included in the model for PWV, LDL-C was no more an explanatory factor for PWV. Conclusions: LDL-C is independently associated with BP via systemic vascular resistance and wave reflection. These results suggest that LDL-C may play a role in the pathogenesis of primary hypertension. Specialties of internal medicine Diseases of the circulatory (Cardiovascular) system Arttu Eräranta verfasserin aut Antti J. Tikkakoski verfasserin aut Jenni Koskela verfasserin aut Elina Hautaniemi verfasserin aut Mika Kähönen verfasserin aut Jukka Mustonen verfasserin aut Ilkka Pörsti verfasserin aut In Artery Research BMC, 2020 24(2018) (DE-627)534057489 (DE-600)2364789-9 18764401 nnns volume:24 year:2018 https://doi.org/10.1016/j.artres.2018.10.172 kostenfrei https://doaj.org/article/269d039f0a5243d2be79734631772b3f kostenfrei https://www.atlantis-press.com/article/125930120/view kostenfrei https://doaj.org/toc/1876-4401 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2018
allfieldsGer	10.1016/j.artres.2018.10.172 doi (DE-627)DOAJ042267501 (DE-599)DOAJ269d039f0a5243d2be79734631772b3f DE-627 ger DE-627 rakwb eng RC581-951 RC666-701 Manoj kumar Choudhary verfasserin aut P119 LDL CHOLESTEROL IS ASSOCIATED WITH SYSTEMIC VASCULAR RESISTANCE AND WAVE REFLECTION IN SUBJECTS NOT USING MEDICATIONS WITH HAEMODYNAMIC INFLUENCES 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Aim: Low density lipoprotein cholesterol (LDL-C) is a primary risk factor for atherosclerosis, but it is also associated with elevated blood pressure (BP) and future development of hypertension. We examined the relationship between LDL-C and haemodynamic variables in normotensive and never-treated hypertensive subjects. Methods: Altogether 615 volunteers (19–72 years) without lipid- and BP-lowering medication were recruited. Supine haemodynamics were recorded using continuous radial pulse wave analysis, whole-body impedance cardiography, and single channel electrocardiogram. The haemodynamic relations of LDL-C were examined using linear regression analyses with age, sex, body mass index (BMI) (or height and weight as appropriate), smoking status, alcohol use, and plasma C-reactive protein, sodium, uric acid, high density lipoprotein cholesterol (HDL-C), triglycerides, estimated glomerular filtration rate, and quantitative insulin sensitivity check index as the other included variables. Results: The mean (SD) characteristics of the subjects were: age 45 (12) years, BMI 27 (4) kg/m2, office BP 141/89 (21/13) mmHg, creatinine 74 (14) μmol/l, total cholesterol 5.2 (1.0), LDL-C 3.1 (0.6), triglycerides 1.2 (0.8), and HDL-C 1.6 (0.4) mmol/l. LDL-C was an independent explanatory factor for aortic systolic and diastolic BP, aortic pulse pressure, augmentation index, pulse wave velocity (PWV), and systemic vascular resistance index (p ≤ 0.013 for all). When central BP was included in the model for PWV, LDL-C was no more an explanatory factor for PWV. Conclusions: LDL-C is independently associated with BP via systemic vascular resistance and wave reflection. These results suggest that LDL-C may play a role in the pathogenesis of primary hypertension. Specialties of internal medicine Diseases of the circulatory (Cardiovascular) system Arttu Eräranta verfasserin aut Antti J. Tikkakoski verfasserin aut Jenni Koskela verfasserin aut Elina Hautaniemi verfasserin aut Mika Kähönen verfasserin aut Jukka Mustonen verfasserin aut Ilkka Pörsti verfasserin aut In Artery Research BMC, 2020 24(2018) (DE-627)534057489 (DE-600)2364789-9 18764401 nnns volume:24 year:2018 https://doi.org/10.1016/j.artres.2018.10.172 kostenfrei https://doaj.org/article/269d039f0a5243d2be79734631772b3f kostenfrei https://www.atlantis-press.com/article/125930120/view kostenfrei https://doaj.org/toc/1876-4401 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2018
allfieldsSound	10.1016/j.artres.2018.10.172 doi (DE-627)DOAJ042267501 (DE-599)DOAJ269d039f0a5243d2be79734631772b3f DE-627 ger DE-627 rakwb eng RC581-951 RC666-701 Manoj kumar Choudhary verfasserin aut P119 LDL CHOLESTEROL IS ASSOCIATED WITH SYSTEMIC VASCULAR RESISTANCE AND WAVE REFLECTION IN SUBJECTS NOT USING MEDICATIONS WITH HAEMODYNAMIC INFLUENCES 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Aim: Low density lipoprotein cholesterol (LDL-C) is a primary risk factor for atherosclerosis, but it is also associated with elevated blood pressure (BP) and future development of hypertension. We examined the relationship between LDL-C and haemodynamic variables in normotensive and never-treated hypertensive subjects. Methods: Altogether 615 volunteers (19–72 years) without lipid- and BP-lowering medication were recruited. Supine haemodynamics were recorded using continuous radial pulse wave analysis, whole-body impedance cardiography, and single channel electrocardiogram. The haemodynamic relations of LDL-C were examined using linear regression analyses with age, sex, body mass index (BMI) (or height and weight as appropriate), smoking status, alcohol use, and plasma C-reactive protein, sodium, uric acid, high density lipoprotein cholesterol (HDL-C), triglycerides, estimated glomerular filtration rate, and quantitative insulin sensitivity check index as the other included variables. Results: The mean (SD) characteristics of the subjects were: age 45 (12) years, BMI 27 (4) kg/m2, office BP 141/89 (21/13) mmHg, creatinine 74 (14) μmol/l, total cholesterol 5.2 (1.0), LDL-C 3.1 (0.6), triglycerides 1.2 (0.8), and HDL-C 1.6 (0.4) mmol/l. LDL-C was an independent explanatory factor for aortic systolic and diastolic BP, aortic pulse pressure, augmentation index, pulse wave velocity (PWV), and systemic vascular resistance index (p ≤ 0.013 for all). When central BP was included in the model for PWV, LDL-C was no more an explanatory factor for PWV. Conclusions: LDL-C is independently associated with BP via systemic vascular resistance and wave reflection. These results suggest that LDL-C may play a role in the pathogenesis of primary hypertension. Specialties of internal medicine Diseases of the circulatory (Cardiovascular) system Arttu Eräranta verfasserin aut Antti J. Tikkakoski verfasserin aut Jenni Koskela verfasserin aut Elina Hautaniemi verfasserin aut Mika Kähönen verfasserin aut Jukka Mustonen verfasserin aut Ilkka Pörsti verfasserin aut In Artery Research BMC, 2020 24(2018) (DE-627)534057489 (DE-600)2364789-9 18764401 nnns volume:24 year:2018 https://doi.org/10.1016/j.artres.2018.10.172 kostenfrei https://doaj.org/article/269d039f0a5243d2be79734631772b3f kostenfrei https://www.atlantis-press.com/article/125930120/view kostenfrei https://doaj.org/toc/1876-4401 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2018
language	English
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authorswithroles_txt_mv	Manoj kumar Choudhary @@aut@@ Arttu Eräranta @@aut@@ Antti J. Tikkakoski @@aut@@ Jenni Koskela @@aut@@ Elina Hautaniemi @@aut@@ Mika Kähönen @@aut@@ Jukka Mustonen @@aut@@ Ilkka Pörsti @@aut@@
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callnumber-first	R - Medicine
author	Manoj kumar Choudhary
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topic_title	RC581-951 RC666-701 P119 LDL CHOLESTEROL IS ASSOCIATED WITH SYSTEMIC VASCULAR RESISTANCE AND WAVE REFLECTION IN SUBJECTS NOT USING MEDICATIONS WITH HAEMODYNAMIC INFLUENCES
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title	P119 LDL CHOLESTEROL IS ASSOCIATED WITH SYSTEMIC VASCULAR RESISTANCE AND WAVE REFLECTION IN SUBJECTS NOT USING MEDICATIONS WITH HAEMODYNAMIC INFLUENCES
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title_sort	p119 ldl cholesterol is associated with systemic vascular resistance and wave reflection in subjects not using medications with haemodynamic influences
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title_auth	P119 LDL CHOLESTEROL IS ASSOCIATED WITH SYSTEMIC VASCULAR RESISTANCE AND WAVE REFLECTION IN SUBJECTS NOT USING MEDICATIONS WITH HAEMODYNAMIC INFLUENCES
abstract	Background and Aim: Low density lipoprotein cholesterol (LDL-C) is a primary risk factor for atherosclerosis, but it is also associated with elevated blood pressure (BP) and future development of hypertension. We examined the relationship between LDL-C and haemodynamic variables in normotensive and never-treated hypertensive subjects. Methods: Altogether 615 volunteers (19–72 years) without lipid- and BP-lowering medication were recruited. Supine haemodynamics were recorded using continuous radial pulse wave analysis, whole-body impedance cardiography, and single channel electrocardiogram. The haemodynamic relations of LDL-C were examined using linear regression analyses with age, sex, body mass index (BMI) (or height and weight as appropriate), smoking status, alcohol use, and plasma C-reactive protein, sodium, uric acid, high density lipoprotein cholesterol (HDL-C), triglycerides, estimated glomerular filtration rate, and quantitative insulin sensitivity check index as the other included variables. Results: The mean (SD) characteristics of the subjects were: age 45 (12) years, BMI 27 (4) kg/m2, office BP 141/89 (21/13) mmHg, creatinine 74 (14) μmol/l, total cholesterol 5.2 (1.0), LDL-C 3.1 (0.6), triglycerides 1.2 (0.8), and HDL-C 1.6 (0.4) mmol/l. LDL-C was an independent explanatory factor for aortic systolic and diastolic BP, aortic pulse pressure, augmentation index, pulse wave velocity (PWV), and systemic vascular resistance index (p ≤ 0.013 for all). When central BP was included in the model for PWV, LDL-C was no more an explanatory factor for PWV. Conclusions: LDL-C is independently associated with BP via systemic vascular resistance and wave reflection. These results suggest that LDL-C may play a role in the pathogenesis of primary hypertension.
abstractGer	Background and Aim: Low density lipoprotein cholesterol (LDL-C) is a primary risk factor for atherosclerosis, but it is also associated with elevated blood pressure (BP) and future development of hypertension. We examined the relationship between LDL-C and haemodynamic variables in normotensive and never-treated hypertensive subjects. Methods: Altogether 615 volunteers (19–72 years) without lipid- and BP-lowering medication were recruited. Supine haemodynamics were recorded using continuous radial pulse wave analysis, whole-body impedance cardiography, and single channel electrocardiogram. The haemodynamic relations of LDL-C were examined using linear regression analyses with age, sex, body mass index (BMI) (or height and weight as appropriate), smoking status, alcohol use, and plasma C-reactive protein, sodium, uric acid, high density lipoprotein cholesterol (HDL-C), triglycerides, estimated glomerular filtration rate, and quantitative insulin sensitivity check index as the other included variables. Results: The mean (SD) characteristics of the subjects were: age 45 (12) years, BMI 27 (4) kg/m2, office BP 141/89 (21/13) mmHg, creatinine 74 (14) μmol/l, total cholesterol 5.2 (1.0), LDL-C 3.1 (0.6), triglycerides 1.2 (0.8), and HDL-C 1.6 (0.4) mmol/l. LDL-C was an independent explanatory factor for aortic systolic and diastolic BP, aortic pulse pressure, augmentation index, pulse wave velocity (PWV), and systemic vascular resistance index (p ≤ 0.013 for all). When central BP was included in the model for PWV, LDL-C was no more an explanatory factor for PWV. Conclusions: LDL-C is independently associated with BP via systemic vascular resistance and wave reflection. These results suggest that LDL-C may play a role in the pathogenesis of primary hypertension.
abstract_unstemmed	Background and Aim: Low density lipoprotein cholesterol (LDL-C) is a primary risk factor for atherosclerosis, but it is also associated with elevated blood pressure (BP) and future development of hypertension. We examined the relationship between LDL-C and haemodynamic variables in normotensive and never-treated hypertensive subjects. Methods: Altogether 615 volunteers (19–72 years) without lipid- and BP-lowering medication were recruited. Supine haemodynamics were recorded using continuous radial pulse wave analysis, whole-body impedance cardiography, and single channel electrocardiogram. The haemodynamic relations of LDL-C were examined using linear regression analyses with age, sex, body mass index (BMI) (or height and weight as appropriate), smoking status, alcohol use, and plasma C-reactive protein, sodium, uric acid, high density lipoprotein cholesterol (HDL-C), triglycerides, estimated glomerular filtration rate, and quantitative insulin sensitivity check index as the other included variables. Results: The mean (SD) characteristics of the subjects were: age 45 (12) years, BMI 27 (4) kg/m2, office BP 141/89 (21/13) mmHg, creatinine 74 (14) μmol/l, total cholesterol 5.2 (1.0), LDL-C 3.1 (0.6), triglycerides 1.2 (0.8), and HDL-C 1.6 (0.4) mmol/l. LDL-C was an independent explanatory factor for aortic systolic and diastolic BP, aortic pulse pressure, augmentation index, pulse wave velocity (PWV), and systemic vascular resistance index (p ≤ 0.013 for all). When central BP was included in the model for PWV, LDL-C was no more an explanatory factor for PWV. Conclusions: LDL-C is independently associated with BP via systemic vascular resistance and wave reflection. These results suggest that LDL-C may play a role in the pathogenesis of primary hypertension.
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title_short	P119 LDL CHOLESTEROL IS ASSOCIATED WITH SYSTEMIC VASCULAR RESISTANCE AND WAVE REFLECTION IN SUBJECTS NOT USING MEDICATIONS WITH HAEMODYNAMIC INFLUENCES
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author2	Arttu Eräranta Antti J. Tikkakoski Jenni Koskela Elina Hautaniemi Mika Kähönen Jukka Mustonen Ilkka Pörsti
author2Str	Arttu Eräranta Antti J. Tikkakoski Jenni Koskela Elina Hautaniemi Mika Kähönen Jukka Mustonen Ilkka Pörsti
ppnlink	534057489
callnumber-subject	RC - Internal Medicine
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doi_str	10.1016/j.artres.2018.10.172
callnumber-a	RC581-951
up_date	2024-07-04T00:18:27.194Z
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We examined the relationship between LDL-C and haemodynamic variables in normotensive and never-treated hypertensive subjects. Methods: Altogether 615 volunteers (19–72 years) without lipid- and BP-lowering medication were recruited. Supine haemodynamics were recorded using continuous radial pulse wave analysis, whole-body impedance cardiography, and single channel electrocardiogram. The haemodynamic relations of LDL-C were examined using linear regression analyses with age, sex, body mass index (BMI) (or height and weight as appropriate), smoking status, alcohol use, and plasma C-reactive protein, sodium, uric acid, high density lipoprotein cholesterol (HDL-C), triglycerides, estimated glomerular filtration rate, and quantitative insulin sensitivity check index as the other included variables. Results: The mean (SD) characteristics of the subjects were: age 45 (12) years, BMI 27 (4) kg/m2, office BP 141/89 (21/13) mmHg, creatinine 74 (14) μmol/l, total cholesterol 5.2 (1.0), LDL-C 3.1 (0.6), triglycerides 1.2 (0.8), and HDL-C 1.6 (0.4) mmol/l. LDL-C was an independent explanatory factor for aortic systolic and diastolic BP, aortic pulse pressure, augmentation index, pulse wave velocity (PWV), and systemic vascular resistance index (p ≤ 0.013 for all). When central BP was included in the model for PWV, LDL-C was no more an explanatory factor for PWV. Conclusions: LDL-C is independently associated with BP via systemic vascular resistance and wave reflection. 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P119 LDL CHOLESTEROL IS ASSOCIATED WITH SYSTEMIC VASCULAR RESISTANCE AND WAVE REFLECTION IN SUBJECTS NOT USING MEDICATIONS WITH HAEMODYNAMIC INFLUENCES

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