Extracellular Vesicles and Damage-Associated Molecular Patterns: A Pandora’s Box in Health and Disease

Sterile inflammation develops as part of an innate immunity response to molecules released upon tissue injury and collectively indicated as damage-associated molecular patterns (DAMPs). While coordinating the clearance of potential harmful stimuli, promotion of tissue repair, and restoration of tiss...
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Gespeichert in:

Autor*in:	Anna Picca [verfasserIn] Flora Guerra [verfasserIn] Riccardo Calvani [verfasserIn] Hélio José Coelho-Júnior [verfasserIn] Francesco Landi [verfasserIn] Roberto Bernabei [verfasserIn] Roberta Romano [verfasserIn] Cecilia Bucci [verfasserIn] Emanuele Marzetti [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Alzheimer’s disease damage-associated molecular patterns endo-lysosomal system inflammation innate immunity mitochondrial-derived vesicles

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 11(2020)
Übergeordnetes Werk:	volume:11 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2020.601740

Katalog-ID:	DOAJ042346843

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allfieldsSound	10.3389/fimmu.2020.601740 doi (DE-627)DOAJ042346843 (DE-599)DOAJ5b3db8f2442542b98dbae2159bbfc35e DE-627 ger DE-627 rakwb eng RC581-607 Anna Picca verfasserin aut Extracellular Vesicles and Damage-Associated Molecular Patterns: A Pandora’s Box in Health and Disease 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Sterile inflammation develops as part of an innate immunity response to molecules released upon tissue injury and collectively indicated as damage-associated molecular patterns (DAMPs). While coordinating the clearance of potential harmful stimuli, promotion of tissue repair, and restoration of tissue homeostasis, a hyper-activation of such an inflammatory response may be detrimental. The complex regulatory pathways modulating DAMPs generation and trafficking are actively investigated for their potential to provide relevant insights into physiological and pathological conditions. Abnormal circulating extracellular vesicles (EVs) stemming from altered endosomal-lysosomal system have also been reported in several age-related conditions, including cancer and neurodegeneration, and indicated as a promising route for therapeutic purposes. Along this pathway, mitochondria may dispose altered components to preserve organelle homeostasis. However, whether a common thread exists between DAMPs and EVs generation is yet to be clarified. A deeper understanding of the highly complex, dynamic, and variable intracellular and extracellular trafficking of DAMPs and EVs, including those of mitochondrial origin, is needed to unveil relevant pathogenic pathways and novel targets for drug development. Herein, we describe the mechanisms of generation of EVs and mitochondrial-derived vesicles along the endocytic pathway and discuss the involvement of the endosomal-lysosomal in cancer and neurodegeneration (i.e., Alzheimer’s and Parkinson’s disease). Alzheimer’s disease damage-associated molecular patterns endo-lysosomal system inflammation innate immunity mitochondrial-derived vesicles Immunologic diseases. Allergy Anna Picca verfasserin aut Flora Guerra verfasserin aut Riccardo Calvani verfasserin aut Riccardo Calvani verfasserin aut Hélio José Coelho-Júnior verfasserin aut Francesco Landi verfasserin aut Francesco Landi verfasserin aut Roberto Bernabei verfasserin aut Roberto Bernabei verfasserin aut Roberta Romano verfasserin aut Cecilia Bucci verfasserin aut Emanuele Marzetti verfasserin aut Emanuele Marzetti verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 11(2020) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:11 year:2020 https://doi.org/10.3389/fimmu.2020.601740 kostenfrei https://doaj.org/article/5b3db8f2442542b98dbae2159bbfc35e kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2020.601740/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020
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callnumber-first	R - Medicine
author	Anna Picca
spellingShingle	Anna Picca misc RC581-607 misc Alzheimer’s disease misc damage-associated molecular patterns misc endo-lysosomal system misc inflammation misc innate immunity misc mitochondrial-derived vesicles misc Immunologic diseases. Allergy Extracellular Vesicles and Damage-Associated Molecular Patterns: A Pandora’s Box in Health and Disease
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topic_title	RC581-607 Extracellular Vesicles and Damage-Associated Molecular Patterns: A Pandora’s Box in Health and Disease Alzheimer’s disease damage-associated molecular patterns endo-lysosomal system inflammation innate immunity mitochondrial-derived vesicles
topic	misc RC581-607 misc Alzheimer’s disease misc damage-associated molecular patterns misc endo-lysosomal system misc inflammation misc innate immunity misc mitochondrial-derived vesicles misc Immunologic diseases. Allergy
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title	Extracellular Vesicles and Damage-Associated Molecular Patterns: A Pandora’s Box in Health and Disease
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title_full	Extracellular Vesicles and Damage-Associated Molecular Patterns: A Pandora’s Box in Health and Disease
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title_sort	extracellular vesicles and damage-associated molecular patterns: a pandora’s box in health and disease
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title_auth	Extracellular Vesicles and Damage-Associated Molecular Patterns: A Pandora’s Box in Health and Disease
abstract	Sterile inflammation develops as part of an innate immunity response to molecules released upon tissue injury and collectively indicated as damage-associated molecular patterns (DAMPs). While coordinating the clearance of potential harmful stimuli, promotion of tissue repair, and restoration of tissue homeostasis, a hyper-activation of such an inflammatory response may be detrimental. The complex regulatory pathways modulating DAMPs generation and trafficking are actively investigated for their potential to provide relevant insights into physiological and pathological conditions. Abnormal circulating extracellular vesicles (EVs) stemming from altered endosomal-lysosomal system have also been reported in several age-related conditions, including cancer and neurodegeneration, and indicated as a promising route for therapeutic purposes. Along this pathway, mitochondria may dispose altered components to preserve organelle homeostasis. However, whether a common thread exists between DAMPs and EVs generation is yet to be clarified. A deeper understanding of the highly complex, dynamic, and variable intracellular and extracellular trafficking of DAMPs and EVs, including those of mitochondrial origin, is needed to unveil relevant pathogenic pathways and novel targets for drug development. Herein, we describe the mechanisms of generation of EVs and mitochondrial-derived vesicles along the endocytic pathway and discuss the involvement of the endosomal-lysosomal in cancer and neurodegeneration (i.e., Alzheimer’s and Parkinson’s disease).
abstractGer	Sterile inflammation develops as part of an innate immunity response to molecules released upon tissue injury and collectively indicated as damage-associated molecular patterns (DAMPs). While coordinating the clearance of potential harmful stimuli, promotion of tissue repair, and restoration of tissue homeostasis, a hyper-activation of such an inflammatory response may be detrimental. The complex regulatory pathways modulating DAMPs generation and trafficking are actively investigated for their potential to provide relevant insights into physiological and pathological conditions. Abnormal circulating extracellular vesicles (EVs) stemming from altered endosomal-lysosomal system have also been reported in several age-related conditions, including cancer and neurodegeneration, and indicated as a promising route for therapeutic purposes. Along this pathway, mitochondria may dispose altered components to preserve organelle homeostasis. However, whether a common thread exists between DAMPs and EVs generation is yet to be clarified. A deeper understanding of the highly complex, dynamic, and variable intracellular and extracellular trafficking of DAMPs and EVs, including those of mitochondrial origin, is needed to unveil relevant pathogenic pathways and novel targets for drug development. Herein, we describe the mechanisms of generation of EVs and mitochondrial-derived vesicles along the endocytic pathway and discuss the involvement of the endosomal-lysosomal in cancer and neurodegeneration (i.e., Alzheimer’s and Parkinson’s disease).
abstract_unstemmed	Sterile inflammation develops as part of an innate immunity response to molecules released upon tissue injury and collectively indicated as damage-associated molecular patterns (DAMPs). While coordinating the clearance of potential harmful stimuli, promotion of tissue repair, and restoration of tissue homeostasis, a hyper-activation of such an inflammatory response may be detrimental. The complex regulatory pathways modulating DAMPs generation and trafficking are actively investigated for their potential to provide relevant insights into physiological and pathological conditions. Abnormal circulating extracellular vesicles (EVs) stemming from altered endosomal-lysosomal system have also been reported in several age-related conditions, including cancer and neurodegeneration, and indicated as a promising route for therapeutic purposes. Along this pathway, mitochondria may dispose altered components to preserve organelle homeostasis. However, whether a common thread exists between DAMPs and EVs generation is yet to be clarified. A deeper understanding of the highly complex, dynamic, and variable intracellular and extracellular trafficking of DAMPs and EVs, including those of mitochondrial origin, is needed to unveil relevant pathogenic pathways and novel targets for drug development. Herein, we describe the mechanisms of generation of EVs and mitochondrial-derived vesicles along the endocytic pathway and discuss the involvement of the endosomal-lysosomal in cancer and neurodegeneration (i.e., Alzheimer’s and Parkinson’s disease).
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title_short	Extracellular Vesicles and Damage-Associated Molecular Patterns: A Pandora’s Box in Health and Disease
url	https://doi.org/10.3389/fimmu.2020.601740 https://doaj.org/article/5b3db8f2442542b98dbae2159bbfc35e https://www.frontiersin.org/articles/10.3389/fimmu.2020.601740/full https://doaj.org/toc/1664-3224
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up_date	2024-07-04T00:37:05.612Z
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