The burden of polypharmacy and potentially inappropriate medication in Nigeria: a clarion call for deprescribing practice
Abstract Background Polypharmacy and potentially inappropriate medications (PIMs) could cause adverse drug events leading to poor health outcomes. This burden is addressed through deprescribing practice. However, data on deprescribing practices are lacking in Nigeria, where the healthcare systems ar...
Ausführliche Beschreibung
Autor*in: |
Safiya Bala Borodo [verfasserIn] Abubakar Ibrahim Jatau [verfasserIn] Mustapha Mohammed [verfasserIn] Nafiu Aminu [verfasserIn] Zayyanu Shitu [verfasserIn] Abubakar Sha’aban [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2022 |
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In: Bulletin of the National Research Centre - SpringerOpen, 2018, 46(2022), 1, Seite 8 |
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Übergeordnetes Werk: |
volume:46 ; year:2022 ; number:1 ; pages:8 |
Links: |
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DOI / URN: |
10.1186/s42269-022-00864-3 |
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DOAJ042486335 |
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520 | |a Abstract Background Polypharmacy and potentially inappropriate medications (PIMs) could cause adverse drug events leading to poor health outcomes. This burden is addressed through deprescribing practice. However, data on deprescribing practices are lacking in Nigeria, where the healthcare systems are fragile. Aim This review aimed to summarise the literature on the burden of polypharmacy and PIMs and identify the need for deprescribing practice in Nigeria. Method A systematic search of the literature was conducted on MEDLINE through PubMed (Public Medline), Google Scholar, and a manual search of included articles to identify information on deprescribing, polypharmacy, and PIMs in Nigeria from the inception of the database to date. Relevant information from the articles was summarised and presented as subsections in the manuscript. Results In this review, we reported the burden of polypharmacy, PIMs, and the need for deprescribing practice in Nigeria. The estimated prevalence of polypharmacy was up to 23.8% among older patients with chronic disorders. Polypharmacy and PIMs have been reported to be a significant cause of medication non-adherence, drug addiction, drug interactions, adverse drug reactions, hospitalisation, morbidity, and mortality. Thus, there is the need to consider deprescription practice in the country. Conclusion This review revealed that polypharmacy and PIMs are common in Nigeria. Therefore, there is a need for deprescribing practice to improve drug safety in the country. This could be achieved through patient education, increasing awareness of deprescribing practice among the healthcare professionals, and ensuring adherence to the core prescribing indicators of the World Health Organization (WHO) and National Standard Treatment Guidelines. | ||
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10.1186/s42269-022-00864-3 doi (DE-627)DOAJ042486335 (DE-599)DOAJ335c43570056467dbdc42141d0390dd0 DE-627 ger DE-627 rakwb eng Safiya Bala Borodo verfasserin aut The burden of polypharmacy and potentially inappropriate medication in Nigeria: a clarion call for deprescribing practice 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Polypharmacy and potentially inappropriate medications (PIMs) could cause adverse drug events leading to poor health outcomes. This burden is addressed through deprescribing practice. However, data on deprescribing practices are lacking in Nigeria, where the healthcare systems are fragile. Aim This review aimed to summarise the literature on the burden of polypharmacy and PIMs and identify the need for deprescribing practice in Nigeria. Method A systematic search of the literature was conducted on MEDLINE through PubMed (Public Medline), Google Scholar, and a manual search of included articles to identify information on deprescribing, polypharmacy, and PIMs in Nigeria from the inception of the database to date. Relevant information from the articles was summarised and presented as subsections in the manuscript. Results In this review, we reported the burden of polypharmacy, PIMs, and the need for deprescribing practice in Nigeria. The estimated prevalence of polypharmacy was up to 23.8% among older patients with chronic disorders. Polypharmacy and PIMs have been reported to be a significant cause of medication non-adherence, drug addiction, drug interactions, adverse drug reactions, hospitalisation, morbidity, and mortality. Thus, there is the need to consider deprescription practice in the country. Conclusion This review revealed that polypharmacy and PIMs are common in Nigeria. Therefore, there is a need for deprescribing practice to improve drug safety in the country. This could be achieved through patient education, increasing awareness of deprescribing practice among the healthcare professionals, and ensuring adherence to the core prescribing indicators of the World Health Organization (WHO) and National Standard Treatment Guidelines. Polypharmacy Deprescribing Nigeria Science Q Abubakar Ibrahim Jatau verfasserin aut Mustapha Mohammed verfasserin aut Nafiu Aminu verfasserin aut Zayyanu Shitu verfasserin aut Abubakar Sha’aban verfasserin aut In Bulletin of the National Research Centre SpringerOpen, 2018 46(2022), 1, Seite 8 (DE-627)1035877007 25228307 nnns volume:46 year:2022 number:1 pages:8 https://doi.org/10.1186/s42269-022-00864-3 kostenfrei https://doaj.org/article/335c43570056467dbdc42141d0390dd0 kostenfrei https://doi.org/10.1186/s42269-022-00864-3 kostenfrei https://doaj.org/toc/2522-8307 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 46 2022 1 8 |
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10.1186/s42269-022-00864-3 doi (DE-627)DOAJ042486335 (DE-599)DOAJ335c43570056467dbdc42141d0390dd0 DE-627 ger DE-627 rakwb eng Safiya Bala Borodo verfasserin aut The burden of polypharmacy and potentially inappropriate medication in Nigeria: a clarion call for deprescribing practice 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Polypharmacy and potentially inappropriate medications (PIMs) could cause adverse drug events leading to poor health outcomes. This burden is addressed through deprescribing practice. However, data on deprescribing practices are lacking in Nigeria, where the healthcare systems are fragile. Aim This review aimed to summarise the literature on the burden of polypharmacy and PIMs and identify the need for deprescribing practice in Nigeria. Method A systematic search of the literature was conducted on MEDLINE through PubMed (Public Medline), Google Scholar, and a manual search of included articles to identify information on deprescribing, polypharmacy, and PIMs in Nigeria from the inception of the database to date. Relevant information from the articles was summarised and presented as subsections in the manuscript. Results In this review, we reported the burden of polypharmacy, PIMs, and the need for deprescribing practice in Nigeria. The estimated prevalence of polypharmacy was up to 23.8% among older patients with chronic disorders. Polypharmacy and PIMs have been reported to be a significant cause of medication non-adherence, drug addiction, drug interactions, adverse drug reactions, hospitalisation, morbidity, and mortality. Thus, there is the need to consider deprescription practice in the country. Conclusion This review revealed that polypharmacy and PIMs are common in Nigeria. Therefore, there is a need for deprescribing practice to improve drug safety in the country. This could be achieved through patient education, increasing awareness of deprescribing practice among the healthcare professionals, and ensuring adherence to the core prescribing indicators of the World Health Organization (WHO) and National Standard Treatment Guidelines. Polypharmacy Deprescribing Nigeria Science Q Abubakar Ibrahim Jatau verfasserin aut Mustapha Mohammed verfasserin aut Nafiu Aminu verfasserin aut Zayyanu Shitu verfasserin aut Abubakar Sha’aban verfasserin aut In Bulletin of the National Research Centre SpringerOpen, 2018 46(2022), 1, Seite 8 (DE-627)1035877007 25228307 nnns volume:46 year:2022 number:1 pages:8 https://doi.org/10.1186/s42269-022-00864-3 kostenfrei https://doaj.org/article/335c43570056467dbdc42141d0390dd0 kostenfrei https://doi.org/10.1186/s42269-022-00864-3 kostenfrei https://doaj.org/toc/2522-8307 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 46 2022 1 8 |
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10.1186/s42269-022-00864-3 doi (DE-627)DOAJ042486335 (DE-599)DOAJ335c43570056467dbdc42141d0390dd0 DE-627 ger DE-627 rakwb eng Safiya Bala Borodo verfasserin aut The burden of polypharmacy and potentially inappropriate medication in Nigeria: a clarion call for deprescribing practice 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Polypharmacy and potentially inappropriate medications (PIMs) could cause adverse drug events leading to poor health outcomes. This burden is addressed through deprescribing practice. However, data on deprescribing practices are lacking in Nigeria, where the healthcare systems are fragile. Aim This review aimed to summarise the literature on the burden of polypharmacy and PIMs and identify the need for deprescribing practice in Nigeria. Method A systematic search of the literature was conducted on MEDLINE through PubMed (Public Medline), Google Scholar, and a manual search of included articles to identify information on deprescribing, polypharmacy, and PIMs in Nigeria from the inception of the database to date. Relevant information from the articles was summarised and presented as subsections in the manuscript. Results In this review, we reported the burden of polypharmacy, PIMs, and the need for deprescribing practice in Nigeria. The estimated prevalence of polypharmacy was up to 23.8% among older patients with chronic disorders. Polypharmacy and PIMs have been reported to be a significant cause of medication non-adherence, drug addiction, drug interactions, adverse drug reactions, hospitalisation, morbidity, and mortality. Thus, there is the need to consider deprescription practice in the country. Conclusion This review revealed that polypharmacy and PIMs are common in Nigeria. Therefore, there is a need for deprescribing practice to improve drug safety in the country. This could be achieved through patient education, increasing awareness of deprescribing practice among the healthcare professionals, and ensuring adherence to the core prescribing indicators of the World Health Organization (WHO) and National Standard Treatment Guidelines. Polypharmacy Deprescribing Nigeria Science Q Abubakar Ibrahim Jatau verfasserin aut Mustapha Mohammed verfasserin aut Nafiu Aminu verfasserin aut Zayyanu Shitu verfasserin aut Abubakar Sha’aban verfasserin aut In Bulletin of the National Research Centre SpringerOpen, 2018 46(2022), 1, Seite 8 (DE-627)1035877007 25228307 nnns volume:46 year:2022 number:1 pages:8 https://doi.org/10.1186/s42269-022-00864-3 kostenfrei https://doaj.org/article/335c43570056467dbdc42141d0390dd0 kostenfrei https://doi.org/10.1186/s42269-022-00864-3 kostenfrei https://doaj.org/toc/2522-8307 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 46 2022 1 8 |
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10.1186/s42269-022-00864-3 doi (DE-627)DOAJ042486335 (DE-599)DOAJ335c43570056467dbdc42141d0390dd0 DE-627 ger DE-627 rakwb eng Safiya Bala Borodo verfasserin aut The burden of polypharmacy and potentially inappropriate medication in Nigeria: a clarion call for deprescribing practice 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Polypharmacy and potentially inappropriate medications (PIMs) could cause adverse drug events leading to poor health outcomes. This burden is addressed through deprescribing practice. However, data on deprescribing practices are lacking in Nigeria, where the healthcare systems are fragile. Aim This review aimed to summarise the literature on the burden of polypharmacy and PIMs and identify the need for deprescribing practice in Nigeria. Method A systematic search of the literature was conducted on MEDLINE through PubMed (Public Medline), Google Scholar, and a manual search of included articles to identify information on deprescribing, polypharmacy, and PIMs in Nigeria from the inception of the database to date. Relevant information from the articles was summarised and presented as subsections in the manuscript. Results In this review, we reported the burden of polypharmacy, PIMs, and the need for deprescribing practice in Nigeria. The estimated prevalence of polypharmacy was up to 23.8% among older patients with chronic disorders. Polypharmacy and PIMs have been reported to be a significant cause of medication non-adherence, drug addiction, drug interactions, adverse drug reactions, hospitalisation, morbidity, and mortality. Thus, there is the need to consider deprescription practice in the country. Conclusion This review revealed that polypharmacy and PIMs are common in Nigeria. Therefore, there is a need for deprescribing practice to improve drug safety in the country. This could be achieved through patient education, increasing awareness of deprescribing practice among the healthcare professionals, and ensuring adherence to the core prescribing indicators of the World Health Organization (WHO) and National Standard Treatment Guidelines. Polypharmacy Deprescribing Nigeria Science Q Abubakar Ibrahim Jatau verfasserin aut Mustapha Mohammed verfasserin aut Nafiu Aminu verfasserin aut Zayyanu Shitu verfasserin aut Abubakar Sha’aban verfasserin aut In Bulletin of the National Research Centre SpringerOpen, 2018 46(2022), 1, Seite 8 (DE-627)1035877007 25228307 nnns volume:46 year:2022 number:1 pages:8 https://doi.org/10.1186/s42269-022-00864-3 kostenfrei https://doaj.org/article/335c43570056467dbdc42141d0390dd0 kostenfrei https://doi.org/10.1186/s42269-022-00864-3 kostenfrei https://doaj.org/toc/2522-8307 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 46 2022 1 8 |
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10.1186/s42269-022-00864-3 doi (DE-627)DOAJ042486335 (DE-599)DOAJ335c43570056467dbdc42141d0390dd0 DE-627 ger DE-627 rakwb eng Safiya Bala Borodo verfasserin aut The burden of polypharmacy and potentially inappropriate medication in Nigeria: a clarion call for deprescribing practice 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Polypharmacy and potentially inappropriate medications (PIMs) could cause adverse drug events leading to poor health outcomes. This burden is addressed through deprescribing practice. However, data on deprescribing practices are lacking in Nigeria, where the healthcare systems are fragile. Aim This review aimed to summarise the literature on the burden of polypharmacy and PIMs and identify the need for deprescribing practice in Nigeria. Method A systematic search of the literature was conducted on MEDLINE through PubMed (Public Medline), Google Scholar, and a manual search of included articles to identify information on deprescribing, polypharmacy, and PIMs in Nigeria from the inception of the database to date. Relevant information from the articles was summarised and presented as subsections in the manuscript. Results In this review, we reported the burden of polypharmacy, PIMs, and the need for deprescribing practice in Nigeria. The estimated prevalence of polypharmacy was up to 23.8% among older patients with chronic disorders. Polypharmacy and PIMs have been reported to be a significant cause of medication non-adherence, drug addiction, drug interactions, adverse drug reactions, hospitalisation, morbidity, and mortality. Thus, there is the need to consider deprescription practice in the country. Conclusion This review revealed that polypharmacy and PIMs are common in Nigeria. Therefore, there is a need for deprescribing practice to improve drug safety in the country. This could be achieved through patient education, increasing awareness of deprescribing practice among the healthcare professionals, and ensuring adherence to the core prescribing indicators of the World Health Organization (WHO) and National Standard Treatment Guidelines. Polypharmacy Deprescribing Nigeria Science Q Abubakar Ibrahim Jatau verfasserin aut Mustapha Mohammed verfasserin aut Nafiu Aminu verfasserin aut Zayyanu Shitu verfasserin aut Abubakar Sha’aban verfasserin aut In Bulletin of the National Research Centre SpringerOpen, 2018 46(2022), 1, Seite 8 (DE-627)1035877007 25228307 nnns volume:46 year:2022 number:1 pages:8 https://doi.org/10.1186/s42269-022-00864-3 kostenfrei https://doaj.org/article/335c43570056467dbdc42141d0390dd0 kostenfrei https://doi.org/10.1186/s42269-022-00864-3 kostenfrei https://doaj.org/toc/2522-8307 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 46 2022 1 8 |
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The burden of polypharmacy and potentially inappropriate medication in Nigeria: a clarion call for deprescribing practice |
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Abstract Background Polypharmacy and potentially inappropriate medications (PIMs) could cause adverse drug events leading to poor health outcomes. This burden is addressed through deprescribing practice. However, data on deprescribing practices are lacking in Nigeria, where the healthcare systems are fragile. Aim This review aimed to summarise the literature on the burden of polypharmacy and PIMs and identify the need for deprescribing practice in Nigeria. Method A systematic search of the literature was conducted on MEDLINE through PubMed (Public Medline), Google Scholar, and a manual search of included articles to identify information on deprescribing, polypharmacy, and PIMs in Nigeria from the inception of the database to date. Relevant information from the articles was summarised and presented as subsections in the manuscript. Results In this review, we reported the burden of polypharmacy, PIMs, and the need for deprescribing practice in Nigeria. The estimated prevalence of polypharmacy was up to 23.8% among older patients with chronic disorders. Polypharmacy and PIMs have been reported to be a significant cause of medication non-adherence, drug addiction, drug interactions, adverse drug reactions, hospitalisation, morbidity, and mortality. Thus, there is the need to consider deprescription practice in the country. Conclusion This review revealed that polypharmacy and PIMs are common in Nigeria. Therefore, there is a need for deprescribing practice to improve drug safety in the country. This could be achieved through patient education, increasing awareness of deprescribing practice among the healthcare professionals, and ensuring adherence to the core prescribing indicators of the World Health Organization (WHO) and National Standard Treatment Guidelines. |
abstractGer |
Abstract Background Polypharmacy and potentially inappropriate medications (PIMs) could cause adverse drug events leading to poor health outcomes. This burden is addressed through deprescribing practice. However, data on deprescribing practices are lacking in Nigeria, where the healthcare systems are fragile. Aim This review aimed to summarise the literature on the burden of polypharmacy and PIMs and identify the need for deprescribing practice in Nigeria. Method A systematic search of the literature was conducted on MEDLINE through PubMed (Public Medline), Google Scholar, and a manual search of included articles to identify information on deprescribing, polypharmacy, and PIMs in Nigeria from the inception of the database to date. Relevant information from the articles was summarised and presented as subsections in the manuscript. Results In this review, we reported the burden of polypharmacy, PIMs, and the need for deprescribing practice in Nigeria. The estimated prevalence of polypharmacy was up to 23.8% among older patients with chronic disorders. Polypharmacy and PIMs have been reported to be a significant cause of medication non-adherence, drug addiction, drug interactions, adverse drug reactions, hospitalisation, morbidity, and mortality. Thus, there is the need to consider deprescription practice in the country. Conclusion This review revealed that polypharmacy and PIMs are common in Nigeria. Therefore, there is a need for deprescribing practice to improve drug safety in the country. This could be achieved through patient education, increasing awareness of deprescribing practice among the healthcare professionals, and ensuring adherence to the core prescribing indicators of the World Health Organization (WHO) and National Standard Treatment Guidelines. |
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Abstract Background Polypharmacy and potentially inappropriate medications (PIMs) could cause adverse drug events leading to poor health outcomes. This burden is addressed through deprescribing practice. However, data on deprescribing practices are lacking in Nigeria, where the healthcare systems are fragile. Aim This review aimed to summarise the literature on the burden of polypharmacy and PIMs and identify the need for deprescribing practice in Nigeria. Method A systematic search of the literature was conducted on MEDLINE through PubMed (Public Medline), Google Scholar, and a manual search of included articles to identify information on deprescribing, polypharmacy, and PIMs in Nigeria from the inception of the database to date. Relevant information from the articles was summarised and presented as subsections in the manuscript. Results In this review, we reported the burden of polypharmacy, PIMs, and the need for deprescribing practice in Nigeria. The estimated prevalence of polypharmacy was up to 23.8% among older patients with chronic disorders. Polypharmacy and PIMs have been reported to be a significant cause of medication non-adherence, drug addiction, drug interactions, adverse drug reactions, hospitalisation, morbidity, and mortality. Thus, there is the need to consider deprescription practice in the country. Conclusion This review revealed that polypharmacy and PIMs are common in Nigeria. Therefore, there is a need for deprescribing practice to improve drug safety in the country. This could be achieved through patient education, increasing awareness of deprescribing practice among the healthcare professionals, and ensuring adherence to the core prescribing indicators of the World Health Organization (WHO) and National Standard Treatment Guidelines. |
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Polypharmacy and PIMs have been reported to be a significant cause of medication non-adherence, drug addiction, drug interactions, adverse drug reactions, hospitalisation, morbidity, and mortality. Thus, there is the need to consider deprescription practice in the country. Conclusion This review revealed that polypharmacy and PIMs are common in Nigeria. Therefore, there is a need for deprescribing practice to improve drug safety in the country. 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