Bile acid signaling and biliary functions

This review focuses on various components of bile acid signaling in relation to cholangiocytes. Their roles as targets for potential therapies for cholangiopathies are also explored. While many factors are involved in these complex signaling pathways, this review emphasizes the roles of transmembran...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Hannah Jones [verfasserIn] Gianfranco Alpini [verfasserIn] Heather Francis [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Bile acids Cholangiocytes Receptors Signaling

Übergeordnetes Werk:	In: Acta Pharmaceutica Sinica B - Elsevier, 2013, 5(2015), 2, Seite 123-128
Übergeordnetes Werk:	volume:5 ; year:2015 ; number:2 ; pages:123-128

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1016/j.apsb.2015.01.009

Katalog-ID:	DOAJ042517389

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language	English
source	In Acta Pharmaceutica Sinica B 5(2015), 2, Seite 123-128 volume:5 year:2015 number:2 pages:123-128
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topic_facet	Bile acids Cholangiocytes Receptors Signaling Therapeutics. Pharmacology
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container_title	Acta Pharmaceutica Sinica B
authorswithroles_txt_mv	Hannah Jones @@aut@@ Gianfranco Alpini @@aut@@ Heather Francis @@aut@@
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author	Hannah Jones
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topic_title	RM1-950 Bile acid signaling and biliary functions Bile acids Cholangiocytes Receptors Signaling
topic	misc RM1-950 misc Bile acids misc Cholangiocytes misc Receptors misc Signaling misc Therapeutics. Pharmacology
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title	Bile acid signaling and biliary functions
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title_full	Bile acid signaling and biliary functions
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title_sort	bile acid signaling and biliary functions
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title_auth	Bile acid signaling and biliary functions
abstract	This review focuses on various components of bile acid signaling in relation to cholangiocytes. Their roles as targets for potential therapies for cholangiopathies are also explored. While many factors are involved in these complex signaling pathways, this review emphasizes the roles of transmembrane G protein coupled receptor (TGR5), farnesoid X receptor (FXR), ursodeoxycholic acid (UDCA) and the bicarbonate umbrella. Following a general background on cholangiocytes and bile acids, we will expand the review and include sections that are most recently known (within 5–7 years) regarding the field of bile acid signaling and cholangiocyte function. These findings all demonstrate that bile acids influence biliary functions which can, in turn, regulate the cholangiocyte response during pathological events.
abstractGer	This review focuses on various components of bile acid signaling in relation to cholangiocytes. Their roles as targets for potential therapies for cholangiopathies are also explored. While many factors are involved in these complex signaling pathways, this review emphasizes the roles of transmembrane G protein coupled receptor (TGR5), farnesoid X receptor (FXR), ursodeoxycholic acid (UDCA) and the bicarbonate umbrella. Following a general background on cholangiocytes and bile acids, we will expand the review and include sections that are most recently known (within 5–7 years) regarding the field of bile acid signaling and cholangiocyte function. These findings all demonstrate that bile acids influence biliary functions which can, in turn, regulate the cholangiocyte response during pathological events.
abstract_unstemmed	This review focuses on various components of bile acid signaling in relation to cholangiocytes. Their roles as targets for potential therapies for cholangiopathies are also explored. While many factors are involved in these complex signaling pathways, this review emphasizes the roles of transmembrane G protein coupled receptor (TGR5), farnesoid X receptor (FXR), ursodeoxycholic acid (UDCA) and the bicarbonate umbrella. Following a general background on cholangiocytes and bile acids, we will expand the review and include sections that are most recently known (within 5–7 years) regarding the field of bile acid signaling and cholangiocyte function. These findings all demonstrate that bile acids influence biliary functions which can, in turn, regulate the cholangiocyte response during pathological events.
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title_short	Bile acid signaling and biliary functions
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