Co-Infection of Oral <i<Candida albicans</i< and <i<Porphyromonas gingivalis</i< Is Associated with Active Periodontitis in Middle-Aged and Older Japanese People

<i<Background and Objectives: Candida albicans</i< can be detected in subgingival sites of patients with periodontitis. However, the association between oral <i<Candida albicans</i< and periodontitis has not been fully elucidated in Japanese adults. The aim of this study is to clarify the relationship between oral <i<Candida albicans</i< infection/co-infection of oral <i<C. albicans</i< and <i<Porphyromonas gingivalis</i< and periodontitis among middle-aged and older Japanese people. <i<Materials and Methods:</i< Eighty-six patients (mean age 70.4 years) who visited the Hiroshima University Hospital from April to September 2021 were investigated in this study. Oral swab samples were collected from the tongue surface. <i<C. albicans</i< and <i<P. gingivalis</i< DNA was detected by real-time PCR using specific DNA primer sets. <i<C. albicans</i<-positive participants were classified into two groups according to the presence or absence of intron insertion of <i<C. albicans</i< DNA by PCR analysis. <i<Results: C. albicans</i< was detected in 22 (25.6%) of the 86 patients. Patients in their 80s recorded a higher <i<C. albicans</i<-positive rate (35.3%) compared with other participants. However, there was no significant association between the <i<C. albicans</i< positivity rate and clinical parameters such as sex, age, systemic disease, denture use, or oral health status. Of the 22 <i<C. albicans</i<-positive participants, 10 participants (45.5%) had <i<C. albicans</i< with intron insertion; 70% of participants who had <i<C. albicans</i< with intron insertion exhibited ≥6 mm probing depth. <i<C. albicans</i</<i<P. gingivalis</i< co-infection was found in 12 patients (14%). Importantly, binomial logistic regression analysis revealed that <i<C. albicans</i</<i<P. gingivalis</i< co-infection was significantly associated with ≥6 mm periodontal pockets with bleeding on probing (<i<p</i< = 0.02). <i<Conclusions:</i< Co-infection of <i<C. albicans</i< and <i<P. gingivalis</i< is involved in active periodontitis in middle-aged and older people. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Iori Oka [verfasserIn] Hideo Shigeishi [verfasserIn] Kouji Ohta [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	periodontitis polymerase chain reaction

Übergeordnetes Werk:	In: Medicina - MDPI AG, 2016, 58(2022), 6, p 723
Übergeordnetes Werk:	volume:58 ; year:2022 ; number:6, p 723

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/medicina58060723

Katalog-ID:	DOAJ04253951X

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520			\|a <i<Background and Objectives: Candida albicans</i< can be detected in subgingival sites of patients with periodontitis. However, the association between oral <i<Candida albicans</i< and periodontitis has not been fully elucidated in Japanese adults. The aim of this study is to clarify the relationship between oral <i<Candida albicans</i< infection/co-infection of oral <i<C. albicans</i< and <i<Porphyromonas gingivalis</i< and periodontitis among middle-aged and older Japanese people. <i<Materials and Methods:</i< Eighty-six patients (mean age 70.4 years) who visited the Hiroshima University Hospital from April to September 2021 were investigated in this study. Oral swab samples were collected from the tongue surface. <i<C. albicans</i< and <i<P. gingivalis</i< DNA was detected by real-time PCR using specific DNA primer sets. <i<C. albicans</i<-positive participants were classified into two groups according to the presence or absence of intron insertion of <i<C. albicans</i< DNA by PCR analysis. <i<Results: C. albicans</i< was detected in 22 (25.6%) of the 86 patients. Patients in their 80s recorded a higher <i<C. albicans</i<-positive rate (35.3%) compared with other participants. However, there was no significant association between the <i<C. albicans</i< positivity rate and clinical parameters such as sex, age, systemic disease, denture use, or oral health status. Of the 22 <i<C. albicans</i<-positive participants, 10 participants (45.5%) had <i<C. albicans</i< with intron insertion; 70% of participants who had <i<C. albicans</i< with intron insertion exhibited ≥6 mm probing depth. <i<C. albicans</i</<i<P. gingivalis</i< co-infection was found in 12 patients (14%). Importantly, binomial logistic regression analysis revealed that <i<C. albicans</i</<i<P. gingivalis</i< co-infection was significantly associated with ≥6 mm periodontal pockets with bleeding on probing (<i<p</i< = 0.02). <i<Conclusions:</i< Co-infection of <i<C. albicans</i< and <i<P. gingivalis</i< is involved in active periodontitis in middle-aged and older people.
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matchkey_str	article:16489144:2022----::onetoooaiaddabcniniopyooagniaiissoitdihcieeidnii
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allfields	10.3390/medicina58060723 doi (DE-627)DOAJ04253951X (DE-599)DOAJaf17793bc0044e54a73c94352f773d50 DE-627 ger DE-627 rakwb eng R5-920 Iori Oka verfasserin aut Co-Infection of Oral <i<Candida albicans</i< and <i<Porphyromonas gingivalis</i< Is Associated with Active Periodontitis in Middle-Aged and Older Japanese People 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Background and Objectives: Candida albicans</i< can be detected in subgingival sites of patients with periodontitis. However, the association between oral <i<Candida albicans</i< and periodontitis has not been fully elucidated in Japanese adults. The aim of this study is to clarify the relationship between oral <i<Candida albicans</i< infection/co-infection of oral <i<C. albicans</i< and <i<Porphyromonas gingivalis</i< and periodontitis among middle-aged and older Japanese people. <i<Materials and Methods:</i< Eighty-six patients (mean age 70.4 years) who visited the Hiroshima University Hospital from April to September 2021 were investigated in this study. Oral swab samples were collected from the tongue surface. <i<C. albicans</i< and <i<P. gingivalis</i< DNA was detected by real-time PCR using specific DNA primer sets. <i<C. albicans</i<-positive participants were classified into two groups according to the presence or absence of intron insertion of <i<C. albicans</i< DNA by PCR analysis. <i<Results: C. albicans</i< was detected in 22 (25.6%) of the 86 patients. Patients in their 80s recorded a higher <i<C. albicans</i<-positive rate (35.3%) compared with other participants. However, there was no significant association between the <i<C. albicans</i< positivity rate and clinical parameters such as sex, age, systemic disease, denture use, or oral health status. Of the 22 <i<C. albicans</i<-positive participants, 10 participants (45.5%) had <i<C. albicans</i< with intron insertion; 70% of participants who had <i<C. albicans</i< with intron insertion exhibited ≥6 mm probing depth. <i<C. albicans</i</<i<P. gingivalis</i< co-infection was found in 12 patients (14%). Importantly, binomial logistic regression analysis revealed that <i<C. albicans</i</<i<P. gingivalis</i< co-infection was significantly associated with ≥6 mm periodontal pockets with bleeding on probing (<i<p</i< = 0.02). <i<Conclusions:</i< Co-infection of <i<C. albicans</i< and <i<P. gingivalis</i< is involved in active periodontitis in middle-aged and older people. <i<Candida albicans</i< <i<Porphyromonas gingivalis</i< periodontitis polymerase chain reaction Medicine (General) Hideo Shigeishi verfasserin aut Kouji Ohta verfasserin aut In Medicina MDPI AG, 2016 58(2022), 6, p 723 (DE-627)354543296 (DE-600)2088820-X 16489144 nnns volume:58 year:2022 number:6, p 723 https://doi.org/10.3390/medicina58060723 kostenfrei https://doaj.org/article/af17793bc0044e54a73c94352f773d50 kostenfrei https://www.mdpi.com/1648-9144/58/6/723 kostenfrei https://doaj.org/toc/1010-660X Journal toc kostenfrei https://doaj.org/toc/1648-9144 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 58 2022 6, p 723
spelling	10.3390/medicina58060723 doi (DE-627)DOAJ04253951X (DE-599)DOAJaf17793bc0044e54a73c94352f773d50 DE-627 ger DE-627 rakwb eng R5-920 Iori Oka verfasserin aut Co-Infection of Oral <i<Candida albicans</i< and <i<Porphyromonas gingivalis</i< Is Associated with Active Periodontitis in Middle-Aged and Older Japanese People 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Background and Objectives: Candida albicans</i< can be detected in subgingival sites of patients with periodontitis. However, the association between oral <i<Candida albicans</i< and periodontitis has not been fully elucidated in Japanese adults. The aim of this study is to clarify the relationship between oral <i<Candida albicans</i< infection/co-infection of oral <i<C. albicans</i< and <i<Porphyromonas gingivalis</i< and periodontitis among middle-aged and older Japanese people. <i<Materials and Methods:</i< Eighty-six patients (mean age 70.4 years) who visited the Hiroshima University Hospital from April to September 2021 were investigated in this study. Oral swab samples were collected from the tongue surface. <i<C. albicans</i< and <i<P. gingivalis</i< DNA was detected by real-time PCR using specific DNA primer sets. <i<C. albicans</i<-positive participants were classified into two groups according to the presence or absence of intron insertion of <i<C. albicans</i< DNA by PCR analysis. <i<Results: C. albicans</i< was detected in 22 (25.6%) of the 86 patients. Patients in their 80s recorded a higher <i<C. albicans</i<-positive rate (35.3%) compared with other participants. However, there was no significant association between the <i<C. albicans</i< positivity rate and clinical parameters such as sex, age, systemic disease, denture use, or oral health status. Of the 22 <i<C. albicans</i<-positive participants, 10 participants (45.5%) had <i<C. albicans</i< with intron insertion; 70% of participants who had <i<C. albicans</i< with intron insertion exhibited ≥6 mm probing depth. <i<C. albicans</i</<i<P. gingivalis</i< co-infection was found in 12 patients (14%). Importantly, binomial logistic regression analysis revealed that <i<C. albicans</i</<i<P. gingivalis</i< co-infection was significantly associated with ≥6 mm periodontal pockets with bleeding on probing (<i<p</i< = 0.02). <i<Conclusions:</i< Co-infection of <i<C. albicans</i< and <i<P. gingivalis</i< is involved in active periodontitis in middle-aged and older people. <i<Candida albicans</i< <i<Porphyromonas gingivalis</i< periodontitis polymerase chain reaction Medicine (General) Hideo Shigeishi verfasserin aut Kouji Ohta verfasserin aut In Medicina MDPI AG, 2016 58(2022), 6, p 723 (DE-627)354543296 (DE-600)2088820-X 16489144 nnns volume:58 year:2022 number:6, p 723 https://doi.org/10.3390/medicina58060723 kostenfrei https://doaj.org/article/af17793bc0044e54a73c94352f773d50 kostenfrei https://www.mdpi.com/1648-9144/58/6/723 kostenfrei https://doaj.org/toc/1010-660X Journal toc kostenfrei https://doaj.org/toc/1648-9144 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 58 2022 6, p 723
allfields_unstemmed	10.3390/medicina58060723 doi (DE-627)DOAJ04253951X (DE-599)DOAJaf17793bc0044e54a73c94352f773d50 DE-627 ger DE-627 rakwb eng R5-920 Iori Oka verfasserin aut Co-Infection of Oral <i<Candida albicans</i< and <i<Porphyromonas gingivalis</i< Is Associated with Active Periodontitis in Middle-Aged and Older Japanese People 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Background and Objectives: Candida albicans</i< can be detected in subgingival sites of patients with periodontitis. However, the association between oral <i<Candida albicans</i< and periodontitis has not been fully elucidated in Japanese adults. The aim of this study is to clarify the relationship between oral <i<Candida albicans</i< infection/co-infection of oral <i<C. albicans</i< and <i<Porphyromonas gingivalis</i< and periodontitis among middle-aged and older Japanese people. <i<Materials and Methods:</i< Eighty-six patients (mean age 70.4 years) who visited the Hiroshima University Hospital from April to September 2021 were investigated in this study. Oral swab samples were collected from the tongue surface. <i<C. albicans</i< and <i<P. gingivalis</i< DNA was detected by real-time PCR using specific DNA primer sets. <i<C. albicans</i<-positive participants were classified into two groups according to the presence or absence of intron insertion of <i<C. albicans</i< DNA by PCR analysis. <i<Results: C. albicans</i< was detected in 22 (25.6%) of the 86 patients. Patients in their 80s recorded a higher <i<C. albicans</i<-positive rate (35.3%) compared with other participants. However, there was no significant association between the <i<C. albicans</i< positivity rate and clinical parameters such as sex, age, systemic disease, denture use, or oral health status. Of the 22 <i<C. albicans</i<-positive participants, 10 participants (45.5%) had <i<C. albicans</i< with intron insertion; 70% of participants who had <i<C. albicans</i< with intron insertion exhibited ≥6 mm probing depth. <i<C. albicans</i</<i<P. gingivalis</i< co-infection was found in 12 patients (14%). Importantly, binomial logistic regression analysis revealed that <i<C. albicans</i</<i<P. gingivalis</i< co-infection was significantly associated with ≥6 mm periodontal pockets with bleeding on probing (<i<p</i< = 0.02). <i<Conclusions:</i< Co-infection of <i<C. albicans</i< and <i<P. gingivalis</i< is involved in active periodontitis in middle-aged and older people. <i<Candida albicans</i< <i<Porphyromonas gingivalis</i< periodontitis polymerase chain reaction Medicine (General) Hideo Shigeishi verfasserin aut Kouji Ohta verfasserin aut In Medicina MDPI AG, 2016 58(2022), 6, p 723 (DE-627)354543296 (DE-600)2088820-X 16489144 nnns volume:58 year:2022 number:6, p 723 https://doi.org/10.3390/medicina58060723 kostenfrei https://doaj.org/article/af17793bc0044e54a73c94352f773d50 kostenfrei https://www.mdpi.com/1648-9144/58/6/723 kostenfrei https://doaj.org/toc/1010-660X Journal toc kostenfrei https://doaj.org/toc/1648-9144 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 58 2022 6, p 723
allfieldsGer	10.3390/medicina58060723 doi (DE-627)DOAJ04253951X (DE-599)DOAJaf17793bc0044e54a73c94352f773d50 DE-627 ger DE-627 rakwb eng R5-920 Iori Oka verfasserin aut Co-Infection of Oral <i<Candida albicans</i< and <i<Porphyromonas gingivalis</i< Is Associated with Active Periodontitis in Middle-Aged and Older Japanese People 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Background and Objectives: Candida albicans</i< can be detected in subgingival sites of patients with periodontitis. However, the association between oral <i<Candida albicans</i< and periodontitis has not been fully elucidated in Japanese adults. The aim of this study is to clarify the relationship between oral <i<Candida albicans</i< infection/co-infection of oral <i<C. albicans</i< and <i<Porphyromonas gingivalis</i< and periodontitis among middle-aged and older Japanese people. <i<Materials and Methods:</i< Eighty-six patients (mean age 70.4 years) who visited the Hiroshima University Hospital from April to September 2021 were investigated in this study. Oral swab samples were collected from the tongue surface. <i<C. albicans</i< and <i<P. gingivalis</i< DNA was detected by real-time PCR using specific DNA primer sets. <i<C. albicans</i<-positive participants were classified into two groups according to the presence or absence of intron insertion of <i<C. albicans</i< DNA by PCR analysis. <i<Results: C. albicans</i< was detected in 22 (25.6%) of the 86 patients. Patients in their 80s recorded a higher <i<C. albicans</i<-positive rate (35.3%) compared with other participants. However, there was no significant association between the <i<C. albicans</i< positivity rate and clinical parameters such as sex, age, systemic disease, denture use, or oral health status. Of the 22 <i<C. albicans</i<-positive participants, 10 participants (45.5%) had <i<C. albicans</i< with intron insertion; 70% of participants who had <i<C. albicans</i< with intron insertion exhibited ≥6 mm probing depth. <i<C. albicans</i</<i<P. gingivalis</i< co-infection was found in 12 patients (14%). Importantly, binomial logistic regression analysis revealed that <i<C. albicans</i</<i<P. gingivalis</i< co-infection was significantly associated with ≥6 mm periodontal pockets with bleeding on probing (<i<p</i< = 0.02). <i<Conclusions:</i< Co-infection of <i<C. albicans</i< and <i<P. gingivalis</i< is involved in active periodontitis in middle-aged and older people. <i<Candida albicans</i< <i<Porphyromonas gingivalis</i< periodontitis polymerase chain reaction Medicine (General) Hideo Shigeishi verfasserin aut Kouji Ohta verfasserin aut In Medicina MDPI AG, 2016 58(2022), 6, p 723 (DE-627)354543296 (DE-600)2088820-X 16489144 nnns volume:58 year:2022 number:6, p 723 https://doi.org/10.3390/medicina58060723 kostenfrei https://doaj.org/article/af17793bc0044e54a73c94352f773d50 kostenfrei https://www.mdpi.com/1648-9144/58/6/723 kostenfrei https://doaj.org/toc/1010-660X Journal toc kostenfrei https://doaj.org/toc/1648-9144 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 58 2022 6, p 723
allfieldsSound	10.3390/medicina58060723 doi (DE-627)DOAJ04253951X (DE-599)DOAJaf17793bc0044e54a73c94352f773d50 DE-627 ger DE-627 rakwb eng R5-920 Iori Oka verfasserin aut Co-Infection of Oral <i<Candida albicans</i< and <i<Porphyromonas gingivalis</i< Is Associated with Active Periodontitis in Middle-Aged and Older Japanese People 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Background and Objectives: Candida albicans</i< can be detected in subgingival sites of patients with periodontitis. However, the association between oral <i<Candida albicans</i< and periodontitis has not been fully elucidated in Japanese adults. The aim of this study is to clarify the relationship between oral <i<Candida albicans</i< infection/co-infection of oral <i<C. albicans</i< and <i<Porphyromonas gingivalis</i< and periodontitis among middle-aged and older Japanese people. <i<Materials and Methods:</i< Eighty-six patients (mean age 70.4 years) who visited the Hiroshima University Hospital from April to September 2021 were investigated in this study. Oral swab samples were collected from the tongue surface. <i<C. albicans</i< and <i<P. gingivalis</i< DNA was detected by real-time PCR using specific DNA primer sets. <i<C. albicans</i<-positive participants were classified into two groups according to the presence or absence of intron insertion of <i<C. albicans</i< DNA by PCR analysis. <i<Results: C. albicans</i< was detected in 22 (25.6%) of the 86 patients. Patients in their 80s recorded a higher <i<C. albicans</i<-positive rate (35.3%) compared with other participants. However, there was no significant association between the <i<C. albicans</i< positivity rate and clinical parameters such as sex, age, systemic disease, denture use, or oral health status. Of the 22 <i<C. albicans</i<-positive participants, 10 participants (45.5%) had <i<C. albicans</i< with intron insertion; 70% of participants who had <i<C. albicans</i< with intron insertion exhibited ≥6 mm probing depth. <i<C. albicans</i</<i<P. gingivalis</i< co-infection was found in 12 patients (14%). Importantly, binomial logistic regression analysis revealed that <i<C. albicans</i</<i<P. gingivalis</i< co-infection was significantly associated with ≥6 mm periodontal pockets with bleeding on probing (<i<p</i< = 0.02). <i<Conclusions:</i< Co-infection of <i<C. albicans</i< and <i<P. gingivalis</i< is involved in active periodontitis in middle-aged and older people. <i<Candida albicans</i< <i<Porphyromonas gingivalis</i< periodontitis polymerase chain reaction Medicine (General) Hideo Shigeishi verfasserin aut Kouji Ohta verfasserin aut In Medicina MDPI AG, 2016 58(2022), 6, p 723 (DE-627)354543296 (DE-600)2088820-X 16489144 nnns volume:58 year:2022 number:6, p 723 https://doi.org/10.3390/medicina58060723 kostenfrei https://doaj.org/article/af17793bc0044e54a73c94352f773d50 kostenfrei https://www.mdpi.com/1648-9144/58/6/723 kostenfrei https://doaj.org/toc/1010-660X Journal toc kostenfrei https://doaj.org/toc/1648-9144 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 58 2022 6, p 723
language	English
source	In Medicina 58(2022), 6, p 723 volume:58 year:2022 number:6, p 723
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authorswithroles_txt_mv	Iori Oka @@aut@@ Hideo Shigeishi @@aut@@ Kouji Ohta @@aut@@
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topic_title	R5-920 Co-Infection of Oral <i<Candida albicans</i< and <i<Porphyromonas gingivalis</i< Is Associated with Active Periodontitis in Middle-Aged and Older Japanese People <i<Candida albicans</i< <i<Porphyromonas gingivalis</i< periodontitis polymerase chain reaction
topic	misc R5-920 misc <i<Candida albicans</i< misc <i<Porphyromonas gingivalis</i< misc periodontitis misc polymerase chain reaction misc Medicine (General)
topic_unstemmed	misc R5-920 misc <i<Candida albicans</i< misc <i<Porphyromonas gingivalis</i< misc periodontitis misc polymerase chain reaction misc Medicine (General)
topic_browse	misc R5-920 misc <i<Candida albicans</i< misc <i<Porphyromonas gingivalis</i< misc periodontitis misc polymerase chain reaction misc Medicine (General)
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title	Co-Infection of Oral <i<Candida albicans</i< and <i<Porphyromonas gingivalis</i< Is Associated with Active Periodontitis in Middle-Aged and Older Japanese People
ctrlnum	(DE-627)DOAJ04253951X (DE-599)DOAJaf17793bc0044e54a73c94352f773d50
title_full	Co-Infection of Oral <i<Candida albicans</i< and <i<Porphyromonas gingivalis</i< Is Associated with Active Periodontitis in Middle-Aged and Older Japanese People
author_sort	Iori Oka
journal	Medicina
journalStr	Medicina
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lang_code	eng
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author_browse	Iori Oka Hideo Shigeishi Kouji Ohta
container_volume	58
class	R5-920
format_se	Elektronische Aufsätze
author-letter	Iori Oka
doi_str_mv	10.3390/medicina58060723
author2-role	verfasserin
title_sort	co-infection of oral <i<candida albicans</i< and <i<porphyromonas gingivalis</i< is associated with active periodontitis in middle-aged and older japanese people
callnumber	R5-920
title_auth	Co-Infection of Oral <i<Candida albicans</i< and <i<Porphyromonas gingivalis</i< Is Associated with Active Periodontitis in Middle-Aged and Older Japanese People
abstract	<i<Background and Objectives: Candida albicans</i< can be detected in subgingival sites of patients with periodontitis. However, the association between oral <i<Candida albicans</i< and periodontitis has not been fully elucidated in Japanese adults. The aim of this study is to clarify the relationship between oral <i<Candida albicans</i< infection/co-infection of oral <i<C. albicans</i< and <i<Porphyromonas gingivalis</i< and periodontitis among middle-aged and older Japanese people. <i<Materials and Methods:</i< Eighty-six patients (mean age 70.4 years) who visited the Hiroshima University Hospital from April to September 2021 were investigated in this study. Oral swab samples were collected from the tongue surface. <i<C. albicans</i< and <i<P. gingivalis</i< DNA was detected by real-time PCR using specific DNA primer sets. <i<C. albicans</i<-positive participants were classified into two groups according to the presence or absence of intron insertion of <i<C. albicans</i< DNA by PCR analysis. <i<Results: C. albicans</i< was detected in 22 (25.6%) of the 86 patients. Patients in their 80s recorded a higher <i<C. albicans</i<-positive rate (35.3%) compared with other participants. However, there was no significant association between the <i<C. albicans</i< positivity rate and clinical parameters such as sex, age, systemic disease, denture use, or oral health status. Of the 22 <i<C. albicans</i<-positive participants, 10 participants (45.5%) had <i<C. albicans</i< with intron insertion; 70% of participants who had <i<C. albicans</i< with intron insertion exhibited ≥6 mm probing depth. <i<C. albicans</i</<i<P. gingivalis</i< co-infection was found in 12 patients (14%). Importantly, binomial logistic regression analysis revealed that <i<C. albicans</i</<i<P. gingivalis</i< co-infection was significantly associated with ≥6 mm periodontal pockets with bleeding on probing (<i<p</i< = 0.02). <i<Conclusions:</i< Co-infection of <i<C. albicans</i< and <i<P. gingivalis</i< is involved in active periodontitis in middle-aged and older people.
abstractGer	<i<Background and Objectives: Candida albicans</i< can be detected in subgingival sites of patients with periodontitis. However, the association between oral <i<Candida albicans</i< and periodontitis has not been fully elucidated in Japanese adults. The aim of this study is to clarify the relationship between oral <i<Candida albicans</i< infection/co-infection of oral <i<C. albicans</i< and <i<Porphyromonas gingivalis</i< and periodontitis among middle-aged and older Japanese people. <i<Materials and Methods:</i< Eighty-six patients (mean age 70.4 years) who visited the Hiroshima University Hospital from April to September 2021 were investigated in this study. Oral swab samples were collected from the tongue surface. <i<C. albicans</i< and <i<P. gingivalis</i< DNA was detected by real-time PCR using specific DNA primer sets. <i<C. albicans</i<-positive participants were classified into two groups according to the presence or absence of intron insertion of <i<C. albicans</i< DNA by PCR analysis. <i<Results: C. albicans</i< was detected in 22 (25.6%) of the 86 patients. Patients in their 80s recorded a higher <i<C. albicans</i<-positive rate (35.3%) compared with other participants. However, there was no significant association between the <i<C. albicans</i< positivity rate and clinical parameters such as sex, age, systemic disease, denture use, or oral health status. Of the 22 <i<C. albicans</i<-positive participants, 10 participants (45.5%) had <i<C. albicans</i< with intron insertion; 70% of participants who had <i<C. albicans</i< with intron insertion exhibited ≥6 mm probing depth. <i<C. albicans</i</<i<P. gingivalis</i< co-infection was found in 12 patients (14%). Importantly, binomial logistic regression analysis revealed that <i<C. albicans</i</<i<P. gingivalis</i< co-infection was significantly associated with ≥6 mm periodontal pockets with bleeding on probing (<i<p</i< = 0.02). <i<Conclusions:</i< Co-infection of <i<C. albicans</i< and <i<P. gingivalis</i< is involved in active periodontitis in middle-aged and older people.
abstract_unstemmed	<i<Background and Objectives: Candida albicans</i< can be detected in subgingival sites of patients with periodontitis. However, the association between oral <i<Candida albicans</i< and periodontitis has not been fully elucidated in Japanese adults. The aim of this study is to clarify the relationship between oral <i<Candida albicans</i< infection/co-infection of oral <i<C. albicans</i< and <i<Porphyromonas gingivalis</i< and periodontitis among middle-aged and older Japanese people. <i<Materials and Methods:</i< Eighty-six patients (mean age 70.4 years) who visited the Hiroshima University Hospital from April to September 2021 were investigated in this study. Oral swab samples were collected from the tongue surface. <i<C. albicans</i< and <i<P. gingivalis</i< DNA was detected by real-time PCR using specific DNA primer sets. <i<C. albicans</i<-positive participants were classified into two groups according to the presence or absence of intron insertion of <i<C. albicans</i< DNA by PCR analysis. <i<Results: C. albicans</i< was detected in 22 (25.6%) of the 86 patients. Patients in their 80s recorded a higher <i<C. albicans</i<-positive rate (35.3%) compared with other participants. However, there was no significant association between the <i<C. albicans</i< positivity rate and clinical parameters such as sex, age, systemic disease, denture use, or oral health status. Of the 22 <i<C. albicans</i<-positive participants, 10 participants (45.5%) had <i<C. albicans</i< with intron insertion; 70% of participants who had <i<C. albicans</i< with intron insertion exhibited ≥6 mm probing depth. <i<C. albicans</i</<i<P. gingivalis</i< co-infection was found in 12 patients (14%). Importantly, binomial logistic regression analysis revealed that <i<C. albicans</i</<i<P. gingivalis</i< co-infection was significantly associated with ≥6 mm periodontal pockets with bleeding on probing (<i<p</i< = 0.02). <i<Conclusions:</i< Co-infection of <i<C. albicans</i< and <i<P. gingivalis</i< is involved in active periodontitis in middle-aged and older people.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
container_issue	6, p 723
title_short	Co-Infection of Oral <i<Candida albicans</i< and <i<Porphyromonas gingivalis</i< Is Associated with Active Periodontitis in Middle-Aged and Older Japanese People
url	https://doi.org/10.3390/medicina58060723 https://doaj.org/article/af17793bc0044e54a73c94352f773d50 https://www.mdpi.com/1648-9144/58/6/723 https://doaj.org/toc/1010-660X https://doaj.org/toc/1648-9144
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author2	Hideo Shigeishi Kouji Ohta
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up_date	2024-07-04T01:20:23.175Z
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