A comprehensive study of phospholipid fatty acid rearrangements in metabolic syndrome: correlations with organ dysfunction

The balance within phospholipids (PLs) between saturated fatty acids and monounsaturated or polyunsaturated fatty acids is known to regulate the biophysical properties of cellular membranes. As a consequence, in many cell types, perturbing this balance alters crucial cellular processes, such as vesi...
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Autor*in:	Amélie Bacle [verfasserIn] Linette Kadri [verfasserIn] Spiro Khoury [verfasserIn] Romain Ferru-Clément [verfasserIn] Jean-François Faivre [verfasserIn] Christian Cognard [verfasserIn] Jocelyn Bescond [verfasserIn] Amandine Krzesiak [verfasserIn] Hugo Contzler [verfasserIn] Nathalie Delpech [verfasserIn] Jenny Colas [verfasserIn] Clarisse Vandebrouck [verfasserIn] Stéphane Sébille [verfasserIn] Thierry Ferreira [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	saturated fat phospholipids type 2 diabetes cardiovascular disease hepatic steatosis polyunsaturated fatty acids

Übergeordnetes Werk:	In: Disease Models & Mechanisms - The Company of Biologists, 2011, 13(2020), 6
Übergeordnetes Werk:	volume:13 ; year:2020 ; number:6

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1242/dmm.043927

Katalog-ID:	DOAJ042603943

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spelling	10.1242/dmm.043927 doi (DE-627)DOAJ042603943 (DE-599)DOAJa344f484cf76454994b222c29cf0b056 DE-627 ger DE-627 rakwb eng RB1-214 Amélie Bacle verfasserin aut A comprehensive study of phospholipid fatty acid rearrangements in metabolic syndrome: correlations with organ dysfunction 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The balance within phospholipids (PLs) between saturated fatty acids and monounsaturated or polyunsaturated fatty acids is known to regulate the biophysical properties of cellular membranes. As a consequence, in many cell types, perturbing this balance alters crucial cellular processes, such as vesicular budding and the trafficking/function of membrane-anchored proteins. The worldwide spread of the Western diet, which is highly enriched in saturated fats, has been clearly correlated with the emergence of a complex syndrome known as metabolic syndrome (MetS). MetS is defined as a cluster of risk factors for cardiovascular diseases, type 2 diabetes and hepatic steatosis; however, no clear correlations have been established between diet-induced fatty acid redistribution within cellular PLs and the severity/chronology of the symptoms associated with MetS or the function of the targeted organs. To address this issue, in this study we analyzed PL remodeling in rats exposed to a high-fat/high-fructose diet (HFHF) over a 15-week period. PL remodeling was analyzed in several organs, including known MetS targets. We show that fatty acids from the diet can redistribute within PLs in a very selective manner, with phosphatidylcholine being the preferred sink for this redistribution. Moreover, in the HFHF rat model, most organs are protected from this redistribution, at least during the early onset of MetS, at the expense of the liver and skeletal muscles. Interestingly, such a redistribution correlates with clear-cut alterations in the function of these organs. This article has an associated First Person interview with the first author of the paper. saturated fat phospholipids type 2 diabetes cardiovascular disease hepatic steatosis polyunsaturated fatty acids Medicine R Pathology Linette Kadri verfasserin aut Spiro Khoury verfasserin aut Romain Ferru-Clément verfasserin aut Jean-François Faivre verfasserin aut Christian Cognard verfasserin aut Jocelyn Bescond verfasserin aut Amandine Krzesiak verfasserin aut Hugo Contzler verfasserin aut Nathalie Delpech verfasserin aut Jenny Colas verfasserin aut Clarisse Vandebrouck verfasserin aut Stéphane Sébille verfasserin aut Thierry Ferreira verfasserin aut In Disease Models & Mechanisms The Company of Biologists, 2011 13(2020), 6 (DE-627)578531917 (DE-600)2451104-3 17548411 nnns volume:13 year:2020 number:6 https://doi.org/10.1242/dmm.043927 kostenfrei https://doaj.org/article/a344f484cf76454994b222c29cf0b056 kostenfrei http://dmm.biologists.org/content/13/6/dmm043927 kostenfrei https://doaj.org/toc/1754-8403 Journal toc kostenfrei https://doaj.org/toc/1754-8411 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2020 6
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allfieldsSound	10.1242/dmm.043927 doi (DE-627)DOAJ042603943 (DE-599)DOAJa344f484cf76454994b222c29cf0b056 DE-627 ger DE-627 rakwb eng RB1-214 Amélie Bacle verfasserin aut A comprehensive study of phospholipid fatty acid rearrangements in metabolic syndrome: correlations with organ dysfunction 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The balance within phospholipids (PLs) between saturated fatty acids and monounsaturated or polyunsaturated fatty acids is known to regulate the biophysical properties of cellular membranes. As a consequence, in many cell types, perturbing this balance alters crucial cellular processes, such as vesicular budding and the trafficking/function of membrane-anchored proteins. The worldwide spread of the Western diet, which is highly enriched in saturated fats, has been clearly correlated with the emergence of a complex syndrome known as metabolic syndrome (MetS). MetS is defined as a cluster of risk factors for cardiovascular diseases, type 2 diabetes and hepatic steatosis; however, no clear correlations have been established between diet-induced fatty acid redistribution within cellular PLs and the severity/chronology of the symptoms associated with MetS or the function of the targeted organs. To address this issue, in this study we analyzed PL remodeling in rats exposed to a high-fat/high-fructose diet (HFHF) over a 15-week period. PL remodeling was analyzed in several organs, including known MetS targets. We show that fatty acids from the diet can redistribute within PLs in a very selective manner, with phosphatidylcholine being the preferred sink for this redistribution. Moreover, in the HFHF rat model, most organs are protected from this redistribution, at least during the early onset of MetS, at the expense of the liver and skeletal muscles. Interestingly, such a redistribution correlates with clear-cut alterations in the function of these organs. This article has an associated First Person interview with the first author of the paper. saturated fat phospholipids type 2 diabetes cardiovascular disease hepatic steatosis polyunsaturated fatty acids Medicine R Pathology Linette Kadri verfasserin aut Spiro Khoury verfasserin aut Romain Ferru-Clément verfasserin aut Jean-François Faivre verfasserin aut Christian Cognard verfasserin aut Jocelyn Bescond verfasserin aut Amandine Krzesiak verfasserin aut Hugo Contzler verfasserin aut Nathalie Delpech verfasserin aut Jenny Colas verfasserin aut Clarisse Vandebrouck verfasserin aut Stéphane Sébille verfasserin aut Thierry Ferreira verfasserin aut In Disease Models & Mechanisms The Company of Biologists, 2011 13(2020), 6 (DE-627)578531917 (DE-600)2451104-3 17548411 nnns volume:13 year:2020 number:6 https://doi.org/10.1242/dmm.043927 kostenfrei https://doaj.org/article/a344f484cf76454994b222c29cf0b056 kostenfrei http://dmm.biologists.org/content/13/6/dmm043927 kostenfrei https://doaj.org/toc/1754-8403 Journal toc kostenfrei https://doaj.org/toc/1754-8411 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2020 6
language	English
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author	Amélie Bacle
spellingShingle	Amélie Bacle misc RB1-214 misc saturated fat misc phospholipids misc type 2 diabetes misc cardiovascular disease misc hepatic steatosis misc polyunsaturated fatty acids misc Medicine misc R misc Pathology A comprehensive study of phospholipid fatty acid rearrangements in metabolic syndrome: correlations with organ dysfunction
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topic	misc RB1-214 misc saturated fat misc phospholipids misc type 2 diabetes misc cardiovascular disease misc hepatic steatosis misc polyunsaturated fatty acids misc Medicine misc R misc Pathology
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title_auth	A comprehensive study of phospholipid fatty acid rearrangements in metabolic syndrome: correlations with organ dysfunction
abstract	The balance within phospholipids (PLs) between saturated fatty acids and monounsaturated or polyunsaturated fatty acids is known to regulate the biophysical properties of cellular membranes. As a consequence, in many cell types, perturbing this balance alters crucial cellular processes, such as vesicular budding and the trafficking/function of membrane-anchored proteins. The worldwide spread of the Western diet, which is highly enriched in saturated fats, has been clearly correlated with the emergence of a complex syndrome known as metabolic syndrome (MetS). MetS is defined as a cluster of risk factors for cardiovascular diseases, type 2 diabetes and hepatic steatosis; however, no clear correlations have been established between diet-induced fatty acid redistribution within cellular PLs and the severity/chronology of the symptoms associated with MetS or the function of the targeted organs. To address this issue, in this study we analyzed PL remodeling in rats exposed to a high-fat/high-fructose diet (HFHF) over a 15-week period. PL remodeling was analyzed in several organs, including known MetS targets. We show that fatty acids from the diet can redistribute within PLs in a very selective manner, with phosphatidylcholine being the preferred sink for this redistribution. Moreover, in the HFHF rat model, most organs are protected from this redistribution, at least during the early onset of MetS, at the expense of the liver and skeletal muscles. Interestingly, such a redistribution correlates with clear-cut alterations in the function of these organs. This article has an associated First Person interview with the first author of the paper.
abstractGer	The balance within phospholipids (PLs) between saturated fatty acids and monounsaturated or polyunsaturated fatty acids is known to regulate the biophysical properties of cellular membranes. As a consequence, in many cell types, perturbing this balance alters crucial cellular processes, such as vesicular budding and the trafficking/function of membrane-anchored proteins. The worldwide spread of the Western diet, which is highly enriched in saturated fats, has been clearly correlated with the emergence of a complex syndrome known as metabolic syndrome (MetS). MetS is defined as a cluster of risk factors for cardiovascular diseases, type 2 diabetes and hepatic steatosis; however, no clear correlations have been established between diet-induced fatty acid redistribution within cellular PLs and the severity/chronology of the symptoms associated with MetS or the function of the targeted organs. To address this issue, in this study we analyzed PL remodeling in rats exposed to a high-fat/high-fructose diet (HFHF) over a 15-week period. PL remodeling was analyzed in several organs, including known MetS targets. We show that fatty acids from the diet can redistribute within PLs in a very selective manner, with phosphatidylcholine being the preferred sink for this redistribution. Moreover, in the HFHF rat model, most organs are protected from this redistribution, at least during the early onset of MetS, at the expense of the liver and skeletal muscles. Interestingly, such a redistribution correlates with clear-cut alterations in the function of these organs. This article has an associated First Person interview with the first author of the paper.
abstract_unstemmed	The balance within phospholipids (PLs) between saturated fatty acids and monounsaturated or polyunsaturated fatty acids is known to regulate the biophysical properties of cellular membranes. As a consequence, in many cell types, perturbing this balance alters crucial cellular processes, such as vesicular budding and the trafficking/function of membrane-anchored proteins. The worldwide spread of the Western diet, which is highly enriched in saturated fats, has been clearly correlated with the emergence of a complex syndrome known as metabolic syndrome (MetS). MetS is defined as a cluster of risk factors for cardiovascular diseases, type 2 diabetes and hepatic steatosis; however, no clear correlations have been established between diet-induced fatty acid redistribution within cellular PLs and the severity/chronology of the symptoms associated with MetS or the function of the targeted organs. To address this issue, in this study we analyzed PL remodeling in rats exposed to a high-fat/high-fructose diet (HFHF) over a 15-week period. PL remodeling was analyzed in several organs, including known MetS targets. We show that fatty acids from the diet can redistribute within PLs in a very selective manner, with phosphatidylcholine being the preferred sink for this redistribution. Moreover, in the HFHF rat model, most organs are protected from this redistribution, at least during the early onset of MetS, at the expense of the liver and skeletal muscles. Interestingly, such a redistribution correlates with clear-cut alterations in the function of these organs. This article has an associated First Person interview with the first author of the paper.
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title_short	A comprehensive study of phospholipid fatty acid rearrangements in metabolic syndrome: correlations with organ dysfunction
url	https://doi.org/10.1242/dmm.043927 https://doaj.org/article/a344f484cf76454994b222c29cf0b056 http://dmm.biologists.org/content/13/6/dmm043927 https://doaj.org/toc/1754-8403 https://doaj.org/toc/1754-8411
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author2	Linette Kadri Spiro Khoury Romain Ferru-Clément Jean-François Faivre Christian Cognard Jocelyn Bescond Amandine Krzesiak Hugo Contzler Nathalie Delpech Jenny Colas Clarisse Vandebrouck Stéphane Sébille Thierry Ferreira
author2Str	Linette Kadri Spiro Khoury Romain Ferru-Clément Jean-François Faivre Christian Cognard Jocelyn Bescond Amandine Krzesiak Hugo Contzler Nathalie Delpech Jenny Colas Clarisse Vandebrouck Stéphane Sébille Thierry Ferreira
ppnlink	578531917
callnumber-subject	RB - Pathology
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isOA_txt	true
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doi_str	10.1242/dmm.043927
callnumber-a	RB1-214
up_date	2024-07-04T01:34:42.954Z
_version_	1803610366102470656
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As a consequence, in many cell types, perturbing this balance alters crucial cellular processes, such as vesicular budding and the trafficking/function of membrane-anchored proteins. The worldwide spread of the Western diet, which is highly enriched in saturated fats, has been clearly correlated with the emergence of a complex syndrome known as metabolic syndrome (MetS). MetS is defined as a cluster of risk factors for cardiovascular diseases, type 2 diabetes and hepatic steatosis; however, no clear correlations have been established between diet-induced fatty acid redistribution within cellular PLs and the severity/chronology of the symptoms associated with MetS or the function of the targeted organs. To address this issue, in this study we analyzed PL remodeling in rats exposed to a high-fat/high-fructose diet (HFHF) over a 15-week period. PL remodeling was analyzed in several organs, including known MetS targets. We show that fatty acids from the diet can redistribute within PLs in a very selective manner, with phosphatidylcholine being the preferred sink for this redistribution. Moreover, in the HFHF rat model, most organs are protected from this redistribution, at least during the early onset of MetS, at the expense of the liver and skeletal muscles. Interestingly, such a redistribution correlates with clear-cut alterations in the function of these organs. 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A comprehensive study of phospholipid fatty acid rearrangements in metabolic syndrome: correlations with organ dysfunction

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