Is immunocytochemical determination of hormone receptors in breast cancer reliable?
Background: In breast cancer oestrogen receptor (ER) and progesterone receptor (PR) status can be determined by both immunohistochemistry performed on tissue biopsies and immunocytochemistry performed on fine needle aspirates. However, the reliability of immunocytochemistry as the basis for determin...
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| Autor*in: |
Dordi Lea [verfasserIn] Anna M Bofin [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Dänisch ; Norwegisch ; Schwedisch |
| Erschienen: |
2011 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Bioingeniøren - NITO - Bioingeniørfaglig institutt, 2022, 46(2011), 3, Seite 6-12 |
|---|---|
| Übergeordnetes Werk: |
volume:46 ; year:2011 ; number:3 ; pages:6-12 |
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DOAJ042697980 |
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| 520 | |a Background: In breast cancer oestrogen receptor (ER) and progesterone receptor (PR) status can be determined by both immunohistochemistry performed on tissue biopsies and immunocytochemistry performed on fine needle aspirates. However, the reliability of immunocytochemistry as the basis for determining treatment is still uncertain. Material and methods: The study comprised journal records of 612 breast cancer patients diagnosed between 2000 and 2005, all of whom had undergone fine needle aspiration. In 232 cases both immunocytochemistry and immunohistochemistry for hormone receptor status were performed. The results were compared and reasons for any discrepancies were elucidated. Results: There was full agreement for ER in 204/229 cases (Kappa value (ĸ) = 0.56) and for PR in 170/209 (ĸ = 0.68) cases. Sensitivity for ER was 89.4 % and the specificity was 87.5 %. Positive predictive value (PPV) was 97.1 % and negative predictive value (NPV) was 63.6 %. Sensitivity for PR was 78.3 % and specificity was 87.3 %. PPV was 92.3 % and NPV was 67.4 %. Conclusion: Immunocytochemistry for hormone receptors in fine needle aspiration smears is a reliable method in cases with positive immunostaining. In the case of negative immunostaining, examination with immunohistochemistry should be performed on tissue biopsies. Correct preparation of the cytological smear is vital for a successful result. | ||
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(DE-627)DOAJ042697980 (DE-599)DOAJ3afea6cd49a44b64a2c07ad3df3da1a2 DE-627 ger DE-627 rakwb dan nor swe Dordi Lea verfasserin aut Is immunocytochemical determination of hormone receptors in breast cancer reliable? 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: In breast cancer oestrogen receptor (ER) and progesterone receptor (PR) status can be determined by both immunohistochemistry performed on tissue biopsies and immunocytochemistry performed on fine needle aspirates. However, the reliability of immunocytochemistry as the basis for determining treatment is still uncertain. Material and methods: The study comprised journal records of 612 breast cancer patients diagnosed between 2000 and 2005, all of whom had undergone fine needle aspiration. In 232 cases both immunocytochemistry and immunohistochemistry for hormone receptor status were performed. The results were compared and reasons for any discrepancies were elucidated. Results: There was full agreement for ER in 204/229 cases (Kappa value (ĸ) = 0.56) and for PR in 170/209 (ĸ = 0.68) cases. Sensitivity for ER was 89.4 % and the specificity was 87.5 %. Positive predictive value (PPV) was 97.1 % and negative predictive value (NPV) was 63.6 %. Sensitivity for PR was 78.3 % and specificity was 87.3 %. PPV was 92.3 % and NPV was 67.4 %. Conclusion: Immunocytochemistry for hormone receptors in fine needle aspiration smears is a reliable method in cases with positive immunostaining. In the case of negative immunostaining, examination with immunohistochemistry should be performed on tissue biopsies. Correct preparation of the cytological smear is vital for a successful result. oestrogen receptor progesterone receptor tissue biopsies fine needle aspirates breast cancer Medicine R Anna M Bofin verfasserin aut In Bioingeniøren NITO - Bioingeniørfaglig institutt, 2022 46(2011), 3, Seite 6-12 (DE-627)DOAJ078604915 18901875 nnns volume:46 year:2011 number:3 pages:6-12 https://doaj.org/article/3afea6cd49a44b64a2c07ad3df3da1a2 kostenfrei https://bioingenioren.no/fag/fag-originalartikkel/er-hormonundersokelse-av-cytologisk-materiale-i-brystkreftsvulster-til-a-stole-pa/ kostenfrei https://doaj.org/toc/0801-6828 Journal toc kostenfrei https://doaj.org/toc/1890-1875 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 46 2011 3 6-12 |
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(DE-627)DOAJ042697980 (DE-599)DOAJ3afea6cd49a44b64a2c07ad3df3da1a2 DE-627 ger DE-627 rakwb dan nor swe Dordi Lea verfasserin aut Is immunocytochemical determination of hormone receptors in breast cancer reliable? 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: In breast cancer oestrogen receptor (ER) and progesterone receptor (PR) status can be determined by both immunohistochemistry performed on tissue biopsies and immunocytochemistry performed on fine needle aspirates. However, the reliability of immunocytochemistry as the basis for determining treatment is still uncertain. Material and methods: The study comprised journal records of 612 breast cancer patients diagnosed between 2000 and 2005, all of whom had undergone fine needle aspiration. In 232 cases both immunocytochemistry and immunohistochemistry for hormone receptor status were performed. The results were compared and reasons for any discrepancies were elucidated. Results: There was full agreement for ER in 204/229 cases (Kappa value (ĸ) = 0.56) and for PR in 170/209 (ĸ = 0.68) cases. Sensitivity for ER was 89.4 % and the specificity was 87.5 %. Positive predictive value (PPV) was 97.1 % and negative predictive value (NPV) was 63.6 %. Sensitivity for PR was 78.3 % and specificity was 87.3 %. PPV was 92.3 % and NPV was 67.4 %. Conclusion: Immunocytochemistry for hormone receptors in fine needle aspiration smears is a reliable method in cases with positive immunostaining. In the case of negative immunostaining, examination with immunohistochemistry should be performed on tissue biopsies. Correct preparation of the cytological smear is vital for a successful result. oestrogen receptor progesterone receptor tissue biopsies fine needle aspirates breast cancer Medicine R Anna M Bofin verfasserin aut In Bioingeniøren NITO - Bioingeniørfaglig institutt, 2022 46(2011), 3, Seite 6-12 (DE-627)DOAJ078604915 18901875 nnns volume:46 year:2011 number:3 pages:6-12 https://doaj.org/article/3afea6cd49a44b64a2c07ad3df3da1a2 kostenfrei https://bioingenioren.no/fag/fag-originalartikkel/er-hormonundersokelse-av-cytologisk-materiale-i-brystkreftsvulster-til-a-stole-pa/ kostenfrei https://doaj.org/toc/0801-6828 Journal toc kostenfrei https://doaj.org/toc/1890-1875 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 46 2011 3 6-12 |
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(DE-627)DOAJ042697980 (DE-599)DOAJ3afea6cd49a44b64a2c07ad3df3da1a2 DE-627 ger DE-627 rakwb dan nor swe Dordi Lea verfasserin aut Is immunocytochemical determination of hormone receptors in breast cancer reliable? 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: In breast cancer oestrogen receptor (ER) and progesterone receptor (PR) status can be determined by both immunohistochemistry performed on tissue biopsies and immunocytochemistry performed on fine needle aspirates. However, the reliability of immunocytochemistry as the basis for determining treatment is still uncertain. Material and methods: The study comprised journal records of 612 breast cancer patients diagnosed between 2000 and 2005, all of whom had undergone fine needle aspiration. In 232 cases both immunocytochemistry and immunohistochemistry for hormone receptor status were performed. The results were compared and reasons for any discrepancies were elucidated. Results: There was full agreement for ER in 204/229 cases (Kappa value (ĸ) = 0.56) and for PR in 170/209 (ĸ = 0.68) cases. Sensitivity for ER was 89.4 % and the specificity was 87.5 %. Positive predictive value (PPV) was 97.1 % and negative predictive value (NPV) was 63.6 %. Sensitivity for PR was 78.3 % and specificity was 87.3 %. PPV was 92.3 % and NPV was 67.4 %. Conclusion: Immunocytochemistry for hormone receptors in fine needle aspiration smears is a reliable method in cases with positive immunostaining. In the case of negative immunostaining, examination with immunohistochemistry should be performed on tissue biopsies. Correct preparation of the cytological smear is vital for a successful result. oestrogen receptor progesterone receptor tissue biopsies fine needle aspirates breast cancer Medicine R Anna M Bofin verfasserin aut In Bioingeniøren NITO - Bioingeniørfaglig institutt, 2022 46(2011), 3, Seite 6-12 (DE-627)DOAJ078604915 18901875 nnns volume:46 year:2011 number:3 pages:6-12 https://doaj.org/article/3afea6cd49a44b64a2c07ad3df3da1a2 kostenfrei https://bioingenioren.no/fag/fag-originalartikkel/er-hormonundersokelse-av-cytologisk-materiale-i-brystkreftsvulster-til-a-stole-pa/ kostenfrei https://doaj.org/toc/0801-6828 Journal toc kostenfrei https://doaj.org/toc/1890-1875 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 46 2011 3 6-12 |
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(DE-627)DOAJ042697980 (DE-599)DOAJ3afea6cd49a44b64a2c07ad3df3da1a2 DE-627 ger DE-627 rakwb dan nor swe Dordi Lea verfasserin aut Is immunocytochemical determination of hormone receptors in breast cancer reliable? 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: In breast cancer oestrogen receptor (ER) and progesterone receptor (PR) status can be determined by both immunohistochemistry performed on tissue biopsies and immunocytochemistry performed on fine needle aspirates. However, the reliability of immunocytochemistry as the basis for determining treatment is still uncertain. Material and methods: The study comprised journal records of 612 breast cancer patients diagnosed between 2000 and 2005, all of whom had undergone fine needle aspiration. In 232 cases both immunocytochemistry and immunohistochemistry for hormone receptor status were performed. The results were compared and reasons for any discrepancies were elucidated. Results: There was full agreement for ER in 204/229 cases (Kappa value (ĸ) = 0.56) and for PR in 170/209 (ĸ = 0.68) cases. Sensitivity for ER was 89.4 % and the specificity was 87.5 %. Positive predictive value (PPV) was 97.1 % and negative predictive value (NPV) was 63.6 %. Sensitivity for PR was 78.3 % and specificity was 87.3 %. PPV was 92.3 % and NPV was 67.4 %. Conclusion: Immunocytochemistry for hormone receptors in fine needle aspiration smears is a reliable method in cases with positive immunostaining. In the case of negative immunostaining, examination with immunohistochemistry should be performed on tissue biopsies. Correct preparation of the cytological smear is vital for a successful result. oestrogen receptor progesterone receptor tissue biopsies fine needle aspirates breast cancer Medicine R Anna M Bofin verfasserin aut In Bioingeniøren NITO - Bioingeniørfaglig institutt, 2022 46(2011), 3, Seite 6-12 (DE-627)DOAJ078604915 18901875 nnns volume:46 year:2011 number:3 pages:6-12 https://doaj.org/article/3afea6cd49a44b64a2c07ad3df3da1a2 kostenfrei https://bioingenioren.no/fag/fag-originalartikkel/er-hormonundersokelse-av-cytologisk-materiale-i-brystkreftsvulster-til-a-stole-pa/ kostenfrei https://doaj.org/toc/0801-6828 Journal toc kostenfrei https://doaj.org/toc/1890-1875 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 46 2011 3 6-12 |
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(DE-627)DOAJ042697980 (DE-599)DOAJ3afea6cd49a44b64a2c07ad3df3da1a2 DE-627 ger DE-627 rakwb dan nor swe Dordi Lea verfasserin aut Is immunocytochemical determination of hormone receptors in breast cancer reliable? 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: In breast cancer oestrogen receptor (ER) and progesterone receptor (PR) status can be determined by both immunohistochemistry performed on tissue biopsies and immunocytochemistry performed on fine needle aspirates. However, the reliability of immunocytochemistry as the basis for determining treatment is still uncertain. Material and methods: The study comprised journal records of 612 breast cancer patients diagnosed between 2000 and 2005, all of whom had undergone fine needle aspiration. In 232 cases both immunocytochemistry and immunohistochemistry for hormone receptor status were performed. The results were compared and reasons for any discrepancies were elucidated. Results: There was full agreement for ER in 204/229 cases (Kappa value (ĸ) = 0.56) and for PR in 170/209 (ĸ = 0.68) cases. Sensitivity for ER was 89.4 % and the specificity was 87.5 %. Positive predictive value (PPV) was 97.1 % and negative predictive value (NPV) was 63.6 %. Sensitivity for PR was 78.3 % and specificity was 87.3 %. PPV was 92.3 % and NPV was 67.4 %. Conclusion: Immunocytochemistry for hormone receptors in fine needle aspiration smears is a reliable method in cases with positive immunostaining. In the case of negative immunostaining, examination with immunohistochemistry should be performed on tissue biopsies. Correct preparation of the cytological smear is vital for a successful result. oestrogen receptor progesterone receptor tissue biopsies fine needle aspirates breast cancer Medicine R Anna M Bofin verfasserin aut In Bioingeniøren NITO - Bioingeniørfaglig institutt, 2022 46(2011), 3, Seite 6-12 (DE-627)DOAJ078604915 18901875 nnns volume:46 year:2011 number:3 pages:6-12 https://doaj.org/article/3afea6cd49a44b64a2c07ad3df3da1a2 kostenfrei https://bioingenioren.no/fag/fag-originalartikkel/er-hormonundersokelse-av-cytologisk-materiale-i-brystkreftsvulster-til-a-stole-pa/ kostenfrei https://doaj.org/toc/0801-6828 Journal toc kostenfrei https://doaj.org/toc/1890-1875 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 46 2011 3 6-12 |
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Is immunocytochemical determination of hormone receptors in breast cancer reliable? |
| abstract |
Background: In breast cancer oestrogen receptor (ER) and progesterone receptor (PR) status can be determined by both immunohistochemistry performed on tissue biopsies and immunocytochemistry performed on fine needle aspirates. However, the reliability of immunocytochemistry as the basis for determining treatment is still uncertain. Material and methods: The study comprised journal records of 612 breast cancer patients diagnosed between 2000 and 2005, all of whom had undergone fine needle aspiration. In 232 cases both immunocytochemistry and immunohistochemistry for hormone receptor status were performed. The results were compared and reasons for any discrepancies were elucidated. Results: There was full agreement for ER in 204/229 cases (Kappa value (ĸ) = 0.56) and for PR in 170/209 (ĸ = 0.68) cases. Sensitivity for ER was 89.4 % and the specificity was 87.5 %. Positive predictive value (PPV) was 97.1 % and negative predictive value (NPV) was 63.6 %. Sensitivity for PR was 78.3 % and specificity was 87.3 %. PPV was 92.3 % and NPV was 67.4 %. Conclusion: Immunocytochemistry for hormone receptors in fine needle aspiration smears is a reliable method in cases with positive immunostaining. In the case of negative immunostaining, examination with immunohistochemistry should be performed on tissue biopsies. Correct preparation of the cytological smear is vital for a successful result. |
| abstractGer |
Background: In breast cancer oestrogen receptor (ER) and progesterone receptor (PR) status can be determined by both immunohistochemistry performed on tissue biopsies and immunocytochemistry performed on fine needle aspirates. However, the reliability of immunocytochemistry as the basis for determining treatment is still uncertain. Material and methods: The study comprised journal records of 612 breast cancer patients diagnosed between 2000 and 2005, all of whom had undergone fine needle aspiration. In 232 cases both immunocytochemistry and immunohistochemistry for hormone receptor status were performed. The results were compared and reasons for any discrepancies were elucidated. Results: There was full agreement for ER in 204/229 cases (Kappa value (ĸ) = 0.56) and for PR in 170/209 (ĸ = 0.68) cases. Sensitivity for ER was 89.4 % and the specificity was 87.5 %. Positive predictive value (PPV) was 97.1 % and negative predictive value (NPV) was 63.6 %. Sensitivity for PR was 78.3 % and specificity was 87.3 %. PPV was 92.3 % and NPV was 67.4 %. Conclusion: Immunocytochemistry for hormone receptors in fine needle aspiration smears is a reliable method in cases with positive immunostaining. In the case of negative immunostaining, examination with immunohistochemistry should be performed on tissue biopsies. Correct preparation of the cytological smear is vital for a successful result. |
| abstract_unstemmed |
Background: In breast cancer oestrogen receptor (ER) and progesterone receptor (PR) status can be determined by both immunohistochemistry performed on tissue biopsies and immunocytochemistry performed on fine needle aspirates. However, the reliability of immunocytochemistry as the basis for determining treatment is still uncertain. Material and methods: The study comprised journal records of 612 breast cancer patients diagnosed between 2000 and 2005, all of whom had undergone fine needle aspiration. In 232 cases both immunocytochemistry and immunohistochemistry for hormone receptor status were performed. The results were compared and reasons for any discrepancies were elucidated. Results: There was full agreement for ER in 204/229 cases (Kappa value (ĸ) = 0.56) and for PR in 170/209 (ĸ = 0.68) cases. Sensitivity for ER was 89.4 % and the specificity was 87.5 %. Positive predictive value (PPV) was 97.1 % and negative predictive value (NPV) was 63.6 %. Sensitivity for PR was 78.3 % and specificity was 87.3 %. PPV was 92.3 % and NPV was 67.4 %. Conclusion: Immunocytochemistry for hormone receptors in fine needle aspiration smears is a reliable method in cases with positive immunostaining. In the case of negative immunostaining, examination with immunohistochemistry should be performed on tissue biopsies. Correct preparation of the cytological smear is vital for a successful result. |
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Is immunocytochemical determination of hormone receptors in breast cancer reliable? |
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https://doaj.org/article/3afea6cd49a44b64a2c07ad3df3da1a2 https://bioingenioren.no/fag/fag-originalartikkel/er-hormonundersokelse-av-cytologisk-materiale-i-brystkreftsvulster-til-a-stole-pa/ https://doaj.org/toc/0801-6828 https://doaj.org/toc/1890-1875 |
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Anna M Bofin |
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2024-07-03T13:33:57.560Z |
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