The affect of goserelin on the QoL of women having chemotherapy for EBC: Results from the OPTION trial

Background: The OPTION trial results showed that premenopausal women with early stage breast cancer (EBC) receiving chemotherapy benefited from ovarian function protection with goserelin. The impact of treatments on patient reported Quality of Life (QoL) were also examined. Patients and methods: 227...
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Autor*in:	Leonard R [verfasserIn] Yellowlees A [verfasserIn] Mansi J [verfasserIn] Fallowfield L [verfasserIn] Jenkins V [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	OPTION trial Pre-menopausal Breast cancer Goserelin Chemotherapy Quality of life

Übergeordnetes Werk:	In: Breast - Elsevier, 2020, 52(2020), Seite 122-131
Übergeordnetes Werk:	volume:52 ; year:2020 ; pages:122-131

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.breast.2020.05.009

Katalog-ID:	DOAJ042717396

Internformat


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520			\|a Background: The OPTION trial results showed that premenopausal women with early stage breast cancer (EBC) receiving chemotherapy benefited from ovarian function protection with goserelin. The impact of treatments on patient reported Quality of Life (QoL) were also examined. Patients and methods: 227 pre-menopausal women with EBC, were randomly assigned to chemotherapy±goserelin (C±G); 132 (58%) were ER-ve. Patients were stratified by age (≤40 years and <40 years). QoL was assessed with the Functional Assessment of Cancer Therapy – Breast, and Endocrine Symptom checklist at baseline (pre-treatment), 3, 6, 12, 18 and 24 months, then annually to 5 years. Treatment Outcome Index (TOI) score was the primary outcome. Results: 213 patients were available for QoL analysis. There was a significant decrease in TOI scores for both treatment groups at 3 and 6 months that returned to pre-treatment levels at 12 months, then continued to increase reflecting improved QoL. By 3 months there was a significant difference from baseline in both groups for menopausal symptoms, and between groups in the proportion experiencing hot flushes at any time. The C + G group experienced higher levels of vasomotor symptoms generally during the treatment phase; by 24 months, the short-term negative effect of goserelin was reversed, with hot flushes twice as frequent in the chemotherapy only group (40.9% vs 21.3%). Conclusions: These results show that young women diagnosed with breast cancer experienced only a short-term decrease in QoL from the addition of goserelin, in order to preserve ovarian function during chemotherapy treatment.
650		4	\|a OPTION trial
650		4	\|a Pre-menopausal
650		4	\|a Breast cancer
650		4	\|a Goserelin
650		4	\|a Chemotherapy
650		4	\|a Quality of life
653		0	\|a Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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publishDate	2020
allfields	10.1016/j.breast.2020.05.009 doi (DE-627)DOAJ042717396 (DE-599)DOAJ45a79d5c936f40f7a3c52aaf1a5233c2 DE-627 ger DE-627 rakwb eng RC254-282 Leonard R verfasserin aut The affect of goserelin on the QoL of women having chemotherapy for EBC: Results from the OPTION trial 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The OPTION trial results showed that premenopausal women with early stage breast cancer (EBC) receiving chemotherapy benefited from ovarian function protection with goserelin. The impact of treatments on patient reported Quality of Life (QoL) were also examined. Patients and methods: 227 pre-menopausal women with EBC, were randomly assigned to chemotherapy±goserelin (C±G); 132 (58%) were ER-ve. Patients were stratified by age (≤40 years and <40 years). QoL was assessed with the Functional Assessment of Cancer Therapy – Breast, and Endocrine Symptom checklist at baseline (pre-treatment), 3, 6, 12, 18 and 24 months, then annually to 5 years. Treatment Outcome Index (TOI) score was the primary outcome. Results: 213 patients were available for QoL analysis. There was a significant decrease in TOI scores for both treatment groups at 3 and 6 months that returned to pre-treatment levels at 12 months, then continued to increase reflecting improved QoL. By 3 months there was a significant difference from baseline in both groups for menopausal symptoms, and between groups in the proportion experiencing hot flushes at any time. The C + G group experienced higher levels of vasomotor symptoms generally during the treatment phase; by 24 months, the short-term negative effect of goserelin was reversed, with hot flushes twice as frequent in the chemotherapy only group (40.9% vs 21.3%). Conclusions: These results show that young women diagnosed with breast cancer experienced only a short-term decrease in QoL from the addition of goserelin, in order to preserve ovarian function during chemotherapy treatment. OPTION trial Pre-menopausal Breast cancer Goserelin Chemotherapy Quality of life Neoplasms. Tumors. Oncology. Including cancer and carcinogens Yellowlees A verfasserin aut Mansi J verfasserin aut Fallowfield L verfasserin aut Jenkins V verfasserin aut In Breast Elsevier, 2020 52(2020), Seite 122-131 (DE-627)320475042 (DE-600)2009043-2 15323080 nnns volume:52 year:2020 pages:122-131 https://doi.org/10.1016/j.breast.2020.05.009 kostenfrei https://doaj.org/article/45a79d5c936f40f7a3c52aaf1a5233c2 kostenfrei http://www.sciencedirect.com/science/article/pii/S0960977620301168 kostenfrei https://doaj.org/toc/1532-3080 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 52 2020 122-131
spelling	10.1016/j.breast.2020.05.009 doi (DE-627)DOAJ042717396 (DE-599)DOAJ45a79d5c936f40f7a3c52aaf1a5233c2 DE-627 ger DE-627 rakwb eng RC254-282 Leonard R verfasserin aut The affect of goserelin on the QoL of women having chemotherapy for EBC: Results from the OPTION trial 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The OPTION trial results showed that premenopausal women with early stage breast cancer (EBC) receiving chemotherapy benefited from ovarian function protection with goserelin. The impact of treatments on patient reported Quality of Life (QoL) were also examined. Patients and methods: 227 pre-menopausal women with EBC, were randomly assigned to chemotherapy±goserelin (C±G); 132 (58%) were ER-ve. Patients were stratified by age (≤40 years and <40 years). QoL was assessed with the Functional Assessment of Cancer Therapy – Breast, and Endocrine Symptom checklist at baseline (pre-treatment), 3, 6, 12, 18 and 24 months, then annually to 5 years. Treatment Outcome Index (TOI) score was the primary outcome. Results: 213 patients were available for QoL analysis. There was a significant decrease in TOI scores for both treatment groups at 3 and 6 months that returned to pre-treatment levels at 12 months, then continued to increase reflecting improved QoL. By 3 months there was a significant difference from baseline in both groups for menopausal symptoms, and between groups in the proportion experiencing hot flushes at any time. The C + G group experienced higher levels of vasomotor symptoms generally during the treatment phase; by 24 months, the short-term negative effect of goserelin was reversed, with hot flushes twice as frequent in the chemotherapy only group (40.9% vs 21.3%). Conclusions: These results show that young women diagnosed with breast cancer experienced only a short-term decrease in QoL from the addition of goserelin, in order to preserve ovarian function during chemotherapy treatment. OPTION trial Pre-menopausal Breast cancer Goserelin Chemotherapy Quality of life Neoplasms. Tumors. Oncology. Including cancer and carcinogens Yellowlees A verfasserin aut Mansi J verfasserin aut Fallowfield L verfasserin aut Jenkins V verfasserin aut In Breast Elsevier, 2020 52(2020), Seite 122-131 (DE-627)320475042 (DE-600)2009043-2 15323080 nnns volume:52 year:2020 pages:122-131 https://doi.org/10.1016/j.breast.2020.05.009 kostenfrei https://doaj.org/article/45a79d5c936f40f7a3c52aaf1a5233c2 kostenfrei http://www.sciencedirect.com/science/article/pii/S0960977620301168 kostenfrei https://doaj.org/toc/1532-3080 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 52 2020 122-131
allfields_unstemmed	10.1016/j.breast.2020.05.009 doi (DE-627)DOAJ042717396 (DE-599)DOAJ45a79d5c936f40f7a3c52aaf1a5233c2 DE-627 ger DE-627 rakwb eng RC254-282 Leonard R verfasserin aut The affect of goserelin on the QoL of women having chemotherapy for EBC: Results from the OPTION trial 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The OPTION trial results showed that premenopausal women with early stage breast cancer (EBC) receiving chemotherapy benefited from ovarian function protection with goserelin. The impact of treatments on patient reported Quality of Life (QoL) were also examined. Patients and methods: 227 pre-menopausal women with EBC, were randomly assigned to chemotherapy±goserelin (C±G); 132 (58%) were ER-ve. Patients were stratified by age (≤40 years and <40 years). QoL was assessed with the Functional Assessment of Cancer Therapy – Breast, and Endocrine Symptom checklist at baseline (pre-treatment), 3, 6, 12, 18 and 24 months, then annually to 5 years. Treatment Outcome Index (TOI) score was the primary outcome. Results: 213 patients were available for QoL analysis. There was a significant decrease in TOI scores for both treatment groups at 3 and 6 months that returned to pre-treatment levels at 12 months, then continued to increase reflecting improved QoL. By 3 months there was a significant difference from baseline in both groups for menopausal symptoms, and between groups in the proportion experiencing hot flushes at any time. The C + G group experienced higher levels of vasomotor symptoms generally during the treatment phase; by 24 months, the short-term negative effect of goserelin was reversed, with hot flushes twice as frequent in the chemotherapy only group (40.9% vs 21.3%). Conclusions: These results show that young women diagnosed with breast cancer experienced only a short-term decrease in QoL from the addition of goserelin, in order to preserve ovarian function during chemotherapy treatment. OPTION trial Pre-menopausal Breast cancer Goserelin Chemotherapy Quality of life Neoplasms. Tumors. Oncology. Including cancer and carcinogens Yellowlees A verfasserin aut Mansi J verfasserin aut Fallowfield L verfasserin aut Jenkins V verfasserin aut In Breast Elsevier, 2020 52(2020), Seite 122-131 (DE-627)320475042 (DE-600)2009043-2 15323080 nnns volume:52 year:2020 pages:122-131 https://doi.org/10.1016/j.breast.2020.05.009 kostenfrei https://doaj.org/article/45a79d5c936f40f7a3c52aaf1a5233c2 kostenfrei http://www.sciencedirect.com/science/article/pii/S0960977620301168 kostenfrei https://doaj.org/toc/1532-3080 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 52 2020 122-131
allfieldsGer	10.1016/j.breast.2020.05.009 doi (DE-627)DOAJ042717396 (DE-599)DOAJ45a79d5c936f40f7a3c52aaf1a5233c2 DE-627 ger DE-627 rakwb eng RC254-282 Leonard R verfasserin aut The affect of goserelin on the QoL of women having chemotherapy for EBC: Results from the OPTION trial 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The OPTION trial results showed that premenopausal women with early stage breast cancer (EBC) receiving chemotherapy benefited from ovarian function protection with goserelin. The impact of treatments on patient reported Quality of Life (QoL) were also examined. Patients and methods: 227 pre-menopausal women with EBC, were randomly assigned to chemotherapy±goserelin (C±G); 132 (58%) were ER-ve. Patients were stratified by age (≤40 years and <40 years). QoL was assessed with the Functional Assessment of Cancer Therapy – Breast, and Endocrine Symptom checklist at baseline (pre-treatment), 3, 6, 12, 18 and 24 months, then annually to 5 years. Treatment Outcome Index (TOI) score was the primary outcome. Results: 213 patients were available for QoL analysis. There was a significant decrease in TOI scores for both treatment groups at 3 and 6 months that returned to pre-treatment levels at 12 months, then continued to increase reflecting improved QoL. By 3 months there was a significant difference from baseline in both groups for menopausal symptoms, and between groups in the proportion experiencing hot flushes at any time. The C + G group experienced higher levels of vasomotor symptoms generally during the treatment phase; by 24 months, the short-term negative effect of goserelin was reversed, with hot flushes twice as frequent in the chemotherapy only group (40.9% vs 21.3%). Conclusions: These results show that young women diagnosed with breast cancer experienced only a short-term decrease in QoL from the addition of goserelin, in order to preserve ovarian function during chemotherapy treatment. OPTION trial Pre-menopausal Breast cancer Goserelin Chemotherapy Quality of life Neoplasms. Tumors. Oncology. Including cancer and carcinogens Yellowlees A verfasserin aut Mansi J verfasserin aut Fallowfield L verfasserin aut Jenkins V verfasserin aut In Breast Elsevier, 2020 52(2020), Seite 122-131 (DE-627)320475042 (DE-600)2009043-2 15323080 nnns volume:52 year:2020 pages:122-131 https://doi.org/10.1016/j.breast.2020.05.009 kostenfrei https://doaj.org/article/45a79d5c936f40f7a3c52aaf1a5233c2 kostenfrei http://www.sciencedirect.com/science/article/pii/S0960977620301168 kostenfrei https://doaj.org/toc/1532-3080 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 52 2020 122-131
allfieldsSound	10.1016/j.breast.2020.05.009 doi (DE-627)DOAJ042717396 (DE-599)DOAJ45a79d5c936f40f7a3c52aaf1a5233c2 DE-627 ger DE-627 rakwb eng RC254-282 Leonard R verfasserin aut The affect of goserelin on the QoL of women having chemotherapy for EBC: Results from the OPTION trial 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The OPTION trial results showed that premenopausal women with early stage breast cancer (EBC) receiving chemotherapy benefited from ovarian function protection with goserelin. The impact of treatments on patient reported Quality of Life (QoL) were also examined. Patients and methods: 227 pre-menopausal women with EBC, were randomly assigned to chemotherapy±goserelin (C±G); 132 (58%) were ER-ve. Patients were stratified by age (≤40 years and <40 years). QoL was assessed with the Functional Assessment of Cancer Therapy – Breast, and Endocrine Symptom checklist at baseline (pre-treatment), 3, 6, 12, 18 and 24 months, then annually to 5 years. Treatment Outcome Index (TOI) score was the primary outcome. Results: 213 patients were available for QoL analysis. There was a significant decrease in TOI scores for both treatment groups at 3 and 6 months that returned to pre-treatment levels at 12 months, then continued to increase reflecting improved QoL. By 3 months there was a significant difference from baseline in both groups for menopausal symptoms, and between groups in the proportion experiencing hot flushes at any time. The C + G group experienced higher levels of vasomotor symptoms generally during the treatment phase; by 24 months, the short-term negative effect of goserelin was reversed, with hot flushes twice as frequent in the chemotherapy only group (40.9% vs 21.3%). Conclusions: These results show that young women diagnosed with breast cancer experienced only a short-term decrease in QoL from the addition of goserelin, in order to preserve ovarian function during chemotherapy treatment. OPTION trial Pre-menopausal Breast cancer Goserelin Chemotherapy Quality of life Neoplasms. Tumors. Oncology. Including cancer and carcinogens Yellowlees A verfasserin aut Mansi J verfasserin aut Fallowfield L verfasserin aut Jenkins V verfasserin aut In Breast Elsevier, 2020 52(2020), Seite 122-131 (DE-627)320475042 (DE-600)2009043-2 15323080 nnns volume:52 year:2020 pages:122-131 https://doi.org/10.1016/j.breast.2020.05.009 kostenfrei https://doaj.org/article/45a79d5c936f40f7a3c52aaf1a5233c2 kostenfrei http://www.sciencedirect.com/science/article/pii/S0960977620301168 kostenfrei https://doaj.org/toc/1532-3080 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 52 2020 122-131
language	English
source	In Breast 52(2020), Seite 122-131 volume:52 year:2020 pages:122-131
sourceStr	In Breast 52(2020), Seite 122-131 volume:52 year:2020 pages:122-131
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	OPTION trial Pre-menopausal Breast cancer Goserelin Chemotherapy Quality of life Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Breast
authorswithroles_txt_mv	Leonard R @@aut@@ Yellowlees A @@aut@@ Mansi J @@aut@@ Fallowfield L @@aut@@ Jenkins V @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	320475042
id	DOAJ042717396
language_de	englisch
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callnumber-first	R - Medicine
author	Leonard R
spellingShingle	Leonard R misc RC254-282 misc OPTION trial misc Pre-menopausal misc Breast cancer misc Goserelin misc Chemotherapy misc Quality of life misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens The affect of goserelin on the QoL of women having chemotherapy for EBC: Results from the OPTION trial
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topic_title	RC254-282 The affect of goserelin on the QoL of women having chemotherapy for EBC: Results from the OPTION trial OPTION trial Pre-menopausal Breast cancer Goserelin Chemotherapy Quality of life
topic	misc RC254-282 misc OPTION trial misc Pre-menopausal misc Breast cancer misc Goserelin misc Chemotherapy misc Quality of life misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc OPTION trial misc Pre-menopausal misc Breast cancer misc Goserelin misc Chemotherapy misc Quality of life misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc OPTION trial misc Pre-menopausal misc Breast cancer misc Goserelin misc Chemotherapy misc Quality of life misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	The affect of goserelin on the QoL of women having chemotherapy for EBC: Results from the OPTION trial
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title_full	The affect of goserelin on the QoL of women having chemotherapy for EBC: Results from the OPTION trial
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author_browse	Leonard R Yellowlees A Mansi J Fallowfield L Jenkins V
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title_sort	affect of goserelin on the qol of women having chemotherapy for ebc: results from the option trial
callnumber	RC254-282
title_auth	The affect of goserelin on the QoL of women having chemotherapy for EBC: Results from the OPTION trial
abstract	Background: The OPTION trial results showed that premenopausal women with early stage breast cancer (EBC) receiving chemotherapy benefited from ovarian function protection with goserelin. The impact of treatments on patient reported Quality of Life (QoL) were also examined. Patients and methods: 227 pre-menopausal women with EBC, were randomly assigned to chemotherapy±goserelin (C±G); 132 (58%) were ER-ve. Patients were stratified by age (≤40 years and <40 years). QoL was assessed with the Functional Assessment of Cancer Therapy – Breast, and Endocrine Symptom checklist at baseline (pre-treatment), 3, 6, 12, 18 and 24 months, then annually to 5 years. Treatment Outcome Index (TOI) score was the primary outcome. Results: 213 patients were available for QoL analysis. There was a significant decrease in TOI scores for both treatment groups at 3 and 6 months that returned to pre-treatment levels at 12 months, then continued to increase reflecting improved QoL. By 3 months there was a significant difference from baseline in both groups for menopausal symptoms, and between groups in the proportion experiencing hot flushes at any time. The C + G group experienced higher levels of vasomotor symptoms generally during the treatment phase; by 24 months, the short-term negative effect of goserelin was reversed, with hot flushes twice as frequent in the chemotherapy only group (40.9% vs 21.3%). Conclusions: These results show that young women diagnosed with breast cancer experienced only a short-term decrease in QoL from the addition of goserelin, in order to preserve ovarian function during chemotherapy treatment.
abstractGer	Background: The OPTION trial results showed that premenopausal women with early stage breast cancer (EBC) receiving chemotherapy benefited from ovarian function protection with goserelin. The impact of treatments on patient reported Quality of Life (QoL) were also examined. Patients and methods: 227 pre-menopausal women with EBC, were randomly assigned to chemotherapy±goserelin (C±G); 132 (58%) were ER-ve. Patients were stratified by age (≤40 years and <40 years). QoL was assessed with the Functional Assessment of Cancer Therapy – Breast, and Endocrine Symptom checklist at baseline (pre-treatment), 3, 6, 12, 18 and 24 months, then annually to 5 years. Treatment Outcome Index (TOI) score was the primary outcome. Results: 213 patients were available for QoL analysis. There was a significant decrease in TOI scores for both treatment groups at 3 and 6 months that returned to pre-treatment levels at 12 months, then continued to increase reflecting improved QoL. By 3 months there was a significant difference from baseline in both groups for menopausal symptoms, and between groups in the proportion experiencing hot flushes at any time. The C + G group experienced higher levels of vasomotor symptoms generally during the treatment phase; by 24 months, the short-term negative effect of goserelin was reversed, with hot flushes twice as frequent in the chemotherapy only group (40.9% vs 21.3%). Conclusions: These results show that young women diagnosed with breast cancer experienced only a short-term decrease in QoL from the addition of goserelin, in order to preserve ovarian function during chemotherapy treatment.
abstract_unstemmed	Background: The OPTION trial results showed that premenopausal women with early stage breast cancer (EBC) receiving chemotherapy benefited from ovarian function protection with goserelin. The impact of treatments on patient reported Quality of Life (QoL) were also examined. Patients and methods: 227 pre-menopausal women with EBC, were randomly assigned to chemotherapy±goserelin (C±G); 132 (58%) were ER-ve. Patients were stratified by age (≤40 years and <40 years). QoL was assessed with the Functional Assessment of Cancer Therapy – Breast, and Endocrine Symptom checklist at baseline (pre-treatment), 3, 6, 12, 18 and 24 months, then annually to 5 years. Treatment Outcome Index (TOI) score was the primary outcome. Results: 213 patients were available for QoL analysis. There was a significant decrease in TOI scores for both treatment groups at 3 and 6 months that returned to pre-treatment levels at 12 months, then continued to increase reflecting improved QoL. By 3 months there was a significant difference from baseline in both groups for menopausal symptoms, and between groups in the proportion experiencing hot flushes at any time. The C + G group experienced higher levels of vasomotor symptoms generally during the treatment phase; by 24 months, the short-term negative effect of goserelin was reversed, with hot flushes twice as frequent in the chemotherapy only group (40.9% vs 21.3%). Conclusions: These results show that young women diagnosed with breast cancer experienced only a short-term decrease in QoL from the addition of goserelin, in order to preserve ovarian function during chemotherapy treatment.
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title_short	The affect of goserelin on the QoL of women having chemotherapy for EBC: Results from the OPTION trial
url	https://doi.org/10.1016/j.breast.2020.05.009 https://doaj.org/article/45a79d5c936f40f7a3c52aaf1a5233c2 http://www.sciencedirect.com/science/article/pii/S0960977620301168 https://doaj.org/toc/1532-3080
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The affect of goserelin on the QoL of women having chemotherapy for EBC: Results from the OPTION trial

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