Chimeric Peptide Tat-HA-NR2B9c Improves Regenerative Repair after Transient Global Ischemia

Transient global ischemia (TGI) is a major public health problem, and it heightens the need of effective treatments. The present study was undertaken to investigate whether recombinant polypeptide Tat-HA-NR2B9c improves spatial learning and memory deficits in rats after TGI. Rats were subjected to 2...
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Gespeichert in:

Autor*in:	Hai-Hui Zhou [verfasserIn] Li Zhang [verfasserIn] Hai-Xia Zhang [verfasserIn] Jin-Ping Zhang [verfasserIn] Wei-Hong Ge [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	transient global ischemia hippocampus PSD95 regenerative repair spatial learning and memory

Übergeordnetes Werk:	In: Frontiers in Neurology - Frontiers Media S.A., 2010, 8(2017)
Übergeordnetes Werk:	volume:8 ; year:2017

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fneur.2017.00509

Katalog-ID:	DOAJ042717787

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allfieldsGer	10.3389/fneur.2017.00509 doi (DE-627)DOAJ042717787 (DE-599)DOAJfe20757110034426b0881a878ee58b42 DE-627 ger DE-627 rakwb eng RC346-429 Hai-Hui Zhou verfasserin aut Chimeric Peptide Tat-HA-NR2B9c Improves Regenerative Repair after Transient Global Ischemia 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Transient global ischemia (TGI) is a major public health problem, and it heightens the need of effective treatments. The present study was undertaken to investigate whether recombinant polypeptide Tat-HA-NR2B9c improves spatial learning and memory deficits in rats after TGI. Rats were subjected to 20-min ischemia induced by four-vessel occlusion (4-VO) method and daily injected with Tat-HA-NR2B9c (1.12 mg/kg) for 1 week. Tat-HA-NR2B9c increased CREB activity, upregulated B-cell lymphoma-2 (Bcl-2) expression after treated for 24 h. There was a significant increase in dendrite spine density in hippocampal CA1 region and BrdU-positive cells and BrdU/NeuN-positive cells in the dentate gyrus after Tat-HA-NR2B9c treatment, compared with ischemia group at postischemic day 28. Inhibition of the CREB activation by recombinant lentivirus, LV-CREB133-GFP, abolished the upregulation effects of Tat-HA-NR2B9c on Bcl-2 expression. Moreover, Tat-HA-NR2B9c improved the impaired spatial learning and memory ability in Morris water maze. These results suggest that Tat-HA-NR2B9c substantially ameliorated the TGI-induced loss of dendrite spine in hippocampal CA1, increased neurogenesis in dentate gyrus, and significantly improved cognitive abilities by the CREB pathway in rats after transient global cerebral ischemia. It may be served as a treatment for TGI. transient global ischemia hippocampus PSD95 regenerative repair spatial learning and memory Neurology. Diseases of the nervous system Li Zhang verfasserin aut Hai-Xia Zhang verfasserin aut Jin-Ping Zhang verfasserin aut Wei-Hong Ge verfasserin aut In Frontiers in Neurology Frontiers Media S.A., 2010 8(2017) (DE-627)631498753 (DE-600)2564214-5 16642295 nnns volume:8 year:2017 https://doi.org/10.3389/fneur.2017.00509 kostenfrei https://doaj.org/article/fe20757110034426b0881a878ee58b42 kostenfrei http://journal.frontiersin.org/article/10.3389/fneur.2017.00509/full kostenfrei https://doaj.org/toc/1664-2295 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017
allfieldsSound	10.3389/fneur.2017.00509 doi (DE-627)DOAJ042717787 (DE-599)DOAJfe20757110034426b0881a878ee58b42 DE-627 ger DE-627 rakwb eng RC346-429 Hai-Hui Zhou verfasserin aut Chimeric Peptide Tat-HA-NR2B9c Improves Regenerative Repair after Transient Global Ischemia 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Transient global ischemia (TGI) is a major public health problem, and it heightens the need of effective treatments. The present study was undertaken to investigate whether recombinant polypeptide Tat-HA-NR2B9c improves spatial learning and memory deficits in rats after TGI. Rats were subjected to 20-min ischemia induced by four-vessel occlusion (4-VO) method and daily injected with Tat-HA-NR2B9c (1.12 mg/kg) for 1 week. Tat-HA-NR2B9c increased CREB activity, upregulated B-cell lymphoma-2 (Bcl-2) expression after treated for 24 h. There was a significant increase in dendrite spine density in hippocampal CA1 region and BrdU-positive cells and BrdU/NeuN-positive cells in the dentate gyrus after Tat-HA-NR2B9c treatment, compared with ischemia group at postischemic day 28. Inhibition of the CREB activation by recombinant lentivirus, LV-CREB133-GFP, abolished the upregulation effects of Tat-HA-NR2B9c on Bcl-2 expression. Moreover, Tat-HA-NR2B9c improved the impaired spatial learning and memory ability in Morris water maze. These results suggest that Tat-HA-NR2B9c substantially ameliorated the TGI-induced loss of dendrite spine in hippocampal CA1, increased neurogenesis in dentate gyrus, and significantly improved cognitive abilities by the CREB pathway in rats after transient global cerebral ischemia. It may be served as a treatment for TGI. transient global ischemia hippocampus PSD95 regenerative repair spatial learning and memory Neurology. Diseases of the nervous system Li Zhang verfasserin aut Hai-Xia Zhang verfasserin aut Jin-Ping Zhang verfasserin aut Wei-Hong Ge verfasserin aut In Frontiers in Neurology Frontiers Media S.A., 2010 8(2017) (DE-627)631498753 (DE-600)2564214-5 16642295 nnns volume:8 year:2017 https://doi.org/10.3389/fneur.2017.00509 kostenfrei https://doaj.org/article/fe20757110034426b0881a878ee58b42 kostenfrei http://journal.frontiersin.org/article/10.3389/fneur.2017.00509/full kostenfrei https://doaj.org/toc/1664-2295 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017
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callnumber-first	R - Medicine
author	Hai-Hui Zhou
spellingShingle	Hai-Hui Zhou misc RC346-429 misc transient global ischemia misc hippocampus misc PSD95 misc regenerative repair misc spatial learning and memory misc Neurology. Diseases of the nervous system Chimeric Peptide Tat-HA-NR2B9c Improves Regenerative Repair after Transient Global Ischemia
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topic_title	RC346-429 Chimeric Peptide Tat-HA-NR2B9c Improves Regenerative Repair after Transient Global Ischemia transient global ischemia hippocampus PSD95 regenerative repair spatial learning and memory
topic	misc RC346-429 misc transient global ischemia misc hippocampus misc PSD95 misc regenerative repair misc spatial learning and memory misc Neurology. Diseases of the nervous system
topic_unstemmed	misc RC346-429 misc transient global ischemia misc hippocampus misc PSD95 misc regenerative repair misc spatial learning and memory misc Neurology. Diseases of the nervous system
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title	Chimeric Peptide Tat-HA-NR2B9c Improves Regenerative Repair after Transient Global Ischemia
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title_full	Chimeric Peptide Tat-HA-NR2B9c Improves Regenerative Repair after Transient Global Ischemia
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title_sort	chimeric peptide tat-ha-nr2b9c improves regenerative repair after transient global ischemia
callnumber	RC346-429
title_auth	Chimeric Peptide Tat-HA-NR2B9c Improves Regenerative Repair after Transient Global Ischemia
abstract	Transient global ischemia (TGI) is a major public health problem, and it heightens the need of effective treatments. The present study was undertaken to investigate whether recombinant polypeptide Tat-HA-NR2B9c improves spatial learning and memory deficits in rats after TGI. Rats were subjected to 20-min ischemia induced by four-vessel occlusion (4-VO) method and daily injected with Tat-HA-NR2B9c (1.12 mg/kg) for 1 week. Tat-HA-NR2B9c increased CREB activity, upregulated B-cell lymphoma-2 (Bcl-2) expression after treated for 24 h. There was a significant increase in dendrite spine density in hippocampal CA1 region and BrdU-positive cells and BrdU/NeuN-positive cells in the dentate gyrus after Tat-HA-NR2B9c treatment, compared with ischemia group at postischemic day 28. Inhibition of the CREB activation by recombinant lentivirus, LV-CREB133-GFP, abolished the upregulation effects of Tat-HA-NR2B9c on Bcl-2 expression. Moreover, Tat-HA-NR2B9c improved the impaired spatial learning and memory ability in Morris water maze. These results suggest that Tat-HA-NR2B9c substantially ameliorated the TGI-induced loss of dendrite spine in hippocampal CA1, increased neurogenesis in dentate gyrus, and significantly improved cognitive abilities by the CREB pathway in rats after transient global cerebral ischemia. It may be served as a treatment for TGI.
abstractGer	Transient global ischemia (TGI) is a major public health problem, and it heightens the need of effective treatments. The present study was undertaken to investigate whether recombinant polypeptide Tat-HA-NR2B9c improves spatial learning and memory deficits in rats after TGI. Rats were subjected to 20-min ischemia induced by four-vessel occlusion (4-VO) method and daily injected with Tat-HA-NR2B9c (1.12 mg/kg) for 1 week. Tat-HA-NR2B9c increased CREB activity, upregulated B-cell lymphoma-2 (Bcl-2) expression after treated for 24 h. There was a significant increase in dendrite spine density in hippocampal CA1 region and BrdU-positive cells and BrdU/NeuN-positive cells in the dentate gyrus after Tat-HA-NR2B9c treatment, compared with ischemia group at postischemic day 28. Inhibition of the CREB activation by recombinant lentivirus, LV-CREB133-GFP, abolished the upregulation effects of Tat-HA-NR2B9c on Bcl-2 expression. Moreover, Tat-HA-NR2B9c improved the impaired spatial learning and memory ability in Morris water maze. These results suggest that Tat-HA-NR2B9c substantially ameliorated the TGI-induced loss of dendrite spine in hippocampal CA1, increased neurogenesis in dentate gyrus, and significantly improved cognitive abilities by the CREB pathway in rats after transient global cerebral ischemia. It may be served as a treatment for TGI.
abstract_unstemmed	Transient global ischemia (TGI) is a major public health problem, and it heightens the need of effective treatments. The present study was undertaken to investigate whether recombinant polypeptide Tat-HA-NR2B9c improves spatial learning and memory deficits in rats after TGI. Rats were subjected to 20-min ischemia induced by four-vessel occlusion (4-VO) method and daily injected with Tat-HA-NR2B9c (1.12 mg/kg) for 1 week. Tat-HA-NR2B9c increased CREB activity, upregulated B-cell lymphoma-2 (Bcl-2) expression after treated for 24 h. There was a significant increase in dendrite spine density in hippocampal CA1 region and BrdU-positive cells and BrdU/NeuN-positive cells in the dentate gyrus after Tat-HA-NR2B9c treatment, compared with ischemia group at postischemic day 28. Inhibition of the CREB activation by recombinant lentivirus, LV-CREB133-GFP, abolished the upregulation effects of Tat-HA-NR2B9c on Bcl-2 expression. Moreover, Tat-HA-NR2B9c improved the impaired spatial learning and memory ability in Morris water maze. These results suggest that Tat-HA-NR2B9c substantially ameliorated the TGI-induced loss of dendrite spine in hippocampal CA1, increased neurogenesis in dentate gyrus, and significantly improved cognitive abilities by the CREB pathway in rats after transient global cerebral ischemia. It may be served as a treatment for TGI.
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title_short	Chimeric Peptide Tat-HA-NR2B9c Improves Regenerative Repair after Transient Global Ischemia
url	https://doi.org/10.3389/fneur.2017.00509 https://doaj.org/article/fe20757110034426b0881a878ee58b42 http://journal.frontiersin.org/article/10.3389/fneur.2017.00509/full https://doaj.org/toc/1664-2295
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up_date	2024-07-03T13:40:12.733Z
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Chimeric Peptide Tat-HA-NR2B9c Improves Regenerative Repair after Transient Global Ischemia

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