Relationship between gut microbiota composition and sensitization to inhaled allergens

Background: An imbalance in gut microbiota is implicated in several pathological conditions, including allergic diseases. This study investigates the association between gut microbiota composition and sensitization to two inhaled antigens. Methods: The study comprised 1109 local residents who had pa...
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Autor*in:	Ayami Nomura [verfasserIn] Atsushi Matsubara [verfasserIn] Sinichi Goto [verfasserIn] Junko Takahata [verfasserIn] Kaori Sawada [verfasserIn] Kazushige Ihara [verfasserIn] Shigeyuki Nakaji [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Bacteroidales Bifidobacteriales Lactobacillales Sensitization Specific IgE

Übergeordnetes Werk:	In: Allergology International - Elsevier, 2002, 69(2020), 3, Seite 437-442
Übergeordnetes Werk:	volume:69 ; year:2020 ; number:3 ; pages:437-442

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.alit.2019.12.010

Katalog-ID:	DOAJ04278106X

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520			\|a Background: An imbalance in gut microbiota is implicated in several pathological conditions, including allergic diseases. This study investigates the association between gut microbiota composition and sensitization to two inhaled antigens. Methods: The study comprised 1109 local residents who had participated in the Iwaki Health Promotion Project in 2016. Blood samples were analyzed for levels of antigen-specific IgE against Japanese cedar pollen (JCP) and house dust (HD1). Fecal samples were analyzed for bacterial 16S rRNA (ribosomal ribonucleic acid) using next generation sequencing. The percent composition of gut microbes was compared between patients sensitized and unsensitized group for JCP and HD1 to determine whether the rate of sensitization to inhaled antigens associates with specific bacterial orders composing the gut microbiota. Results: In participants aged 20–49 years, the percent composition of Bacteroidales was significantly higher among participants sensitized to JCP than in those unsensitized. The percent composition of Lactobacillales was significantly higher in participants unsensitized to HD group than in those sensitized to that antigen. In addition, participants with low Bacteroidales and high Bifidobacteriales or Lactobacillales has low sensitization rates to HD compared with high Bacteroidales and low Bifidobacteriales or Lactobacillales. Conclusions: The presence of bacteria of order Lactobacillales, Bifidobacteriales, and Bacteroidales in the gut microbiota may affect sensitization to inhaled allergens.
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allfields	10.1016/j.alit.2019.12.010 doi (DE-627)DOAJ04278106X (DE-599)DOAJ23a12482b4234979828ff2ff1deafb28 DE-627 ger DE-627 rakwb eng RC581-607 Ayami Nomura verfasserin aut Relationship between gut microbiota composition and sensitization to inhaled allergens 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: An imbalance in gut microbiota is implicated in several pathological conditions, including allergic diseases. This study investigates the association between gut microbiota composition and sensitization to two inhaled antigens. Methods: The study comprised 1109 local residents who had participated in the Iwaki Health Promotion Project in 2016. Blood samples were analyzed for levels of antigen-specific IgE against Japanese cedar pollen (JCP) and house dust (HD1). Fecal samples were analyzed for bacterial 16S rRNA (ribosomal ribonucleic acid) using next generation sequencing. The percent composition of gut microbes was compared between patients sensitized and unsensitized group for JCP and HD1 to determine whether the rate of sensitization to inhaled antigens associates with specific bacterial orders composing the gut microbiota. Results: In participants aged 20–49 years, the percent composition of Bacteroidales was significantly higher among participants sensitized to JCP than in those unsensitized. The percent composition of Lactobacillales was significantly higher in participants unsensitized to HD group than in those sensitized to that antigen. In addition, participants with low Bacteroidales and high Bifidobacteriales or Lactobacillales has low sensitization rates to HD compared with high Bacteroidales and low Bifidobacteriales or Lactobacillales. Conclusions: The presence of bacteria of order Lactobacillales, Bifidobacteriales, and Bacteroidales in the gut microbiota may affect sensitization to inhaled allergens. Bacteroidales Bifidobacteriales Lactobacillales Sensitization Specific IgE Immunologic diseases. Allergy Atsushi Matsubara verfasserin aut Sinichi Goto verfasserin aut Junko Takahata verfasserin aut Kaori Sawada verfasserin aut Kazushige Ihara verfasserin aut Shigeyuki Nakaji verfasserin aut In Allergology International Elsevier, 2002 69(2020), 3, Seite 437-442 (DE-627)320425320 (DE-600)2003098-8 14401592 nnns volume:69 year:2020 number:3 pages:437-442 https://doi.org/10.1016/j.alit.2019.12.010 kostenfrei https://doaj.org/article/23a12482b4234979828ff2ff1deafb28 kostenfrei http://www.sciencedirect.com/science/article/pii/S1323893020300046 kostenfrei https://doaj.org/toc/1323-8930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 69 2020 3 437-442
spelling	10.1016/j.alit.2019.12.010 doi (DE-627)DOAJ04278106X (DE-599)DOAJ23a12482b4234979828ff2ff1deafb28 DE-627 ger DE-627 rakwb eng RC581-607 Ayami Nomura verfasserin aut Relationship between gut microbiota composition and sensitization to inhaled allergens 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: An imbalance in gut microbiota is implicated in several pathological conditions, including allergic diseases. This study investigates the association between gut microbiota composition and sensitization to two inhaled antigens. Methods: The study comprised 1109 local residents who had participated in the Iwaki Health Promotion Project in 2016. Blood samples were analyzed for levels of antigen-specific IgE against Japanese cedar pollen (JCP) and house dust (HD1). Fecal samples were analyzed for bacterial 16S rRNA (ribosomal ribonucleic acid) using next generation sequencing. The percent composition of gut microbes was compared between patients sensitized and unsensitized group for JCP and HD1 to determine whether the rate of sensitization to inhaled antigens associates with specific bacterial orders composing the gut microbiota. Results: In participants aged 20–49 years, the percent composition of Bacteroidales was significantly higher among participants sensitized to JCP than in those unsensitized. The percent composition of Lactobacillales was significantly higher in participants unsensitized to HD group than in those sensitized to that antigen. In addition, participants with low Bacteroidales and high Bifidobacteriales or Lactobacillales has low sensitization rates to HD compared with high Bacteroidales and low Bifidobacteriales or Lactobacillales. Conclusions: The presence of bacteria of order Lactobacillales, Bifidobacteriales, and Bacteroidales in the gut microbiota may affect sensitization to inhaled allergens. Bacteroidales Bifidobacteriales Lactobacillales Sensitization Specific IgE Immunologic diseases. Allergy Atsushi Matsubara verfasserin aut Sinichi Goto verfasserin aut Junko Takahata verfasserin aut Kaori Sawada verfasserin aut Kazushige Ihara verfasserin aut Shigeyuki Nakaji verfasserin aut In Allergology International Elsevier, 2002 69(2020), 3, Seite 437-442 (DE-627)320425320 (DE-600)2003098-8 14401592 nnns volume:69 year:2020 number:3 pages:437-442 https://doi.org/10.1016/j.alit.2019.12.010 kostenfrei https://doaj.org/article/23a12482b4234979828ff2ff1deafb28 kostenfrei http://www.sciencedirect.com/science/article/pii/S1323893020300046 kostenfrei https://doaj.org/toc/1323-8930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 69 2020 3 437-442
allfields_unstemmed	10.1016/j.alit.2019.12.010 doi (DE-627)DOAJ04278106X (DE-599)DOAJ23a12482b4234979828ff2ff1deafb28 DE-627 ger DE-627 rakwb eng RC581-607 Ayami Nomura verfasserin aut Relationship between gut microbiota composition and sensitization to inhaled allergens 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: An imbalance in gut microbiota is implicated in several pathological conditions, including allergic diseases. This study investigates the association between gut microbiota composition and sensitization to two inhaled antigens. Methods: The study comprised 1109 local residents who had participated in the Iwaki Health Promotion Project in 2016. Blood samples were analyzed for levels of antigen-specific IgE against Japanese cedar pollen (JCP) and house dust (HD1). Fecal samples were analyzed for bacterial 16S rRNA (ribosomal ribonucleic acid) using next generation sequencing. The percent composition of gut microbes was compared between patients sensitized and unsensitized group for JCP and HD1 to determine whether the rate of sensitization to inhaled antigens associates with specific bacterial orders composing the gut microbiota. Results: In participants aged 20–49 years, the percent composition of Bacteroidales was significantly higher among participants sensitized to JCP than in those unsensitized. The percent composition of Lactobacillales was significantly higher in participants unsensitized to HD group than in those sensitized to that antigen. In addition, participants with low Bacteroidales and high Bifidobacteriales or Lactobacillales has low sensitization rates to HD compared with high Bacteroidales and low Bifidobacteriales or Lactobacillales. Conclusions: The presence of bacteria of order Lactobacillales, Bifidobacteriales, and Bacteroidales in the gut microbiota may affect sensitization to inhaled allergens. Bacteroidales Bifidobacteriales Lactobacillales Sensitization Specific IgE Immunologic diseases. Allergy Atsushi Matsubara verfasserin aut Sinichi Goto verfasserin aut Junko Takahata verfasserin aut Kaori Sawada verfasserin aut Kazushige Ihara verfasserin aut Shigeyuki Nakaji verfasserin aut In Allergology International Elsevier, 2002 69(2020), 3, Seite 437-442 (DE-627)320425320 (DE-600)2003098-8 14401592 nnns volume:69 year:2020 number:3 pages:437-442 https://doi.org/10.1016/j.alit.2019.12.010 kostenfrei https://doaj.org/article/23a12482b4234979828ff2ff1deafb28 kostenfrei http://www.sciencedirect.com/science/article/pii/S1323893020300046 kostenfrei https://doaj.org/toc/1323-8930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 69 2020 3 437-442
allfieldsGer	10.1016/j.alit.2019.12.010 doi (DE-627)DOAJ04278106X (DE-599)DOAJ23a12482b4234979828ff2ff1deafb28 DE-627 ger DE-627 rakwb eng RC581-607 Ayami Nomura verfasserin aut Relationship between gut microbiota composition and sensitization to inhaled allergens 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: An imbalance in gut microbiota is implicated in several pathological conditions, including allergic diseases. This study investigates the association between gut microbiota composition and sensitization to two inhaled antigens. Methods: The study comprised 1109 local residents who had participated in the Iwaki Health Promotion Project in 2016. Blood samples were analyzed for levels of antigen-specific IgE against Japanese cedar pollen (JCP) and house dust (HD1). Fecal samples were analyzed for bacterial 16S rRNA (ribosomal ribonucleic acid) using next generation sequencing. The percent composition of gut microbes was compared between patients sensitized and unsensitized group for JCP and HD1 to determine whether the rate of sensitization to inhaled antigens associates with specific bacterial orders composing the gut microbiota. Results: In participants aged 20–49 years, the percent composition of Bacteroidales was significantly higher among participants sensitized to JCP than in those unsensitized. The percent composition of Lactobacillales was significantly higher in participants unsensitized to HD group than in those sensitized to that antigen. In addition, participants with low Bacteroidales and high Bifidobacteriales or Lactobacillales has low sensitization rates to HD compared with high Bacteroidales and low Bifidobacteriales or Lactobacillales. Conclusions: The presence of bacteria of order Lactobacillales, Bifidobacteriales, and Bacteroidales in the gut microbiota may affect sensitization to inhaled allergens. Bacteroidales Bifidobacteriales Lactobacillales Sensitization Specific IgE Immunologic diseases. Allergy Atsushi Matsubara verfasserin aut Sinichi Goto verfasserin aut Junko Takahata verfasserin aut Kaori Sawada verfasserin aut Kazushige Ihara verfasserin aut Shigeyuki Nakaji verfasserin aut In Allergology International Elsevier, 2002 69(2020), 3, Seite 437-442 (DE-627)320425320 (DE-600)2003098-8 14401592 nnns volume:69 year:2020 number:3 pages:437-442 https://doi.org/10.1016/j.alit.2019.12.010 kostenfrei https://doaj.org/article/23a12482b4234979828ff2ff1deafb28 kostenfrei http://www.sciencedirect.com/science/article/pii/S1323893020300046 kostenfrei https://doaj.org/toc/1323-8930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 69 2020 3 437-442
allfieldsSound	10.1016/j.alit.2019.12.010 doi (DE-627)DOAJ04278106X (DE-599)DOAJ23a12482b4234979828ff2ff1deafb28 DE-627 ger DE-627 rakwb eng RC581-607 Ayami Nomura verfasserin aut Relationship between gut microbiota composition and sensitization to inhaled allergens 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: An imbalance in gut microbiota is implicated in several pathological conditions, including allergic diseases. This study investigates the association between gut microbiota composition and sensitization to two inhaled antigens. Methods: The study comprised 1109 local residents who had participated in the Iwaki Health Promotion Project in 2016. Blood samples were analyzed for levels of antigen-specific IgE against Japanese cedar pollen (JCP) and house dust (HD1). Fecal samples were analyzed for bacterial 16S rRNA (ribosomal ribonucleic acid) using next generation sequencing. The percent composition of gut microbes was compared between patients sensitized and unsensitized group for JCP and HD1 to determine whether the rate of sensitization to inhaled antigens associates with specific bacterial orders composing the gut microbiota. Results: In participants aged 20–49 years, the percent composition of Bacteroidales was significantly higher among participants sensitized to JCP than in those unsensitized. The percent composition of Lactobacillales was significantly higher in participants unsensitized to HD group than in those sensitized to that antigen. In addition, participants with low Bacteroidales and high Bifidobacteriales or Lactobacillales has low sensitization rates to HD compared with high Bacteroidales and low Bifidobacteriales or Lactobacillales. Conclusions: The presence of bacteria of order Lactobacillales, Bifidobacteriales, and Bacteroidales in the gut microbiota may affect sensitization to inhaled allergens. Bacteroidales Bifidobacteriales Lactobacillales Sensitization Specific IgE Immunologic diseases. Allergy Atsushi Matsubara verfasserin aut Sinichi Goto verfasserin aut Junko Takahata verfasserin aut Kaori Sawada verfasserin aut Kazushige Ihara verfasserin aut Shigeyuki Nakaji verfasserin aut In Allergology International Elsevier, 2002 69(2020), 3, Seite 437-442 (DE-627)320425320 (DE-600)2003098-8 14401592 nnns volume:69 year:2020 number:3 pages:437-442 https://doi.org/10.1016/j.alit.2019.12.010 kostenfrei https://doaj.org/article/23a12482b4234979828ff2ff1deafb28 kostenfrei http://www.sciencedirect.com/science/article/pii/S1323893020300046 kostenfrei https://doaj.org/toc/1323-8930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 69 2020 3 437-442
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authorswithroles_txt_mv	Ayami Nomura @@aut@@ Atsushi Matsubara @@aut@@ Sinichi Goto @@aut@@ Junko Takahata @@aut@@ Kaori Sawada @@aut@@ Kazushige Ihara @@aut@@ Shigeyuki Nakaji @@aut@@
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The percent composition of Lactobacillales was significantly higher in participants unsensitized to HD group than in those sensitized to that antigen. In addition, participants with low Bacteroidales and high Bifidobacteriales or Lactobacillales has low sensitization rates to HD compared with high Bacteroidales and low Bifidobacteriales or Lactobacillales. 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callnumber-first	R - Medicine
author	Ayami Nomura
spellingShingle	Ayami Nomura misc RC581-607 misc Bacteroidales misc Bifidobacteriales misc Lactobacillales misc Sensitization misc Specific IgE misc Immunologic diseases. Allergy Relationship between gut microbiota composition and sensitization to inhaled allergens
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topic_title	RC581-607 Relationship between gut microbiota composition and sensitization to inhaled allergens Bacteroidales Bifidobacteriales Lactobacillales Sensitization Specific IgE
topic	misc RC581-607 misc Bacteroidales misc Bifidobacteriales misc Lactobacillales misc Sensitization misc Specific IgE misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc Bacteroidales misc Bifidobacteriales misc Lactobacillales misc Sensitization misc Specific IgE misc Immunologic diseases. Allergy
topic_browse	misc RC581-607 misc Bacteroidales misc Bifidobacteriales misc Lactobacillales misc Sensitization misc Specific IgE misc Immunologic diseases. Allergy
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title	Relationship between gut microbiota composition and sensitization to inhaled allergens
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title_full	Relationship between gut microbiota composition and sensitization to inhaled allergens
author_sort	Ayami Nomura
journal	Allergology International
journalStr	Allergology International
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author_browse	Ayami Nomura Atsushi Matsubara Sinichi Goto Junko Takahata Kaori Sawada Kazushige Ihara Shigeyuki Nakaji
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author-letter	Ayami Nomura
doi_str_mv	10.1016/j.alit.2019.12.010
author2-role	verfasserin
title_sort	relationship between gut microbiota composition and sensitization to inhaled allergens
callnumber	RC581-607
title_auth	Relationship between gut microbiota composition and sensitization to inhaled allergens
abstract	Background: An imbalance in gut microbiota is implicated in several pathological conditions, including allergic diseases. This study investigates the association between gut microbiota composition and sensitization to two inhaled antigens. Methods: The study comprised 1109 local residents who had participated in the Iwaki Health Promotion Project in 2016. Blood samples were analyzed for levels of antigen-specific IgE against Japanese cedar pollen (JCP) and house dust (HD1). Fecal samples were analyzed for bacterial 16S rRNA (ribosomal ribonucleic acid) using next generation sequencing. The percent composition of gut microbes was compared between patients sensitized and unsensitized group for JCP and HD1 to determine whether the rate of sensitization to inhaled antigens associates with specific bacterial orders composing the gut microbiota. Results: In participants aged 20–49 years, the percent composition of Bacteroidales was significantly higher among participants sensitized to JCP than in those unsensitized. The percent composition of Lactobacillales was significantly higher in participants unsensitized to HD group than in those sensitized to that antigen. In addition, participants with low Bacteroidales and high Bifidobacteriales or Lactobacillales has low sensitization rates to HD compared with high Bacteroidales and low Bifidobacteriales or Lactobacillales. Conclusions: The presence of bacteria of order Lactobacillales, Bifidobacteriales, and Bacteroidales in the gut microbiota may affect sensitization to inhaled allergens.
abstractGer	Background: An imbalance in gut microbiota is implicated in several pathological conditions, including allergic diseases. This study investigates the association between gut microbiota composition and sensitization to two inhaled antigens. Methods: The study comprised 1109 local residents who had participated in the Iwaki Health Promotion Project in 2016. Blood samples were analyzed for levels of antigen-specific IgE against Japanese cedar pollen (JCP) and house dust (HD1). Fecal samples were analyzed for bacterial 16S rRNA (ribosomal ribonucleic acid) using next generation sequencing. The percent composition of gut microbes was compared between patients sensitized and unsensitized group for JCP and HD1 to determine whether the rate of sensitization to inhaled antigens associates with specific bacterial orders composing the gut microbiota. Results: In participants aged 20–49 years, the percent composition of Bacteroidales was significantly higher among participants sensitized to JCP than in those unsensitized. The percent composition of Lactobacillales was significantly higher in participants unsensitized to HD group than in those sensitized to that antigen. In addition, participants with low Bacteroidales and high Bifidobacteriales or Lactobacillales has low sensitization rates to HD compared with high Bacteroidales and low Bifidobacteriales or Lactobacillales. Conclusions: The presence of bacteria of order Lactobacillales, Bifidobacteriales, and Bacteroidales in the gut microbiota may affect sensitization to inhaled allergens.
abstract_unstemmed	Background: An imbalance in gut microbiota is implicated in several pathological conditions, including allergic diseases. This study investigates the association between gut microbiota composition and sensitization to two inhaled antigens. Methods: The study comprised 1109 local residents who had participated in the Iwaki Health Promotion Project in 2016. Blood samples were analyzed for levels of antigen-specific IgE against Japanese cedar pollen (JCP) and house dust (HD1). Fecal samples were analyzed for bacterial 16S rRNA (ribosomal ribonucleic acid) using next generation sequencing. The percent composition of gut microbes was compared between patients sensitized and unsensitized group for JCP and HD1 to determine whether the rate of sensitization to inhaled antigens associates with specific bacterial orders composing the gut microbiota. Results: In participants aged 20–49 years, the percent composition of Bacteroidales was significantly higher among participants sensitized to JCP than in those unsensitized. The percent composition of Lactobacillales was significantly higher in participants unsensitized to HD group than in those sensitized to that antigen. In addition, participants with low Bacteroidales and high Bifidobacteriales or Lactobacillales has low sensitization rates to HD compared with high Bacteroidales and low Bifidobacteriales or Lactobacillales. Conclusions: The presence of bacteria of order Lactobacillales, Bifidobacteriales, and Bacteroidales in the gut microbiota may affect sensitization to inhaled allergens.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
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title_short	Relationship between gut microbiota composition and sensitization to inhaled allergens
url	https://doi.org/10.1016/j.alit.2019.12.010 https://doaj.org/article/23a12482b4234979828ff2ff1deafb28 http://www.sciencedirect.com/science/article/pii/S1323893020300046 https://doaj.org/toc/1323-8930
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author2	Atsushi Matsubara Sinichi Goto Junko Takahata Kaori Sawada Kazushige Ihara Shigeyuki Nakaji
author2Str	Atsushi Matsubara Sinichi Goto Junko Takahata Kaori Sawada Kazushige Ihara Shigeyuki Nakaji
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doi_str	10.1016/j.alit.2019.12.010
callnumber-a	RC581-607
up_date	2024-07-03T13:59:37.921Z
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The percent composition of Lactobacillales was significantly higher in participants unsensitized to HD group than in those sensitized to that antigen. In addition, participants with low Bacteroidales and high Bifidobacteriales or Lactobacillales has low sensitization rates to HD compared with high Bacteroidales and low Bifidobacteriales or Lactobacillales. 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code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Allergology International</subfield><subfield code="d">Elsevier, 2002</subfield><subfield code="g">69(2020), 3, Seite 437-442</subfield><subfield code="w">(DE-627)320425320</subfield><subfield code="w">(DE-600)2003098-8</subfield><subfield code="x">14401592</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:69</subfield><subfield code="g">year:2020</subfield><subfield code="g">number:3</subfield><subfield code="g">pages:437-442</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.alit.2019.12.010</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/23a12482b4234979828ff2ff1deafb28</subfield><subfield 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Relationship between gut microbiota composition and sensitization to inhaled allergens

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