No evidence of human papillomaviruses in non-genital seborrheic keratosis

Background: Seborrheic keratosis (SK) is a benign epidermal tumor of unknown etiology. Because of its wart-like morphology, Human papillomaviruses (HPVs) have been suggested as a possible causative agent. Viral involvement, however, has not been confirmed yet despite research and the association bet...
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Autor*in:	Naser Tayyebi Meibodi [verfasserIn] Yalda Nahidi [verfasserIn] Zahra Meshkat [verfasserIn] Habibollah Esmaili [verfasserIn] Masoumeh Gharib [verfasserIn] Aida Gholoobi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	Human papillomaviruses polymerase chain reaction seborrheic keratosis

Übergeordnetes Werk:	In: Indian Journal of Dermatology - Wolters Kluwer Medknow Publications, 2005, 58(2013), 4, Seite 326-326
Übergeordnetes Werk:	volume:58 ; year:2013 ; number:4 ; pages:326-326

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.4103/0019-5154.113949

Katalog-ID:	DOAJ042811376

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520			\|a Background: Seborrheic keratosis (SK) is a benign epidermal tumor of unknown etiology. Because of its wart-like morphology, Human papillomaviruses (HPVs) have been suggested as a possible causative agent. Viral involvement, however, has not been confirmed yet despite research and the association between HPVs and seborrheic keratosis has not been studied among Iranian population by PCR. Objectives: The aim of this case-control study was to evaluate the presence of HPVs DNA in non-genital SK by PCR. Materials and Methods: Fifty biopsy specimens obtained from patients with non-genital SK and 50 controls were analyzed using polymerase chain reaction (PCR). Results: No HPVs DNA was detected by PCR within the tissue extracts from paraffin-embedded SK samples, while one of the controls was HPVs DNA positive. The age range of the patients was 20 to 82 yrs (mean = 52). Twenty-eight patients (56%) were males and 22 patients (44%) were females. The most common anatomic site was the face. Histopathologic changes due to viral infection such as koilocytosis (10%), dyskeratosis (66%), mitosis (28%), and parakeratosis (88%) were evident within the lesions. The most common histologic type was acanthotic type. Conclusion: Our results showed that there is no association between HPVs and seborrheic keratosis in investigated subjects.
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allfields	10.4103/0019-5154.113949 doi (DE-627)DOAJ042811376 (DE-599)DOAJ9fe2fdd64b564c4187aa639e2e2ed6ec DE-627 ger DE-627 rakwb eng RL1-803 Naser Tayyebi Meibodi verfasserin aut No evidence of human papillomaviruses in non-genital seborrheic keratosis 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Seborrheic keratosis (SK) is a benign epidermal tumor of unknown etiology. Because of its wart-like morphology, Human papillomaviruses (HPVs) have been suggested as a possible causative agent. Viral involvement, however, has not been confirmed yet despite research and the association between HPVs and seborrheic keratosis has not been studied among Iranian population by PCR. Objectives: The aim of this case-control study was to evaluate the presence of HPVs DNA in non-genital SK by PCR. Materials and Methods: Fifty biopsy specimens obtained from patients with non-genital SK and 50 controls were analyzed using polymerase chain reaction (PCR). Results: No HPVs DNA was detected by PCR within the tissue extracts from paraffin-embedded SK samples, while one of the controls was HPVs DNA positive. The age range of the patients was 20 to 82 yrs (mean = 52). Twenty-eight patients (56%) were males and 22 patients (44%) were females. The most common anatomic site was the face. Histopathologic changes due to viral infection such as koilocytosis (10%), dyskeratosis (66%), mitosis (28%), and parakeratosis (88%) were evident within the lesions. The most common histologic type was acanthotic type. Conclusion: Our results showed that there is no association between HPVs and seborrheic keratosis in investigated subjects. Human papillomaviruses polymerase chain reaction seborrheic keratosis Dermatology Yalda Nahidi verfasserin aut Zahra Meshkat verfasserin aut Habibollah Esmaili verfasserin aut Masoumeh Gharib verfasserin aut Aida Gholoobi verfasserin aut In Indian Journal of Dermatology Wolters Kluwer Medknow Publications, 2005 58(2013), 4, Seite 326-326 (DE-627)50486064X (DE-600)2213845-6 19983611 nnns volume:58 year:2013 number:4 pages:326-326 https://doi.org/10.4103/0019-5154.113949 kostenfrei https://doaj.org/article/9fe2fdd64b564c4187aa639e2e2ed6ec kostenfrei http://www.e-ijd.org/article.asp?issn=0019-5154;year=2013;volume=58;issue=4;spage=326;epage=326;aulast=Meibodi kostenfrei https://doaj.org/toc/0019-5154 Journal toc kostenfrei https://doaj.org/toc/1998-3611 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 58 2013 4 326-326
spelling	10.4103/0019-5154.113949 doi (DE-627)DOAJ042811376 (DE-599)DOAJ9fe2fdd64b564c4187aa639e2e2ed6ec DE-627 ger DE-627 rakwb eng RL1-803 Naser Tayyebi Meibodi verfasserin aut No evidence of human papillomaviruses in non-genital seborrheic keratosis 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Seborrheic keratosis (SK) is a benign epidermal tumor of unknown etiology. Because of its wart-like morphology, Human papillomaviruses (HPVs) have been suggested as a possible causative agent. Viral involvement, however, has not been confirmed yet despite research and the association between HPVs and seborrheic keratosis has not been studied among Iranian population by PCR. Objectives: The aim of this case-control study was to evaluate the presence of HPVs DNA in non-genital SK by PCR. Materials and Methods: Fifty biopsy specimens obtained from patients with non-genital SK and 50 controls were analyzed using polymerase chain reaction (PCR). Results: No HPVs DNA was detected by PCR within the tissue extracts from paraffin-embedded SK samples, while one of the controls was HPVs DNA positive. The age range of the patients was 20 to 82 yrs (mean = 52). Twenty-eight patients (56%) were males and 22 patients (44%) were females. The most common anatomic site was the face. Histopathologic changes due to viral infection such as koilocytosis (10%), dyskeratosis (66%), mitosis (28%), and parakeratosis (88%) were evident within the lesions. The most common histologic type was acanthotic type. Conclusion: Our results showed that there is no association between HPVs and seborrheic keratosis in investigated subjects. Human papillomaviruses polymerase chain reaction seborrheic keratosis Dermatology Yalda Nahidi verfasserin aut Zahra Meshkat verfasserin aut Habibollah Esmaili verfasserin aut Masoumeh Gharib verfasserin aut Aida Gholoobi verfasserin aut In Indian Journal of Dermatology Wolters Kluwer Medknow Publications, 2005 58(2013), 4, Seite 326-326 (DE-627)50486064X (DE-600)2213845-6 19983611 nnns volume:58 year:2013 number:4 pages:326-326 https://doi.org/10.4103/0019-5154.113949 kostenfrei https://doaj.org/article/9fe2fdd64b564c4187aa639e2e2ed6ec kostenfrei http://www.e-ijd.org/article.asp?issn=0019-5154;year=2013;volume=58;issue=4;spage=326;epage=326;aulast=Meibodi kostenfrei https://doaj.org/toc/0019-5154 Journal toc kostenfrei https://doaj.org/toc/1998-3611 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 58 2013 4 326-326
allfields_unstemmed	10.4103/0019-5154.113949 doi (DE-627)DOAJ042811376 (DE-599)DOAJ9fe2fdd64b564c4187aa639e2e2ed6ec DE-627 ger DE-627 rakwb eng RL1-803 Naser Tayyebi Meibodi verfasserin aut No evidence of human papillomaviruses in non-genital seborrheic keratosis 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Seborrheic keratosis (SK) is a benign epidermal tumor of unknown etiology. Because of its wart-like morphology, Human papillomaviruses (HPVs) have been suggested as a possible causative agent. Viral involvement, however, has not been confirmed yet despite research and the association between HPVs and seborrheic keratosis has not been studied among Iranian population by PCR. Objectives: The aim of this case-control study was to evaluate the presence of HPVs DNA in non-genital SK by PCR. Materials and Methods: Fifty biopsy specimens obtained from patients with non-genital SK and 50 controls were analyzed using polymerase chain reaction (PCR). Results: No HPVs DNA was detected by PCR within the tissue extracts from paraffin-embedded SK samples, while one of the controls was HPVs DNA positive. The age range of the patients was 20 to 82 yrs (mean = 52). Twenty-eight patients (56%) were males and 22 patients (44%) were females. The most common anatomic site was the face. Histopathologic changes due to viral infection such as koilocytosis (10%), dyskeratosis (66%), mitosis (28%), and parakeratosis (88%) were evident within the lesions. The most common histologic type was acanthotic type. Conclusion: Our results showed that there is no association between HPVs and seborrheic keratosis in investigated subjects. Human papillomaviruses polymerase chain reaction seborrheic keratosis Dermatology Yalda Nahidi verfasserin aut Zahra Meshkat verfasserin aut Habibollah Esmaili verfasserin aut Masoumeh Gharib verfasserin aut Aida Gholoobi verfasserin aut In Indian Journal of Dermatology Wolters Kluwer Medknow Publications, 2005 58(2013), 4, Seite 326-326 (DE-627)50486064X (DE-600)2213845-6 19983611 nnns volume:58 year:2013 number:4 pages:326-326 https://doi.org/10.4103/0019-5154.113949 kostenfrei https://doaj.org/article/9fe2fdd64b564c4187aa639e2e2ed6ec kostenfrei http://www.e-ijd.org/article.asp?issn=0019-5154;year=2013;volume=58;issue=4;spage=326;epage=326;aulast=Meibodi kostenfrei https://doaj.org/toc/0019-5154 Journal toc kostenfrei https://doaj.org/toc/1998-3611 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 58 2013 4 326-326
allfieldsGer	10.4103/0019-5154.113949 doi (DE-627)DOAJ042811376 (DE-599)DOAJ9fe2fdd64b564c4187aa639e2e2ed6ec DE-627 ger DE-627 rakwb eng RL1-803 Naser Tayyebi Meibodi verfasserin aut No evidence of human papillomaviruses in non-genital seborrheic keratosis 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Seborrheic keratosis (SK) is a benign epidermal tumor of unknown etiology. Because of its wart-like morphology, Human papillomaviruses (HPVs) have been suggested as a possible causative agent. Viral involvement, however, has not been confirmed yet despite research and the association between HPVs and seborrheic keratosis has not been studied among Iranian population by PCR. Objectives: The aim of this case-control study was to evaluate the presence of HPVs DNA in non-genital SK by PCR. Materials and Methods: Fifty biopsy specimens obtained from patients with non-genital SK and 50 controls were analyzed using polymerase chain reaction (PCR). Results: No HPVs DNA was detected by PCR within the tissue extracts from paraffin-embedded SK samples, while one of the controls was HPVs DNA positive. The age range of the patients was 20 to 82 yrs (mean = 52). Twenty-eight patients (56%) were males and 22 patients (44%) were females. The most common anatomic site was the face. Histopathologic changes due to viral infection such as koilocytosis (10%), dyskeratosis (66%), mitosis (28%), and parakeratosis (88%) were evident within the lesions. The most common histologic type was acanthotic type. Conclusion: Our results showed that there is no association between HPVs and seborrheic keratosis in investigated subjects. Human papillomaviruses polymerase chain reaction seborrheic keratosis Dermatology Yalda Nahidi verfasserin aut Zahra Meshkat verfasserin aut Habibollah Esmaili verfasserin aut Masoumeh Gharib verfasserin aut Aida Gholoobi verfasserin aut In Indian Journal of Dermatology Wolters Kluwer Medknow Publications, 2005 58(2013), 4, Seite 326-326 (DE-627)50486064X (DE-600)2213845-6 19983611 nnns volume:58 year:2013 number:4 pages:326-326 https://doi.org/10.4103/0019-5154.113949 kostenfrei https://doaj.org/article/9fe2fdd64b564c4187aa639e2e2ed6ec kostenfrei http://www.e-ijd.org/article.asp?issn=0019-5154;year=2013;volume=58;issue=4;spage=326;epage=326;aulast=Meibodi kostenfrei https://doaj.org/toc/0019-5154 Journal toc kostenfrei https://doaj.org/toc/1998-3611 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 58 2013 4 326-326
allfieldsSound	10.4103/0019-5154.113949 doi (DE-627)DOAJ042811376 (DE-599)DOAJ9fe2fdd64b564c4187aa639e2e2ed6ec DE-627 ger DE-627 rakwb eng RL1-803 Naser Tayyebi Meibodi verfasserin aut No evidence of human papillomaviruses in non-genital seborrheic keratosis 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Seborrheic keratosis (SK) is a benign epidermal tumor of unknown etiology. Because of its wart-like morphology, Human papillomaviruses (HPVs) have been suggested as a possible causative agent. Viral involvement, however, has not been confirmed yet despite research and the association between HPVs and seborrheic keratosis has not been studied among Iranian population by PCR. Objectives: The aim of this case-control study was to evaluate the presence of HPVs DNA in non-genital SK by PCR. Materials and Methods: Fifty biopsy specimens obtained from patients with non-genital SK and 50 controls were analyzed using polymerase chain reaction (PCR). Results: No HPVs DNA was detected by PCR within the tissue extracts from paraffin-embedded SK samples, while one of the controls was HPVs DNA positive. The age range of the patients was 20 to 82 yrs (mean = 52). Twenty-eight patients (56%) were males and 22 patients (44%) were females. The most common anatomic site was the face. Histopathologic changes due to viral infection such as koilocytosis (10%), dyskeratosis (66%), mitosis (28%), and parakeratosis (88%) were evident within the lesions. The most common histologic type was acanthotic type. Conclusion: Our results showed that there is no association between HPVs and seborrheic keratosis in investigated subjects. Human papillomaviruses polymerase chain reaction seborrheic keratosis Dermatology Yalda Nahidi verfasserin aut Zahra Meshkat verfasserin aut Habibollah Esmaili verfasserin aut Masoumeh Gharib verfasserin aut Aida Gholoobi verfasserin aut In Indian Journal of Dermatology Wolters Kluwer Medknow Publications, 2005 58(2013), 4, Seite 326-326 (DE-627)50486064X (DE-600)2213845-6 19983611 nnns volume:58 year:2013 number:4 pages:326-326 https://doi.org/10.4103/0019-5154.113949 kostenfrei https://doaj.org/article/9fe2fdd64b564c4187aa639e2e2ed6ec kostenfrei http://www.e-ijd.org/article.asp?issn=0019-5154;year=2013;volume=58;issue=4;spage=326;epage=326;aulast=Meibodi kostenfrei https://doaj.org/toc/0019-5154 Journal toc kostenfrei https://doaj.org/toc/1998-3611 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 58 2013 4 326-326
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source	In Indian Journal of Dermatology 58(2013), 4, Seite 326-326 volume:58 year:2013 number:4 pages:326-326
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authorswithroles_txt_mv	Naser Tayyebi Meibodi @@aut@@ Yalda Nahidi @@aut@@ Zahra Meshkat @@aut@@ Habibollah Esmaili @@aut@@ Masoumeh Gharib @@aut@@ Aida Gholoobi @@aut@@
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Histopathologic changes due to viral infection such as koilocytosis (10%), dyskeratosis (66%), mitosis (28%), and parakeratosis (88%) were evident within the lesions. The most common histologic type was acanthotic type. 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callnumber-first	R - Medicine
author	Naser Tayyebi Meibodi
spellingShingle	Naser Tayyebi Meibodi misc RL1-803 misc Human papillomaviruses misc polymerase chain reaction misc seborrheic keratosis misc Dermatology No evidence of human papillomaviruses in non-genital seborrheic keratosis
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topic_title	RL1-803 No evidence of human papillomaviruses in non-genital seborrheic keratosis Human papillomaviruses polymerase chain reaction seborrheic keratosis
topic	misc RL1-803 misc Human papillomaviruses misc polymerase chain reaction misc seborrheic keratosis misc Dermatology
topic_unstemmed	misc RL1-803 misc Human papillomaviruses misc polymerase chain reaction misc seborrheic keratosis misc Dermatology
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title	No evidence of human papillomaviruses in non-genital seborrheic keratosis
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title_full	No evidence of human papillomaviruses in non-genital seborrheic keratosis
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author_browse	Naser Tayyebi Meibodi Yalda Nahidi Zahra Meshkat Habibollah Esmaili Masoumeh Gharib Aida Gholoobi
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doi_str_mv	10.4103/0019-5154.113949
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title_sort	no evidence of human papillomaviruses in non-genital seborrheic keratosis
callnumber	RL1-803
title_auth	No evidence of human papillomaviruses in non-genital seborrheic keratosis
abstract	Background: Seborrheic keratosis (SK) is a benign epidermal tumor of unknown etiology. Because of its wart-like morphology, Human papillomaviruses (HPVs) have been suggested as a possible causative agent. Viral involvement, however, has not been confirmed yet despite research and the association between HPVs and seborrheic keratosis has not been studied among Iranian population by PCR. Objectives: The aim of this case-control study was to evaluate the presence of HPVs DNA in non-genital SK by PCR. Materials and Methods: Fifty biopsy specimens obtained from patients with non-genital SK and 50 controls were analyzed using polymerase chain reaction (PCR). Results: No HPVs DNA was detected by PCR within the tissue extracts from paraffin-embedded SK samples, while one of the controls was HPVs DNA positive. The age range of the patients was 20 to 82 yrs (mean = 52). Twenty-eight patients (56%) were males and 22 patients (44%) were females. The most common anatomic site was the face. Histopathologic changes due to viral infection such as koilocytosis (10%), dyskeratosis (66%), mitosis (28%), and parakeratosis (88%) were evident within the lesions. The most common histologic type was acanthotic type. Conclusion: Our results showed that there is no association between HPVs and seborrheic keratosis in investigated subjects.
abstractGer	Background: Seborrheic keratosis (SK) is a benign epidermal tumor of unknown etiology. Because of its wart-like morphology, Human papillomaviruses (HPVs) have been suggested as a possible causative agent. Viral involvement, however, has not been confirmed yet despite research and the association between HPVs and seborrheic keratosis has not been studied among Iranian population by PCR. Objectives: The aim of this case-control study was to evaluate the presence of HPVs DNA in non-genital SK by PCR. Materials and Methods: Fifty biopsy specimens obtained from patients with non-genital SK and 50 controls were analyzed using polymerase chain reaction (PCR). Results: No HPVs DNA was detected by PCR within the tissue extracts from paraffin-embedded SK samples, while one of the controls was HPVs DNA positive. The age range of the patients was 20 to 82 yrs (mean = 52). Twenty-eight patients (56%) were males and 22 patients (44%) were females. The most common anatomic site was the face. Histopathologic changes due to viral infection such as koilocytosis (10%), dyskeratosis (66%), mitosis (28%), and parakeratosis (88%) were evident within the lesions. The most common histologic type was acanthotic type. Conclusion: Our results showed that there is no association between HPVs and seborrheic keratosis in investigated subjects.
abstract_unstemmed	Background: Seborrheic keratosis (SK) is a benign epidermal tumor of unknown etiology. Because of its wart-like morphology, Human papillomaviruses (HPVs) have been suggested as a possible causative agent. Viral involvement, however, has not been confirmed yet despite research and the association between HPVs and seborrheic keratosis has not been studied among Iranian population by PCR. Objectives: The aim of this case-control study was to evaluate the presence of HPVs DNA in non-genital SK by PCR. Materials and Methods: Fifty biopsy specimens obtained from patients with non-genital SK and 50 controls were analyzed using polymerase chain reaction (PCR). Results: No HPVs DNA was detected by PCR within the tissue extracts from paraffin-embedded SK samples, while one of the controls was HPVs DNA positive. The age range of the patients was 20 to 82 yrs (mean = 52). Twenty-eight patients (56%) were males and 22 patients (44%) were females. The most common anatomic site was the face. Histopathologic changes due to viral infection such as koilocytosis (10%), dyskeratosis (66%), mitosis (28%), and parakeratosis (88%) were evident within the lesions. The most common histologic type was acanthotic type. Conclusion: Our results showed that there is no association between HPVs and seborrheic keratosis in investigated subjects.
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title_short	No evidence of human papillomaviruses in non-genital seborrheic keratosis
url	https://doi.org/10.4103/0019-5154.113949 https://doaj.org/article/9fe2fdd64b564c4187aa639e2e2ed6ec http://www.e-ijd.org/article.asp?issn=0019-5154;year=2013;volume=58;issue=4;spage=326;epage=326;aulast=Meibodi https://doaj.org/toc/0019-5154 https://doaj.org/toc/1998-3611
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doi_str	10.4103/0019-5154.113949
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up_date	2024-07-03T14:09:07.982Z
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Histopathologic changes due to viral infection such as koilocytosis (10%), dyskeratosis (66%), mitosis (28%), and parakeratosis (88%) were evident within the lesions. The most common histologic type was acanthotic type. 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No evidence of human papillomaviruses in non-genital seborrheic keratosis

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