Potential Interplay of the Gatipotuzumab Epitope TA-MUC1 and Estrogen Receptors in Ovarian Cancer

Anti-tumor efficacy of Gatipotuzumab, a therapeutic antibody targeting Tumor-Associated Mucin-1 (TA-MUC1), in relapsed ovarian cancer (OC) appeared to be rather heterogeneous. Whether adding a second anti-neoplastic drug may augment response towards Gatipotuzumab, has not been elucidated so far. Sin...
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Gespeichert in:

Autor*in:	Sabine Heublein [verfasserIn] Sabina Page [verfasserIn] Doris Mayr [verfasserIn] Elisa Schmoeckel [verfasserIn] Fabian Trillsch [verfasserIn] Frederik Marmé [verfasserIn] Sven Mahner [verfasserIn] Udo Jeschke [verfasserIn] Aurelia Vattai [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Gatipotuzumab Tamoxifen ovarian cancer 4-Hydroxy-Tamoxifen (4-OHT) survival

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 20(2019), 2, p 295
Übergeordnetes Werk:	volume:20 ; year:2019 ; number:2, p 295

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/ijms20020295

Katalog-ID:	DOAJ042820243

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allfields	10.3390/ijms20020295 doi (DE-627)DOAJ042820243 (DE-599)DOAJ707fa1b01f2c45b5a5a176b37328886b DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Sabine Heublein verfasserin aut Potential Interplay of the Gatipotuzumab Epitope TA-MUC1 and Estrogen Receptors in Ovarian Cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Anti-tumor efficacy of Gatipotuzumab, a therapeutic antibody targeting Tumor-Associated Mucin-1 (TA-MUC1), in relapsed ovarian cancer (OC) appeared to be rather heterogeneous. Whether adding a second anti-neoplastic drug may augment response towards Gatipotuzumab, has not been elucidated so far. Since it is known that anti-MUC1 antibodies may alter estrogen receptor activity in breast cancer, this potential interplay was investigated in OC. The correlation between TA-MUC1, estrogen receptors (ERs) and another 12 protein markers as well as their correlation with clinico-pathological parameters in 138 ovarian cancer cases was studied. Finally, Gatipotuzumab and 4-Hydroxy-TTamoxifen (4-OHT) as well as the combination of both was tested for its impact on cell viability in COV318, OV-90, OVCAR-3, and SKOV-3 cells. A strong positive correlation between TA-MUC1 and ERs was detected in OC tissue. Those cases missing ERs but staining positive for TA-MUC1 had significantly reduced overall survival. The combination of 4-OHT and Gatipotuzumab significantly reduced cell viability and was more effective than treatment with Gatipotuzumab alone. Co-stimulation with Gatipotuzumab enhanced the efficacy of 4-OHT in OVCAR-3 and SKOV-3. The data suggest an interplay of TA-MUC1 and ERs in OC. Whether the combination of Gatipotuzumab and TTamoxifen may enhance efficacy of either of the two drugs in vivo, or may even translate into a clinically relevant benefit over the respective monotherapies, remains to be investigated. Gatipotuzumab Tamoxifen ovarian cancer 4-Hydroxy-Tamoxifen (4-OHT) survival Biology (General) Chemistry Sabina Page verfasserin aut Doris Mayr verfasserin aut Elisa Schmoeckel verfasserin aut Fabian Trillsch verfasserin aut Frederik Marmé verfasserin aut Sven Mahner verfasserin aut Udo Jeschke verfasserin aut Aurelia Vattai verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 2, p 295 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:2, p 295 https://doi.org/10.3390/ijms20020295 kostenfrei https://doaj.org/article/707fa1b01f2c45b5a5a176b37328886b kostenfrei http://www.mdpi.com/1422-0067/20/2/295 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 2, p 295
spelling	10.3390/ijms20020295 doi (DE-627)DOAJ042820243 (DE-599)DOAJ707fa1b01f2c45b5a5a176b37328886b DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Sabine Heublein verfasserin aut Potential Interplay of the Gatipotuzumab Epitope TA-MUC1 and Estrogen Receptors in Ovarian Cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Anti-tumor efficacy of Gatipotuzumab, a therapeutic antibody targeting Tumor-Associated Mucin-1 (TA-MUC1), in relapsed ovarian cancer (OC) appeared to be rather heterogeneous. Whether adding a second anti-neoplastic drug may augment response towards Gatipotuzumab, has not been elucidated so far. Since it is known that anti-MUC1 antibodies may alter estrogen receptor activity in breast cancer, this potential interplay was investigated in OC. The correlation between TA-MUC1, estrogen receptors (ERs) and another 12 protein markers as well as their correlation with clinico-pathological parameters in 138 ovarian cancer cases was studied. Finally, Gatipotuzumab and 4-Hydroxy-TTamoxifen (4-OHT) as well as the combination of both was tested for its impact on cell viability in COV318, OV-90, OVCAR-3, and SKOV-3 cells. A strong positive correlation between TA-MUC1 and ERs was detected in OC tissue. Those cases missing ERs but staining positive for TA-MUC1 had significantly reduced overall survival. The combination of 4-OHT and Gatipotuzumab significantly reduced cell viability and was more effective than treatment with Gatipotuzumab alone. Co-stimulation with Gatipotuzumab enhanced the efficacy of 4-OHT in OVCAR-3 and SKOV-3. The data suggest an interplay of TA-MUC1 and ERs in OC. Whether the combination of Gatipotuzumab and TTamoxifen may enhance efficacy of either of the two drugs in vivo, or may even translate into a clinically relevant benefit over the respective monotherapies, remains to be investigated. Gatipotuzumab Tamoxifen ovarian cancer 4-Hydroxy-Tamoxifen (4-OHT) survival Biology (General) Chemistry Sabina Page verfasserin aut Doris Mayr verfasserin aut Elisa Schmoeckel verfasserin aut Fabian Trillsch verfasserin aut Frederik Marmé verfasserin aut Sven Mahner verfasserin aut Udo Jeschke verfasserin aut Aurelia Vattai verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 2, p 295 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:2, p 295 https://doi.org/10.3390/ijms20020295 kostenfrei https://doaj.org/article/707fa1b01f2c45b5a5a176b37328886b kostenfrei http://www.mdpi.com/1422-0067/20/2/295 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 2, p 295
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allfieldsGer	10.3390/ijms20020295 doi (DE-627)DOAJ042820243 (DE-599)DOAJ707fa1b01f2c45b5a5a176b37328886b DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Sabine Heublein verfasserin aut Potential Interplay of the Gatipotuzumab Epitope TA-MUC1 and Estrogen Receptors in Ovarian Cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Anti-tumor efficacy of Gatipotuzumab, a therapeutic antibody targeting Tumor-Associated Mucin-1 (TA-MUC1), in relapsed ovarian cancer (OC) appeared to be rather heterogeneous. Whether adding a second anti-neoplastic drug may augment response towards Gatipotuzumab, has not been elucidated so far. Since it is known that anti-MUC1 antibodies may alter estrogen receptor activity in breast cancer, this potential interplay was investigated in OC. The correlation between TA-MUC1, estrogen receptors (ERs) and another 12 protein markers as well as their correlation with clinico-pathological parameters in 138 ovarian cancer cases was studied. Finally, Gatipotuzumab and 4-Hydroxy-TTamoxifen (4-OHT) as well as the combination of both was tested for its impact on cell viability in COV318, OV-90, OVCAR-3, and SKOV-3 cells. A strong positive correlation between TA-MUC1 and ERs was detected in OC tissue. Those cases missing ERs but staining positive for TA-MUC1 had significantly reduced overall survival. The combination of 4-OHT and Gatipotuzumab significantly reduced cell viability and was more effective than treatment with Gatipotuzumab alone. Co-stimulation with Gatipotuzumab enhanced the efficacy of 4-OHT in OVCAR-3 and SKOV-3. The data suggest an interplay of TA-MUC1 and ERs in OC. Whether the combination of Gatipotuzumab and TTamoxifen may enhance efficacy of either of the two drugs in vivo, or may even translate into a clinically relevant benefit over the respective monotherapies, remains to be investigated. Gatipotuzumab Tamoxifen ovarian cancer 4-Hydroxy-Tamoxifen (4-OHT) survival Biology (General) Chemistry Sabina Page verfasserin aut Doris Mayr verfasserin aut Elisa Schmoeckel verfasserin aut Fabian Trillsch verfasserin aut Frederik Marmé verfasserin aut Sven Mahner verfasserin aut Udo Jeschke verfasserin aut Aurelia Vattai verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 2, p 295 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:2, p 295 https://doi.org/10.3390/ijms20020295 kostenfrei https://doaj.org/article/707fa1b01f2c45b5a5a176b37328886b kostenfrei http://www.mdpi.com/1422-0067/20/2/295 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 2, p 295
allfieldsSound	10.3390/ijms20020295 doi (DE-627)DOAJ042820243 (DE-599)DOAJ707fa1b01f2c45b5a5a176b37328886b DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Sabine Heublein verfasserin aut Potential Interplay of the Gatipotuzumab Epitope TA-MUC1 and Estrogen Receptors in Ovarian Cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Anti-tumor efficacy of Gatipotuzumab, a therapeutic antibody targeting Tumor-Associated Mucin-1 (TA-MUC1), in relapsed ovarian cancer (OC) appeared to be rather heterogeneous. Whether adding a second anti-neoplastic drug may augment response towards Gatipotuzumab, has not been elucidated so far. Since it is known that anti-MUC1 antibodies may alter estrogen receptor activity in breast cancer, this potential interplay was investigated in OC. The correlation between TA-MUC1, estrogen receptors (ERs) and another 12 protein markers as well as their correlation with clinico-pathological parameters in 138 ovarian cancer cases was studied. Finally, Gatipotuzumab and 4-Hydroxy-TTamoxifen (4-OHT) as well as the combination of both was tested for its impact on cell viability in COV318, OV-90, OVCAR-3, and SKOV-3 cells. A strong positive correlation between TA-MUC1 and ERs was detected in OC tissue. Those cases missing ERs but staining positive for TA-MUC1 had significantly reduced overall survival. The combination of 4-OHT and Gatipotuzumab significantly reduced cell viability and was more effective than treatment with Gatipotuzumab alone. Co-stimulation with Gatipotuzumab enhanced the efficacy of 4-OHT in OVCAR-3 and SKOV-3. The data suggest an interplay of TA-MUC1 and ERs in OC. Whether the combination of Gatipotuzumab and TTamoxifen may enhance efficacy of either of the two drugs in vivo, or may even translate into a clinically relevant benefit over the respective monotherapies, remains to be investigated. Gatipotuzumab Tamoxifen ovarian cancer 4-Hydroxy-Tamoxifen (4-OHT) survival Biology (General) Chemistry Sabina Page verfasserin aut Doris Mayr verfasserin aut Elisa Schmoeckel verfasserin aut Fabian Trillsch verfasserin aut Frederik Marmé verfasserin aut Sven Mahner verfasserin aut Udo Jeschke verfasserin aut Aurelia Vattai verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 2, p 295 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:2, p 295 https://doi.org/10.3390/ijms20020295 kostenfrei https://doaj.org/article/707fa1b01f2c45b5a5a176b37328886b kostenfrei http://www.mdpi.com/1422-0067/20/2/295 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 2, p 295
language	English
source	In International Journal of Molecular Sciences 20(2019), 2, p 295 volume:20 year:2019 number:2, p 295
sourceStr	In International Journal of Molecular Sciences 20(2019), 2, p 295 volume:20 year:2019 number:2, p 295
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Gatipotuzumab Tamoxifen ovarian cancer 4-Hydroxy-Tamoxifen (4-OHT) survival Biology (General) Chemistry
isfreeaccess_bool	true
container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Sabine Heublein @@aut@@ Sabina Page @@aut@@ Doris Mayr @@aut@@ Elisa Schmoeckel @@aut@@ Fabian Trillsch @@aut@@ Frederik Marmé @@aut@@ Sven Mahner @@aut@@ Udo Jeschke @@aut@@ Aurelia Vattai @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	316340715
id	DOAJ042820243
language_de	englisch
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callnumber-first	Q - Science
author	Sabine Heublein
spellingShingle	Sabine Heublein misc QH301-705.5 misc QD1-999 misc Gatipotuzumab misc Tamoxifen misc ovarian cancer misc 4-Hydroxy-Tamoxifen (4-OHT) misc survival misc Biology (General) misc Chemistry Potential Interplay of the Gatipotuzumab Epitope TA-MUC1 and Estrogen Receptors in Ovarian Cancer
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topic_title	QH301-705.5 QD1-999 Potential Interplay of the Gatipotuzumab Epitope TA-MUC1 and Estrogen Receptors in Ovarian Cancer Gatipotuzumab Tamoxifen ovarian cancer 4-Hydroxy-Tamoxifen (4-OHT) survival
topic	misc QH301-705.5 misc QD1-999 misc Gatipotuzumab misc Tamoxifen misc ovarian cancer misc 4-Hydroxy-Tamoxifen (4-OHT) misc survival misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc Gatipotuzumab misc Tamoxifen misc ovarian cancer misc 4-Hydroxy-Tamoxifen (4-OHT) misc survival misc Biology (General) misc Chemistry
topic_browse	misc QH301-705.5 misc QD1-999 misc Gatipotuzumab misc Tamoxifen misc ovarian cancer misc 4-Hydroxy-Tamoxifen (4-OHT) misc survival misc Biology (General) misc Chemistry
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title	Potential Interplay of the Gatipotuzumab Epitope TA-MUC1 and Estrogen Receptors in Ovarian Cancer
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title_full	Potential Interplay of the Gatipotuzumab Epitope TA-MUC1 and Estrogen Receptors in Ovarian Cancer
author_sort	Sabine Heublein
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author_browse	Sabine Heublein Sabina Page Doris Mayr Elisa Schmoeckel Fabian Trillsch Frederik Marmé Sven Mahner Udo Jeschke Aurelia Vattai
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author-letter	Sabine Heublein
doi_str_mv	10.3390/ijms20020295
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title_sort	potential interplay of the gatipotuzumab epitope ta-muc1 and estrogen receptors in ovarian cancer
callnumber	QH301-705.5
title_auth	Potential Interplay of the Gatipotuzumab Epitope TA-MUC1 and Estrogen Receptors in Ovarian Cancer
abstract	Anti-tumor efficacy of Gatipotuzumab, a therapeutic antibody targeting Tumor-Associated Mucin-1 (TA-MUC1), in relapsed ovarian cancer (OC) appeared to be rather heterogeneous. Whether adding a second anti-neoplastic drug may augment response towards Gatipotuzumab, has not been elucidated so far. Since it is known that anti-MUC1 antibodies may alter estrogen receptor activity in breast cancer, this potential interplay was investigated in OC. The correlation between TA-MUC1, estrogen receptors (ERs) and another 12 protein markers as well as their correlation with clinico-pathological parameters in 138 ovarian cancer cases was studied. Finally, Gatipotuzumab and 4-Hydroxy-TTamoxifen (4-OHT) as well as the combination of both was tested for its impact on cell viability in COV318, OV-90, OVCAR-3, and SKOV-3 cells. A strong positive correlation between TA-MUC1 and ERs was detected in OC tissue. Those cases missing ERs but staining positive for TA-MUC1 had significantly reduced overall survival. The combination of 4-OHT and Gatipotuzumab significantly reduced cell viability and was more effective than treatment with Gatipotuzumab alone. Co-stimulation with Gatipotuzumab enhanced the efficacy of 4-OHT in OVCAR-3 and SKOV-3. The data suggest an interplay of TA-MUC1 and ERs in OC. Whether the combination of Gatipotuzumab and TTamoxifen may enhance efficacy of either of the two drugs in vivo, or may even translate into a clinically relevant benefit over the respective monotherapies, remains to be investigated.
abstractGer	Anti-tumor efficacy of Gatipotuzumab, a therapeutic antibody targeting Tumor-Associated Mucin-1 (TA-MUC1), in relapsed ovarian cancer (OC) appeared to be rather heterogeneous. Whether adding a second anti-neoplastic drug may augment response towards Gatipotuzumab, has not been elucidated so far. Since it is known that anti-MUC1 antibodies may alter estrogen receptor activity in breast cancer, this potential interplay was investigated in OC. The correlation between TA-MUC1, estrogen receptors (ERs) and another 12 protein markers as well as their correlation with clinico-pathological parameters in 138 ovarian cancer cases was studied. Finally, Gatipotuzumab and 4-Hydroxy-TTamoxifen (4-OHT) as well as the combination of both was tested for its impact on cell viability in COV318, OV-90, OVCAR-3, and SKOV-3 cells. A strong positive correlation between TA-MUC1 and ERs was detected in OC tissue. Those cases missing ERs but staining positive for TA-MUC1 had significantly reduced overall survival. The combination of 4-OHT and Gatipotuzumab significantly reduced cell viability and was more effective than treatment with Gatipotuzumab alone. Co-stimulation with Gatipotuzumab enhanced the efficacy of 4-OHT in OVCAR-3 and SKOV-3. The data suggest an interplay of TA-MUC1 and ERs in OC. Whether the combination of Gatipotuzumab and TTamoxifen may enhance efficacy of either of the two drugs in vivo, or may even translate into a clinically relevant benefit over the respective monotherapies, remains to be investigated.
abstract_unstemmed	Anti-tumor efficacy of Gatipotuzumab, a therapeutic antibody targeting Tumor-Associated Mucin-1 (TA-MUC1), in relapsed ovarian cancer (OC) appeared to be rather heterogeneous. Whether adding a second anti-neoplastic drug may augment response towards Gatipotuzumab, has not been elucidated so far. Since it is known that anti-MUC1 antibodies may alter estrogen receptor activity in breast cancer, this potential interplay was investigated in OC. The correlation between TA-MUC1, estrogen receptors (ERs) and another 12 protein markers as well as their correlation with clinico-pathological parameters in 138 ovarian cancer cases was studied. Finally, Gatipotuzumab and 4-Hydroxy-TTamoxifen (4-OHT) as well as the combination of both was tested for its impact on cell viability in COV318, OV-90, OVCAR-3, and SKOV-3 cells. A strong positive correlation between TA-MUC1 and ERs was detected in OC tissue. Those cases missing ERs but staining positive for TA-MUC1 had significantly reduced overall survival. The combination of 4-OHT and Gatipotuzumab significantly reduced cell viability and was more effective than treatment with Gatipotuzumab alone. Co-stimulation with Gatipotuzumab enhanced the efficacy of 4-OHT in OVCAR-3 and SKOV-3. The data suggest an interplay of TA-MUC1 and ERs in OC. Whether the combination of Gatipotuzumab and TTamoxifen may enhance efficacy of either of the two drugs in vivo, or may even translate into a clinically relevant benefit over the respective monotherapies, remains to be investigated.
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container_issue	2, p 295
title_short	Potential Interplay of the Gatipotuzumab Epitope TA-MUC1 and Estrogen Receptors in Ovarian Cancer
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