Myelin-associated Glycoprotein gene and brain morphometry in schizophrenia

Myelin and oligodendrocyte disruption may be a core feature of schizophrenia pathophysiology. The purpose of the present study was to localize the effects of previously identified risk variants in the myelin associated glycoprotein gene on brain morphometry in schizophrenia patients and healthy cont...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Daniel eFelsky [verfasserIn] Aristotle N Voineskos [verfasserIn] Jason P Lerch [verfasserIn] Arash eNazeri [verfasserIn] Sajid A Shaikh [verfasserIn] Tarek K Rajji [verfasserIn] Benoit H Mulsant [verfasserIn] James eKennedy [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	Myelin-Associated Glycoprotein Parietal Lobe Schizophrenia Temporal Lobe imaging-genetics gray matter volume

Übergeordnetes Werk:	In: Frontiers in Psychiatry - Frontiers Media S.A., 2010, 3(2012)
Übergeordnetes Werk:	volume:3 ; year:2012

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fpsyt.2012.00040

Katalog-ID:	DOAJ042979773

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allfieldsSound	10.3389/fpsyt.2012.00040 doi (DE-627)DOAJ042979773 (DE-599)DOAJd2a19c74cee44e1487fec3f0ce57df53 DE-627 ger DE-627 rakwb eng RC435-571 Daniel eFelsky verfasserin aut Myelin-associated Glycoprotein gene and brain morphometry in schizophrenia 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Myelin and oligodendrocyte disruption may be a core feature of schizophrenia pathophysiology. The purpose of the present study was to localize the effects of previously identified risk variants in the myelin associated glycoprotein gene on brain morphometry in schizophrenia patients and healthy controls. 45 schizophrenia patients and 47 matched healthy controls underwent clinical, structural magnetic resonance imaging, and genetics procedures. Gray and white matter cortical lobe volumes along with subcortical structure volumes were calculated from T1-weighted MRI scans. Each subject was also genotyped for the two disease-associated MAG single nucleotide polymorphisms (rs720308 and rs720309). Repeated measures general linear model analysis found significant region by genotype and region by diagnosis interactions for the effects of MAG risk variants on lobar gray matter volumes. No significant associations were found with lobar white matter volumes or subcortical structure volumes. Follow-up univariate general linear models found the AA genotype of rs720308 predisposed schizophrenia patients to left temporal and parietal gray matter volume deficits. These results suggest that the effects of the MAG gene on cortical gray matter volume in schizophrenia patients can be localized to temporal and parietal cortices. Our results support a role for MAG gene variation in brain morphometry in schizophrenia, align with other lines of evidence implicating MAG in schizophrenia, and provide genetically-based insight into the heterogeneity of brain imaging findings in this disorder. Myelin-Associated Glycoprotein Parietal Lobe Schizophrenia Temporal Lobe imaging-genetics gray matter volume Psychiatry Aristotle N Voineskos verfasserin aut Jason P Lerch verfasserin aut Arash eNazeri verfasserin aut Arash eNazeri verfasserin aut Sajid A Shaikh verfasserin aut Tarek K Rajji verfasserin aut Benoit H Mulsant verfasserin aut James eKennedy verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 3(2012) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:3 year:2012 https://doi.org/10.3389/fpsyt.2012.00040 kostenfrei https://doaj.org/article/d2a19c74cee44e1487fec3f0ce57df53 kostenfrei http://journal.frontiersin.org/Journal/10.3389/fpsyt.2012.00040/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2012
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authorswithroles_txt_mv	Daniel eFelsky @@aut@@ Aristotle N Voineskos @@aut@@ Jason P Lerch @@aut@@ Arash eNazeri @@aut@@ Sajid A Shaikh @@aut@@ Tarek K Rajji @@aut@@ Benoit H Mulsant @@aut@@ James eKennedy @@aut@@
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callnumber-first	R - Medicine
author	Daniel eFelsky
spellingShingle	Daniel eFelsky misc RC435-571 misc Myelin-Associated Glycoprotein misc Parietal Lobe misc Schizophrenia misc Temporal Lobe misc imaging-genetics misc gray matter volume misc Psychiatry Myelin-associated Glycoprotein gene and brain morphometry in schizophrenia
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topic_title	RC435-571 Myelin-associated Glycoprotein gene and brain morphometry in schizophrenia Myelin-Associated Glycoprotein Parietal Lobe Schizophrenia Temporal Lobe imaging-genetics gray matter volume
topic	misc RC435-571 misc Myelin-Associated Glycoprotein misc Parietal Lobe misc Schizophrenia misc Temporal Lobe misc imaging-genetics misc gray matter volume misc Psychiatry
topic_unstemmed	misc RC435-571 misc Myelin-Associated Glycoprotein misc Parietal Lobe misc Schizophrenia misc Temporal Lobe misc imaging-genetics misc gray matter volume misc Psychiatry
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title	Myelin-associated Glycoprotein gene and brain morphometry in schizophrenia
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title_full	Myelin-associated Glycoprotein gene and brain morphometry in schizophrenia
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title_sort	myelin-associated glycoprotein gene and brain morphometry in schizophrenia
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title_auth	Myelin-associated Glycoprotein gene and brain morphometry in schizophrenia
abstract	Myelin and oligodendrocyte disruption may be a core feature of schizophrenia pathophysiology. The purpose of the present study was to localize the effects of previously identified risk variants in the myelin associated glycoprotein gene on brain morphometry in schizophrenia patients and healthy controls. 45 schizophrenia patients and 47 matched healthy controls underwent clinical, structural magnetic resonance imaging, and genetics procedures. Gray and white matter cortical lobe volumes along with subcortical structure volumes were calculated from T1-weighted MRI scans. Each subject was also genotyped for the two disease-associated MAG single nucleotide polymorphisms (rs720308 and rs720309). Repeated measures general linear model analysis found significant region by genotype and region by diagnosis interactions for the effects of MAG risk variants on lobar gray matter volumes. No significant associations were found with lobar white matter volumes or subcortical structure volumes. Follow-up univariate general linear models found the AA genotype of rs720308 predisposed schizophrenia patients to left temporal and parietal gray matter volume deficits. These results suggest that the effects of the MAG gene on cortical gray matter volume in schizophrenia patients can be localized to temporal and parietal cortices. Our results support a role for MAG gene variation in brain morphometry in schizophrenia, align with other lines of evidence implicating MAG in schizophrenia, and provide genetically-based insight into the heterogeneity of brain imaging findings in this disorder.
abstractGer	Myelin and oligodendrocyte disruption may be a core feature of schizophrenia pathophysiology. The purpose of the present study was to localize the effects of previously identified risk variants in the myelin associated glycoprotein gene on brain morphometry in schizophrenia patients and healthy controls. 45 schizophrenia patients and 47 matched healthy controls underwent clinical, structural magnetic resonance imaging, and genetics procedures. Gray and white matter cortical lobe volumes along with subcortical structure volumes were calculated from T1-weighted MRI scans. Each subject was also genotyped for the two disease-associated MAG single nucleotide polymorphisms (rs720308 and rs720309). Repeated measures general linear model analysis found significant region by genotype and region by diagnosis interactions for the effects of MAG risk variants on lobar gray matter volumes. No significant associations were found with lobar white matter volumes or subcortical structure volumes. Follow-up univariate general linear models found the AA genotype of rs720308 predisposed schizophrenia patients to left temporal and parietal gray matter volume deficits. These results suggest that the effects of the MAG gene on cortical gray matter volume in schizophrenia patients can be localized to temporal and parietal cortices. Our results support a role for MAG gene variation in brain morphometry in schizophrenia, align with other lines of evidence implicating MAG in schizophrenia, and provide genetically-based insight into the heterogeneity of brain imaging findings in this disorder.
abstract_unstemmed	Myelin and oligodendrocyte disruption may be a core feature of schizophrenia pathophysiology. The purpose of the present study was to localize the effects of previously identified risk variants in the myelin associated glycoprotein gene on brain morphometry in schizophrenia patients and healthy controls. 45 schizophrenia patients and 47 matched healthy controls underwent clinical, structural magnetic resonance imaging, and genetics procedures. Gray and white matter cortical lobe volumes along with subcortical structure volumes were calculated from T1-weighted MRI scans. Each subject was also genotyped for the two disease-associated MAG single nucleotide polymorphisms (rs720308 and rs720309). Repeated measures general linear model analysis found significant region by genotype and region by diagnosis interactions for the effects of MAG risk variants on lobar gray matter volumes. No significant associations were found with lobar white matter volumes or subcortical structure volumes. Follow-up univariate general linear models found the AA genotype of rs720308 predisposed schizophrenia patients to left temporal and parietal gray matter volume deficits. These results suggest that the effects of the MAG gene on cortical gray matter volume in schizophrenia patients can be localized to temporal and parietal cortices. Our results support a role for MAG gene variation in brain morphometry in schizophrenia, align with other lines of evidence implicating MAG in schizophrenia, and provide genetically-based insight into the heterogeneity of brain imaging findings in this disorder.
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title_short	Myelin-associated Glycoprotein gene and brain morphometry in schizophrenia
url	https://doi.org/10.3389/fpsyt.2012.00040 https://doaj.org/article/d2a19c74cee44e1487fec3f0ce57df53 http://journal.frontiersin.org/Journal/10.3389/fpsyt.2012.00040/full https://doaj.org/toc/1664-0640
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Myelin-associated Glycoprotein gene and brain morphometry in schizophrenia

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