Serum osteocalcin level and its association with carotid atherosclerosis in patients with type 2 diabetes

<p<Abstract</p< <p<Objective</p< <p<To investigate the association of serum osteocalcin with carotid atherosclerosis in patients with type 2 diabetes.</p< <p<Methods</p< <p<We performed a cross-sectional community-based study in metropolitan area...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Sheng Li [verfasserIn] Cao Wenjie [verfasserIn] Cha Bingbing [verfasserIn] Chen Zhaoping [verfasserIn] Wang Fang [verfasserIn] Liu Jun [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	Osteocalcin Intima-media thickness Carotid atherosclerotic plaques Atherosclerosis

Übergeordnetes Werk:	In: Cardiovascular Diabetology - BMC, 2003, 12(2013), 1, p 22
Übergeordnetes Werk:	volume:12 ; year:2013 ; number:1, p 22

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1475-2840-12-22

Katalog-ID:	DOAJ042984408

Internformat


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520			\|a <p<Abstract</p< <p<Objective</p< <p<To investigate the association of serum osteocalcin with carotid atherosclerosis in patients with type 2 diabetes.</p< <p<Methods</p< <p<We performed a cross-sectional community-based study in metropolitan area. Serum total osteocalcin was measured by radioimmunoassay in 382 men and 435 postmenopausal women. The carotid artery intima-media thickness (IMT) and carotid plaques (PLQ) were measured by B-mode ultrasound.</p< <p<Results</p< <p<The crude mean of serum osteocalcin concentrations were 4.52±2.43 ng/ml for men and 5.75±2.92 ng/ml for postmenopausal women (P <0.001), respectively. Osteocalcin levels were associated inversely with age, fasting serum insulin, HOMA-IR, ALT, triglycerides, total cholesterol, LDL- cholesterol, CRP (all <it<P</it<<0.001) and positively with adiponectin and HOMA-B (all P<0.05). After multiple adjustment, the odds ratios (ORs) were substantially higher risk for carotid plaques (OR 1.77 for 1 SD decrease in osteocalcin, 95% CI 1.23-2.76, p=0.005). These associations remained significant after further adjustment for potential confounder.</p< <p<Conclusions</p< <p<Serum osteocalcin levels is an independent risk factor for carotid atherosclerosis in patients with type 2 diabetes.</p<
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allfields	10.1186/1475-2840-12-22 doi (DE-627)DOAJ042984408 (DE-599)DOAJd945dd95d5184056963446fb9c7c5086 DE-627 ger DE-627 rakwb eng RC666-701 Sheng Li verfasserin aut Serum osteocalcin level and its association with carotid atherosclerosis in patients with type 2 diabetes 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Objective</p< <p<To investigate the association of serum osteocalcin with carotid atherosclerosis in patients with type 2 diabetes.</p< <p<Methods</p< <p<We performed a cross-sectional community-based study in metropolitan area. Serum total osteocalcin was measured by radioimmunoassay in 382 men and 435 postmenopausal women. The carotid artery intima-media thickness (IMT) and carotid plaques (PLQ) were measured by B-mode ultrasound.</p< <p<Results</p< <p<The crude mean of serum osteocalcin concentrations were 4.52±2.43 ng/ml for men and 5.75±2.92 ng/ml for postmenopausal women (P <0.001), respectively. Osteocalcin levels were associated inversely with age, fasting serum insulin, HOMA-IR, ALT, triglycerides, total cholesterol, LDL- cholesterol, CRP (all <it<P</it<<0.001) and positively with adiponectin and HOMA-B (all P<0.05). After multiple adjustment, the odds ratios (ORs) were substantially higher risk for carotid plaques (OR 1.77 for 1 SD decrease in osteocalcin, 95% CI 1.23-2.76, p=0.005). These associations remained significant after further adjustment for potential confounder.</p< <p<Conclusions</p< <p<Serum osteocalcin levels is an independent risk factor for carotid atherosclerosis in patients with type 2 diabetes.</p< Osteocalcin Intima-media thickness Carotid atherosclerotic plaques Atherosclerosis Diseases of the circulatory (Cardiovascular) system Cao Wenjie verfasserin aut Cha Bingbing verfasserin aut Chen Zhaoping verfasserin aut Wang Fang verfasserin aut Liu Jun verfasserin aut In Cardiovascular Diabetology BMC, 2003 12(2013), 1, p 22 (DE-627)356593665 (DE-600)2093769-6 14752840 nnns volume:12 year:2013 number:1, p 22 https://doi.org/10.1186/1475-2840-12-22 kostenfrei https://doaj.org/article/d945dd95d5184056963446fb9c7c5086 kostenfrei http://www.cardiab.com/content/12/1/22 kostenfrei https://doaj.org/toc/1475-2840 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2013 1, p 22
spelling	10.1186/1475-2840-12-22 doi (DE-627)DOAJ042984408 (DE-599)DOAJd945dd95d5184056963446fb9c7c5086 DE-627 ger DE-627 rakwb eng RC666-701 Sheng Li verfasserin aut Serum osteocalcin level and its association with carotid atherosclerosis in patients with type 2 diabetes 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Objective</p< <p<To investigate the association of serum osteocalcin with carotid atherosclerosis in patients with type 2 diabetes.</p< <p<Methods</p< <p<We performed a cross-sectional community-based study in metropolitan area. Serum total osteocalcin was measured by radioimmunoassay in 382 men and 435 postmenopausal women. The carotid artery intima-media thickness (IMT) and carotid plaques (PLQ) were measured by B-mode ultrasound.</p< <p<Results</p< <p<The crude mean of serum osteocalcin concentrations were 4.52±2.43 ng/ml for men and 5.75±2.92 ng/ml for postmenopausal women (P <0.001), respectively. Osteocalcin levels were associated inversely with age, fasting serum insulin, HOMA-IR, ALT, triglycerides, total cholesterol, LDL- cholesterol, CRP (all <it<P</it<<0.001) and positively with adiponectin and HOMA-B (all P<0.05). After multiple adjustment, the odds ratios (ORs) were substantially higher risk for carotid plaques (OR 1.77 for 1 SD decrease in osteocalcin, 95% CI 1.23-2.76, p=0.005). These associations remained significant after further adjustment for potential confounder.</p< <p<Conclusions</p< <p<Serum osteocalcin levels is an independent risk factor for carotid atherosclerosis in patients with type 2 diabetes.</p< Osteocalcin Intima-media thickness Carotid atherosclerotic plaques Atherosclerosis Diseases of the circulatory (Cardiovascular) system Cao Wenjie verfasserin aut Cha Bingbing verfasserin aut Chen Zhaoping verfasserin aut Wang Fang verfasserin aut Liu Jun verfasserin aut In Cardiovascular Diabetology BMC, 2003 12(2013), 1, p 22 (DE-627)356593665 (DE-600)2093769-6 14752840 nnns volume:12 year:2013 number:1, p 22 https://doi.org/10.1186/1475-2840-12-22 kostenfrei https://doaj.org/article/d945dd95d5184056963446fb9c7c5086 kostenfrei http://www.cardiab.com/content/12/1/22 kostenfrei https://doaj.org/toc/1475-2840 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2013 1, p 22
allfields_unstemmed	10.1186/1475-2840-12-22 doi (DE-627)DOAJ042984408 (DE-599)DOAJd945dd95d5184056963446fb9c7c5086 DE-627 ger DE-627 rakwb eng RC666-701 Sheng Li verfasserin aut Serum osteocalcin level and its association with carotid atherosclerosis in patients with type 2 diabetes 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Objective</p< <p<To investigate the association of serum osteocalcin with carotid atherosclerosis in patients with type 2 diabetes.</p< <p<Methods</p< <p<We performed a cross-sectional community-based study in metropolitan area. Serum total osteocalcin was measured by radioimmunoassay in 382 men and 435 postmenopausal women. The carotid artery intima-media thickness (IMT) and carotid plaques (PLQ) were measured by B-mode ultrasound.</p< <p<Results</p< <p<The crude mean of serum osteocalcin concentrations were 4.52±2.43 ng/ml for men and 5.75±2.92 ng/ml for postmenopausal women (P <0.001), respectively. Osteocalcin levels were associated inversely with age, fasting serum insulin, HOMA-IR, ALT, triglycerides, total cholesterol, LDL- cholesterol, CRP (all <it<P</it<<0.001) and positively with adiponectin and HOMA-B (all P<0.05). After multiple adjustment, the odds ratios (ORs) were substantially higher risk for carotid plaques (OR 1.77 for 1 SD decrease in osteocalcin, 95% CI 1.23-2.76, p=0.005). These associations remained significant after further adjustment for potential confounder.</p< <p<Conclusions</p< <p<Serum osteocalcin levels is an independent risk factor for carotid atherosclerosis in patients with type 2 diabetes.</p< Osteocalcin Intima-media thickness Carotid atherosclerotic plaques Atherosclerosis Diseases of the circulatory (Cardiovascular) system Cao Wenjie verfasserin aut Cha Bingbing verfasserin aut Chen Zhaoping verfasserin aut Wang Fang verfasserin aut Liu Jun verfasserin aut In Cardiovascular Diabetology BMC, 2003 12(2013), 1, p 22 (DE-627)356593665 (DE-600)2093769-6 14752840 nnns volume:12 year:2013 number:1, p 22 https://doi.org/10.1186/1475-2840-12-22 kostenfrei https://doaj.org/article/d945dd95d5184056963446fb9c7c5086 kostenfrei http://www.cardiab.com/content/12/1/22 kostenfrei https://doaj.org/toc/1475-2840 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2013 1, p 22
allfieldsGer	10.1186/1475-2840-12-22 doi (DE-627)DOAJ042984408 (DE-599)DOAJd945dd95d5184056963446fb9c7c5086 DE-627 ger DE-627 rakwb eng RC666-701 Sheng Li verfasserin aut Serum osteocalcin level and its association with carotid atherosclerosis in patients with type 2 diabetes 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Objective</p< <p<To investigate the association of serum osteocalcin with carotid atherosclerosis in patients with type 2 diabetes.</p< <p<Methods</p< <p<We performed a cross-sectional community-based study in metropolitan area. Serum total osteocalcin was measured by radioimmunoassay in 382 men and 435 postmenopausal women. The carotid artery intima-media thickness (IMT) and carotid plaques (PLQ) were measured by B-mode ultrasound.</p< <p<Results</p< <p<The crude mean of serum osteocalcin concentrations were 4.52±2.43 ng/ml for men and 5.75±2.92 ng/ml for postmenopausal women (P <0.001), respectively. Osteocalcin levels were associated inversely with age, fasting serum insulin, HOMA-IR, ALT, triglycerides, total cholesterol, LDL- cholesterol, CRP (all <it<P</it<<0.001) and positively with adiponectin and HOMA-B (all P<0.05). After multiple adjustment, the odds ratios (ORs) were substantially higher risk for carotid plaques (OR 1.77 for 1 SD decrease in osteocalcin, 95% CI 1.23-2.76, p=0.005). These associations remained significant after further adjustment for potential confounder.</p< <p<Conclusions</p< <p<Serum osteocalcin levels is an independent risk factor for carotid atherosclerosis in patients with type 2 diabetes.</p< Osteocalcin Intima-media thickness Carotid atherosclerotic plaques Atherosclerosis Diseases of the circulatory (Cardiovascular) system Cao Wenjie verfasserin aut Cha Bingbing verfasserin aut Chen Zhaoping verfasserin aut Wang Fang verfasserin aut Liu Jun verfasserin aut In Cardiovascular Diabetology BMC, 2003 12(2013), 1, p 22 (DE-627)356593665 (DE-600)2093769-6 14752840 nnns volume:12 year:2013 number:1, p 22 https://doi.org/10.1186/1475-2840-12-22 kostenfrei https://doaj.org/article/d945dd95d5184056963446fb9c7c5086 kostenfrei http://www.cardiab.com/content/12/1/22 kostenfrei https://doaj.org/toc/1475-2840 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2013 1, p 22
allfieldsSound	10.1186/1475-2840-12-22 doi (DE-627)DOAJ042984408 (DE-599)DOAJd945dd95d5184056963446fb9c7c5086 DE-627 ger DE-627 rakwb eng RC666-701 Sheng Li verfasserin aut Serum osteocalcin level and its association with carotid atherosclerosis in patients with type 2 diabetes 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Objective</p< <p<To investigate the association of serum osteocalcin with carotid atherosclerosis in patients with type 2 diabetes.</p< <p<Methods</p< <p<We performed a cross-sectional community-based study in metropolitan area. Serum total osteocalcin was measured by radioimmunoassay in 382 men and 435 postmenopausal women. The carotid artery intima-media thickness (IMT) and carotid plaques (PLQ) were measured by B-mode ultrasound.</p< <p<Results</p< <p<The crude mean of serum osteocalcin concentrations were 4.52±2.43 ng/ml for men and 5.75±2.92 ng/ml for postmenopausal women (P <0.001), respectively. Osteocalcin levels were associated inversely with age, fasting serum insulin, HOMA-IR, ALT, triglycerides, total cholesterol, LDL- cholesterol, CRP (all <it<P</it<<0.001) and positively with adiponectin and HOMA-B (all P<0.05). After multiple adjustment, the odds ratios (ORs) were substantially higher risk for carotid plaques (OR 1.77 for 1 SD decrease in osteocalcin, 95% CI 1.23-2.76, p=0.005). These associations remained significant after further adjustment for potential confounder.</p< <p<Conclusions</p< <p<Serum osteocalcin levels is an independent risk factor for carotid atherosclerosis in patients with type 2 diabetes.</p< Osteocalcin Intima-media thickness Carotid atherosclerotic plaques Atherosclerosis Diseases of the circulatory (Cardiovascular) system Cao Wenjie verfasserin aut Cha Bingbing verfasserin aut Chen Zhaoping verfasserin aut Wang Fang verfasserin aut Liu Jun verfasserin aut In Cardiovascular Diabetology BMC, 2003 12(2013), 1, p 22 (DE-627)356593665 (DE-600)2093769-6 14752840 nnns volume:12 year:2013 number:1, p 22 https://doi.org/10.1186/1475-2840-12-22 kostenfrei https://doaj.org/article/d945dd95d5184056963446fb9c7c5086 kostenfrei http://www.cardiab.com/content/12/1/22 kostenfrei https://doaj.org/toc/1475-2840 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2013 1, p 22
language	English
source	In Cardiovascular Diabetology 12(2013), 1, p 22 volume:12 year:2013 number:1, p 22
sourceStr	In Cardiovascular Diabetology 12(2013), 1, p 22 volume:12 year:2013 number:1, p 22
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Osteocalcin Intima-media thickness Carotid atherosclerotic plaques Atherosclerosis Diseases of the circulatory (Cardiovascular) system
isfreeaccess_bool	true
container_title	Cardiovascular Diabetology
authorswithroles_txt_mv	Sheng Li @@aut@@ Cao Wenjie @@aut@@ Cha Bingbing @@aut@@ Chen Zhaoping @@aut@@ Wang Fang @@aut@@ Liu Jun @@aut@@
publishDateDaySort_date	2013-01-01T00:00:00Z
hierarchy_top_id	356593665
id	DOAJ042984408
language_de	englisch
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callnumber-first	R - Medicine
author	Sheng Li
spellingShingle	Sheng Li misc RC666-701 misc Osteocalcin misc Intima-media thickness misc Carotid atherosclerotic plaques misc Atherosclerosis misc Diseases of the circulatory (Cardiovascular) system Serum osteocalcin level and its association with carotid atherosclerosis in patients with type 2 diabetes
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topic_title	RC666-701 Serum osteocalcin level and its association with carotid atherosclerosis in patients with type 2 diabetes Osteocalcin Intima-media thickness Carotid atherosclerotic plaques Atherosclerosis
topic	misc RC666-701 misc Osteocalcin misc Intima-media thickness misc Carotid atherosclerotic plaques misc Atherosclerosis misc Diseases of the circulatory (Cardiovascular) system
topic_unstemmed	misc RC666-701 misc Osteocalcin misc Intima-media thickness misc Carotid atherosclerotic plaques misc Atherosclerosis misc Diseases of the circulatory (Cardiovascular) system
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title	Serum osteocalcin level and its association with carotid atherosclerosis in patients with type 2 diabetes
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title_full	Serum osteocalcin level and its association with carotid atherosclerosis in patients with type 2 diabetes
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journal	Cardiovascular Diabetology
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author_browse	Sheng Li Cao Wenjie Cha Bingbing Chen Zhaoping Wang Fang Liu Jun
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title_sort	serum osteocalcin level and its association with carotid atherosclerosis in patients with type 2 diabetes
callnumber	RC666-701
title_auth	Serum osteocalcin level and its association with carotid atherosclerosis in patients with type 2 diabetes
abstract	<p<Abstract</p< <p<Objective</p< <p<To investigate the association of serum osteocalcin with carotid atherosclerosis in patients with type 2 diabetes.</p< <p<Methods</p< <p<We performed a cross-sectional community-based study in metropolitan area. Serum total osteocalcin was measured by radioimmunoassay in 382 men and 435 postmenopausal women. The carotid artery intima-media thickness (IMT) and carotid plaques (PLQ) were measured by B-mode ultrasound.</p< <p<Results</p< <p<The crude mean of serum osteocalcin concentrations were 4.52±2.43 ng/ml for men and 5.75±2.92 ng/ml for postmenopausal women (P <0.001), respectively. Osteocalcin levels were associated inversely with age, fasting serum insulin, HOMA-IR, ALT, triglycerides, total cholesterol, LDL- cholesterol, CRP (all <it<P</it<<0.001) and positively with adiponectin and HOMA-B (all P<0.05). After multiple adjustment, the odds ratios (ORs) were substantially higher risk for carotid plaques (OR 1.77 for 1 SD decrease in osteocalcin, 95% CI 1.23-2.76, p=0.005). These associations remained significant after further adjustment for potential confounder.</p< <p<Conclusions</p< <p<Serum osteocalcin levels is an independent risk factor for carotid atherosclerosis in patients with type 2 diabetes.</p<
abstractGer	<p<Abstract</p< <p<Objective</p< <p<To investigate the association of serum osteocalcin with carotid atherosclerosis in patients with type 2 diabetes.</p< <p<Methods</p< <p<We performed a cross-sectional community-based study in metropolitan area. Serum total osteocalcin was measured by radioimmunoassay in 382 men and 435 postmenopausal women. The carotid artery intima-media thickness (IMT) and carotid plaques (PLQ) were measured by B-mode ultrasound.</p< <p<Results</p< <p<The crude mean of serum osteocalcin concentrations were 4.52±2.43 ng/ml for men and 5.75±2.92 ng/ml for postmenopausal women (P <0.001), respectively. Osteocalcin levels were associated inversely with age, fasting serum insulin, HOMA-IR, ALT, triglycerides, total cholesterol, LDL- cholesterol, CRP (all <it<P</it<<0.001) and positively with adiponectin and HOMA-B (all P<0.05). After multiple adjustment, the odds ratios (ORs) were substantially higher risk for carotid plaques (OR 1.77 for 1 SD decrease in osteocalcin, 95% CI 1.23-2.76, p=0.005). These associations remained significant after further adjustment for potential confounder.</p< <p<Conclusions</p< <p<Serum osteocalcin levels is an independent risk factor for carotid atherosclerosis in patients with type 2 diabetes.</p<
abstract_unstemmed	<p<Abstract</p< <p<Objective</p< <p<To investigate the association of serum osteocalcin with carotid atherosclerosis in patients with type 2 diabetes.</p< <p<Methods</p< <p<We performed a cross-sectional community-based study in metropolitan area. Serum total osteocalcin was measured by radioimmunoassay in 382 men and 435 postmenopausal women. The carotid artery intima-media thickness (IMT) and carotid plaques (PLQ) were measured by B-mode ultrasound.</p< <p<Results</p< <p<The crude mean of serum osteocalcin concentrations were 4.52±2.43 ng/ml for men and 5.75±2.92 ng/ml for postmenopausal women (P <0.001), respectively. Osteocalcin levels were associated inversely with age, fasting serum insulin, HOMA-IR, ALT, triglycerides, total cholesterol, LDL- cholesterol, CRP (all <it<P</it<<0.001) and positively with adiponectin and HOMA-B (all P<0.05). After multiple adjustment, the odds ratios (ORs) were substantially higher risk for carotid plaques (OR 1.77 for 1 SD decrease in osteocalcin, 95% CI 1.23-2.76, p=0.005). These associations remained significant after further adjustment for potential confounder.</p< <p<Conclusions</p< <p<Serum osteocalcin levels is an independent risk factor for carotid atherosclerosis in patients with type 2 diabetes.</p<
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Serum osteocalcin level and its association with carotid atherosclerosis in patients with type 2 diabetes

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