Galectins-1, -3, and -7 Are Prognostic Markers for Survival of Ovarian Cancer Patients

There is a tremendous need for developing new useful prognostic factors in ovarian cancer. Galectins are a family of carbohydrate binding proteins which have been suggested to serve as prognostic factors for various cancer types. In this study, the presence of Galectin-1, -3, and -7 was investigated...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Heiko Schulz [verfasserIn] Elisa Schmoeckel [verfasserIn] Christina Kuhn [verfasserIn] Simone Hofmann [verfasserIn] Doris Mayr [verfasserIn] Sven Mahner [verfasserIn] Udo Jeschke [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Galectin-1 Galectin-3 Galectin-7 ovarian cancer overall survival

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 18(2017), 6, p 1230
Übergeordnetes Werk:	volume:18 ; year:2017 ; number:6, p 1230

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/ijms18061230

Katalog-ID:	DOAJ043059155

Internformat


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allfields	10.3390/ijms18061230 doi (DE-627)DOAJ043059155 (DE-599)DOAJ8157f6db55a04e9eb5ce56e81cc541da DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Heiko Schulz verfasserin aut Galectins-1, -3, and -7 Are Prognostic Markers for Survival of Ovarian Cancer Patients 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier There is a tremendous need for developing new useful prognostic factors in ovarian cancer. Galectins are a family of carbohydrate binding proteins which have been suggested to serve as prognostic factors for various cancer types. In this study, the presence of Galectin-1, -3, and -7 was investigated in 156 ovarian cancer specimens by immunochemical staining. Staining was evaluated in the cytoplasm and nucleus of cancer cells as well as the peritumoral stroma using a semi quantitative score (Remmele (IR) score). Patients’ overall survival was compared between different groups of Galectin expression. Galectin (Gal)-1 and -3 staining was observed in the peritumoral stroma as well as the nucleus and cytoplasm of tumor cells, while Gal-7 was only present in the cytoplasm of tumor cells. Patients with Gal-1 expression in the cytoplasm or high Gal-1 expression in the peritumoral stroma showed reduced overall survival. Nuclear Gal-3 staining correlated with a better outcome. We observed a significantly reduced overall survival for cases with high Gal-7 expression and a better survival for Gal-7 negative cases, when compared to cases with low expression of Gal-7. We were able to show that both tumor and stroma staining of Gal-1 could serve as negative prognostic factors for ovarian cancer. We were able to confirm cytoplasmic Gal-7 as a negative prognostic factor. Gal-3 staining in the nucleus could be a new positive prognosticator for ovarian cancer. Galectin-1 Galectin-3 Galectin-7 ovarian cancer overall survival Biology (General) Chemistry Elisa Schmoeckel verfasserin aut Christina Kuhn verfasserin aut Simone Hofmann verfasserin aut Doris Mayr verfasserin aut Sven Mahner verfasserin aut Udo Jeschke verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 18(2017), 6, p 1230 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:18 year:2017 number:6, p 1230 https://doi.org/10.3390/ijms18061230 kostenfrei https://doaj.org/article/8157f6db55a04e9eb5ce56e81cc541da kostenfrei http://www.mdpi.com/1422-0067/18/6/1230 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 6, p 1230
spelling	10.3390/ijms18061230 doi (DE-627)DOAJ043059155 (DE-599)DOAJ8157f6db55a04e9eb5ce56e81cc541da DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Heiko Schulz verfasserin aut Galectins-1, -3, and -7 Are Prognostic Markers for Survival of Ovarian Cancer Patients 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier There is a tremendous need for developing new useful prognostic factors in ovarian cancer. Galectins are a family of carbohydrate binding proteins which have been suggested to serve as prognostic factors for various cancer types. In this study, the presence of Galectin-1, -3, and -7 was investigated in 156 ovarian cancer specimens by immunochemical staining. Staining was evaluated in the cytoplasm and nucleus of cancer cells as well as the peritumoral stroma using a semi quantitative score (Remmele (IR) score). Patients’ overall survival was compared between different groups of Galectin expression. Galectin (Gal)-1 and -3 staining was observed in the peritumoral stroma as well as the nucleus and cytoplasm of tumor cells, while Gal-7 was only present in the cytoplasm of tumor cells. Patients with Gal-1 expression in the cytoplasm or high Gal-1 expression in the peritumoral stroma showed reduced overall survival. Nuclear Gal-3 staining correlated with a better outcome. We observed a significantly reduced overall survival for cases with high Gal-7 expression and a better survival for Gal-7 negative cases, when compared to cases with low expression of Gal-7. We were able to show that both tumor and stroma staining of Gal-1 could serve as negative prognostic factors for ovarian cancer. We were able to confirm cytoplasmic Gal-7 as a negative prognostic factor. Gal-3 staining in the nucleus could be a new positive prognosticator for ovarian cancer. Galectin-1 Galectin-3 Galectin-7 ovarian cancer overall survival Biology (General) Chemistry Elisa Schmoeckel verfasserin aut Christina Kuhn verfasserin aut Simone Hofmann verfasserin aut Doris Mayr verfasserin aut Sven Mahner verfasserin aut Udo Jeschke verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 18(2017), 6, p 1230 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:18 year:2017 number:6, p 1230 https://doi.org/10.3390/ijms18061230 kostenfrei https://doaj.org/article/8157f6db55a04e9eb5ce56e81cc541da kostenfrei http://www.mdpi.com/1422-0067/18/6/1230 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 6, p 1230
allfields_unstemmed	10.3390/ijms18061230 doi (DE-627)DOAJ043059155 (DE-599)DOAJ8157f6db55a04e9eb5ce56e81cc541da DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Heiko Schulz verfasserin aut Galectins-1, -3, and -7 Are Prognostic Markers for Survival of Ovarian Cancer Patients 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier There is a tremendous need for developing new useful prognostic factors in ovarian cancer. Galectins are a family of carbohydrate binding proteins which have been suggested to serve as prognostic factors for various cancer types. In this study, the presence of Galectin-1, -3, and -7 was investigated in 156 ovarian cancer specimens by immunochemical staining. Staining was evaluated in the cytoplasm and nucleus of cancer cells as well as the peritumoral stroma using a semi quantitative score (Remmele (IR) score). Patients’ overall survival was compared between different groups of Galectin expression. Galectin (Gal)-1 and -3 staining was observed in the peritumoral stroma as well as the nucleus and cytoplasm of tumor cells, while Gal-7 was only present in the cytoplasm of tumor cells. Patients with Gal-1 expression in the cytoplasm or high Gal-1 expression in the peritumoral stroma showed reduced overall survival. Nuclear Gal-3 staining correlated with a better outcome. We observed a significantly reduced overall survival for cases with high Gal-7 expression and a better survival for Gal-7 negative cases, when compared to cases with low expression of Gal-7. We were able to show that both tumor and stroma staining of Gal-1 could serve as negative prognostic factors for ovarian cancer. We were able to confirm cytoplasmic Gal-7 as a negative prognostic factor. Gal-3 staining in the nucleus could be a new positive prognosticator for ovarian cancer. Galectin-1 Galectin-3 Galectin-7 ovarian cancer overall survival Biology (General) Chemistry Elisa Schmoeckel verfasserin aut Christina Kuhn verfasserin aut Simone Hofmann verfasserin aut Doris Mayr verfasserin aut Sven Mahner verfasserin aut Udo Jeschke verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 18(2017), 6, p 1230 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:18 year:2017 number:6, p 1230 https://doi.org/10.3390/ijms18061230 kostenfrei https://doaj.org/article/8157f6db55a04e9eb5ce56e81cc541da kostenfrei http://www.mdpi.com/1422-0067/18/6/1230 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 6, p 1230
allfieldsGer	10.3390/ijms18061230 doi (DE-627)DOAJ043059155 (DE-599)DOAJ8157f6db55a04e9eb5ce56e81cc541da DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Heiko Schulz verfasserin aut Galectins-1, -3, and -7 Are Prognostic Markers for Survival of Ovarian Cancer Patients 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier There is a tremendous need for developing new useful prognostic factors in ovarian cancer. Galectins are a family of carbohydrate binding proteins which have been suggested to serve as prognostic factors for various cancer types. In this study, the presence of Galectin-1, -3, and -7 was investigated in 156 ovarian cancer specimens by immunochemical staining. Staining was evaluated in the cytoplasm and nucleus of cancer cells as well as the peritumoral stroma using a semi quantitative score (Remmele (IR) score). Patients’ overall survival was compared between different groups of Galectin expression. Galectin (Gal)-1 and -3 staining was observed in the peritumoral stroma as well as the nucleus and cytoplasm of tumor cells, while Gal-7 was only present in the cytoplasm of tumor cells. Patients with Gal-1 expression in the cytoplasm or high Gal-1 expression in the peritumoral stroma showed reduced overall survival. Nuclear Gal-3 staining correlated with a better outcome. We observed a significantly reduced overall survival for cases with high Gal-7 expression and a better survival for Gal-7 negative cases, when compared to cases with low expression of Gal-7. We were able to show that both tumor and stroma staining of Gal-1 could serve as negative prognostic factors for ovarian cancer. We were able to confirm cytoplasmic Gal-7 as a negative prognostic factor. Gal-3 staining in the nucleus could be a new positive prognosticator for ovarian cancer. Galectin-1 Galectin-3 Galectin-7 ovarian cancer overall survival Biology (General) Chemistry Elisa Schmoeckel verfasserin aut Christina Kuhn verfasserin aut Simone Hofmann verfasserin aut Doris Mayr verfasserin aut Sven Mahner verfasserin aut Udo Jeschke verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 18(2017), 6, p 1230 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:18 year:2017 number:6, p 1230 https://doi.org/10.3390/ijms18061230 kostenfrei https://doaj.org/article/8157f6db55a04e9eb5ce56e81cc541da kostenfrei http://www.mdpi.com/1422-0067/18/6/1230 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 6, p 1230
allfieldsSound	10.3390/ijms18061230 doi (DE-627)DOAJ043059155 (DE-599)DOAJ8157f6db55a04e9eb5ce56e81cc541da DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Heiko Schulz verfasserin aut Galectins-1, -3, and -7 Are Prognostic Markers for Survival of Ovarian Cancer Patients 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier There is a tremendous need for developing new useful prognostic factors in ovarian cancer. Galectins are a family of carbohydrate binding proteins which have been suggested to serve as prognostic factors for various cancer types. In this study, the presence of Galectin-1, -3, and -7 was investigated in 156 ovarian cancer specimens by immunochemical staining. Staining was evaluated in the cytoplasm and nucleus of cancer cells as well as the peritumoral stroma using a semi quantitative score (Remmele (IR) score). Patients’ overall survival was compared between different groups of Galectin expression. Galectin (Gal)-1 and -3 staining was observed in the peritumoral stroma as well as the nucleus and cytoplasm of tumor cells, while Gal-7 was only present in the cytoplasm of tumor cells. Patients with Gal-1 expression in the cytoplasm or high Gal-1 expression in the peritumoral stroma showed reduced overall survival. Nuclear Gal-3 staining correlated with a better outcome. We observed a significantly reduced overall survival for cases with high Gal-7 expression and a better survival for Gal-7 negative cases, when compared to cases with low expression of Gal-7. We were able to show that both tumor and stroma staining of Gal-1 could serve as negative prognostic factors for ovarian cancer. We were able to confirm cytoplasmic Gal-7 as a negative prognostic factor. Gal-3 staining in the nucleus could be a new positive prognosticator for ovarian cancer. Galectin-1 Galectin-3 Galectin-7 ovarian cancer overall survival Biology (General) Chemistry Elisa Schmoeckel verfasserin aut Christina Kuhn verfasserin aut Simone Hofmann verfasserin aut Doris Mayr verfasserin aut Sven Mahner verfasserin aut Udo Jeschke verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 18(2017), 6, p 1230 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:18 year:2017 number:6, p 1230 https://doi.org/10.3390/ijms18061230 kostenfrei https://doaj.org/article/8157f6db55a04e9eb5ce56e81cc541da kostenfrei http://www.mdpi.com/1422-0067/18/6/1230 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 6, p 1230
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source	In International Journal of Molecular Sciences 18(2017), 6, p 1230 volume:18 year:2017 number:6, p 1230
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callnumber-first	Q - Science
author	Heiko Schulz
spellingShingle	Heiko Schulz misc QH301-705.5 misc QD1-999 misc Galectin-1 misc Galectin-3 misc Galectin-7 misc ovarian cancer misc overall survival misc Biology (General) misc Chemistry Galectins-1, -3, and -7 Are Prognostic Markers for Survival of Ovarian Cancer Patients
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topic_title	QH301-705.5 QD1-999 Galectins-1, -3, and -7 Are Prognostic Markers for Survival of Ovarian Cancer Patients Galectin-1 Galectin-3 Galectin-7 ovarian cancer overall survival
topic	misc QH301-705.5 misc QD1-999 misc Galectin-1 misc Galectin-3 misc Galectin-7 misc ovarian cancer misc overall survival misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc Galectin-1 misc Galectin-3 misc Galectin-7 misc ovarian cancer misc overall survival misc Biology (General) misc Chemistry
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title	Galectins-1, -3, and -7 Are Prognostic Markers for Survival of Ovarian Cancer Patients
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title_full	Galectins-1, -3, and -7 Are Prognostic Markers for Survival of Ovarian Cancer Patients
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title_sort	galectins-1, -3, and -7 are prognostic markers for survival of ovarian cancer patients
callnumber	QH301-705.5
title_auth	Galectins-1, -3, and -7 Are Prognostic Markers for Survival of Ovarian Cancer Patients
abstract	There is a tremendous need for developing new useful prognostic factors in ovarian cancer. Galectins are a family of carbohydrate binding proteins which have been suggested to serve as prognostic factors for various cancer types. In this study, the presence of Galectin-1, -3, and -7 was investigated in 156 ovarian cancer specimens by immunochemical staining. Staining was evaluated in the cytoplasm and nucleus of cancer cells as well as the peritumoral stroma using a semi quantitative score (Remmele (IR) score). Patients’ overall survival was compared between different groups of Galectin expression. Galectin (Gal)-1 and -3 staining was observed in the peritumoral stroma as well as the nucleus and cytoplasm of tumor cells, while Gal-7 was only present in the cytoplasm of tumor cells. Patients with Gal-1 expression in the cytoplasm or high Gal-1 expression in the peritumoral stroma showed reduced overall survival. Nuclear Gal-3 staining correlated with a better outcome. We observed a significantly reduced overall survival for cases with high Gal-7 expression and a better survival for Gal-7 negative cases, when compared to cases with low expression of Gal-7. We were able to show that both tumor and stroma staining of Gal-1 could serve as negative prognostic factors for ovarian cancer. We were able to confirm cytoplasmic Gal-7 as a negative prognostic factor. Gal-3 staining in the nucleus could be a new positive prognosticator for ovarian cancer.
abstractGer	There is a tremendous need for developing new useful prognostic factors in ovarian cancer. Galectins are a family of carbohydrate binding proteins which have been suggested to serve as prognostic factors for various cancer types. In this study, the presence of Galectin-1, -3, and -7 was investigated in 156 ovarian cancer specimens by immunochemical staining. Staining was evaluated in the cytoplasm and nucleus of cancer cells as well as the peritumoral stroma using a semi quantitative score (Remmele (IR) score). Patients’ overall survival was compared between different groups of Galectin expression. Galectin (Gal)-1 and -3 staining was observed in the peritumoral stroma as well as the nucleus and cytoplasm of tumor cells, while Gal-7 was only present in the cytoplasm of tumor cells. Patients with Gal-1 expression in the cytoplasm or high Gal-1 expression in the peritumoral stroma showed reduced overall survival. Nuclear Gal-3 staining correlated with a better outcome. We observed a significantly reduced overall survival for cases with high Gal-7 expression and a better survival for Gal-7 negative cases, when compared to cases with low expression of Gal-7. We were able to show that both tumor and stroma staining of Gal-1 could serve as negative prognostic factors for ovarian cancer. We were able to confirm cytoplasmic Gal-7 as a negative prognostic factor. Gal-3 staining in the nucleus could be a new positive prognosticator for ovarian cancer.
abstract_unstemmed	There is a tremendous need for developing new useful prognostic factors in ovarian cancer. Galectins are a family of carbohydrate binding proteins which have been suggested to serve as prognostic factors for various cancer types. In this study, the presence of Galectin-1, -3, and -7 was investigated in 156 ovarian cancer specimens by immunochemical staining. Staining was evaluated in the cytoplasm and nucleus of cancer cells as well as the peritumoral stroma using a semi quantitative score (Remmele (IR) score). Patients’ overall survival was compared between different groups of Galectin expression. Galectin (Gal)-1 and -3 staining was observed in the peritumoral stroma as well as the nucleus and cytoplasm of tumor cells, while Gal-7 was only present in the cytoplasm of tumor cells. Patients with Gal-1 expression in the cytoplasm or high Gal-1 expression in the peritumoral stroma showed reduced overall survival. Nuclear Gal-3 staining correlated with a better outcome. We observed a significantly reduced overall survival for cases with high Gal-7 expression and a better survival for Gal-7 negative cases, when compared to cases with low expression of Gal-7. We were able to show that both tumor and stroma staining of Gal-1 could serve as negative prognostic factors for ovarian cancer. We were able to confirm cytoplasmic Gal-7 as a negative prognostic factor. Gal-3 staining in the nucleus could be a new positive prognosticator for ovarian cancer.
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container_issue	6, p 1230
title_short	Galectins-1, -3, and -7 Are Prognostic Markers for Survival of Ovarian Cancer Patients
url	https://doi.org/10.3390/ijms18061230 https://doaj.org/article/8157f6db55a04e9eb5ce56e81cc541da http://www.mdpi.com/1422-0067/18/6/1230 https://doaj.org/toc/1422-0067
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up_date	2024-07-03T15:29:05.278Z
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Galectins-1, -3, and -7 Are Prognostic Markers for Survival of Ovarian Cancer Patients

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