Detection and Distribution of Low Level and High Level Mupirocin Resistance among Clinical Methicillin Resistant Staphylococcus aureus Isolates

Introduction: Prolonged and improper use of antibiotics increases the resistance among pathogens and leads to life-threatening implications and increases mortality. The incidence of mupirocin resistance in Methicillin Resistant Staphylococcus aureus (MRSA) clinical isolates were reportedly increasing. Aim: To determine the rate of high level and low level mupirocin resistance in clinical MRSA isolates in a tertiary care hospital. Materials and Methods: A cross-sectional study was carried out for a period of three months from December 2019 to February 2020 in Department of Microbiology, PSG Institute of Medical Sciences and Research (PSG IMSR), Coimbatore, Tamil Nadu, India. A total of 100 non duplicate Staphylococcus aureus isolates from different specimens were subjected to mupirocin susceptibility by Kirby-Bauer disc diffusion method as per Clinical and Laboratory Standards Institute (CLSI) 2019 standards. The low (MuL) and high (MuH) level mupirocin resistance were detected by using 5 and 200 μg mupirocin discs (Himedia) respectively. The isolate exhibiting diameter of ≥14 mm indicates its susceptibility. The isolate exhibiting diameter ≤13 mm for both 5 and 200 μg indicates MuL and MuH strains respectively. Pearson’s Chi-square test was calculated and p-value of <0.05 was considered as statistically significant. Results: Total 51% Staphylococcus aureus isolates were found to be MRSA. In present study, 6 out of 51 (11.8%) MRSA isolates were found to exhibit MuL and 5 out of 51 (9.8%) MRSA isolates were found to be having MuH. Low level and high level mupirocin resistance were not observed in Methicillin Sensitive Staphylococcus aureus (MSSA). Conclusion: The incidence of MuH and MuL resistance among MRSA were found to be 9.8% and 11.8%, respectively. Screening for mupirocin resistant MRSA to be carried out periodically and stringent infection control practices to be in place to prevent further spread of mupirocin resistant MRSA. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	P Ganesh Perumal [verfasserIn] Subisha Kannan [verfasserIn] B Appalaraju [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	clinical isolates inducible clindamycin resistance mupirocin resistant staphylococcus aureus

Übergeordnetes Werk:	In: Journal of Clinical and Diagnostic Research - JCDR Research and Publications Private Limited, 2009, 16(2022), 5, Seite DC06-DC10
Übergeordnetes Werk:	volume:16 ; year:2022 ; number:5 ; pages:DC06-DC10

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.7860/JCDR/2022/55943.16298

Katalog-ID:	DOAJ043288944

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245	1	0	\|a Detection and Distribution of Low Level and High Level Mupirocin Resistance among Clinical Methicillin Resistant Staphylococcus aureus Isolates
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520			\|a Introduction: Prolonged and improper use of antibiotics increases the resistance among pathogens and leads to life-threatening implications and increases mortality. The incidence of mupirocin resistance in Methicillin Resistant Staphylococcus aureus (MRSA) clinical isolates were reportedly increasing. Aim: To determine the rate of high level and low level mupirocin resistance in clinical MRSA isolates in a tertiary care hospital. Materials and Methods: A cross-sectional study was carried out for a period of three months from December 2019 to February 2020 in Department of Microbiology, PSG Institute of Medical Sciences and Research (PSG IMSR), Coimbatore, Tamil Nadu, India. A total of 100 non duplicate Staphylococcus aureus isolates from different specimens were subjected to mupirocin susceptibility by Kirby-Bauer disc diffusion method as per Clinical and Laboratory Standards Institute (CLSI) 2019 standards. The low (MuL) and high (MuH) level mupirocin resistance were detected by using 5 and 200 μg mupirocin discs (Himedia) respectively. The isolate exhibiting diameter of ≥14 mm indicates its susceptibility. The isolate exhibiting diameter ≤13 mm for both 5 and 200 μg indicates MuL and MuH strains respectively. Pearson’s Chi-square test was calculated and p-value of <0.05 was considered as statistically significant. Results: Total 51% Staphylococcus aureus isolates were found to be MRSA. In present study, 6 out of 51 (11.8%) MRSA isolates were found to exhibit MuL and 5 out of 51 (9.8%) MRSA isolates were found to be having MuH. Low level and high level mupirocin resistance were not observed in Methicillin Sensitive Staphylococcus aureus (MSSA). Conclusion: The incidence of MuH and MuL resistance among MRSA were found to be 9.8% and 11.8%, respectively. Screening for mupirocin resistant MRSA to be carried out periodically and stringent infection control practices to be in place to prevent further spread of mupirocin resistant MRSA.
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allfields	10.7860/JCDR/2022/55943.16298 doi (DE-627)DOAJ043288944 (DE-599)DOAJbcdd818580b34e6ab54a51299ddada53 DE-627 ger DE-627 rakwb eng P Ganesh Perumal verfasserin aut Detection and Distribution of Low Level and High Level Mupirocin Resistance among Clinical Methicillin Resistant Staphylococcus aureus Isolates 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Prolonged and improper use of antibiotics increases the resistance among pathogens and leads to life-threatening implications and increases mortality. The incidence of mupirocin resistance in Methicillin Resistant Staphylococcus aureus (MRSA) clinical isolates were reportedly increasing. Aim: To determine the rate of high level and low level mupirocin resistance in clinical MRSA isolates in a tertiary care hospital. Materials and Methods: A cross-sectional study was carried out for a period of three months from December 2019 to February 2020 in Department of Microbiology, PSG Institute of Medical Sciences and Research (PSG IMSR), Coimbatore, Tamil Nadu, India. A total of 100 non duplicate Staphylococcus aureus isolates from different specimens were subjected to mupirocin susceptibility by Kirby-Bauer disc diffusion method as per Clinical and Laboratory Standards Institute (CLSI) 2019 standards. The low (MuL) and high (MuH) level mupirocin resistance were detected by using 5 and 200 μg mupirocin discs (Himedia) respectively. The isolate exhibiting diameter of ≥14 mm indicates its susceptibility. The isolate exhibiting diameter ≤13 mm for both 5 and 200 μg indicates MuL and MuH strains respectively. Pearson’s Chi-square test was calculated and p-value of <0.05 was considered as statistically significant. Results: Total 51% Staphylococcus aureus isolates were found to be MRSA. In present study, 6 out of 51 (11.8%) MRSA isolates were found to exhibit MuL and 5 out of 51 (9.8%) MRSA isolates were found to be having MuH. Low level and high level mupirocin resistance were not observed in Methicillin Sensitive Staphylococcus aureus (MSSA). Conclusion: The incidence of MuH and MuL resistance among MRSA were found to be 9.8% and 11.8%, respectively. Screening for mupirocin resistant MRSA to be carried out periodically and stringent infection control practices to be in place to prevent further spread of mupirocin resistant MRSA. clinical isolates inducible clindamycin resistance mupirocin resistant staphylococcus aureus Medicine R Subisha Kannan verfasserin aut B Appalaraju verfasserin aut In Journal of Clinical and Diagnostic Research JCDR Research and Publications Private Limited, 2009 16(2022), 5, Seite DC06-DC10 (DE-627)789478048 (DE-600)2775283-5 0973709X nnns volume:16 year:2022 number:5 pages:DC06-DC10 https://doi.org/10.7860/JCDR/2022/55943.16298 kostenfrei https://doaj.org/article/bcdd818580b34e6ab54a51299ddada53 kostenfrei https://www.jcdr.net/articles/PDF/16298/55943_CE[Ra1]_F[SH]_PF1(AG_SS)_PFA(AG_KM)_PN(KM).pdf kostenfrei https://doaj.org/toc/2249-782X Journal toc kostenfrei https://doaj.org/toc/0973-709X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2022 5 DC06-DC10
spelling	10.7860/JCDR/2022/55943.16298 doi (DE-627)DOAJ043288944 (DE-599)DOAJbcdd818580b34e6ab54a51299ddada53 DE-627 ger DE-627 rakwb eng P Ganesh Perumal verfasserin aut Detection and Distribution of Low Level and High Level Mupirocin Resistance among Clinical Methicillin Resistant Staphylococcus aureus Isolates 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Prolonged and improper use of antibiotics increases the resistance among pathogens and leads to life-threatening implications and increases mortality. The incidence of mupirocin resistance in Methicillin Resistant Staphylococcus aureus (MRSA) clinical isolates were reportedly increasing. Aim: To determine the rate of high level and low level mupirocin resistance in clinical MRSA isolates in a tertiary care hospital. Materials and Methods: A cross-sectional study was carried out for a period of three months from December 2019 to February 2020 in Department of Microbiology, PSG Institute of Medical Sciences and Research (PSG IMSR), Coimbatore, Tamil Nadu, India. A total of 100 non duplicate Staphylococcus aureus isolates from different specimens were subjected to mupirocin susceptibility by Kirby-Bauer disc diffusion method as per Clinical and Laboratory Standards Institute (CLSI) 2019 standards. The low (MuL) and high (MuH) level mupirocin resistance were detected by using 5 and 200 μg mupirocin discs (Himedia) respectively. The isolate exhibiting diameter of ≥14 mm indicates its susceptibility. The isolate exhibiting diameter ≤13 mm for both 5 and 200 μg indicates MuL and MuH strains respectively. Pearson’s Chi-square test was calculated and p-value of <0.05 was considered as statistically significant. Results: Total 51% Staphylococcus aureus isolates were found to be MRSA. In present study, 6 out of 51 (11.8%) MRSA isolates were found to exhibit MuL and 5 out of 51 (9.8%) MRSA isolates were found to be having MuH. Low level and high level mupirocin resistance were not observed in Methicillin Sensitive Staphylococcus aureus (MSSA). Conclusion: The incidence of MuH and MuL resistance among MRSA were found to be 9.8% and 11.8%, respectively. Screening for mupirocin resistant MRSA to be carried out periodically and stringent infection control practices to be in place to prevent further spread of mupirocin resistant MRSA. clinical isolates inducible clindamycin resistance mupirocin resistant staphylococcus aureus Medicine R Subisha Kannan verfasserin aut B Appalaraju verfasserin aut In Journal of Clinical and Diagnostic Research JCDR Research and Publications Private Limited, 2009 16(2022), 5, Seite DC06-DC10 (DE-627)789478048 (DE-600)2775283-5 0973709X nnns volume:16 year:2022 number:5 pages:DC06-DC10 https://doi.org/10.7860/JCDR/2022/55943.16298 kostenfrei https://doaj.org/article/bcdd818580b34e6ab54a51299ddada53 kostenfrei https://www.jcdr.net/articles/PDF/16298/55943_CE[Ra1]_F[SH]_PF1(AG_SS)_PFA(AG_KM)_PN(KM).pdf kostenfrei https://doaj.org/toc/2249-782X Journal toc kostenfrei https://doaj.org/toc/0973-709X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2022 5 DC06-DC10
allfields_unstemmed	10.7860/JCDR/2022/55943.16298 doi (DE-627)DOAJ043288944 (DE-599)DOAJbcdd818580b34e6ab54a51299ddada53 DE-627 ger DE-627 rakwb eng P Ganesh Perumal verfasserin aut Detection and Distribution of Low Level and High Level Mupirocin Resistance among Clinical Methicillin Resistant Staphylococcus aureus Isolates 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Prolonged and improper use of antibiotics increases the resistance among pathogens and leads to life-threatening implications and increases mortality. The incidence of mupirocin resistance in Methicillin Resistant Staphylococcus aureus (MRSA) clinical isolates were reportedly increasing. Aim: To determine the rate of high level and low level mupirocin resistance in clinical MRSA isolates in a tertiary care hospital. Materials and Methods: A cross-sectional study was carried out for a period of three months from December 2019 to February 2020 in Department of Microbiology, PSG Institute of Medical Sciences and Research (PSG IMSR), Coimbatore, Tamil Nadu, India. A total of 100 non duplicate Staphylococcus aureus isolates from different specimens were subjected to mupirocin susceptibility by Kirby-Bauer disc diffusion method as per Clinical and Laboratory Standards Institute (CLSI) 2019 standards. The low (MuL) and high (MuH) level mupirocin resistance were detected by using 5 and 200 μg mupirocin discs (Himedia) respectively. The isolate exhibiting diameter of ≥14 mm indicates its susceptibility. The isolate exhibiting diameter ≤13 mm for both 5 and 200 μg indicates MuL and MuH strains respectively. Pearson’s Chi-square test was calculated and p-value of <0.05 was considered as statistically significant. Results: Total 51% Staphylococcus aureus isolates were found to be MRSA. In present study, 6 out of 51 (11.8%) MRSA isolates were found to exhibit MuL and 5 out of 51 (9.8%) MRSA isolates were found to be having MuH. Low level and high level mupirocin resistance were not observed in Methicillin Sensitive Staphylococcus aureus (MSSA). Conclusion: The incidence of MuH and MuL resistance among MRSA were found to be 9.8% and 11.8%, respectively. Screening for mupirocin resistant MRSA to be carried out periodically and stringent infection control practices to be in place to prevent further spread of mupirocin resistant MRSA. clinical isolates inducible clindamycin resistance mupirocin resistant staphylococcus aureus Medicine R Subisha Kannan verfasserin aut B Appalaraju verfasserin aut In Journal of Clinical and Diagnostic Research JCDR Research and Publications Private Limited, 2009 16(2022), 5, Seite DC06-DC10 (DE-627)789478048 (DE-600)2775283-5 0973709X nnns volume:16 year:2022 number:5 pages:DC06-DC10 https://doi.org/10.7860/JCDR/2022/55943.16298 kostenfrei https://doaj.org/article/bcdd818580b34e6ab54a51299ddada53 kostenfrei https://www.jcdr.net/articles/PDF/16298/55943_CE[Ra1]_F[SH]_PF1(AG_SS)_PFA(AG_KM)_PN(KM).pdf kostenfrei https://doaj.org/toc/2249-782X Journal toc kostenfrei https://doaj.org/toc/0973-709X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2022 5 DC06-DC10
allfieldsGer	10.7860/JCDR/2022/55943.16298 doi (DE-627)DOAJ043288944 (DE-599)DOAJbcdd818580b34e6ab54a51299ddada53 DE-627 ger DE-627 rakwb eng P Ganesh Perumal verfasserin aut Detection and Distribution of Low Level and High Level Mupirocin Resistance among Clinical Methicillin Resistant Staphylococcus aureus Isolates 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Prolonged and improper use of antibiotics increases the resistance among pathogens and leads to life-threatening implications and increases mortality. The incidence of mupirocin resistance in Methicillin Resistant Staphylococcus aureus (MRSA) clinical isolates were reportedly increasing. Aim: To determine the rate of high level and low level mupirocin resistance in clinical MRSA isolates in a tertiary care hospital. Materials and Methods: A cross-sectional study was carried out for a period of three months from December 2019 to February 2020 in Department of Microbiology, PSG Institute of Medical Sciences and Research (PSG IMSR), Coimbatore, Tamil Nadu, India. A total of 100 non duplicate Staphylococcus aureus isolates from different specimens were subjected to mupirocin susceptibility by Kirby-Bauer disc diffusion method as per Clinical and Laboratory Standards Institute (CLSI) 2019 standards. The low (MuL) and high (MuH) level mupirocin resistance were detected by using 5 and 200 μg mupirocin discs (Himedia) respectively. The isolate exhibiting diameter of ≥14 mm indicates its susceptibility. The isolate exhibiting diameter ≤13 mm for both 5 and 200 μg indicates MuL and MuH strains respectively. Pearson’s Chi-square test was calculated and p-value of <0.05 was considered as statistically significant. Results: Total 51% Staphylococcus aureus isolates were found to be MRSA. In present study, 6 out of 51 (11.8%) MRSA isolates were found to exhibit MuL and 5 out of 51 (9.8%) MRSA isolates were found to be having MuH. Low level and high level mupirocin resistance were not observed in Methicillin Sensitive Staphylococcus aureus (MSSA). Conclusion: The incidence of MuH and MuL resistance among MRSA were found to be 9.8% and 11.8%, respectively. Screening for mupirocin resistant MRSA to be carried out periodically and stringent infection control practices to be in place to prevent further spread of mupirocin resistant MRSA. clinical isolates inducible clindamycin resistance mupirocin resistant staphylococcus aureus Medicine R Subisha Kannan verfasserin aut B Appalaraju verfasserin aut In Journal of Clinical and Diagnostic Research JCDR Research and Publications Private Limited, 2009 16(2022), 5, Seite DC06-DC10 (DE-627)789478048 (DE-600)2775283-5 0973709X nnns volume:16 year:2022 number:5 pages:DC06-DC10 https://doi.org/10.7860/JCDR/2022/55943.16298 kostenfrei https://doaj.org/article/bcdd818580b34e6ab54a51299ddada53 kostenfrei https://www.jcdr.net/articles/PDF/16298/55943_CE[Ra1]_F[SH]_PF1(AG_SS)_PFA(AG_KM)_PN(KM).pdf kostenfrei https://doaj.org/toc/2249-782X Journal toc kostenfrei https://doaj.org/toc/0973-709X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2022 5 DC06-DC10
allfieldsSound	10.7860/JCDR/2022/55943.16298 doi (DE-627)DOAJ043288944 (DE-599)DOAJbcdd818580b34e6ab54a51299ddada53 DE-627 ger DE-627 rakwb eng P Ganesh Perumal verfasserin aut Detection and Distribution of Low Level and High Level Mupirocin Resistance among Clinical Methicillin Resistant Staphylococcus aureus Isolates 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Prolonged and improper use of antibiotics increases the resistance among pathogens and leads to life-threatening implications and increases mortality. The incidence of mupirocin resistance in Methicillin Resistant Staphylococcus aureus (MRSA) clinical isolates were reportedly increasing. Aim: To determine the rate of high level and low level mupirocin resistance in clinical MRSA isolates in a tertiary care hospital. Materials and Methods: A cross-sectional study was carried out for a period of three months from December 2019 to February 2020 in Department of Microbiology, PSG Institute of Medical Sciences and Research (PSG IMSR), Coimbatore, Tamil Nadu, India. A total of 100 non duplicate Staphylococcus aureus isolates from different specimens were subjected to mupirocin susceptibility by Kirby-Bauer disc diffusion method as per Clinical and Laboratory Standards Institute (CLSI) 2019 standards. The low (MuL) and high (MuH) level mupirocin resistance were detected by using 5 and 200 μg mupirocin discs (Himedia) respectively. The isolate exhibiting diameter of ≥14 mm indicates its susceptibility. The isolate exhibiting diameter ≤13 mm for both 5 and 200 μg indicates MuL and MuH strains respectively. Pearson’s Chi-square test was calculated and p-value of <0.05 was considered as statistically significant. Results: Total 51% Staphylococcus aureus isolates were found to be MRSA. In present study, 6 out of 51 (11.8%) MRSA isolates were found to exhibit MuL and 5 out of 51 (9.8%) MRSA isolates were found to be having MuH. Low level and high level mupirocin resistance were not observed in Methicillin Sensitive Staphylococcus aureus (MSSA). Conclusion: The incidence of MuH and MuL resistance among MRSA were found to be 9.8% and 11.8%, respectively. Screening for mupirocin resistant MRSA to be carried out periodically and stringent infection control practices to be in place to prevent further spread of mupirocin resistant MRSA. clinical isolates inducible clindamycin resistance mupirocin resistant staphylococcus aureus Medicine R Subisha Kannan verfasserin aut B Appalaraju verfasserin aut In Journal of Clinical and Diagnostic Research JCDR Research and Publications Private Limited, 2009 16(2022), 5, Seite DC06-DC10 (DE-627)789478048 (DE-600)2775283-5 0973709X nnns volume:16 year:2022 number:5 pages:DC06-DC10 https://doi.org/10.7860/JCDR/2022/55943.16298 kostenfrei https://doaj.org/article/bcdd818580b34e6ab54a51299ddada53 kostenfrei https://www.jcdr.net/articles/PDF/16298/55943_CE[Ra1]_F[SH]_PF1(AG_SS)_PFA(AG_KM)_PN(KM).pdf kostenfrei https://doaj.org/toc/2249-782X Journal toc kostenfrei https://doaj.org/toc/0973-709X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2022 5 DC06-DC10
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author	P Ganesh Perumal
spellingShingle	P Ganesh Perumal misc clinical isolates misc inducible clindamycin resistance misc mupirocin resistant staphylococcus aureus misc Medicine misc R Detection and Distribution of Low Level and High Level Mupirocin Resistance among Clinical Methicillin Resistant Staphylococcus aureus Isolates
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topic_title	Detection and Distribution of Low Level and High Level Mupirocin Resistance among Clinical Methicillin Resistant Staphylococcus aureus Isolates clinical isolates inducible clindamycin resistance mupirocin resistant staphylococcus aureus
topic	misc clinical isolates misc inducible clindamycin resistance misc mupirocin resistant staphylococcus aureus misc Medicine misc R
topic_unstemmed	misc clinical isolates misc inducible clindamycin resistance misc mupirocin resistant staphylococcus aureus misc Medicine misc R
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title	Detection and Distribution of Low Level and High Level Mupirocin Resistance among Clinical Methicillin Resistant Staphylococcus aureus Isolates
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title_full	Detection and Distribution of Low Level and High Level Mupirocin Resistance among Clinical Methicillin Resistant Staphylococcus aureus Isolates
author_sort	P Ganesh Perumal
journal	Journal of Clinical and Diagnostic Research
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author_browse	P Ganesh Perumal Subisha Kannan B Appalaraju
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doi_str_mv	10.7860/JCDR/2022/55943.16298
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title_sort	detection and distribution of low level and high level mupirocin resistance among clinical methicillin resistant staphylococcus aureus isolates
title_auth	Detection and Distribution of Low Level and High Level Mupirocin Resistance among Clinical Methicillin Resistant Staphylococcus aureus Isolates
abstract	Introduction: Prolonged and improper use of antibiotics increases the resistance among pathogens and leads to life-threatening implications and increases mortality. The incidence of mupirocin resistance in Methicillin Resistant Staphylococcus aureus (MRSA) clinical isolates were reportedly increasing. Aim: To determine the rate of high level and low level mupirocin resistance in clinical MRSA isolates in a tertiary care hospital. Materials and Methods: A cross-sectional study was carried out for a period of three months from December 2019 to February 2020 in Department of Microbiology, PSG Institute of Medical Sciences and Research (PSG IMSR), Coimbatore, Tamil Nadu, India. A total of 100 non duplicate Staphylococcus aureus isolates from different specimens were subjected to mupirocin susceptibility by Kirby-Bauer disc diffusion method as per Clinical and Laboratory Standards Institute (CLSI) 2019 standards. The low (MuL) and high (MuH) level mupirocin resistance were detected by using 5 and 200 μg mupirocin discs (Himedia) respectively. The isolate exhibiting diameter of ≥14 mm indicates its susceptibility. The isolate exhibiting diameter ≤13 mm for both 5 and 200 μg indicates MuL and MuH strains respectively. Pearson’s Chi-square test was calculated and p-value of <0.05 was considered as statistically significant. Results: Total 51% Staphylococcus aureus isolates were found to be MRSA. In present study, 6 out of 51 (11.8%) MRSA isolates were found to exhibit MuL and 5 out of 51 (9.8%) MRSA isolates were found to be having MuH. Low level and high level mupirocin resistance were not observed in Methicillin Sensitive Staphylococcus aureus (MSSA). Conclusion: The incidence of MuH and MuL resistance among MRSA were found to be 9.8% and 11.8%, respectively. Screening for mupirocin resistant MRSA to be carried out periodically and stringent infection control practices to be in place to prevent further spread of mupirocin resistant MRSA.
abstractGer	Introduction: Prolonged and improper use of antibiotics increases the resistance among pathogens and leads to life-threatening implications and increases mortality. The incidence of mupirocin resistance in Methicillin Resistant Staphylococcus aureus (MRSA) clinical isolates were reportedly increasing. Aim: To determine the rate of high level and low level mupirocin resistance in clinical MRSA isolates in a tertiary care hospital. Materials and Methods: A cross-sectional study was carried out for a period of three months from December 2019 to February 2020 in Department of Microbiology, PSG Institute of Medical Sciences and Research (PSG IMSR), Coimbatore, Tamil Nadu, India. A total of 100 non duplicate Staphylococcus aureus isolates from different specimens were subjected to mupirocin susceptibility by Kirby-Bauer disc diffusion method as per Clinical and Laboratory Standards Institute (CLSI) 2019 standards. The low (MuL) and high (MuH) level mupirocin resistance were detected by using 5 and 200 μg mupirocin discs (Himedia) respectively. The isolate exhibiting diameter of ≥14 mm indicates its susceptibility. The isolate exhibiting diameter ≤13 mm for both 5 and 200 μg indicates MuL and MuH strains respectively. Pearson’s Chi-square test was calculated and p-value of <0.05 was considered as statistically significant. Results: Total 51% Staphylococcus aureus isolates were found to be MRSA. In present study, 6 out of 51 (11.8%) MRSA isolates were found to exhibit MuL and 5 out of 51 (9.8%) MRSA isolates were found to be having MuH. Low level and high level mupirocin resistance were not observed in Methicillin Sensitive Staphylococcus aureus (MSSA). Conclusion: The incidence of MuH and MuL resistance among MRSA were found to be 9.8% and 11.8%, respectively. Screening for mupirocin resistant MRSA to be carried out periodically and stringent infection control practices to be in place to prevent further spread of mupirocin resistant MRSA.
abstract_unstemmed	Introduction: Prolonged and improper use of antibiotics increases the resistance among pathogens and leads to life-threatening implications and increases mortality. The incidence of mupirocin resistance in Methicillin Resistant Staphylococcus aureus (MRSA) clinical isolates were reportedly increasing. Aim: To determine the rate of high level and low level mupirocin resistance in clinical MRSA isolates in a tertiary care hospital. Materials and Methods: A cross-sectional study was carried out for a period of three months from December 2019 to February 2020 in Department of Microbiology, PSG Institute of Medical Sciences and Research (PSG IMSR), Coimbatore, Tamil Nadu, India. A total of 100 non duplicate Staphylococcus aureus isolates from different specimens were subjected to mupirocin susceptibility by Kirby-Bauer disc diffusion method as per Clinical and Laboratory Standards Institute (CLSI) 2019 standards. The low (MuL) and high (MuH) level mupirocin resistance were detected by using 5 and 200 μg mupirocin discs (Himedia) respectively. The isolate exhibiting diameter of ≥14 mm indicates its susceptibility. The isolate exhibiting diameter ≤13 mm for both 5 and 200 μg indicates MuL and MuH strains respectively. Pearson’s Chi-square test was calculated and p-value of <0.05 was considered as statistically significant. Results: Total 51% Staphylococcus aureus isolates were found to be MRSA. In present study, 6 out of 51 (11.8%) MRSA isolates were found to exhibit MuL and 5 out of 51 (9.8%) MRSA isolates were found to be having MuH. Low level and high level mupirocin resistance were not observed in Methicillin Sensitive Staphylococcus aureus (MSSA). Conclusion: The incidence of MuH and MuL resistance among MRSA were found to be 9.8% and 11.8%, respectively. Screening for mupirocin resistant MRSA to be carried out periodically and stringent infection control practices to be in place to prevent further spread of mupirocin resistant MRSA.
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title_short	Detection and Distribution of Low Level and High Level Mupirocin Resistance among Clinical Methicillin Resistant Staphylococcus aureus Isolates
url	https://doi.org/10.7860/JCDR/2022/55943.16298 https://doaj.org/article/bcdd818580b34e6ab54a51299ddada53 https://www.jcdr.net/articles/PDF/16298/55943_CE[Ra1]_F[SH]_PF1(AG_SS)_PFA(AG_KM)_PN(KM).pdf https://doaj.org/toc/2249-782X https://doaj.org/toc/0973-709X
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Detection and Distribution of Low Level and High Level Mupirocin Resistance among Clinical Methicillin Resistant Staphylococcus aureus Isolates

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