Iron Metabolism at the Interface between Host and Pathogen: From Nutritional Immunity to Antibacterial Development
Nutritional immunity is a form of innate immunity widespread in both vertebrates and invertebrates. The term refers to a rich repertoire of mechanisms set up by the host to inhibit bacterial proliferation by sequestering trace minerals (mainly iron, but also zinc and manganese). This strategy, selec...
Ausführliche Beschreibung
Autor*in: |
Marialaura Marchetti [verfasserIn] Omar De Bei [verfasserIn] Stefano Bettati [verfasserIn] Barbara Campanini [verfasserIn] Sandra Kovachka [verfasserIn] Eleonora Gianquinto [verfasserIn] Francesca Spyrakis [verfasserIn] Luca Ronda [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2020 |
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Übergeordnetes Werk: |
In: International Journal of Molecular Sciences - MDPI AG, 2003, 21(2020), 6, p 2145 |
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Übergeordnetes Werk: |
volume:21 ; year:2020 ; number:6, p 2145 |
Links: |
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DOI / URN: |
10.3390/ijms21062145 |
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Katalog-ID: |
DOAJ043324673 |
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10.3390/ijms21062145 doi (DE-627)DOAJ043324673 (DE-599)DOAJb2cdacb333b946438b859bad33ba63ac DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Marialaura Marchetti verfasserin aut Iron Metabolism at the Interface between Host and Pathogen: From Nutritional Immunity to Antibacterial Development 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nutritional immunity is a form of innate immunity widespread in both vertebrates and invertebrates. The term refers to a rich repertoire of mechanisms set up by the host to inhibit bacterial proliferation by sequestering trace minerals (mainly iron, but also zinc and manganese). This strategy, selected by evolution, represents an effective front-line defense against pathogens and has thus inspired the exploitation of iron restriction in the development of innovative antimicrobials or enhancers of antimicrobial therapy. This review focuses on the mechanisms of nutritional immunity, the strategies adopted by opportunistic human pathogen <i<Staphylococcus aureus</i< to circumvent it, and the impact of deletion mutants on the fitness, infectivity, and persistence inside the host. This information finally converges in an overview of the current development of inhibitors targeting the different stages of iron uptake, an as-yet unexploited target in the field of antistaphylococcal drug discovery. nutritional immunity siderophores hemophores <i<staphylococcus aureus</i< iron virulence Biology (General) Chemistry Omar De Bei verfasserin aut Stefano Bettati verfasserin aut Barbara Campanini verfasserin aut Sandra Kovachka verfasserin aut Eleonora Gianquinto verfasserin aut Francesca Spyrakis verfasserin aut Luca Ronda verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 21(2020), 6, p 2145 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:21 year:2020 number:6, p 2145 https://doi.org/10.3390/ijms21062145 kostenfrei https://doaj.org/article/b2cdacb333b946438b859bad33ba63ac kostenfrei https://www.mdpi.com/1422-0067/21/6/2145 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 6, p 2145 |
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Iron Metabolism at the Interface between Host and Pathogen: From Nutritional Immunity to Antibacterial Development |
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Nutritional immunity is a form of innate immunity widespread in both vertebrates and invertebrates. The term refers to a rich repertoire of mechanisms set up by the host to inhibit bacterial proliferation by sequestering trace minerals (mainly iron, but also zinc and manganese). This strategy, selected by evolution, represents an effective front-line defense against pathogens and has thus inspired the exploitation of iron restriction in the development of innovative antimicrobials or enhancers of antimicrobial therapy. This review focuses on the mechanisms of nutritional immunity, the strategies adopted by opportunistic human pathogen <i<Staphylococcus aureus</i< to circumvent it, and the impact of deletion mutants on the fitness, infectivity, and persistence inside the host. This information finally converges in an overview of the current development of inhibitors targeting the different stages of iron uptake, an as-yet unexploited target in the field of antistaphylococcal drug discovery. |
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Nutritional immunity is a form of innate immunity widespread in both vertebrates and invertebrates. The term refers to a rich repertoire of mechanisms set up by the host to inhibit bacterial proliferation by sequestering trace minerals (mainly iron, but also zinc and manganese). This strategy, selected by evolution, represents an effective front-line defense against pathogens and has thus inspired the exploitation of iron restriction in the development of innovative antimicrobials or enhancers of antimicrobial therapy. This review focuses on the mechanisms of nutritional immunity, the strategies adopted by opportunistic human pathogen <i<Staphylococcus aureus</i< to circumvent it, and the impact of deletion mutants on the fitness, infectivity, and persistence inside the host. This information finally converges in an overview of the current development of inhibitors targeting the different stages of iron uptake, an as-yet unexploited target in the field of antistaphylococcal drug discovery. |
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Nutritional immunity is a form of innate immunity widespread in both vertebrates and invertebrates. The term refers to a rich repertoire of mechanisms set up by the host to inhibit bacterial proliferation by sequestering trace minerals (mainly iron, but also zinc and manganese). This strategy, selected by evolution, represents an effective front-line defense against pathogens and has thus inspired the exploitation of iron restriction in the development of innovative antimicrobials or enhancers of antimicrobial therapy. This review focuses on the mechanisms of nutritional immunity, the strategies adopted by opportunistic human pathogen <i<Staphylococcus aureus</i< to circumvent it, and the impact of deletion mutants on the fitness, infectivity, and persistence inside the host. This information finally converges in an overview of the current development of inhibitors targeting the different stages of iron uptake, an as-yet unexploited target in the field of antistaphylococcal drug discovery. |
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