Research Progress on Improving the Efficiency of CDT by Exacerbating Tumor Acidification
Wenting Chen,1 Jinxi Liu,1 Caiyun Zheng,1 Que Bai,1 Qian Gao,1 Yanni Zhang,1 Kai Dong,2 Tingli Lu1 1Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China; 2School of Pharmacy, Xi’an Jiaotong U...
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Gespeichert in:
| Autor*in: |
Chen W [verfasserIn] Liu J [verfasserIn] Zheng C [verfasserIn] Bai Q [verfasserIn] Gao Q [verfasserIn] Zhang Y [verfasserIn] Dong K [verfasserIn] Lu T [verfasserIn] |
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E-Artikel |
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Englisch |
| Erschienen: |
2022 |
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In: International Journal of Nanomedicine - Dove Medical Press, 2018, (2022), Seite 2611-2628 |
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| Übergeordnetes Werk: |
year:2022 ; pages:2611-2628 |
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DOAJ043565425 |
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| 520 | |a Wenting Chen,1 Jinxi Liu,1 Caiyun Zheng,1 Que Bai,1 Qian Gao,1 Yanni Zhang,1 Kai Dong,2 Tingli Lu1 1Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China; 2School of Pharmacy, Xi’an Jiaotong University, Xi’an, 710072, People’s Republic of ChinaCorrespondence: Tingli Lu, Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China, Tel/Fax +86 29 8846 0332, Email lutinglixinxinnwpu.edu.cn Kai Dong, School of Pharmacy, Xi’an Jiaotong University, Xi’an, 710072, People’s Republic of China, Tel/Fax +86 29-82655139, Email dongkai120@xjtu.edu.cnAbstract: In recent years, chemodynamic therapy (CDT) has received extensive attention as a novel means of cancer treatment. The CDT agents can exert Fenton and Fenton-like reactions in the acidic tumor microenvironment (TME), converting hydrogen peroxide (H2O2) into highly toxic hydroxyl radicals (·OH). However, the pH of TME, as an essential factor in the Fenton reaction, does not catalyze the reaction effectively, hindering its efficiency, which poses a significant challenge for the future clinical application of CDT. Therefore, this paper reviews various strategies to enhance the antitumor properties of nanomaterials by modulating tumor acidity. Ultimately, the performance of CDT can be further improved by inducing strong oxidative stress to produce sufficient ·OH. In this paper, the various acidification pathways and proton pumps with potential acidification functions are mainly discussed, such as catalytic enzymes, exogenous acids, CAIX, MCT, NHE, NBCn1, etc. The problems, opportunities, and challenges of CDT in the cancer field are also discussed, thereby providing new insights for the design of nanomaterials and laying the foundation for their future clinical applications.Graphical Abstract: Keywords: chemodynamic therapy, Fenton/Fenton-like reactions, tumor microenvironment, reactive oxygen specie | ||
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(DE-627)DOAJ043565425 (DE-599)DOAJcea1eb930cee4c8b8746abc33e47316f DE-627 ger DE-627 rakwb eng R5-920 Chen W verfasserin aut Research Progress on Improving the Efficiency of CDT by Exacerbating Tumor Acidification 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Wenting Chen,1 Jinxi Liu,1 Caiyun Zheng,1 Que Bai,1 Qian Gao,1 Yanni Zhang,1 Kai Dong,2 Tingli Lu1 1Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China; 2School of Pharmacy, Xi’an Jiaotong University, Xi’an, 710072, People’s Republic of ChinaCorrespondence: Tingli Lu, Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China, Tel/Fax +86 29 8846 0332, Email lutinglixinxinnwpu.edu.cn Kai Dong, School of Pharmacy, Xi’an Jiaotong University, Xi’an, 710072, People’s Republic of China, Tel/Fax +86 29-82655139, Email dongkai120@xjtu.edu.cnAbstract: In recent years, chemodynamic therapy (CDT) has received extensive attention as a novel means of cancer treatment. The CDT agents can exert Fenton and Fenton-like reactions in the acidic tumor microenvironment (TME), converting hydrogen peroxide (H2O2) into highly toxic hydroxyl radicals (·OH). However, the pH of TME, as an essential factor in the Fenton reaction, does not catalyze the reaction effectively, hindering its efficiency, which poses a significant challenge for the future clinical application of CDT. Therefore, this paper reviews various strategies to enhance the antitumor properties of nanomaterials by modulating tumor acidity. Ultimately, the performance of CDT can be further improved by inducing strong oxidative stress to produce sufficient ·OH. In this paper, the various acidification pathways and proton pumps with potential acidification functions are mainly discussed, such as catalytic enzymes, exogenous acids, CAIX, MCT, NHE, NBCn1, etc. The problems, opportunities, and challenges of CDT in the cancer field are also discussed, thereby providing new insights for the design of nanomaterials and laying the foundation for their future clinical applications.Graphical Abstract: Keywords: chemodynamic therapy, Fenton/Fenton-like reactions, tumor microenvironment, reactive oxygen specie chemodynamic therapy fenton/fenton-like reactions tumor microenvironment reactive oxygen specie Medicine (General) Liu J verfasserin aut Zheng C verfasserin aut Bai Q verfasserin aut Gao Q verfasserin aut Zhang Y verfasserin aut Dong K verfasserin aut Lu T verfasserin aut In International Journal of Nanomedicine Dove Medical Press, 2018 (2022), Seite 2611-2628 (DE-627)537879560 (DE-600)2377464-2 11782013 nnns year:2022 pages:2611-2628 https://doaj.org/article/cea1eb930cee4c8b8746abc33e47316f kostenfrei https://www.dovepress.com/research-progress-on-improving-the-efficiency-of-cdt-by-exacerbating-t-peer-reviewed-fulltext-article-IJN kostenfrei https://doaj.org/toc/1178-2013 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2022 2611-2628 |
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(DE-627)DOAJ043565425 (DE-599)DOAJcea1eb930cee4c8b8746abc33e47316f DE-627 ger DE-627 rakwb eng R5-920 Chen W verfasserin aut Research Progress on Improving the Efficiency of CDT by Exacerbating Tumor Acidification 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Wenting Chen,1 Jinxi Liu,1 Caiyun Zheng,1 Que Bai,1 Qian Gao,1 Yanni Zhang,1 Kai Dong,2 Tingli Lu1 1Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China; 2School of Pharmacy, Xi’an Jiaotong University, Xi’an, 710072, People’s Republic of ChinaCorrespondence: Tingli Lu, Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China, Tel/Fax +86 29 8846 0332, Email lutinglixinxinnwpu.edu.cn Kai Dong, School of Pharmacy, Xi’an Jiaotong University, Xi’an, 710072, People’s Republic of China, Tel/Fax +86 29-82655139, Email dongkai120@xjtu.edu.cnAbstract: In recent years, chemodynamic therapy (CDT) has received extensive attention as a novel means of cancer treatment. The CDT agents can exert Fenton and Fenton-like reactions in the acidic tumor microenvironment (TME), converting hydrogen peroxide (H2O2) into highly toxic hydroxyl radicals (·OH). However, the pH of TME, as an essential factor in the Fenton reaction, does not catalyze the reaction effectively, hindering its efficiency, which poses a significant challenge for the future clinical application of CDT. Therefore, this paper reviews various strategies to enhance the antitumor properties of nanomaterials by modulating tumor acidity. Ultimately, the performance of CDT can be further improved by inducing strong oxidative stress to produce sufficient ·OH. In this paper, the various acidification pathways and proton pumps with potential acidification functions are mainly discussed, such as catalytic enzymes, exogenous acids, CAIX, MCT, NHE, NBCn1, etc. The problems, opportunities, and challenges of CDT in the cancer field are also discussed, thereby providing new insights for the design of nanomaterials and laying the foundation for their future clinical applications.Graphical Abstract: Keywords: chemodynamic therapy, Fenton/Fenton-like reactions, tumor microenvironment, reactive oxygen specie chemodynamic therapy fenton/fenton-like reactions tumor microenvironment reactive oxygen specie Medicine (General) Liu J verfasserin aut Zheng C verfasserin aut Bai Q verfasserin aut Gao Q verfasserin aut Zhang Y verfasserin aut Dong K verfasserin aut Lu T verfasserin aut In International Journal of Nanomedicine Dove Medical Press, 2018 (2022), Seite 2611-2628 (DE-627)537879560 (DE-600)2377464-2 11782013 nnns year:2022 pages:2611-2628 https://doaj.org/article/cea1eb930cee4c8b8746abc33e47316f kostenfrei https://www.dovepress.com/research-progress-on-improving-the-efficiency-of-cdt-by-exacerbating-t-peer-reviewed-fulltext-article-IJN kostenfrei https://doaj.org/toc/1178-2013 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2022 2611-2628 |
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(DE-627)DOAJ043565425 (DE-599)DOAJcea1eb930cee4c8b8746abc33e47316f DE-627 ger DE-627 rakwb eng R5-920 Chen W verfasserin aut Research Progress on Improving the Efficiency of CDT by Exacerbating Tumor Acidification 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Wenting Chen,1 Jinxi Liu,1 Caiyun Zheng,1 Que Bai,1 Qian Gao,1 Yanni Zhang,1 Kai Dong,2 Tingli Lu1 1Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China; 2School of Pharmacy, Xi’an Jiaotong University, Xi’an, 710072, People’s Republic of ChinaCorrespondence: Tingli Lu, Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China, Tel/Fax +86 29 8846 0332, Email lutinglixinxinnwpu.edu.cn Kai Dong, School of Pharmacy, Xi’an Jiaotong University, Xi’an, 710072, People’s Republic of China, Tel/Fax +86 29-82655139, Email dongkai120@xjtu.edu.cnAbstract: In recent years, chemodynamic therapy (CDT) has received extensive attention as a novel means of cancer treatment. The CDT agents can exert Fenton and Fenton-like reactions in the acidic tumor microenvironment (TME), converting hydrogen peroxide (H2O2) into highly toxic hydroxyl radicals (·OH). However, the pH of TME, as an essential factor in the Fenton reaction, does not catalyze the reaction effectively, hindering its efficiency, which poses a significant challenge for the future clinical application of CDT. Therefore, this paper reviews various strategies to enhance the antitumor properties of nanomaterials by modulating tumor acidity. Ultimately, the performance of CDT can be further improved by inducing strong oxidative stress to produce sufficient ·OH. In this paper, the various acidification pathways and proton pumps with potential acidification functions are mainly discussed, such as catalytic enzymes, exogenous acids, CAIX, MCT, NHE, NBCn1, etc. The problems, opportunities, and challenges of CDT in the cancer field are also discussed, thereby providing new insights for the design of nanomaterials and laying the foundation for their future clinical applications.Graphical Abstract: Keywords: chemodynamic therapy, Fenton/Fenton-like reactions, tumor microenvironment, reactive oxygen specie chemodynamic therapy fenton/fenton-like reactions tumor microenvironment reactive oxygen specie Medicine (General) Liu J verfasserin aut Zheng C verfasserin aut Bai Q verfasserin aut Gao Q verfasserin aut Zhang Y verfasserin aut Dong K verfasserin aut Lu T verfasserin aut In International Journal of Nanomedicine Dove Medical Press, 2018 (2022), Seite 2611-2628 (DE-627)537879560 (DE-600)2377464-2 11782013 nnns year:2022 pages:2611-2628 https://doaj.org/article/cea1eb930cee4c8b8746abc33e47316f kostenfrei https://www.dovepress.com/research-progress-on-improving-the-efficiency-of-cdt-by-exacerbating-t-peer-reviewed-fulltext-article-IJN kostenfrei https://doaj.org/toc/1178-2013 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2022 2611-2628 |
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(DE-627)DOAJ043565425 (DE-599)DOAJcea1eb930cee4c8b8746abc33e47316f DE-627 ger DE-627 rakwb eng R5-920 Chen W verfasserin aut Research Progress on Improving the Efficiency of CDT by Exacerbating Tumor Acidification 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Wenting Chen,1 Jinxi Liu,1 Caiyun Zheng,1 Que Bai,1 Qian Gao,1 Yanni Zhang,1 Kai Dong,2 Tingli Lu1 1Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China; 2School of Pharmacy, Xi’an Jiaotong University, Xi’an, 710072, People’s Republic of ChinaCorrespondence: Tingli Lu, Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China, Tel/Fax +86 29 8846 0332, Email lutinglixinxinnwpu.edu.cn Kai Dong, School of Pharmacy, Xi’an Jiaotong University, Xi’an, 710072, People’s Republic of China, Tel/Fax +86 29-82655139, Email dongkai120@xjtu.edu.cnAbstract: In recent years, chemodynamic therapy (CDT) has received extensive attention as a novel means of cancer treatment. The CDT agents can exert Fenton and Fenton-like reactions in the acidic tumor microenvironment (TME), converting hydrogen peroxide (H2O2) into highly toxic hydroxyl radicals (·OH). However, the pH of TME, as an essential factor in the Fenton reaction, does not catalyze the reaction effectively, hindering its efficiency, which poses a significant challenge for the future clinical application of CDT. Therefore, this paper reviews various strategies to enhance the antitumor properties of nanomaterials by modulating tumor acidity. Ultimately, the performance of CDT can be further improved by inducing strong oxidative stress to produce sufficient ·OH. In this paper, the various acidification pathways and proton pumps with potential acidification functions are mainly discussed, such as catalytic enzymes, exogenous acids, CAIX, MCT, NHE, NBCn1, etc. The problems, opportunities, and challenges of CDT in the cancer field are also discussed, thereby providing new insights for the design of nanomaterials and laying the foundation for their future clinical applications.Graphical Abstract: Keywords: chemodynamic therapy, Fenton/Fenton-like reactions, tumor microenvironment, reactive oxygen specie chemodynamic therapy fenton/fenton-like reactions tumor microenvironment reactive oxygen specie Medicine (General) Liu J verfasserin aut Zheng C verfasserin aut Bai Q verfasserin aut Gao Q verfasserin aut Zhang Y verfasserin aut Dong K verfasserin aut Lu T verfasserin aut In International Journal of Nanomedicine Dove Medical Press, 2018 (2022), Seite 2611-2628 (DE-627)537879560 (DE-600)2377464-2 11782013 nnns year:2022 pages:2611-2628 https://doaj.org/article/cea1eb930cee4c8b8746abc33e47316f kostenfrei https://www.dovepress.com/research-progress-on-improving-the-efficiency-of-cdt-by-exacerbating-t-peer-reviewed-fulltext-article-IJN kostenfrei https://doaj.org/toc/1178-2013 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2022 2611-2628 |
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(DE-627)DOAJ043565425 (DE-599)DOAJcea1eb930cee4c8b8746abc33e47316f DE-627 ger DE-627 rakwb eng R5-920 Chen W verfasserin aut Research Progress on Improving the Efficiency of CDT by Exacerbating Tumor Acidification 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Wenting Chen,1 Jinxi Liu,1 Caiyun Zheng,1 Que Bai,1 Qian Gao,1 Yanni Zhang,1 Kai Dong,2 Tingli Lu1 1Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China; 2School of Pharmacy, Xi’an Jiaotong University, Xi’an, 710072, People’s Republic of ChinaCorrespondence: Tingli Lu, Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China, Tel/Fax +86 29 8846 0332, Email lutinglixinxinnwpu.edu.cn Kai Dong, School of Pharmacy, Xi’an Jiaotong University, Xi’an, 710072, People’s Republic of China, Tel/Fax +86 29-82655139, Email dongkai120@xjtu.edu.cnAbstract: In recent years, chemodynamic therapy (CDT) has received extensive attention as a novel means of cancer treatment. The CDT agents can exert Fenton and Fenton-like reactions in the acidic tumor microenvironment (TME), converting hydrogen peroxide (H2O2) into highly toxic hydroxyl radicals (·OH). However, the pH of TME, as an essential factor in the Fenton reaction, does not catalyze the reaction effectively, hindering its efficiency, which poses a significant challenge for the future clinical application of CDT. Therefore, this paper reviews various strategies to enhance the antitumor properties of nanomaterials by modulating tumor acidity. Ultimately, the performance of CDT can be further improved by inducing strong oxidative stress to produce sufficient ·OH. In this paper, the various acidification pathways and proton pumps with potential acidification functions are mainly discussed, such as catalytic enzymes, exogenous acids, CAIX, MCT, NHE, NBCn1, etc. The problems, opportunities, and challenges of CDT in the cancer field are also discussed, thereby providing new insights for the design of nanomaterials and laying the foundation for their future clinical applications.Graphical Abstract: Keywords: chemodynamic therapy, Fenton/Fenton-like reactions, tumor microenvironment, reactive oxygen specie chemodynamic therapy fenton/fenton-like reactions tumor microenvironment reactive oxygen specie Medicine (General) Liu J verfasserin aut Zheng C verfasserin aut Bai Q verfasserin aut Gao Q verfasserin aut Zhang Y verfasserin aut Dong K verfasserin aut Lu T verfasserin aut In International Journal of Nanomedicine Dove Medical Press, 2018 (2022), Seite 2611-2628 (DE-627)537879560 (DE-600)2377464-2 11782013 nnns year:2022 pages:2611-2628 https://doaj.org/article/cea1eb930cee4c8b8746abc33e47316f kostenfrei https://www.dovepress.com/research-progress-on-improving-the-efficiency-of-cdt-by-exacerbating-t-peer-reviewed-fulltext-article-IJN kostenfrei https://doaj.org/toc/1178-2013 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2022 2611-2628 |
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Wenting Chen,1 Jinxi Liu,1 Caiyun Zheng,1 Que Bai,1 Qian Gao,1 Yanni Zhang,1 Kai Dong,2 Tingli Lu1 1Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China; 2School of Pharmacy, Xi’an Jiaotong University, Xi’an, 710072, People’s Republic of ChinaCorrespondence: Tingli Lu, Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China, Tel/Fax +86 29 8846 0332, Email lutinglixinxinnwpu.edu.cn Kai Dong, School of Pharmacy, Xi’an Jiaotong University, Xi’an, 710072, People’s Republic of China, Tel/Fax +86 29-82655139, Email dongkai120@xjtu.edu.cnAbstract: In recent years, chemodynamic therapy (CDT) has received extensive attention as a novel means of cancer treatment. The CDT agents can exert Fenton and Fenton-like reactions in the acidic tumor microenvironment (TME), converting hydrogen peroxide (H2O2) into highly toxic hydroxyl radicals (·OH). However, the pH of TME, as an essential factor in the Fenton reaction, does not catalyze the reaction effectively, hindering its efficiency, which poses a significant challenge for the future clinical application of CDT. Therefore, this paper reviews various strategies to enhance the antitumor properties of nanomaterials by modulating tumor acidity. Ultimately, the performance of CDT can be further improved by inducing strong oxidative stress to produce sufficient ·OH. In this paper, the various acidification pathways and proton pumps with potential acidification functions are mainly discussed, such as catalytic enzymes, exogenous acids, CAIX, MCT, NHE, NBCn1, etc. The problems, opportunities, and challenges of CDT in the cancer field are also discussed, thereby providing new insights for the design of nanomaterials and laying the foundation for their future clinical applications.Graphical Abstract: Keywords: chemodynamic therapy, Fenton/Fenton-like reactions, tumor microenvironment, reactive oxygen specie |
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Wenting Chen,1 Jinxi Liu,1 Caiyun Zheng,1 Que Bai,1 Qian Gao,1 Yanni Zhang,1 Kai Dong,2 Tingli Lu1 1Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China; 2School of Pharmacy, Xi’an Jiaotong University, Xi’an, 710072, People’s Republic of ChinaCorrespondence: Tingli Lu, Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China, Tel/Fax +86 29 8846 0332, Email lutinglixinxinnwpu.edu.cn Kai Dong, School of Pharmacy, Xi’an Jiaotong University, Xi’an, 710072, People’s Republic of China, Tel/Fax +86 29-82655139, Email dongkai120@xjtu.edu.cnAbstract: In recent years, chemodynamic therapy (CDT) has received extensive attention as a novel means of cancer treatment. The CDT agents can exert Fenton and Fenton-like reactions in the acidic tumor microenvironment (TME), converting hydrogen peroxide (H2O2) into highly toxic hydroxyl radicals (·OH). However, the pH of TME, as an essential factor in the Fenton reaction, does not catalyze the reaction effectively, hindering its efficiency, which poses a significant challenge for the future clinical application of CDT. Therefore, this paper reviews various strategies to enhance the antitumor properties of nanomaterials by modulating tumor acidity. Ultimately, the performance of CDT can be further improved by inducing strong oxidative stress to produce sufficient ·OH. In this paper, the various acidification pathways and proton pumps with potential acidification functions are mainly discussed, such as catalytic enzymes, exogenous acids, CAIX, MCT, NHE, NBCn1, etc. The problems, opportunities, and challenges of CDT in the cancer field are also discussed, thereby providing new insights for the design of nanomaterials and laying the foundation for their future clinical applications.Graphical Abstract: Keywords: chemodynamic therapy, Fenton/Fenton-like reactions, tumor microenvironment, reactive oxygen specie |
| abstract_unstemmed |
Wenting Chen,1 Jinxi Liu,1 Caiyun Zheng,1 Que Bai,1 Qian Gao,1 Yanni Zhang,1 Kai Dong,2 Tingli Lu1 1Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China; 2School of Pharmacy, Xi’an Jiaotong University, Xi’an, 710072, People’s Republic of ChinaCorrespondence: Tingli Lu, Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China, Tel/Fax +86 29 8846 0332, Email lutinglixinxinnwpu.edu.cn Kai Dong, School of Pharmacy, Xi’an Jiaotong University, Xi’an, 710072, People’s Republic of China, Tel/Fax +86 29-82655139, Email dongkai120@xjtu.edu.cnAbstract: In recent years, chemodynamic therapy (CDT) has received extensive attention as a novel means of cancer treatment. The CDT agents can exert Fenton and Fenton-like reactions in the acidic tumor microenvironment (TME), converting hydrogen peroxide (H2O2) into highly toxic hydroxyl radicals (·OH). However, the pH of TME, as an essential factor in the Fenton reaction, does not catalyze the reaction effectively, hindering its efficiency, which poses a significant challenge for the future clinical application of CDT. Therefore, this paper reviews various strategies to enhance the antitumor properties of nanomaterials by modulating tumor acidity. Ultimately, the performance of CDT can be further improved by inducing strong oxidative stress to produce sufficient ·OH. In this paper, the various acidification pathways and proton pumps with potential acidification functions are mainly discussed, such as catalytic enzymes, exogenous acids, CAIX, MCT, NHE, NBCn1, etc. The problems, opportunities, and challenges of CDT in the cancer field are also discussed, thereby providing new insights for the design of nanomaterials and laying the foundation for their future clinical applications.Graphical Abstract: Keywords: chemodynamic therapy, Fenton/Fenton-like reactions, tumor microenvironment, reactive oxygen specie |
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Research Progress on Improving the Efficiency of CDT by Exacerbating Tumor Acidification |
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https://doaj.org/article/cea1eb930cee4c8b8746abc33e47316f https://www.dovepress.com/research-progress-on-improving-the-efficiency-of-cdt-by-exacerbating-t-peer-reviewed-fulltext-article-IJN https://doaj.org/toc/1178-2013 |
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