Combining Carbon Nanotubes and Chitosan for the Vectorization of Methotrexate to Lung Cancer Cells

A hybrid system composed of multi-walled carbon nanotubes coated with chitosan was proposed as a pH-responsive carrier for the vectorization of methotrexate to lung cancer. The effective coating of the carbon nanostructure by chitosan, quantified (20% by weight) by thermogravimetric analysis, was as...
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Gespeichert in:

Autor*in:	Giuseppe Cirillo [verfasserIn] Orazio Vittorio [verfasserIn] David Kunhardt [verfasserIn] Emanuele Valli [verfasserIn] Florida Voli [verfasserIn] Annafranca Farfalla [verfasserIn] Manuela Curcio [verfasserIn] Umile Gianfranco Spizzirri [verfasserIn] Silke Hampel [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	multi-walled carbon nanotubes nanohybrids methotrexate pH responsivity lung cancer

Übergeordnetes Werk:	In: Materials - MDPI AG, 2009, 12(2019), 18, p 2889
Übergeordnetes Werk:	volume:12 ; year:2019 ; number:18, p 2889

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/ma12182889

Katalog-ID:	DOAJ043703380

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spelling	10.3390/ma12182889 doi (DE-627)DOAJ043703380 (DE-599)DOAJ55d7ff66f5b7485282ded76bbf048667 DE-627 ger DE-627 rakwb eng TK1-9971 TA1-2040 QH201-278.5 QC120-168.85 Giuseppe Cirillo verfasserin aut Combining Carbon Nanotubes and Chitosan for the Vectorization of Methotrexate to Lung Cancer Cells 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A hybrid system composed of multi-walled carbon nanotubes coated with chitosan was proposed as a pH-responsive carrier for the vectorization of methotrexate to lung cancer. The effective coating of the carbon nanostructure by chitosan, quantified (20% by weight) by thermogravimetric analysis, was assessed by combined scanning and transmission electron microscopy, and X-ray photoelectron spectroscopy (N1<i<s</i< signal), respectively. Furthermore, Raman spectroscopy was used to characterize the interaction between polysaccharide and carbon counterparts. Methotrexate was physically loaded onto the nanohybrid and the release profiles showed a pH-responsive behavior with higher and faster release in acidic (pH 5.0) vs. neutral (pH 7.4) environments. Empty nanoparticles were found to be highly biocompatible in either healthy (MRC-5) or cancerous (H1299) cells, with the nanocarrier being effective in reducing the drug toxicity on MRC-5 while enhancing the anticancer activity on H1299. multi-walled carbon nanotubes nanohybrids methotrexate pH responsivity lung cancer Technology T Electrical engineering. Electronics. Nuclear engineering Engineering (General). Civil engineering (General) Microscopy Descriptive and experimental mechanics Orazio Vittorio verfasserin aut David Kunhardt verfasserin aut Emanuele Valli verfasserin aut Florida Voli verfasserin aut Annafranca Farfalla verfasserin aut Manuela Curcio verfasserin aut Umile Gianfranco Spizzirri verfasserin aut Silke Hampel verfasserin aut In Materials MDPI AG, 2009 12(2019), 18, p 2889 (DE-627)595712649 (DE-600)2487261-1 19961944 nnns volume:12 year:2019 number:18, p 2889 https://doi.org/10.3390/ma12182889 kostenfrei https://doaj.org/article/55d7ff66f5b7485282ded76bbf048667 kostenfrei https://www.mdpi.com/1996-1944/12/18/2889 kostenfrei https://doaj.org/toc/1996-1944 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2019 18, p 2889
allfields_unstemmed	10.3390/ma12182889 doi (DE-627)DOAJ043703380 (DE-599)DOAJ55d7ff66f5b7485282ded76bbf048667 DE-627 ger DE-627 rakwb eng TK1-9971 TA1-2040 QH201-278.5 QC120-168.85 Giuseppe Cirillo verfasserin aut Combining Carbon Nanotubes and Chitosan for the Vectorization of Methotrexate to Lung Cancer Cells 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A hybrid system composed of multi-walled carbon nanotubes coated with chitosan was proposed as a pH-responsive carrier for the vectorization of methotrexate to lung cancer. The effective coating of the carbon nanostructure by chitosan, quantified (20% by weight) by thermogravimetric analysis, was assessed by combined scanning and transmission electron microscopy, and X-ray photoelectron spectroscopy (N1<i<s</i< signal), respectively. Furthermore, Raman spectroscopy was used to characterize the interaction between polysaccharide and carbon counterparts. Methotrexate was physically loaded onto the nanohybrid and the release profiles showed a pH-responsive behavior with higher and faster release in acidic (pH 5.0) vs. neutral (pH 7.4) environments. Empty nanoparticles were found to be highly biocompatible in either healthy (MRC-5) or cancerous (H1299) cells, with the nanocarrier being effective in reducing the drug toxicity on MRC-5 while enhancing the anticancer activity on H1299. multi-walled carbon nanotubes nanohybrids methotrexate pH responsivity lung cancer Technology T Electrical engineering. Electronics. Nuclear engineering Engineering (General). Civil engineering (General) Microscopy Descriptive and experimental mechanics Orazio Vittorio verfasserin aut David Kunhardt verfasserin aut Emanuele Valli verfasserin aut Florida Voli verfasserin aut Annafranca Farfalla verfasserin aut Manuela Curcio verfasserin aut Umile Gianfranco Spizzirri verfasserin aut Silke Hampel verfasserin aut In Materials MDPI AG, 2009 12(2019), 18, p 2889 (DE-627)595712649 (DE-600)2487261-1 19961944 nnns volume:12 year:2019 number:18, p 2889 https://doi.org/10.3390/ma12182889 kostenfrei https://doaj.org/article/55d7ff66f5b7485282ded76bbf048667 kostenfrei https://www.mdpi.com/1996-1944/12/18/2889 kostenfrei https://doaj.org/toc/1996-1944 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2019 18, p 2889
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allfieldsSound	10.3390/ma12182889 doi (DE-627)DOAJ043703380 (DE-599)DOAJ55d7ff66f5b7485282ded76bbf048667 DE-627 ger DE-627 rakwb eng TK1-9971 TA1-2040 QH201-278.5 QC120-168.85 Giuseppe Cirillo verfasserin aut Combining Carbon Nanotubes and Chitosan for the Vectorization of Methotrexate to Lung Cancer Cells 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A hybrid system composed of multi-walled carbon nanotubes coated with chitosan was proposed as a pH-responsive carrier for the vectorization of methotrexate to lung cancer. The effective coating of the carbon nanostructure by chitosan, quantified (20% by weight) by thermogravimetric analysis, was assessed by combined scanning and transmission electron microscopy, and X-ray photoelectron spectroscopy (N1<i<s</i< signal), respectively. Furthermore, Raman spectroscopy was used to characterize the interaction between polysaccharide and carbon counterparts. Methotrexate was physically loaded onto the nanohybrid and the release profiles showed a pH-responsive behavior with higher and faster release in acidic (pH 5.0) vs. neutral (pH 7.4) environments. Empty nanoparticles were found to be highly biocompatible in either healthy (MRC-5) or cancerous (H1299) cells, with the nanocarrier being effective in reducing the drug toxicity on MRC-5 while enhancing the anticancer activity on H1299. multi-walled carbon nanotubes nanohybrids methotrexate pH responsivity lung cancer Technology T Electrical engineering. Electronics. Nuclear engineering Engineering (General). Civil engineering (General) Microscopy Descriptive and experimental mechanics Orazio Vittorio verfasserin aut David Kunhardt verfasserin aut Emanuele Valli verfasserin aut Florida Voli verfasserin aut Annafranca Farfalla verfasserin aut Manuela Curcio verfasserin aut Umile Gianfranco Spizzirri verfasserin aut Silke Hampel verfasserin aut In Materials MDPI AG, 2009 12(2019), 18, p 2889 (DE-627)595712649 (DE-600)2487261-1 19961944 nnns volume:12 year:2019 number:18, p 2889 https://doi.org/10.3390/ma12182889 kostenfrei https://doaj.org/article/55d7ff66f5b7485282ded76bbf048667 kostenfrei https://www.mdpi.com/1996-1944/12/18/2889 kostenfrei https://doaj.org/toc/1996-1944 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2019 18, p 2889
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callnumber-first	T - Technology
author	Giuseppe Cirillo
spellingShingle	Giuseppe Cirillo misc TK1-9971 misc TA1-2040 misc QH201-278.5 misc QC120-168.85 misc multi-walled carbon nanotubes misc nanohybrids misc methotrexate misc pH responsivity misc lung cancer misc Technology misc T misc Electrical engineering. Electronics. Nuclear engineering misc Engineering (General). Civil engineering (General) misc Microscopy misc Descriptive and experimental mechanics Combining Carbon Nanotubes and Chitosan for the Vectorization of Methotrexate to Lung Cancer Cells
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topic_title	TK1-9971 TA1-2040 QH201-278.5 QC120-168.85 Combining Carbon Nanotubes and Chitosan for the Vectorization of Methotrexate to Lung Cancer Cells multi-walled carbon nanotubes nanohybrids methotrexate pH responsivity lung cancer
topic	misc TK1-9971 misc TA1-2040 misc QH201-278.5 misc QC120-168.85 misc multi-walled carbon nanotubes misc nanohybrids misc methotrexate misc pH responsivity misc lung cancer misc Technology misc T misc Electrical engineering. Electronics. Nuclear engineering misc Engineering (General). Civil engineering (General) misc Microscopy misc Descriptive and experimental mechanics
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title	Combining Carbon Nanotubes and Chitosan for the Vectorization of Methotrexate to Lung Cancer Cells
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title_full	Combining Carbon Nanotubes and Chitosan for the Vectorization of Methotrexate to Lung Cancer Cells
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title_sort	combining carbon nanotubes and chitosan for the vectorization of methotrexate to lung cancer cells
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title_auth	Combining Carbon Nanotubes and Chitosan for the Vectorization of Methotrexate to Lung Cancer Cells
abstract	A hybrid system composed of multi-walled carbon nanotubes coated with chitosan was proposed as a pH-responsive carrier for the vectorization of methotrexate to lung cancer. The effective coating of the carbon nanostructure by chitosan, quantified (20% by weight) by thermogravimetric analysis, was assessed by combined scanning and transmission electron microscopy, and X-ray photoelectron spectroscopy (N1<i<s</i< signal), respectively. Furthermore, Raman spectroscopy was used to characterize the interaction between polysaccharide and carbon counterparts. Methotrexate was physically loaded onto the nanohybrid and the release profiles showed a pH-responsive behavior with higher and faster release in acidic (pH 5.0) vs. neutral (pH 7.4) environments. Empty nanoparticles were found to be highly biocompatible in either healthy (MRC-5) or cancerous (H1299) cells, with the nanocarrier being effective in reducing the drug toxicity on MRC-5 while enhancing the anticancer activity on H1299.
abstractGer	A hybrid system composed of multi-walled carbon nanotubes coated with chitosan was proposed as a pH-responsive carrier for the vectorization of methotrexate to lung cancer. The effective coating of the carbon nanostructure by chitosan, quantified (20% by weight) by thermogravimetric analysis, was assessed by combined scanning and transmission electron microscopy, and X-ray photoelectron spectroscopy (N1<i<s</i< signal), respectively. Furthermore, Raman spectroscopy was used to characterize the interaction between polysaccharide and carbon counterparts. Methotrexate was physically loaded onto the nanohybrid and the release profiles showed a pH-responsive behavior with higher and faster release in acidic (pH 5.0) vs. neutral (pH 7.4) environments. Empty nanoparticles were found to be highly biocompatible in either healthy (MRC-5) or cancerous (H1299) cells, with the nanocarrier being effective in reducing the drug toxicity on MRC-5 while enhancing the anticancer activity on H1299.
abstract_unstemmed	A hybrid system composed of multi-walled carbon nanotubes coated with chitosan was proposed as a pH-responsive carrier for the vectorization of methotrexate to lung cancer. The effective coating of the carbon nanostructure by chitosan, quantified (20% by weight) by thermogravimetric analysis, was assessed by combined scanning and transmission electron microscopy, and X-ray photoelectron spectroscopy (N1<i<s</i< signal), respectively. Furthermore, Raman spectroscopy was used to characterize the interaction between polysaccharide and carbon counterparts. Methotrexate was physically loaded onto the nanohybrid and the release profiles showed a pH-responsive behavior with higher and faster release in acidic (pH 5.0) vs. neutral (pH 7.4) environments. Empty nanoparticles were found to be highly biocompatible in either healthy (MRC-5) or cancerous (H1299) cells, with the nanocarrier being effective in reducing the drug toxicity on MRC-5 while enhancing the anticancer activity on H1299.
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title_short	Combining Carbon Nanotubes and Chitosan for the Vectorization of Methotrexate to Lung Cancer Cells
url	https://doi.org/10.3390/ma12182889 https://doaj.org/article/55d7ff66f5b7485282ded76bbf048667 https://www.mdpi.com/1996-1944/12/18/2889 https://doaj.org/toc/1996-1944
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doi_str	10.3390/ma12182889
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up_date	2024-07-03T19:01:03.850Z
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Combining Carbon Nanotubes and Chitosan for the Vectorization of Methotrexate to Lung Cancer Cells

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