A Plasmonic Biosensor Based on Light-Diffusing Fibers Functionalized with Molecularly Imprinted Nanoparticles for Ultralow Sensing of Proteins

Plasmonic bio/chemical sensing based on optical fibers combined with molecularly imprinted nanoparticles (nanoMIPs), which are polymeric receptors prepared by a template-assisted synthesis, has been demonstrated as a powerful method to attain ultra-low detection limits, particularly when exploiting...
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Autor*in:	Francesco Arcadio [verfasserIn] Mimimorena Seggio [verfasserIn] Domenico Del Prete [verfasserIn] Gionatan Buonanno [verfasserIn] João Mendes [verfasserIn] Luís C. C. Coelho [verfasserIn] Pedro A. S. Jorge [verfasserIn] Luigi Zeni [verfasserIn] Alessandra Maria Bossi [verfasserIn] Nunzio Cennamo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	light-diffusing fibers (LDFs) surface plasmon resonance (SPR) molecularly imprinted polymers (MIPs) molecularly imprinted nanoparticles (nanoMIPs) biosensors plasmonic optical fiber biosensors

Übergeordnetes Werk:	In: Nanomaterials - MDPI AG, 2012, 12(2022), 9, p 1400
Übergeordnetes Werk:	volume:12 ; year:2022 ; number:9, p 1400

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/nano12091400

Katalog-ID:	DOAJ043707505

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callnumber-first	Q - Science
author	Francesco Arcadio
spellingShingle	Francesco Arcadio misc QD1-999 misc light-diffusing fibers (LDFs) misc surface plasmon resonance (SPR) misc molecularly imprinted polymers (MIPs) misc molecularly imprinted nanoparticles (nanoMIPs) misc biosensors misc plasmonic optical fiber biosensors misc Chemistry A Plasmonic Biosensor Based on Light-Diffusing Fibers Functionalized with Molecularly Imprinted Nanoparticles for Ultralow Sensing of Proteins
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topic_title	QD1-999 A Plasmonic Biosensor Based on Light-Diffusing Fibers Functionalized with Molecularly Imprinted Nanoparticles for Ultralow Sensing of Proteins light-diffusing fibers (LDFs) surface plasmon resonance (SPR) molecularly imprinted polymers (MIPs) molecularly imprinted nanoparticles (nanoMIPs) biosensors plasmonic optical fiber biosensors
topic	misc QD1-999 misc light-diffusing fibers (LDFs) misc surface plasmon resonance (SPR) misc molecularly imprinted polymers (MIPs) misc molecularly imprinted nanoparticles (nanoMIPs) misc biosensors misc plasmonic optical fiber biosensors misc Chemistry
topic_unstemmed	misc QD1-999 misc light-diffusing fibers (LDFs) misc surface plasmon resonance (SPR) misc molecularly imprinted polymers (MIPs) misc molecularly imprinted nanoparticles (nanoMIPs) misc biosensors misc plasmonic optical fiber biosensors misc Chemistry
topic_browse	misc QD1-999 misc light-diffusing fibers (LDFs) misc surface plasmon resonance (SPR) misc molecularly imprinted polymers (MIPs) misc molecularly imprinted nanoparticles (nanoMIPs) misc biosensors misc plasmonic optical fiber biosensors misc Chemistry
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title	A Plasmonic Biosensor Based on Light-Diffusing Fibers Functionalized with Molecularly Imprinted Nanoparticles for Ultralow Sensing of Proteins
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title_full	A Plasmonic Biosensor Based on Light-Diffusing Fibers Functionalized with Molecularly Imprinted Nanoparticles for Ultralow Sensing of Proteins
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author_browse	Francesco Arcadio Mimimorena Seggio Domenico Del Prete Gionatan Buonanno João Mendes Luís C. C. Coelho Pedro A. S. Jorge Luigi Zeni Alessandra Maria Bossi Nunzio Cennamo
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title_sort	plasmonic biosensor based on light-diffusing fibers functionalized with molecularly imprinted nanoparticles for ultralow sensing of proteins
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title_auth	A Plasmonic Biosensor Based on Light-Diffusing Fibers Functionalized with Molecularly Imprinted Nanoparticles for Ultralow Sensing of Proteins
abstract	Plasmonic bio/chemical sensing based on optical fibers combined with molecularly imprinted nanoparticles (nanoMIPs), which are polymeric receptors prepared by a template-assisted synthesis, has been demonstrated as a powerful method to attain ultra-low detection limits, particularly when exploiting soft nanoMIPs, which are known to deform upon analyte binding. This work presents the development of a surface plasmon resonance (SPR) sensor in silica light-diffusing fibers (LDFs) functionalized with a specific nanoMIP receptor, entailed for the recognition of the protein human serum transferrin (HTR). Despite their great versatility, to date only SPR-LFDs functionalized with antibodies have been reported. Here, the innovative combination of an SPR-LFD platform and nanoMIPs led to the development of a sensor with an ultra-low limit of detection (LOD), equal to about 4 fM, and selective for its target analyte HTR. It is worth noting that the SPR-LDF-nanoMIP sensor was mounted within a specially designed 3D-printed holder yielding a measurement cell suitable for a rapid and reliable setup, and easy for the scaling up of the measurements. Moreover, the fabrication process to realize the SPR platform is minimal, requiring only a metal deposition step.
abstractGer	Plasmonic bio/chemical sensing based on optical fibers combined with molecularly imprinted nanoparticles (nanoMIPs), which are polymeric receptors prepared by a template-assisted synthesis, has been demonstrated as a powerful method to attain ultra-low detection limits, particularly when exploiting soft nanoMIPs, which are known to deform upon analyte binding. This work presents the development of a surface plasmon resonance (SPR) sensor in silica light-diffusing fibers (LDFs) functionalized with a specific nanoMIP receptor, entailed for the recognition of the protein human serum transferrin (HTR). Despite their great versatility, to date only SPR-LFDs functionalized with antibodies have been reported. Here, the innovative combination of an SPR-LFD platform and nanoMIPs led to the development of a sensor with an ultra-low limit of detection (LOD), equal to about 4 fM, and selective for its target analyte HTR. It is worth noting that the SPR-LDF-nanoMIP sensor was mounted within a specially designed 3D-printed holder yielding a measurement cell suitable for a rapid and reliable setup, and easy for the scaling up of the measurements. Moreover, the fabrication process to realize the SPR platform is minimal, requiring only a metal deposition step.
abstract_unstemmed	Plasmonic bio/chemical sensing based on optical fibers combined with molecularly imprinted nanoparticles (nanoMIPs), which are polymeric receptors prepared by a template-assisted synthesis, has been demonstrated as a powerful method to attain ultra-low detection limits, particularly when exploiting soft nanoMIPs, which are known to deform upon analyte binding. This work presents the development of a surface plasmon resonance (SPR) sensor in silica light-diffusing fibers (LDFs) functionalized with a specific nanoMIP receptor, entailed for the recognition of the protein human serum transferrin (HTR). Despite their great versatility, to date only SPR-LFDs functionalized with antibodies have been reported. Here, the innovative combination of an SPR-LFD platform and nanoMIPs led to the development of a sensor with an ultra-low limit of detection (LOD), equal to about 4 fM, and selective for its target analyte HTR. It is worth noting that the SPR-LDF-nanoMIP sensor was mounted within a specially designed 3D-printed holder yielding a measurement cell suitable for a rapid and reliable setup, and easy for the scaling up of the measurements. Moreover, the fabrication process to realize the SPR platform is minimal, requiring only a metal deposition step.
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title_short	A Plasmonic Biosensor Based on Light-Diffusing Fibers Functionalized with Molecularly Imprinted Nanoparticles for Ultralow Sensing of Proteins
url	https://doi.org/10.3390/nano12091400 https://doaj.org/article/82ca50b56e454fa788b17bd29fb640d3 https://www.mdpi.com/2079-4991/12/9/1400 https://doaj.org/toc/2079-4991
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author2	Mimimorena Seggio Domenico Del Prete Gionatan Buonanno João Mendes Luís C. C. Coelho Pedro A. S. Jorge Luigi Zeni Alessandra Maria Bossi Nunzio Cennamo
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A Plasmonic Biosensor Based on Light-Diffusing Fibers Functionalized with Molecularly Imprinted Nanoparticles for Ultralow Sensing of Proteins

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