Kallistatin Attenuates Experimental Autoimmune Uveitis by Inhibiting Activation of T Cells

Experimental autoimmune uveoretinitis (EAU) is a mouse model of human autoimmune uveitis. EAU spontaneously resolves and is marked by ocular autoantigen-specific regulatory immunity in the spleen. Kallikrein binding protein (KBP) or kallistatin is a serine proteinase inhibitor that inhibits angiogen...
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Autor*in:	Fauziyya Muhammad [verfasserIn] Priscilla N. Avalos [verfasserIn] M. H. Mursalin [verfasserIn] Jian-Xing Ma [verfasserIn] Michelle C. Callegan [verfasserIn] Darren J. Lee [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	autoimmune disease autoimmune uveitis kallistatin experimental autoimmune uveitis T cells

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 11(2020)
Übergeordnetes Werk:	volume:11 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2020.00975

Katalog-ID:	DOAJ043744427

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520			\|a Experimental autoimmune uveoretinitis (EAU) is a mouse model of human autoimmune uveitis. EAU spontaneously resolves and is marked by ocular autoantigen-specific regulatory immunity in the spleen. Kallikrein binding protein (KBP) or kallistatin is a serine proteinase inhibitor that inhibits angiogenesis and inflammation, but its role in autoimmune uveitis has not been explored. We report that T cells activation is inhibited and EAU is attenuated in human KBP (HKBP) mice with no significant difference in the Treg population that we previously identified both before and after recovery from EAU. Moreover, following EAU immunization HKBP mice have potent ocular autoantigen specific regulatory immunity that is functionally suppressive.
650		4	\|a autoimmune disease
650		4	\|a autoimmune uveitis
650		4	\|a kallistatin
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650		4	\|a T cells
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allfields	10.3389/fimmu.2020.00975 doi (DE-627)DOAJ043744427 (DE-599)DOAJ5944ea9f565e489186daf391dec7940d DE-627 ger DE-627 rakwb eng RC581-607 Fauziyya Muhammad verfasserin aut Kallistatin Attenuates Experimental Autoimmune Uveitis by Inhibiting Activation of T Cells 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Experimental autoimmune uveoretinitis (EAU) is a mouse model of human autoimmune uveitis. EAU spontaneously resolves and is marked by ocular autoantigen-specific regulatory immunity in the spleen. Kallikrein binding protein (KBP) or kallistatin is a serine proteinase inhibitor that inhibits angiogenesis and inflammation, but its role in autoimmune uveitis has not been explored. We report that T cells activation is inhibited and EAU is attenuated in human KBP (HKBP) mice with no significant difference in the Treg population that we previously identified both before and after recovery from EAU. Moreover, following EAU immunization HKBP mice have potent ocular autoantigen specific regulatory immunity that is functionally suppressive. autoimmune disease autoimmune uveitis kallistatin experimental autoimmune uveitis T cells Immunologic diseases. Allergy Priscilla N. Avalos verfasserin aut M. H. Mursalin verfasserin aut Jian-Xing Ma verfasserin aut Michelle C. Callegan verfasserin aut Michelle C. Callegan verfasserin aut Michelle C. Callegan verfasserin aut Darren J. Lee verfasserin aut Darren J. Lee verfasserin aut Darren J. Lee verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 11(2020) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:11 year:2020 https://doi.org/10.3389/fimmu.2020.00975 kostenfrei https://doaj.org/article/5944ea9f565e489186daf391dec7940d kostenfrei https://www.frontiersin.org/article/10.3389/fimmu.2020.00975/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020
spelling	10.3389/fimmu.2020.00975 doi (DE-627)DOAJ043744427 (DE-599)DOAJ5944ea9f565e489186daf391dec7940d DE-627 ger DE-627 rakwb eng RC581-607 Fauziyya Muhammad verfasserin aut Kallistatin Attenuates Experimental Autoimmune Uveitis by Inhibiting Activation of T Cells 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Experimental autoimmune uveoretinitis (EAU) is a mouse model of human autoimmune uveitis. EAU spontaneously resolves and is marked by ocular autoantigen-specific regulatory immunity in the spleen. Kallikrein binding protein (KBP) or kallistatin is a serine proteinase inhibitor that inhibits angiogenesis and inflammation, but its role in autoimmune uveitis has not been explored. We report that T cells activation is inhibited and EAU is attenuated in human KBP (HKBP) mice with no significant difference in the Treg population that we previously identified both before and after recovery from EAU. Moreover, following EAU immunization HKBP mice have potent ocular autoantigen specific regulatory immunity that is functionally suppressive. autoimmune disease autoimmune uveitis kallistatin experimental autoimmune uveitis T cells Immunologic diseases. Allergy Priscilla N. Avalos verfasserin aut M. H. Mursalin verfasserin aut Jian-Xing Ma verfasserin aut Michelle C. Callegan verfasserin aut Michelle C. Callegan verfasserin aut Michelle C. Callegan verfasserin aut Darren J. Lee verfasserin aut Darren J. Lee verfasserin aut Darren J. Lee verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 11(2020) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:11 year:2020 https://doi.org/10.3389/fimmu.2020.00975 kostenfrei https://doaj.org/article/5944ea9f565e489186daf391dec7940d kostenfrei https://www.frontiersin.org/article/10.3389/fimmu.2020.00975/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020
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allfieldsSound	10.3389/fimmu.2020.00975 doi (DE-627)DOAJ043744427 (DE-599)DOAJ5944ea9f565e489186daf391dec7940d DE-627 ger DE-627 rakwb eng RC581-607 Fauziyya Muhammad verfasserin aut Kallistatin Attenuates Experimental Autoimmune Uveitis by Inhibiting Activation of T Cells 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Experimental autoimmune uveoretinitis (EAU) is a mouse model of human autoimmune uveitis. EAU spontaneously resolves and is marked by ocular autoantigen-specific regulatory immunity in the spleen. Kallikrein binding protein (KBP) or kallistatin is a serine proteinase inhibitor that inhibits angiogenesis and inflammation, but its role in autoimmune uveitis has not been explored. We report that T cells activation is inhibited and EAU is attenuated in human KBP (HKBP) mice with no significant difference in the Treg population that we previously identified both before and after recovery from EAU. Moreover, following EAU immunization HKBP mice have potent ocular autoantigen specific regulatory immunity that is functionally suppressive. autoimmune disease autoimmune uveitis kallistatin experimental autoimmune uveitis T cells Immunologic diseases. Allergy Priscilla N. Avalos verfasserin aut M. H. Mursalin verfasserin aut Jian-Xing Ma verfasserin aut Michelle C. Callegan verfasserin aut Michelle C. Callegan verfasserin aut Michelle C. Callegan verfasserin aut Darren J. Lee verfasserin aut Darren J. Lee verfasserin aut Darren J. Lee verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 11(2020) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:11 year:2020 https://doi.org/10.3389/fimmu.2020.00975 kostenfrei https://doaj.org/article/5944ea9f565e489186daf391dec7940d kostenfrei https://www.frontiersin.org/article/10.3389/fimmu.2020.00975/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020
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callnumber-first	R - Medicine
author	Fauziyya Muhammad
spellingShingle	Fauziyya Muhammad misc RC581-607 misc autoimmune disease misc autoimmune uveitis misc kallistatin misc experimental autoimmune uveitis misc T cells misc Immunologic diseases. Allergy Kallistatin Attenuates Experimental Autoimmune Uveitis by Inhibiting Activation of T Cells
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topic_title	RC581-607 Kallistatin Attenuates Experimental Autoimmune Uveitis by Inhibiting Activation of T Cells autoimmune disease autoimmune uveitis kallistatin experimental autoimmune uveitis T cells
topic	misc RC581-607 misc autoimmune disease misc autoimmune uveitis misc kallistatin misc experimental autoimmune uveitis misc T cells misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc autoimmune disease misc autoimmune uveitis misc kallistatin misc experimental autoimmune uveitis misc T cells misc Immunologic diseases. Allergy
topic_browse	misc RC581-607 misc autoimmune disease misc autoimmune uveitis misc kallistatin misc experimental autoimmune uveitis misc T cells misc Immunologic diseases. Allergy
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title	Kallistatin Attenuates Experimental Autoimmune Uveitis by Inhibiting Activation of T Cells
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title_full	Kallistatin Attenuates Experimental Autoimmune Uveitis by Inhibiting Activation of T Cells
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title_sort	kallistatin attenuates experimental autoimmune uveitis by inhibiting activation of t cells
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title_auth	Kallistatin Attenuates Experimental Autoimmune Uveitis by Inhibiting Activation of T Cells
abstract	Experimental autoimmune uveoretinitis (EAU) is a mouse model of human autoimmune uveitis. EAU spontaneously resolves and is marked by ocular autoantigen-specific regulatory immunity in the spleen. Kallikrein binding protein (KBP) or kallistatin is a serine proteinase inhibitor that inhibits angiogenesis and inflammation, but its role in autoimmune uveitis has not been explored. We report that T cells activation is inhibited and EAU is attenuated in human KBP (HKBP) mice with no significant difference in the Treg population that we previously identified both before and after recovery from EAU. Moreover, following EAU immunization HKBP mice have potent ocular autoantigen specific regulatory immunity that is functionally suppressive.
abstractGer	Experimental autoimmune uveoretinitis (EAU) is a mouse model of human autoimmune uveitis. EAU spontaneously resolves and is marked by ocular autoantigen-specific regulatory immunity in the spleen. Kallikrein binding protein (KBP) or kallistatin is a serine proteinase inhibitor that inhibits angiogenesis and inflammation, but its role in autoimmune uveitis has not been explored. We report that T cells activation is inhibited and EAU is attenuated in human KBP (HKBP) mice with no significant difference in the Treg population that we previously identified both before and after recovery from EAU. Moreover, following EAU immunization HKBP mice have potent ocular autoantigen specific regulatory immunity that is functionally suppressive.
abstract_unstemmed	Experimental autoimmune uveoretinitis (EAU) is a mouse model of human autoimmune uveitis. EAU spontaneously resolves and is marked by ocular autoantigen-specific regulatory immunity in the spleen. Kallikrein binding protein (KBP) or kallistatin is a serine proteinase inhibitor that inhibits angiogenesis and inflammation, but its role in autoimmune uveitis has not been explored. We report that T cells activation is inhibited and EAU is attenuated in human KBP (HKBP) mice with no significant difference in the Treg population that we previously identified both before and after recovery from EAU. Moreover, following EAU immunization HKBP mice have potent ocular autoantigen specific regulatory immunity that is functionally suppressive.
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title_short	Kallistatin Attenuates Experimental Autoimmune Uveitis by Inhibiting Activation of T Cells
url	https://doi.org/10.3389/fimmu.2020.00975 https://doaj.org/article/5944ea9f565e489186daf391dec7940d https://www.frontiersin.org/article/10.3389/fimmu.2020.00975/full https://doaj.org/toc/1664-3224
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up_date	2024-07-03T19:15:31.482Z
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