Role of Placental VDR Expression and Function in Common Late Pregnancy Disorders

Vitamin D, besides its classical role in bone metabolism, plays a distinct role in multiple pathways of the feto-maternal unit. Calcitriol is the major active ligand of the nuclear vitamin D receptor (VDR). The vitamin D receptor (VDR) is expressed in different uteroplacental parts and exerts a vari...
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Gespeichert in:

Autor*in:	Julia Knabl [verfasserIn] Aurelia Vattai [verfasserIn] Yao Ye [verfasserIn] Julia Jueckstock [verfasserIn] Stefan Hutter [verfasserIn] Franz Kainer [verfasserIn] Sven Mahner [verfasserIn] Udo Jeschke [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	vitamin D VDR preterm birth GDM preeclampsia fetal growth restriction

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 18(2017), 11, p 2340
Übergeordnetes Werk:	volume:18 ; year:2017 ; number:11, p 2340

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/ijms18112340

Katalog-ID:	DOAJ043746152

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520			\|a Vitamin D, besides its classical role in bone metabolism, plays a distinct role in multiple pathways of the feto-maternal unit. Calcitriol is the major active ligand of the nuclear vitamin D receptor (VDR). The vitamin D receptor (VDR) is expressed in different uteroplacental parts and exerts a variety of functions in physiologic pregnancy. It regulates decidualisation and implantation, influences hormone secretion and placental immune modulations. This review highlights the role of the vitamin D receptor in physiologic and disturbed pregnancy, as preeclampsia, fetal growth restriction, gestational diabetes and preterm birth. We discuss the existing literature regarding common VDR polymorphisms in these pregnancy disorders.
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spelling	10.3390/ijms18112340 doi (DE-627)DOAJ043746152 (DE-599)DOAJ7e510ed09a5848eab7a6c70286a4a072 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Julia Knabl verfasserin aut Role of Placental VDR Expression and Function in Common Late Pregnancy Disorders 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Vitamin D, besides its classical role in bone metabolism, plays a distinct role in multiple pathways of the feto-maternal unit. Calcitriol is the major active ligand of the nuclear vitamin D receptor (VDR). The vitamin D receptor (VDR) is expressed in different uteroplacental parts and exerts a variety of functions in physiologic pregnancy. It regulates decidualisation and implantation, influences hormone secretion and placental immune modulations. This review highlights the role of the vitamin D receptor in physiologic and disturbed pregnancy, as preeclampsia, fetal growth restriction, gestational diabetes and preterm birth. We discuss the existing literature regarding common VDR polymorphisms in these pregnancy disorders. vitamin D VDR preterm birth GDM preeclampsia fetal growth restriction Biology (General) Chemistry Aurelia Vattai verfasserin aut Yao Ye verfasserin aut Julia Jueckstock verfasserin aut Stefan Hutter verfasserin aut Franz Kainer verfasserin aut Sven Mahner verfasserin aut Udo Jeschke verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 18(2017), 11, p 2340 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:18 year:2017 number:11, p 2340 https://doi.org/10.3390/ijms18112340 kostenfrei https://doaj.org/article/7e510ed09a5848eab7a6c70286a4a072 kostenfrei https://www.mdpi.com/1422-0067/18/11/2340 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 11, p 2340
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language	English
source	In International Journal of Molecular Sciences 18(2017), 11, p 2340 volume:18 year:2017 number:11, p 2340
sourceStr	In International Journal of Molecular Sciences 18(2017), 11, p 2340 volume:18 year:2017 number:11, p 2340
format_phy_str_mv	Article
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topic_facet	vitamin D VDR preterm birth GDM preeclampsia fetal growth restriction Biology (General) Chemistry
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container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Julia Knabl @@aut@@ Aurelia Vattai @@aut@@ Yao Ye @@aut@@ Julia Jueckstock @@aut@@ Stefan Hutter @@aut@@ Franz Kainer @@aut@@ Sven Mahner @@aut@@ Udo Jeschke @@aut@@
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callnumber-first	Q - Science
author	Julia Knabl
spellingShingle	Julia Knabl misc QH301-705.5 misc QD1-999 misc vitamin D misc VDR misc preterm birth misc GDM misc preeclampsia misc fetal growth restriction misc Biology (General) misc Chemistry Role of Placental VDR Expression and Function in Common Late Pregnancy Disorders
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topic_title	QH301-705.5 QD1-999 Role of Placental VDR Expression and Function in Common Late Pregnancy Disorders vitamin D VDR preterm birth GDM preeclampsia fetal growth restriction
topic	misc QH301-705.5 misc QD1-999 misc vitamin D misc VDR misc preterm birth misc GDM misc preeclampsia misc fetal growth restriction misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc vitamin D misc VDR misc preterm birth misc GDM misc preeclampsia misc fetal growth restriction misc Biology (General) misc Chemistry
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title	Role of Placental VDR Expression and Function in Common Late Pregnancy Disorders
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author_browse	Julia Knabl Aurelia Vattai Yao Ye Julia Jueckstock Stefan Hutter Franz Kainer Sven Mahner Udo Jeschke
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title_sort	role of placental vdr expression and function in common late pregnancy disorders
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title_auth	Role of Placental VDR Expression and Function in Common Late Pregnancy Disorders
abstract	Vitamin D, besides its classical role in bone metabolism, plays a distinct role in multiple pathways of the feto-maternal unit. Calcitriol is the major active ligand of the nuclear vitamin D receptor (VDR). The vitamin D receptor (VDR) is expressed in different uteroplacental parts and exerts a variety of functions in physiologic pregnancy. It regulates decidualisation and implantation, influences hormone secretion and placental immune modulations. This review highlights the role of the vitamin D receptor in physiologic and disturbed pregnancy, as preeclampsia, fetal growth restriction, gestational diabetes and preterm birth. We discuss the existing literature regarding common VDR polymorphisms in these pregnancy disorders.
abstractGer	Vitamin D, besides its classical role in bone metabolism, plays a distinct role in multiple pathways of the feto-maternal unit. Calcitriol is the major active ligand of the nuclear vitamin D receptor (VDR). The vitamin D receptor (VDR) is expressed in different uteroplacental parts and exerts a variety of functions in physiologic pregnancy. It regulates decidualisation and implantation, influences hormone secretion and placental immune modulations. This review highlights the role of the vitamin D receptor in physiologic and disturbed pregnancy, as preeclampsia, fetal growth restriction, gestational diabetes and preterm birth. We discuss the existing literature regarding common VDR polymorphisms in these pregnancy disorders.
abstract_unstemmed	Vitamin D, besides its classical role in bone metabolism, plays a distinct role in multiple pathways of the feto-maternal unit. Calcitriol is the major active ligand of the nuclear vitamin D receptor (VDR). The vitamin D receptor (VDR) is expressed in different uteroplacental parts and exerts a variety of functions in physiologic pregnancy. It regulates decidualisation and implantation, influences hormone secretion and placental immune modulations. This review highlights the role of the vitamin D receptor in physiologic and disturbed pregnancy, as preeclampsia, fetal growth restriction, gestational diabetes and preterm birth. We discuss the existing literature regarding common VDR polymorphisms in these pregnancy disorders.
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title_short	Role of Placental VDR Expression and Function in Common Late Pregnancy Disorders
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