Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene

<p<Abstract</p< <p<Background</p< <p<Neuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and coding regions of the bovine <it<NPY </it<gene can...
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Autor*in:	Sweeney Torres [verfasserIn] Bahar Bojlul [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2008

Übergeordnetes Werk:	In: BMC Genetics - BMC, 2003, 9(2008), 1, p 91
Übergeordnetes Werk:	volume:9 ; year:2008 ; number:1, p 91

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DOI / URN:	10.1186/1471-2156-9-91

Katalog-ID:	DOAJ043835201

Internformat


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520			\|a <p<Abstract</p< <p<Background</p< <p<Neuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and coding regions of the bovine <it<NPY </it<gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle. The objectives of this experiment were to: a) fully characterize the bovine <it<NPY </it<gene transcript and b) identify the SNP diversity in both coding and non-coding regions of the <it<NPY </it<gene in a panel of <it<Bos taurus </it<and <it<B. indicus </it<cattle.</p< <p<Results</p< <p<Bovine <it<NPY </it<gene consists of four exons (99, 188, 81 and 195 nucleotides) and three introns. The promoter region of the <it<NPY </it<gene consists of TATA and GC boxes which are separated from the transcription start site (TSS) by 29 and ~100 nt, respectively. Analyses of the tissue specific expression of the bovine <it<NPY </it<gene revealed the presence of highly abundant <it<NPY </it<gene transcripts in the arcuate nucleus, cerebral and cerebellar regions of the bovine brain. We identified a total of 59 SNPs in the 8.4 kb region of the bovine <it<NPY </it<gene. Seven out of nine total SNPs in the promoter region affect binding of putative transcription factors. A high level of nucleotide diversity was evident in the promoter regions (2.84 × 10<sup<-3</sup<) compared to the exonic (1.44 × 10<sup<-3</sup<), intronic (1.30 × 10<sup<-3</sup<) and 3' untranslated (1.26 × 10<sup<-3</sup<) regions.</p< <p<Conclusion</p< <p<The SNPs identified in different regions of bovine <it<NPY </it<gene may serve as a basis for understanding the regulation of the expression of the bovine <it<NPY </it<gene under a variety of physiological conditions and identification of genotypes with high feed energy conversion efficiency.</p<
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allfields	10.1186/1471-2156-9-91 doi (DE-627)DOAJ043835201 (DE-599)DOAJ6350a167d31a46f1a1c62559dbeffc98 DE-627 ger DE-627 rakwb eng QH426-470 Sweeney Torres verfasserin aut Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Neuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and coding regions of the bovine <it<NPY </it<gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle. The objectives of this experiment were to: a) fully characterize the bovine <it<NPY </it<gene transcript and b) identify the SNP diversity in both coding and non-coding regions of the <it<NPY </it<gene in a panel of <it<Bos taurus </it<and <it<B. indicus </it<cattle.</p< <p<Results</p< <p<Bovine <it<NPY </it<gene consists of four exons (99, 188, 81 and 195 nucleotides) and three introns. The promoter region of the <it<NPY </it<gene consists of TATA and GC boxes which are separated from the transcription start site (TSS) by 29 and ~100 nt, respectively. Analyses of the tissue specific expression of the bovine <it<NPY </it<gene revealed the presence of highly abundant <it<NPY </it<gene transcripts in the arcuate nucleus, cerebral and cerebellar regions of the bovine brain. We identified a total of 59 SNPs in the 8.4 kb region of the bovine <it<NPY </it<gene. Seven out of nine total SNPs in the promoter region affect binding of putative transcription factors. A high level of nucleotide diversity was evident in the promoter regions (2.84 × 10<sup<-3</sup<) compared to the exonic (1.44 × 10<sup<-3</sup<), intronic (1.30 × 10<sup<-3</sup<) and 3' untranslated (1.26 × 10<sup<-3</sup<) regions.</p< <p<Conclusion</p< <p<The SNPs identified in different regions of bovine <it<NPY </it<gene may serve as a basis for understanding the regulation of the expression of the bovine <it<NPY </it<gene under a variety of physiological conditions and identification of genotypes with high feed energy conversion efficiency.</p< Genetics Bahar Bojlul verfasserin aut In BMC Genetics BMC, 2003 9(2008), 1, p 91 (DE-627)326644938 (DE-600)2041497-3 14712156 nnns volume:9 year:2008 number:1, p 91 https://doi.org/10.1186/1471-2156-9-91 kostenfrei https://doaj.org/article/6350a167d31a46f1a1c62559dbeffc98 kostenfrei http://www.biomedcentral.com/1471-2156/9/91 kostenfrei https://doaj.org/toc/1471-2156 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2008 1, p 91
spelling	10.1186/1471-2156-9-91 doi (DE-627)DOAJ043835201 (DE-599)DOAJ6350a167d31a46f1a1c62559dbeffc98 DE-627 ger DE-627 rakwb eng QH426-470 Sweeney Torres verfasserin aut Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Neuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and coding regions of the bovine <it<NPY </it<gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle. The objectives of this experiment were to: a) fully characterize the bovine <it<NPY </it<gene transcript and b) identify the SNP diversity in both coding and non-coding regions of the <it<NPY </it<gene in a panel of <it<Bos taurus </it<and <it<B. indicus </it<cattle.</p< <p<Results</p< <p<Bovine <it<NPY </it<gene consists of four exons (99, 188, 81 and 195 nucleotides) and three introns. The promoter region of the <it<NPY </it<gene consists of TATA and GC boxes which are separated from the transcription start site (TSS) by 29 and ~100 nt, respectively. Analyses of the tissue specific expression of the bovine <it<NPY </it<gene revealed the presence of highly abundant <it<NPY </it<gene transcripts in the arcuate nucleus, cerebral and cerebellar regions of the bovine brain. We identified a total of 59 SNPs in the 8.4 kb region of the bovine <it<NPY </it<gene. Seven out of nine total SNPs in the promoter region affect binding of putative transcription factors. A high level of nucleotide diversity was evident in the promoter regions (2.84 × 10<sup<-3</sup<) compared to the exonic (1.44 × 10<sup<-3</sup<), intronic (1.30 × 10<sup<-3</sup<) and 3' untranslated (1.26 × 10<sup<-3</sup<) regions.</p< <p<Conclusion</p< <p<The SNPs identified in different regions of bovine <it<NPY </it<gene may serve as a basis for understanding the regulation of the expression of the bovine <it<NPY </it<gene under a variety of physiological conditions and identification of genotypes with high feed energy conversion efficiency.</p< Genetics Bahar Bojlul verfasserin aut In BMC Genetics BMC, 2003 9(2008), 1, p 91 (DE-627)326644938 (DE-600)2041497-3 14712156 nnns volume:9 year:2008 number:1, p 91 https://doi.org/10.1186/1471-2156-9-91 kostenfrei https://doaj.org/article/6350a167d31a46f1a1c62559dbeffc98 kostenfrei http://www.biomedcentral.com/1471-2156/9/91 kostenfrei https://doaj.org/toc/1471-2156 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2008 1, p 91
allfields_unstemmed	10.1186/1471-2156-9-91 doi (DE-627)DOAJ043835201 (DE-599)DOAJ6350a167d31a46f1a1c62559dbeffc98 DE-627 ger DE-627 rakwb eng QH426-470 Sweeney Torres verfasserin aut Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Neuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and coding regions of the bovine <it<NPY </it<gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle. The objectives of this experiment were to: a) fully characterize the bovine <it<NPY </it<gene transcript and b) identify the SNP diversity in both coding and non-coding regions of the <it<NPY </it<gene in a panel of <it<Bos taurus </it<and <it<B. indicus </it<cattle.</p< <p<Results</p< <p<Bovine <it<NPY </it<gene consists of four exons (99, 188, 81 and 195 nucleotides) and three introns. The promoter region of the <it<NPY </it<gene consists of TATA and GC boxes which are separated from the transcription start site (TSS) by 29 and ~100 nt, respectively. Analyses of the tissue specific expression of the bovine <it<NPY </it<gene revealed the presence of highly abundant <it<NPY </it<gene transcripts in the arcuate nucleus, cerebral and cerebellar regions of the bovine brain. We identified a total of 59 SNPs in the 8.4 kb region of the bovine <it<NPY </it<gene. Seven out of nine total SNPs in the promoter region affect binding of putative transcription factors. A high level of nucleotide diversity was evident in the promoter regions (2.84 × 10<sup<-3</sup<) compared to the exonic (1.44 × 10<sup<-3</sup<), intronic (1.30 × 10<sup<-3</sup<) and 3' untranslated (1.26 × 10<sup<-3</sup<) regions.</p< <p<Conclusion</p< <p<The SNPs identified in different regions of bovine <it<NPY </it<gene may serve as a basis for understanding the regulation of the expression of the bovine <it<NPY </it<gene under a variety of physiological conditions and identification of genotypes with high feed energy conversion efficiency.</p< Genetics Bahar Bojlul verfasserin aut In BMC Genetics BMC, 2003 9(2008), 1, p 91 (DE-627)326644938 (DE-600)2041497-3 14712156 nnns volume:9 year:2008 number:1, p 91 https://doi.org/10.1186/1471-2156-9-91 kostenfrei https://doaj.org/article/6350a167d31a46f1a1c62559dbeffc98 kostenfrei http://www.biomedcentral.com/1471-2156/9/91 kostenfrei https://doaj.org/toc/1471-2156 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2008 1, p 91
allfieldsGer	10.1186/1471-2156-9-91 doi (DE-627)DOAJ043835201 (DE-599)DOAJ6350a167d31a46f1a1c62559dbeffc98 DE-627 ger DE-627 rakwb eng QH426-470 Sweeney Torres verfasserin aut Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Neuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and coding regions of the bovine <it<NPY </it<gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle. The objectives of this experiment were to: a) fully characterize the bovine <it<NPY </it<gene transcript and b) identify the SNP diversity in both coding and non-coding regions of the <it<NPY </it<gene in a panel of <it<Bos taurus </it<and <it<B. indicus </it<cattle.</p< <p<Results</p< <p<Bovine <it<NPY </it<gene consists of four exons (99, 188, 81 and 195 nucleotides) and three introns. The promoter region of the <it<NPY </it<gene consists of TATA and GC boxes which are separated from the transcription start site (TSS) by 29 and ~100 nt, respectively. Analyses of the tissue specific expression of the bovine <it<NPY </it<gene revealed the presence of highly abundant <it<NPY </it<gene transcripts in the arcuate nucleus, cerebral and cerebellar regions of the bovine brain. We identified a total of 59 SNPs in the 8.4 kb region of the bovine <it<NPY </it<gene. Seven out of nine total SNPs in the promoter region affect binding of putative transcription factors. A high level of nucleotide diversity was evident in the promoter regions (2.84 × 10<sup<-3</sup<) compared to the exonic (1.44 × 10<sup<-3</sup<), intronic (1.30 × 10<sup<-3</sup<) and 3' untranslated (1.26 × 10<sup<-3</sup<) regions.</p< <p<Conclusion</p< <p<The SNPs identified in different regions of bovine <it<NPY </it<gene may serve as a basis for understanding the regulation of the expression of the bovine <it<NPY </it<gene under a variety of physiological conditions and identification of genotypes with high feed energy conversion efficiency.</p< Genetics Bahar Bojlul verfasserin aut In BMC Genetics BMC, 2003 9(2008), 1, p 91 (DE-627)326644938 (DE-600)2041497-3 14712156 nnns volume:9 year:2008 number:1, p 91 https://doi.org/10.1186/1471-2156-9-91 kostenfrei https://doaj.org/article/6350a167d31a46f1a1c62559dbeffc98 kostenfrei http://www.biomedcentral.com/1471-2156/9/91 kostenfrei https://doaj.org/toc/1471-2156 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2008 1, p 91
allfieldsSound	10.1186/1471-2156-9-91 doi (DE-627)DOAJ043835201 (DE-599)DOAJ6350a167d31a46f1a1c62559dbeffc98 DE-627 ger DE-627 rakwb eng QH426-470 Sweeney Torres verfasserin aut Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Neuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and coding regions of the bovine <it<NPY </it<gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle. The objectives of this experiment were to: a) fully characterize the bovine <it<NPY </it<gene transcript and b) identify the SNP diversity in both coding and non-coding regions of the <it<NPY </it<gene in a panel of <it<Bos taurus </it<and <it<B. indicus </it<cattle.</p< <p<Results</p< <p<Bovine <it<NPY </it<gene consists of four exons (99, 188, 81 and 195 nucleotides) and three introns. The promoter region of the <it<NPY </it<gene consists of TATA and GC boxes which are separated from the transcription start site (TSS) by 29 and ~100 nt, respectively. Analyses of the tissue specific expression of the bovine <it<NPY </it<gene revealed the presence of highly abundant <it<NPY </it<gene transcripts in the arcuate nucleus, cerebral and cerebellar regions of the bovine brain. We identified a total of 59 SNPs in the 8.4 kb region of the bovine <it<NPY </it<gene. Seven out of nine total SNPs in the promoter region affect binding of putative transcription factors. A high level of nucleotide diversity was evident in the promoter regions (2.84 × 10<sup<-3</sup<) compared to the exonic (1.44 × 10<sup<-3</sup<), intronic (1.30 × 10<sup<-3</sup<) and 3' untranslated (1.26 × 10<sup<-3</sup<) regions.</p< <p<Conclusion</p< <p<The SNPs identified in different regions of bovine <it<NPY </it<gene may serve as a basis for understanding the regulation of the expression of the bovine <it<NPY </it<gene under a variety of physiological conditions and identification of genotypes with high feed energy conversion efficiency.</p< Genetics Bahar Bojlul verfasserin aut In BMC Genetics BMC, 2003 9(2008), 1, p 91 (DE-627)326644938 (DE-600)2041497-3 14712156 nnns volume:9 year:2008 number:1, p 91 https://doi.org/10.1186/1471-2156-9-91 kostenfrei https://doaj.org/article/6350a167d31a46f1a1c62559dbeffc98 kostenfrei http://www.biomedcentral.com/1471-2156/9/91 kostenfrei https://doaj.org/toc/1471-2156 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2008 1, p 91
language	English
source	In BMC Genetics 9(2008), 1, p 91 volume:9 year:2008 number:1, p 91
sourceStr	In BMC Genetics 9(2008), 1, p 91 volume:9 year:2008 number:1, p 91
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Genetics
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container_title	BMC Genetics
authorswithroles_txt_mv	Sweeney Torres @@aut@@ Bahar Bojlul @@aut@@
publishDateDaySort_date	2008-01-01T00:00:00Z
hierarchy_top_id	326644938
id	DOAJ043835201
language_de	englisch
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Mutations in the regulatory and coding regions of the bovine <it<NPY </it<gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle. The objectives of this experiment were to: a) fully characterize the bovine <it<NPY </it<gene transcript and b) identify the SNP diversity in both coding and non-coding regions of the <it<NPY </it<gene in a panel of <it<Bos taurus </it<and <it<B. indicus </it<cattle.</p< <p<Results</p< <p<Bovine <it<NPY </it<gene consists of four exons (99, 188, 81 and 195 nucleotides) and three introns. The promoter region of the <it<NPY </it<gene consists of TATA and GC boxes which are separated from the transcription start site (TSS) by 29 and ~100 nt, respectively. Analyses of the tissue specific expression of the bovine <it<NPY </it<gene revealed the presence of highly abundant <it<NPY </it<gene transcripts in the arcuate nucleus, cerebral and cerebellar regions of the bovine brain. 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callnumber-first	Q - Science
author	Sweeney Torres
spellingShingle	Sweeney Torres misc QH426-470 misc Genetics Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene
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topic_title	QH426-470 Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene
topic	misc QH426-470 misc Genetics
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title	Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene
ctrlnum	(DE-627)DOAJ043835201 (DE-599)DOAJ6350a167d31a46f1a1c62559dbeffc98
title_full	Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene
author_sort	Sweeney Torres
journal	BMC Genetics
journalStr	BMC Genetics
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author_browse	Sweeney Torres Bahar Bojlul
container_volume	9
class	QH426-470
format_se	Elektronische Aufsätze
author-letter	Sweeney Torres
doi_str_mv	10.1186/1471-2156-9-91
author2-role	verfasserin
title_sort	mapping of the transcription start site (tss) and identification of snps in the bovine neuropeptide y (<it<npy</it<) gene
callnumber	QH426-470
title_auth	Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene
abstract	<p<Abstract</p< <p<Background</p< <p<Neuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and coding regions of the bovine <it<NPY </it<gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle. The objectives of this experiment were to: a) fully characterize the bovine <it<NPY </it<gene transcript and b) identify the SNP diversity in both coding and non-coding regions of the <it<NPY </it<gene in a panel of <it<Bos taurus </it<and <it<B. indicus </it<cattle.</p< <p<Results</p< <p<Bovine <it<NPY </it<gene consists of four exons (99, 188, 81 and 195 nucleotides) and three introns. The promoter region of the <it<NPY </it<gene consists of TATA and GC boxes which are separated from the transcription start site (TSS) by 29 and ~100 nt, respectively. Analyses of the tissue specific expression of the bovine <it<NPY </it<gene revealed the presence of highly abundant <it<NPY </it<gene transcripts in the arcuate nucleus, cerebral and cerebellar regions of the bovine brain. We identified a total of 59 SNPs in the 8.4 kb region of the bovine <it<NPY </it<gene. Seven out of nine total SNPs in the promoter region affect binding of putative transcription factors. A high level of nucleotide diversity was evident in the promoter regions (2.84 × 10<sup<-3</sup<) compared to the exonic (1.44 × 10<sup<-3</sup<), intronic (1.30 × 10<sup<-3</sup<) and 3' untranslated (1.26 × 10<sup<-3</sup<) regions.</p< <p<Conclusion</p< <p<The SNPs identified in different regions of bovine <it<NPY </it<gene may serve as a basis for understanding the regulation of the expression of the bovine <it<NPY </it<gene under a variety of physiological conditions and identification of genotypes with high feed energy conversion efficiency.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<Neuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and coding regions of the bovine <it<NPY </it<gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle. The objectives of this experiment were to: a) fully characterize the bovine <it<NPY </it<gene transcript and b) identify the SNP diversity in both coding and non-coding regions of the <it<NPY </it<gene in a panel of <it<Bos taurus </it<and <it<B. indicus </it<cattle.</p< <p<Results</p< <p<Bovine <it<NPY </it<gene consists of four exons (99, 188, 81 and 195 nucleotides) and three introns. The promoter region of the <it<NPY </it<gene consists of TATA and GC boxes which are separated from the transcription start site (TSS) by 29 and ~100 nt, respectively. Analyses of the tissue specific expression of the bovine <it<NPY </it<gene revealed the presence of highly abundant <it<NPY </it<gene transcripts in the arcuate nucleus, cerebral and cerebellar regions of the bovine brain. We identified a total of 59 SNPs in the 8.4 kb region of the bovine <it<NPY </it<gene. Seven out of nine total SNPs in the promoter region affect binding of putative transcription factors. A high level of nucleotide diversity was evident in the promoter regions (2.84 × 10<sup<-3</sup<) compared to the exonic (1.44 × 10<sup<-3</sup<), intronic (1.30 × 10<sup<-3</sup<) and 3' untranslated (1.26 × 10<sup<-3</sup<) regions.</p< <p<Conclusion</p< <p<The SNPs identified in different regions of bovine <it<NPY </it<gene may serve as a basis for understanding the regulation of the expression of the bovine <it<NPY </it<gene under a variety of physiological conditions and identification of genotypes with high feed energy conversion efficiency.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<Neuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and coding regions of the bovine <it<NPY </it<gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle. The objectives of this experiment were to: a) fully characterize the bovine <it<NPY </it<gene transcript and b) identify the SNP diversity in both coding and non-coding regions of the <it<NPY </it<gene in a panel of <it<Bos taurus </it<and <it<B. indicus </it<cattle.</p< <p<Results</p< <p<Bovine <it<NPY </it<gene consists of four exons (99, 188, 81 and 195 nucleotides) and three introns. The promoter region of the <it<NPY </it<gene consists of TATA and GC boxes which are separated from the transcription start site (TSS) by 29 and ~100 nt, respectively. Analyses of the tissue specific expression of the bovine <it<NPY </it<gene revealed the presence of highly abundant <it<NPY </it<gene transcripts in the arcuate nucleus, cerebral and cerebellar regions of the bovine brain. We identified a total of 59 SNPs in the 8.4 kb region of the bovine <it<NPY </it<gene. Seven out of nine total SNPs in the promoter region affect binding of putative transcription factors. A high level of nucleotide diversity was evident in the promoter regions (2.84 × 10<sup<-3</sup<) compared to the exonic (1.44 × 10<sup<-3</sup<), intronic (1.30 × 10<sup<-3</sup<) and 3' untranslated (1.26 × 10<sup<-3</sup<) regions.</p< <p<Conclusion</p< <p<The SNPs identified in different regions of bovine <it<NPY </it<gene may serve as a basis for understanding the regulation of the expression of the bovine <it<NPY </it<gene under a variety of physiological conditions and identification of genotypes with high feed energy conversion efficiency.</p<
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title_short	Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene
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Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene

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