Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene
<p<Abstract</p< <p<Background</p< <p<Neuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and coding regions of the bovine <it<NPY </it<gene can...
Ausführliche Beschreibung
Autor*in: |
Sweeney Torres [verfasserIn] Bahar Bojlul [verfasserIn] |
---|
Format: |
E-Artikel |
---|---|
Sprache: |
Englisch |
Erschienen: |
2008 |
---|
Übergeordnetes Werk: |
In: BMC Genetics - BMC, 2003, 9(2008), 1, p 91 |
---|---|
Übergeordnetes Werk: |
volume:9 ; year:2008 ; number:1, p 91 |
Links: |
---|
DOI / URN: |
10.1186/1471-2156-9-91 |
---|
Katalog-ID: |
DOAJ043835201 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | DOAJ043835201 | ||
003 | DE-627 | ||
005 | 20230308074415.0 | ||
007 | cr uuu---uuuuu | ||
008 | 230227s2008 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1186/1471-2156-9-91 |2 doi | |
035 | |a (DE-627)DOAJ043835201 | ||
035 | |a (DE-599)DOAJ6350a167d31a46f1a1c62559dbeffc98 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
050 | 0 | |a QH426-470 | |
100 | 0 | |a Sweeney Torres |e verfasserin |4 aut | |
245 | 1 | 0 | |a Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene |
264 | 1 | |c 2008 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
520 | |a <p<Abstract</p< <p<Background</p< <p<Neuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and coding regions of the bovine <it<NPY </it<gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle. The objectives of this experiment were to: a) fully characterize the bovine <it<NPY </it<gene transcript and b) identify the SNP diversity in both coding and non-coding regions of the <it<NPY </it<gene in a panel of <it<Bos taurus </it<and <it<B. indicus </it<cattle.</p< <p<Results</p< <p<Bovine <it<NPY </it<gene consists of four exons (99, 188, 81 and 195 nucleotides) and three introns. The promoter region of the <it<NPY </it<gene consists of TATA and GC boxes which are separated from the transcription start site (TSS) by 29 and ~100 nt, respectively. Analyses of the tissue specific expression of the bovine <it<NPY </it<gene revealed the presence of highly abundant <it<NPY </it<gene transcripts in the arcuate nucleus, cerebral and cerebellar regions of the bovine brain. We identified a total of 59 SNPs in the 8.4 kb region of the bovine <it<NPY </it<gene. Seven out of nine total SNPs in the promoter region affect binding of putative transcription factors. A high level of nucleotide diversity was evident in the promoter regions (2.84 × 10<sup<-3</sup<) compared to the exonic (1.44 × 10<sup<-3</sup<), intronic (1.30 × 10<sup<-3</sup<) and 3' untranslated (1.26 × 10<sup<-3</sup<) regions.</p< <p<Conclusion</p< <p<The SNPs identified in different regions of bovine <it<NPY </it<gene may serve as a basis for understanding the regulation of the expression of the bovine <it<NPY </it<gene under a variety of physiological conditions and identification of genotypes with high feed energy conversion efficiency.</p< | ||
653 | 0 | |a Genetics | |
700 | 0 | |a Bahar Bojlul |e verfasserin |4 aut | |
773 | 0 | 8 | |i In |t BMC Genetics |d BMC, 2003 |g 9(2008), 1, p 91 |w (DE-627)326644938 |w (DE-600)2041497-3 |x 14712156 |7 nnns |
773 | 1 | 8 | |g volume:9 |g year:2008 |g number:1, p 91 |
856 | 4 | 0 | |u https://doi.org/10.1186/1471-2156-9-91 |z kostenfrei |
856 | 4 | 0 | |u https://doaj.org/article/6350a167d31a46f1a1c62559dbeffc98 |z kostenfrei |
856 | 4 | 0 | |u http://www.biomedcentral.com/1471-2156/9/91 |z kostenfrei |
856 | 4 | 2 | |u https://doaj.org/toc/1471-2156 |y Journal toc |z kostenfrei |
912 | |a GBV_USEFLAG_A | ||
912 | |a SYSFLAG_A | ||
912 | |a GBV_DOAJ | ||
912 | |a GBV_ILN_11 | ||
912 | |a GBV_ILN_20 | ||
912 | |a GBV_ILN_22 | ||
912 | |a GBV_ILN_23 | ||
912 | |a GBV_ILN_24 | ||
912 | |a GBV_ILN_31 | ||
912 | |a GBV_ILN_39 | ||
912 | |a GBV_ILN_40 | ||
912 | |a GBV_ILN_60 | ||
912 | |a GBV_ILN_62 | ||
912 | |a GBV_ILN_63 | ||
912 | |a GBV_ILN_65 | ||
912 | |a GBV_ILN_69 | ||
912 | |a GBV_ILN_70 | ||
912 | |a GBV_ILN_73 | ||
912 | |a GBV_ILN_74 | ||
912 | |a GBV_ILN_95 | ||
912 | |a GBV_ILN_105 | ||
912 | |a GBV_ILN_110 | ||
912 | |a GBV_ILN_151 | ||
912 | |a GBV_ILN_161 | ||
912 | |a GBV_ILN_170 | ||
912 | |a GBV_ILN_206 | ||
912 | |a GBV_ILN_213 | ||
912 | |a GBV_ILN_230 | ||
912 | |a GBV_ILN_285 | ||
912 | |a GBV_ILN_293 | ||
912 | |a GBV_ILN_602 | ||
912 | |a GBV_ILN_702 | ||
912 | |a GBV_ILN_2001 | ||
912 | |a GBV_ILN_2003 | ||
912 | |a GBV_ILN_2005 | ||
912 | |a GBV_ILN_2006 | ||
912 | |a GBV_ILN_2008 | ||
912 | |a GBV_ILN_2009 | ||
912 | |a GBV_ILN_2010 | ||
912 | |a GBV_ILN_2011 | ||
912 | |a GBV_ILN_2014 | ||
912 | |a GBV_ILN_2015 | ||
912 | |a GBV_ILN_2020 | ||
912 | |a GBV_ILN_2021 | ||
912 | |a GBV_ILN_2025 | ||
912 | |a GBV_ILN_2031 | ||
912 | |a GBV_ILN_2038 | ||
912 | |a GBV_ILN_2044 | ||
912 | |a GBV_ILN_2048 | ||
912 | |a GBV_ILN_2050 | ||
912 | |a GBV_ILN_2055 | ||
912 | |a GBV_ILN_2056 | ||
912 | |a GBV_ILN_2057 | ||
912 | |a GBV_ILN_2061 | ||
912 | |a GBV_ILN_2111 | ||
912 | |a GBV_ILN_2113 | ||
912 | |a GBV_ILN_2190 | ||
912 | |a GBV_ILN_4012 | ||
912 | |a GBV_ILN_4037 | ||
912 | |a GBV_ILN_4112 | ||
912 | |a GBV_ILN_4125 | ||
912 | |a GBV_ILN_4126 | ||
912 | |a GBV_ILN_4249 | ||
912 | |a GBV_ILN_4305 | ||
912 | |a GBV_ILN_4306 | ||
912 | |a GBV_ILN_4307 | ||
912 | |a GBV_ILN_4313 | ||
912 | |a GBV_ILN_4322 | ||
912 | |a GBV_ILN_4323 | ||
912 | |a GBV_ILN_4324 | ||
912 | |a GBV_ILN_4325 | ||
912 | |a GBV_ILN_4338 | ||
912 | |a GBV_ILN_4367 | ||
912 | |a GBV_ILN_4700 | ||
951 | |a AR | ||
952 | |d 9 |j 2008 |e 1, p 91 |
author_variant |
s t st b b bb |
---|---|
matchkey_str |
article:14712156:2008----::apnoterncitosatiesaddniiainfnsnhbv |
hierarchy_sort_str |
2008 |
callnumber-subject-code |
QH |
publishDate |
2008 |
allfields |
10.1186/1471-2156-9-91 doi (DE-627)DOAJ043835201 (DE-599)DOAJ6350a167d31a46f1a1c62559dbeffc98 DE-627 ger DE-627 rakwb eng QH426-470 Sweeney Torres verfasserin aut Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Neuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and coding regions of the bovine <it<NPY </it<gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle. The objectives of this experiment were to: a) fully characterize the bovine <it<NPY </it<gene transcript and b) identify the SNP diversity in both coding and non-coding regions of the <it<NPY </it<gene in a panel of <it<Bos taurus </it<and <it<B. indicus </it<cattle.</p< <p<Results</p< <p<Bovine <it<NPY </it<gene consists of four exons (99, 188, 81 and 195 nucleotides) and three introns. The promoter region of the <it<NPY </it<gene consists of TATA and GC boxes which are separated from the transcription start site (TSS) by 29 and ~100 nt, respectively. Analyses of the tissue specific expression of the bovine <it<NPY </it<gene revealed the presence of highly abundant <it<NPY </it<gene transcripts in the arcuate nucleus, cerebral and cerebellar regions of the bovine brain. We identified a total of 59 SNPs in the 8.4 kb region of the bovine <it<NPY </it<gene. Seven out of nine total SNPs in the promoter region affect binding of putative transcription factors. A high level of nucleotide diversity was evident in the promoter regions (2.84 × 10<sup<-3</sup<) compared to the exonic (1.44 × 10<sup<-3</sup<), intronic (1.30 × 10<sup<-3</sup<) and 3' untranslated (1.26 × 10<sup<-3</sup<) regions.</p< <p<Conclusion</p< <p<The SNPs identified in different regions of bovine <it<NPY </it<gene may serve as a basis for understanding the regulation of the expression of the bovine <it<NPY </it<gene under a variety of physiological conditions and identification of genotypes with high feed energy conversion efficiency.</p< Genetics Bahar Bojlul verfasserin aut In BMC Genetics BMC, 2003 9(2008), 1, p 91 (DE-627)326644938 (DE-600)2041497-3 14712156 nnns volume:9 year:2008 number:1, p 91 https://doi.org/10.1186/1471-2156-9-91 kostenfrei https://doaj.org/article/6350a167d31a46f1a1c62559dbeffc98 kostenfrei http://www.biomedcentral.com/1471-2156/9/91 kostenfrei https://doaj.org/toc/1471-2156 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2008 1, p 91 |
spelling |
10.1186/1471-2156-9-91 doi (DE-627)DOAJ043835201 (DE-599)DOAJ6350a167d31a46f1a1c62559dbeffc98 DE-627 ger DE-627 rakwb eng QH426-470 Sweeney Torres verfasserin aut Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Neuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and coding regions of the bovine <it<NPY </it<gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle. The objectives of this experiment were to: a) fully characterize the bovine <it<NPY </it<gene transcript and b) identify the SNP diversity in both coding and non-coding regions of the <it<NPY </it<gene in a panel of <it<Bos taurus </it<and <it<B. indicus </it<cattle.</p< <p<Results</p< <p<Bovine <it<NPY </it<gene consists of four exons (99, 188, 81 and 195 nucleotides) and three introns. The promoter region of the <it<NPY </it<gene consists of TATA and GC boxes which are separated from the transcription start site (TSS) by 29 and ~100 nt, respectively. Analyses of the tissue specific expression of the bovine <it<NPY </it<gene revealed the presence of highly abundant <it<NPY </it<gene transcripts in the arcuate nucleus, cerebral and cerebellar regions of the bovine brain. We identified a total of 59 SNPs in the 8.4 kb region of the bovine <it<NPY </it<gene. Seven out of nine total SNPs in the promoter region affect binding of putative transcription factors. A high level of nucleotide diversity was evident in the promoter regions (2.84 × 10<sup<-3</sup<) compared to the exonic (1.44 × 10<sup<-3</sup<), intronic (1.30 × 10<sup<-3</sup<) and 3' untranslated (1.26 × 10<sup<-3</sup<) regions.</p< <p<Conclusion</p< <p<The SNPs identified in different regions of bovine <it<NPY </it<gene may serve as a basis for understanding the regulation of the expression of the bovine <it<NPY </it<gene under a variety of physiological conditions and identification of genotypes with high feed energy conversion efficiency.</p< Genetics Bahar Bojlul verfasserin aut In BMC Genetics BMC, 2003 9(2008), 1, p 91 (DE-627)326644938 (DE-600)2041497-3 14712156 nnns volume:9 year:2008 number:1, p 91 https://doi.org/10.1186/1471-2156-9-91 kostenfrei https://doaj.org/article/6350a167d31a46f1a1c62559dbeffc98 kostenfrei http://www.biomedcentral.com/1471-2156/9/91 kostenfrei https://doaj.org/toc/1471-2156 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2008 1, p 91 |
allfields_unstemmed |
10.1186/1471-2156-9-91 doi (DE-627)DOAJ043835201 (DE-599)DOAJ6350a167d31a46f1a1c62559dbeffc98 DE-627 ger DE-627 rakwb eng QH426-470 Sweeney Torres verfasserin aut Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Neuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and coding regions of the bovine <it<NPY </it<gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle. The objectives of this experiment were to: a) fully characterize the bovine <it<NPY </it<gene transcript and b) identify the SNP diversity in both coding and non-coding regions of the <it<NPY </it<gene in a panel of <it<Bos taurus </it<and <it<B. indicus </it<cattle.</p< <p<Results</p< <p<Bovine <it<NPY </it<gene consists of four exons (99, 188, 81 and 195 nucleotides) and three introns. The promoter region of the <it<NPY </it<gene consists of TATA and GC boxes which are separated from the transcription start site (TSS) by 29 and ~100 nt, respectively. Analyses of the tissue specific expression of the bovine <it<NPY </it<gene revealed the presence of highly abundant <it<NPY </it<gene transcripts in the arcuate nucleus, cerebral and cerebellar regions of the bovine brain. We identified a total of 59 SNPs in the 8.4 kb region of the bovine <it<NPY </it<gene. Seven out of nine total SNPs in the promoter region affect binding of putative transcription factors. A high level of nucleotide diversity was evident in the promoter regions (2.84 × 10<sup<-3</sup<) compared to the exonic (1.44 × 10<sup<-3</sup<), intronic (1.30 × 10<sup<-3</sup<) and 3' untranslated (1.26 × 10<sup<-3</sup<) regions.</p< <p<Conclusion</p< <p<The SNPs identified in different regions of bovine <it<NPY </it<gene may serve as a basis for understanding the regulation of the expression of the bovine <it<NPY </it<gene under a variety of physiological conditions and identification of genotypes with high feed energy conversion efficiency.</p< Genetics Bahar Bojlul verfasserin aut In BMC Genetics BMC, 2003 9(2008), 1, p 91 (DE-627)326644938 (DE-600)2041497-3 14712156 nnns volume:9 year:2008 number:1, p 91 https://doi.org/10.1186/1471-2156-9-91 kostenfrei https://doaj.org/article/6350a167d31a46f1a1c62559dbeffc98 kostenfrei http://www.biomedcentral.com/1471-2156/9/91 kostenfrei https://doaj.org/toc/1471-2156 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2008 1, p 91 |
allfieldsGer |
10.1186/1471-2156-9-91 doi (DE-627)DOAJ043835201 (DE-599)DOAJ6350a167d31a46f1a1c62559dbeffc98 DE-627 ger DE-627 rakwb eng QH426-470 Sweeney Torres verfasserin aut Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Neuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and coding regions of the bovine <it<NPY </it<gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle. The objectives of this experiment were to: a) fully characterize the bovine <it<NPY </it<gene transcript and b) identify the SNP diversity in both coding and non-coding regions of the <it<NPY </it<gene in a panel of <it<Bos taurus </it<and <it<B. indicus </it<cattle.</p< <p<Results</p< <p<Bovine <it<NPY </it<gene consists of four exons (99, 188, 81 and 195 nucleotides) and three introns. The promoter region of the <it<NPY </it<gene consists of TATA and GC boxes which are separated from the transcription start site (TSS) by 29 and ~100 nt, respectively. Analyses of the tissue specific expression of the bovine <it<NPY </it<gene revealed the presence of highly abundant <it<NPY </it<gene transcripts in the arcuate nucleus, cerebral and cerebellar regions of the bovine brain. We identified a total of 59 SNPs in the 8.4 kb region of the bovine <it<NPY </it<gene. Seven out of nine total SNPs in the promoter region affect binding of putative transcription factors. A high level of nucleotide diversity was evident in the promoter regions (2.84 × 10<sup<-3</sup<) compared to the exonic (1.44 × 10<sup<-3</sup<), intronic (1.30 × 10<sup<-3</sup<) and 3' untranslated (1.26 × 10<sup<-3</sup<) regions.</p< <p<Conclusion</p< <p<The SNPs identified in different regions of bovine <it<NPY </it<gene may serve as a basis for understanding the regulation of the expression of the bovine <it<NPY </it<gene under a variety of physiological conditions and identification of genotypes with high feed energy conversion efficiency.</p< Genetics Bahar Bojlul verfasserin aut In BMC Genetics BMC, 2003 9(2008), 1, p 91 (DE-627)326644938 (DE-600)2041497-3 14712156 nnns volume:9 year:2008 number:1, p 91 https://doi.org/10.1186/1471-2156-9-91 kostenfrei https://doaj.org/article/6350a167d31a46f1a1c62559dbeffc98 kostenfrei http://www.biomedcentral.com/1471-2156/9/91 kostenfrei https://doaj.org/toc/1471-2156 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2008 1, p 91 |
allfieldsSound |
10.1186/1471-2156-9-91 doi (DE-627)DOAJ043835201 (DE-599)DOAJ6350a167d31a46f1a1c62559dbeffc98 DE-627 ger DE-627 rakwb eng QH426-470 Sweeney Torres verfasserin aut Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Neuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and coding regions of the bovine <it<NPY </it<gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle. The objectives of this experiment were to: a) fully characterize the bovine <it<NPY </it<gene transcript and b) identify the SNP diversity in both coding and non-coding regions of the <it<NPY </it<gene in a panel of <it<Bos taurus </it<and <it<B. indicus </it<cattle.</p< <p<Results</p< <p<Bovine <it<NPY </it<gene consists of four exons (99, 188, 81 and 195 nucleotides) and three introns. The promoter region of the <it<NPY </it<gene consists of TATA and GC boxes which are separated from the transcription start site (TSS) by 29 and ~100 nt, respectively. Analyses of the tissue specific expression of the bovine <it<NPY </it<gene revealed the presence of highly abundant <it<NPY </it<gene transcripts in the arcuate nucleus, cerebral and cerebellar regions of the bovine brain. We identified a total of 59 SNPs in the 8.4 kb region of the bovine <it<NPY </it<gene. Seven out of nine total SNPs in the promoter region affect binding of putative transcription factors. A high level of nucleotide diversity was evident in the promoter regions (2.84 × 10<sup<-3</sup<) compared to the exonic (1.44 × 10<sup<-3</sup<), intronic (1.30 × 10<sup<-3</sup<) and 3' untranslated (1.26 × 10<sup<-3</sup<) regions.</p< <p<Conclusion</p< <p<The SNPs identified in different regions of bovine <it<NPY </it<gene may serve as a basis for understanding the regulation of the expression of the bovine <it<NPY </it<gene under a variety of physiological conditions and identification of genotypes with high feed energy conversion efficiency.</p< Genetics Bahar Bojlul verfasserin aut In BMC Genetics BMC, 2003 9(2008), 1, p 91 (DE-627)326644938 (DE-600)2041497-3 14712156 nnns volume:9 year:2008 number:1, p 91 https://doi.org/10.1186/1471-2156-9-91 kostenfrei https://doaj.org/article/6350a167d31a46f1a1c62559dbeffc98 kostenfrei http://www.biomedcentral.com/1471-2156/9/91 kostenfrei https://doaj.org/toc/1471-2156 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2008 1, p 91 |
language |
English |
source |
In BMC Genetics 9(2008), 1, p 91 volume:9 year:2008 number:1, p 91 |
sourceStr |
In BMC Genetics 9(2008), 1, p 91 volume:9 year:2008 number:1, p 91 |
format_phy_str_mv |
Article |
institution |
findex.gbv.de |
topic_facet |
Genetics |
isfreeaccess_bool |
true |
container_title |
BMC Genetics |
authorswithroles_txt_mv |
Sweeney Torres @@aut@@ Bahar Bojlul @@aut@@ |
publishDateDaySort_date |
2008-01-01T00:00:00Z |
hierarchy_top_id |
326644938 |
id |
DOAJ043835201 |
language_de |
englisch |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ043835201</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230308074415.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2008 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/1471-2156-9-91</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ043835201</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ6350a167d31a46f1a1c62559dbeffc98</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH426-470</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Sweeney Torres</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2008</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a"><p<Abstract</p< <p<Background</p< <p<Neuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and coding regions of the bovine <it<NPY </it<gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle. The objectives of this experiment were to: a) fully characterize the bovine <it<NPY </it<gene transcript and b) identify the SNP diversity in both coding and non-coding regions of the <it<NPY </it<gene in a panel of <it<Bos taurus </it<and <it<B. indicus </it<cattle.</p< <p<Results</p< <p<Bovine <it<NPY </it<gene consists of four exons (99, 188, 81 and 195 nucleotides) and three introns. The promoter region of the <it<NPY </it<gene consists of TATA and GC boxes which are separated from the transcription start site (TSS) by 29 and ~100 nt, respectively. Analyses of the tissue specific expression of the bovine <it<NPY </it<gene revealed the presence of highly abundant <it<NPY </it<gene transcripts in the arcuate nucleus, cerebral and cerebellar regions of the bovine brain. We identified a total of 59 SNPs in the 8.4 kb region of the bovine <it<NPY </it<gene. Seven out of nine total SNPs in the promoter region affect binding of putative transcription factors. A high level of nucleotide diversity was evident in the promoter regions (2.84 × 10<sup<-3</sup<) compared to the exonic (1.44 × 10<sup<-3</sup<), intronic (1.30 × 10<sup<-3</sup<) and 3' untranslated (1.26 × 10<sup<-3</sup<) regions.</p< <p<Conclusion</p< <p<The SNPs identified in different regions of bovine <it<NPY </it<gene may serve as a basis for understanding the regulation of the expression of the bovine <it<NPY </it<gene under a variety of physiological conditions and identification of genotypes with high feed energy conversion efficiency.</p<</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Genetics</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Bahar Bojlul</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">BMC Genetics</subfield><subfield code="d">BMC, 2003</subfield><subfield code="g">9(2008), 1, p 91</subfield><subfield code="w">(DE-627)326644938</subfield><subfield code="w">(DE-600)2041497-3</subfield><subfield code="x">14712156</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:9</subfield><subfield code="g">year:2008</subfield><subfield code="g">number:1, p 91</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1186/1471-2156-9-91</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/6350a167d31a46f1a1c62559dbeffc98</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.biomedcentral.com/1471-2156/9/91</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/1471-2156</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_11</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_702</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2001</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2003</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2006</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2008</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2010</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2015</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2020</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2021</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2025</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2031</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2038</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2044</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2048</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2050</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2056</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2057</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2061</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2113</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2190</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">9</subfield><subfield code="j">2008</subfield><subfield code="e">1, p 91</subfield></datafield></record></collection>
|
callnumber-first |
Q - Science |
author |
Sweeney Torres |
spellingShingle |
Sweeney Torres misc QH426-470 misc Genetics Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene |
authorStr |
Sweeney Torres |
ppnlink_with_tag_str_mv |
@@773@@(DE-627)326644938 |
format |
electronic Article |
delete_txt_mv |
keep |
author_role |
aut aut |
collection |
DOAJ |
remote_str |
true |
callnumber-label |
QH426-470 |
illustrated |
Not Illustrated |
issn |
14712156 |
topic_title |
QH426-470 Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene |
topic |
misc QH426-470 misc Genetics |
topic_unstemmed |
misc QH426-470 misc Genetics |
topic_browse |
misc QH426-470 misc Genetics |
format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
format_main_str_mv |
Text Zeitschrift/Artikel |
carriertype_str_mv |
cr |
hierarchy_parent_title |
BMC Genetics |
hierarchy_parent_id |
326644938 |
hierarchy_top_title |
BMC Genetics |
isfreeaccess_txt |
true |
familylinks_str_mv |
(DE-627)326644938 (DE-600)2041497-3 |
title |
Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene |
ctrlnum |
(DE-627)DOAJ043835201 (DE-599)DOAJ6350a167d31a46f1a1c62559dbeffc98 |
title_full |
Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene |
author_sort |
Sweeney Torres |
journal |
BMC Genetics |
journalStr |
BMC Genetics |
callnumber-first-code |
Q |
lang_code |
eng |
isOA_bool |
true |
recordtype |
marc |
publishDateSort |
2008 |
contenttype_str_mv |
txt |
author_browse |
Sweeney Torres Bahar Bojlul |
container_volume |
9 |
class |
QH426-470 |
format_se |
Elektronische Aufsätze |
author-letter |
Sweeney Torres |
doi_str_mv |
10.1186/1471-2156-9-91 |
author2-role |
verfasserin |
title_sort |
mapping of the transcription start site (tss) and identification of snps in the bovine neuropeptide y (<it<npy</it<) gene |
callnumber |
QH426-470 |
title_auth |
Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene |
abstract |
<p<Abstract</p< <p<Background</p< <p<Neuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and coding regions of the bovine <it<NPY </it<gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle. The objectives of this experiment were to: a) fully characterize the bovine <it<NPY </it<gene transcript and b) identify the SNP diversity in both coding and non-coding regions of the <it<NPY </it<gene in a panel of <it<Bos taurus </it<and <it<B. indicus </it<cattle.</p< <p<Results</p< <p<Bovine <it<NPY </it<gene consists of four exons (99, 188, 81 and 195 nucleotides) and three introns. The promoter region of the <it<NPY </it<gene consists of TATA and GC boxes which are separated from the transcription start site (TSS) by 29 and ~100 nt, respectively. Analyses of the tissue specific expression of the bovine <it<NPY </it<gene revealed the presence of highly abundant <it<NPY </it<gene transcripts in the arcuate nucleus, cerebral and cerebellar regions of the bovine brain. We identified a total of 59 SNPs in the 8.4 kb region of the bovine <it<NPY </it<gene. Seven out of nine total SNPs in the promoter region affect binding of putative transcription factors. A high level of nucleotide diversity was evident in the promoter regions (2.84 × 10<sup<-3</sup<) compared to the exonic (1.44 × 10<sup<-3</sup<), intronic (1.30 × 10<sup<-3</sup<) and 3' untranslated (1.26 × 10<sup<-3</sup<) regions.</p< <p<Conclusion</p< <p<The SNPs identified in different regions of bovine <it<NPY </it<gene may serve as a basis for understanding the regulation of the expression of the bovine <it<NPY </it<gene under a variety of physiological conditions and identification of genotypes with high feed energy conversion efficiency.</p< |
abstractGer |
<p<Abstract</p< <p<Background</p< <p<Neuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and coding regions of the bovine <it<NPY </it<gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle. The objectives of this experiment were to: a) fully characterize the bovine <it<NPY </it<gene transcript and b) identify the SNP diversity in both coding and non-coding regions of the <it<NPY </it<gene in a panel of <it<Bos taurus </it<and <it<B. indicus </it<cattle.</p< <p<Results</p< <p<Bovine <it<NPY </it<gene consists of four exons (99, 188, 81 and 195 nucleotides) and three introns. The promoter region of the <it<NPY </it<gene consists of TATA and GC boxes which are separated from the transcription start site (TSS) by 29 and ~100 nt, respectively. Analyses of the tissue specific expression of the bovine <it<NPY </it<gene revealed the presence of highly abundant <it<NPY </it<gene transcripts in the arcuate nucleus, cerebral and cerebellar regions of the bovine brain. We identified a total of 59 SNPs in the 8.4 kb region of the bovine <it<NPY </it<gene. Seven out of nine total SNPs in the promoter region affect binding of putative transcription factors. A high level of nucleotide diversity was evident in the promoter regions (2.84 × 10<sup<-3</sup<) compared to the exonic (1.44 × 10<sup<-3</sup<), intronic (1.30 × 10<sup<-3</sup<) and 3' untranslated (1.26 × 10<sup<-3</sup<) regions.</p< <p<Conclusion</p< <p<The SNPs identified in different regions of bovine <it<NPY </it<gene may serve as a basis for understanding the regulation of the expression of the bovine <it<NPY </it<gene under a variety of physiological conditions and identification of genotypes with high feed energy conversion efficiency.</p< |
abstract_unstemmed |
<p<Abstract</p< <p<Background</p< <p<Neuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and coding regions of the bovine <it<NPY </it<gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle. The objectives of this experiment were to: a) fully characterize the bovine <it<NPY </it<gene transcript and b) identify the SNP diversity in both coding and non-coding regions of the <it<NPY </it<gene in a panel of <it<Bos taurus </it<and <it<B. indicus </it<cattle.</p< <p<Results</p< <p<Bovine <it<NPY </it<gene consists of four exons (99, 188, 81 and 195 nucleotides) and three introns. The promoter region of the <it<NPY </it<gene consists of TATA and GC boxes which are separated from the transcription start site (TSS) by 29 and ~100 nt, respectively. Analyses of the tissue specific expression of the bovine <it<NPY </it<gene revealed the presence of highly abundant <it<NPY </it<gene transcripts in the arcuate nucleus, cerebral and cerebellar regions of the bovine brain. We identified a total of 59 SNPs in the 8.4 kb region of the bovine <it<NPY </it<gene. Seven out of nine total SNPs in the promoter region affect binding of putative transcription factors. A high level of nucleotide diversity was evident in the promoter regions (2.84 × 10<sup<-3</sup<) compared to the exonic (1.44 × 10<sup<-3</sup<), intronic (1.30 × 10<sup<-3</sup<) and 3' untranslated (1.26 × 10<sup<-3</sup<) regions.</p< <p<Conclusion</p< <p<The SNPs identified in different regions of bovine <it<NPY </it<gene may serve as a basis for understanding the regulation of the expression of the bovine <it<NPY </it<gene under a variety of physiological conditions and identification of genotypes with high feed energy conversion efficiency.</p< |
collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 |
container_issue |
1, p 91 |
title_short |
Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene |
url |
https://doi.org/10.1186/1471-2156-9-91 https://doaj.org/article/6350a167d31a46f1a1c62559dbeffc98 http://www.biomedcentral.com/1471-2156/9/91 https://doaj.org/toc/1471-2156 |
remote_bool |
true |
author2 |
Bahar Bojlul |
author2Str |
Bahar Bojlul |
ppnlink |
326644938 |
callnumber-subject |
QH - Natural History and Biology |
mediatype_str_mv |
c |
isOA_txt |
true |
hochschulschrift_bool |
false |
doi_str |
10.1186/1471-2156-9-91 |
callnumber-a |
QH426-470 |
up_date |
2024-07-03T19:44:19.004Z |
_version_ |
1803588320894124032 |
fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ043835201</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230308074415.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2008 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/1471-2156-9-91</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ043835201</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ6350a167d31a46f1a1c62559dbeffc98</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH426-470</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Sweeney Torres</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (<it<NPY</it<) gene</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2008</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a"><p<Abstract</p< <p<Background</p< <p<Neuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and coding regions of the bovine <it<NPY </it<gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle. The objectives of this experiment were to: a) fully characterize the bovine <it<NPY </it<gene transcript and b) identify the SNP diversity in both coding and non-coding regions of the <it<NPY </it<gene in a panel of <it<Bos taurus </it<and <it<B. indicus </it<cattle.</p< <p<Results</p< <p<Bovine <it<NPY </it<gene consists of four exons (99, 188, 81 and 195 nucleotides) and three introns. The promoter region of the <it<NPY </it<gene consists of TATA and GC boxes which are separated from the transcription start site (TSS) by 29 and ~100 nt, respectively. Analyses of the tissue specific expression of the bovine <it<NPY </it<gene revealed the presence of highly abundant <it<NPY </it<gene transcripts in the arcuate nucleus, cerebral and cerebellar regions of the bovine brain. We identified a total of 59 SNPs in the 8.4 kb region of the bovine <it<NPY </it<gene. Seven out of nine total SNPs in the promoter region affect binding of putative transcription factors. A high level of nucleotide diversity was evident in the promoter regions (2.84 × 10<sup<-3</sup<) compared to the exonic (1.44 × 10<sup<-3</sup<), intronic (1.30 × 10<sup<-3</sup<) and 3' untranslated (1.26 × 10<sup<-3</sup<) regions.</p< <p<Conclusion</p< <p<The SNPs identified in different regions of bovine <it<NPY </it<gene may serve as a basis for understanding the regulation of the expression of the bovine <it<NPY </it<gene under a variety of physiological conditions and identification of genotypes with high feed energy conversion efficiency.</p<</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Genetics</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Bahar Bojlul</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">BMC Genetics</subfield><subfield code="d">BMC, 2003</subfield><subfield code="g">9(2008), 1, p 91</subfield><subfield code="w">(DE-627)326644938</subfield><subfield code="w">(DE-600)2041497-3</subfield><subfield code="x">14712156</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:9</subfield><subfield code="g">year:2008</subfield><subfield code="g">number:1, p 91</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1186/1471-2156-9-91</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/6350a167d31a46f1a1c62559dbeffc98</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.biomedcentral.com/1471-2156/9/91</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/1471-2156</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_11</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_702</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2001</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2003</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2006</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2008</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2010</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2015</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2020</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2021</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2025</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2031</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2038</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2044</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2048</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2050</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2056</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2057</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2061</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2113</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2190</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">9</subfield><subfield code="j">2008</subfield><subfield code="e">1, p 91</subfield></datafield></record></collection>
|
score |
7.3992233 |