Intrinsic and Extrinsic Modulators of the Epithelial to Mesenchymal Transition: Driving the Fate of Tumor Microenvironment

The epithelial to mesenchymal transition (EMT) is an evolutionarily conserved process. In cancer, EMT can activate biochemical changes in tumor cells that enable the destruction of the cellular polarity, leading to the acquisition of invasive capabilities. EMT regulation can be triggered by intrinsi...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Edoardo D'Angelo [verfasserIn] Rafael Soares Lindoso [verfasserIn] Francesca Sensi [verfasserIn] Salvatore Pucciarelli [verfasserIn] Benedetta Bussolati [verfasserIn] Marco Agostini [verfasserIn] Federica Collino [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	epithelial to mesenchymal transition tumor microenvironment extracellular matrix extracellular vesicles personalized medicine

Übergeordnetes Werk:	In: Frontiers in Oncology - Frontiers Media S.A., 2012, 10(2020)
Übergeordnetes Werk:	volume:10 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fonc.2020.01122

Katalog-ID:	DOAJ043912362

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520			\|a The epithelial to mesenchymal transition (EMT) is an evolutionarily conserved process. In cancer, EMT can activate biochemical changes in tumor cells that enable the destruction of the cellular polarity, leading to the acquisition of invasive capabilities. EMT regulation can be triggered by intrinsic and extrinsic signaling, allowing the tumor to adapt to the microenvironment demand in the different stages of tumor progression. In concomitance, tumor cells undergoing EMT actively interact with the surrounding tumor microenvironment (TME) constituted by cell components and extracellular matrix as well as cell secretome elements. As a result, the TME is in turn modulated by the EMT process toward an aggressive behavior. The current review presents the intrinsic and extrinsic modulators of EMT and their relationship with the TME, focusing on the non-cell-derived components, such as secreted metabolites, extracellular matrix, as well as extracellular vesicles. Moreover, we explore how these modulators can be suitable targets for anticancer therapy and personalized medicine.
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spelling	10.3389/fonc.2020.01122 doi (DE-627)DOAJ043912362 (DE-599)DOAJb3b494caa27c4236810c731ed7e422fa DE-627 ger DE-627 rakwb eng RC254-282 Edoardo D'Angelo verfasserin aut Intrinsic and Extrinsic Modulators of the Epithelial to Mesenchymal Transition: Driving the Fate of Tumor Microenvironment 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The epithelial to mesenchymal transition (EMT) is an evolutionarily conserved process. In cancer, EMT can activate biochemical changes in tumor cells that enable the destruction of the cellular polarity, leading to the acquisition of invasive capabilities. EMT regulation can be triggered by intrinsic and extrinsic signaling, allowing the tumor to adapt to the microenvironment demand in the different stages of tumor progression. In concomitance, tumor cells undergoing EMT actively interact with the surrounding tumor microenvironment (TME) constituted by cell components and extracellular matrix as well as cell secretome elements. As a result, the TME is in turn modulated by the EMT process toward an aggressive behavior. The current review presents the intrinsic and extrinsic modulators of EMT and their relationship with the TME, focusing on the non-cell-derived components, such as secreted metabolites, extracellular matrix, as well as extracellular vesicles. Moreover, we explore how these modulators can be suitable targets for anticancer therapy and personalized medicine. epithelial to mesenchymal transition tumor microenvironment extracellular matrix extracellular vesicles personalized medicine Neoplasms. Tumors. Oncology. Including cancer and carcinogens Edoardo D'Angelo verfasserin aut Edoardo D'Angelo verfasserin aut Rafael Soares Lindoso verfasserin aut Rafael Soares Lindoso verfasserin aut Rafael Soares Lindoso verfasserin aut Francesca Sensi verfasserin aut Francesca Sensi verfasserin aut Salvatore Pucciarelli verfasserin aut Benedetta Bussolati verfasserin aut Marco Agostini verfasserin aut Marco Agostini verfasserin aut Marco Agostini verfasserin aut Federica Collino verfasserin aut Federica Collino verfasserin aut Federica Collino verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 10(2020) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:10 year:2020 https://doi.org/10.3389/fonc.2020.01122 kostenfrei https://doaj.org/article/b3b494caa27c4236810c731ed7e422fa kostenfrei https://www.frontiersin.org/article/10.3389/fonc.2020.01122/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020
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allfieldsSound	10.3389/fonc.2020.01122 doi (DE-627)DOAJ043912362 (DE-599)DOAJb3b494caa27c4236810c731ed7e422fa DE-627 ger DE-627 rakwb eng RC254-282 Edoardo D'Angelo verfasserin aut Intrinsic and Extrinsic Modulators of the Epithelial to Mesenchymal Transition: Driving the Fate of Tumor Microenvironment 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The epithelial to mesenchymal transition (EMT) is an evolutionarily conserved process. In cancer, EMT can activate biochemical changes in tumor cells that enable the destruction of the cellular polarity, leading to the acquisition of invasive capabilities. EMT regulation can be triggered by intrinsic and extrinsic signaling, allowing the tumor to adapt to the microenvironment demand in the different stages of tumor progression. In concomitance, tumor cells undergoing EMT actively interact with the surrounding tumor microenvironment (TME) constituted by cell components and extracellular matrix as well as cell secretome elements. As a result, the TME is in turn modulated by the EMT process toward an aggressive behavior. The current review presents the intrinsic and extrinsic modulators of EMT and their relationship with the TME, focusing on the non-cell-derived components, such as secreted metabolites, extracellular matrix, as well as extracellular vesicles. Moreover, we explore how these modulators can be suitable targets for anticancer therapy and personalized medicine. epithelial to mesenchymal transition tumor microenvironment extracellular matrix extracellular vesicles personalized medicine Neoplasms. Tumors. Oncology. Including cancer and carcinogens Edoardo D'Angelo verfasserin aut Edoardo D'Angelo verfasserin aut Rafael Soares Lindoso verfasserin aut Rafael Soares Lindoso verfasserin aut Rafael Soares Lindoso verfasserin aut Francesca Sensi verfasserin aut Francesca Sensi verfasserin aut Salvatore Pucciarelli verfasserin aut Benedetta Bussolati verfasserin aut Marco Agostini verfasserin aut Marco Agostini verfasserin aut Marco Agostini verfasserin aut Federica Collino verfasserin aut Federica Collino verfasserin aut Federica Collino verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 10(2020) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:10 year:2020 https://doi.org/10.3389/fonc.2020.01122 kostenfrei https://doaj.org/article/b3b494caa27c4236810c731ed7e422fa kostenfrei https://www.frontiersin.org/article/10.3389/fonc.2020.01122/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020
language	English
source	In Frontiers in Oncology 10(2020) volume:10 year:2020
sourceStr	In Frontiers in Oncology 10(2020) volume:10 year:2020
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	epithelial to mesenchymal transition tumor microenvironment extracellular matrix extracellular vesicles personalized medicine Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	Frontiers in Oncology
authorswithroles_txt_mv	Edoardo D'Angelo @@aut@@ Rafael Soares Lindoso @@aut@@ Francesca Sensi @@aut@@ Salvatore Pucciarelli @@aut@@ Benedetta Bussolati @@aut@@ Marco Agostini @@aut@@ Federica Collino @@aut@@
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callnumber-first	R - Medicine
author	Edoardo D'Angelo
spellingShingle	Edoardo D'Angelo misc RC254-282 misc epithelial to mesenchymal transition misc tumor microenvironment misc extracellular matrix misc extracellular vesicles misc personalized medicine misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Intrinsic and Extrinsic Modulators of the Epithelial to Mesenchymal Transition: Driving the Fate of Tumor Microenvironment
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topic_title	RC254-282 Intrinsic and Extrinsic Modulators of the Epithelial to Mesenchymal Transition: Driving the Fate of Tumor Microenvironment epithelial to mesenchymal transition tumor microenvironment extracellular matrix extracellular vesicles personalized medicine
topic	misc RC254-282 misc epithelial to mesenchymal transition misc tumor microenvironment misc extracellular matrix misc extracellular vesicles misc personalized medicine misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc epithelial to mesenchymal transition misc tumor microenvironment misc extracellular matrix misc extracellular vesicles misc personalized medicine misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Intrinsic and Extrinsic Modulators of the Epithelial to Mesenchymal Transition: Driving the Fate of Tumor Microenvironment
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title_full	Intrinsic and Extrinsic Modulators of the Epithelial to Mesenchymal Transition: Driving the Fate of Tumor Microenvironment
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title_sort	intrinsic and extrinsic modulators of the epithelial to mesenchymal transition: driving the fate of tumor microenvironment
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title_auth	Intrinsic and Extrinsic Modulators of the Epithelial to Mesenchymal Transition: Driving the Fate of Tumor Microenvironment
abstract	The epithelial to mesenchymal transition (EMT) is an evolutionarily conserved process. In cancer, EMT can activate biochemical changes in tumor cells that enable the destruction of the cellular polarity, leading to the acquisition of invasive capabilities. EMT regulation can be triggered by intrinsic and extrinsic signaling, allowing the tumor to adapt to the microenvironment demand in the different stages of tumor progression. In concomitance, tumor cells undergoing EMT actively interact with the surrounding tumor microenvironment (TME) constituted by cell components and extracellular matrix as well as cell secretome elements. As a result, the TME is in turn modulated by the EMT process toward an aggressive behavior. The current review presents the intrinsic and extrinsic modulators of EMT and their relationship with the TME, focusing on the non-cell-derived components, such as secreted metabolites, extracellular matrix, as well as extracellular vesicles. Moreover, we explore how these modulators can be suitable targets for anticancer therapy and personalized medicine.
abstractGer	The epithelial to mesenchymal transition (EMT) is an evolutionarily conserved process. In cancer, EMT can activate biochemical changes in tumor cells that enable the destruction of the cellular polarity, leading to the acquisition of invasive capabilities. EMT regulation can be triggered by intrinsic and extrinsic signaling, allowing the tumor to adapt to the microenvironment demand in the different stages of tumor progression. In concomitance, tumor cells undergoing EMT actively interact with the surrounding tumor microenvironment (TME) constituted by cell components and extracellular matrix as well as cell secretome elements. As a result, the TME is in turn modulated by the EMT process toward an aggressive behavior. The current review presents the intrinsic and extrinsic modulators of EMT and their relationship with the TME, focusing on the non-cell-derived components, such as secreted metabolites, extracellular matrix, as well as extracellular vesicles. Moreover, we explore how these modulators can be suitable targets for anticancer therapy and personalized medicine.
abstract_unstemmed	The epithelial to mesenchymal transition (EMT) is an evolutionarily conserved process. In cancer, EMT can activate biochemical changes in tumor cells that enable the destruction of the cellular polarity, leading to the acquisition of invasive capabilities. EMT regulation can be triggered by intrinsic and extrinsic signaling, allowing the tumor to adapt to the microenvironment demand in the different stages of tumor progression. In concomitance, tumor cells undergoing EMT actively interact with the surrounding tumor microenvironment (TME) constituted by cell components and extracellular matrix as well as cell secretome elements. As a result, the TME is in turn modulated by the EMT process toward an aggressive behavior. The current review presents the intrinsic and extrinsic modulators of EMT and their relationship with the TME, focusing on the non-cell-derived components, such as secreted metabolites, extracellular matrix, as well as extracellular vesicles. Moreover, we explore how these modulators can be suitable targets for anticancer therapy and personalized medicine.
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title_short	Intrinsic and Extrinsic Modulators of the Epithelial to Mesenchymal Transition: Driving the Fate of Tumor Microenvironment
url	https://doi.org/10.3389/fonc.2020.01122 https://doaj.org/article/b3b494caa27c4236810c731ed7e422fa https://www.frontiersin.org/article/10.3389/fonc.2020.01122/full https://doaj.org/toc/2234-943X
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author2	Edoardo D'Angelo Rafael Soares Lindoso Francesca Sensi Salvatore Pucciarelli Benedetta Bussolati Marco Agostini Federica Collino
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up_date	2024-07-03T20:09:35.135Z
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Intrinsic and Extrinsic Modulators of the Epithelial to Mesenchymal Transition: Driving the Fate of Tumor Microenvironment

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