Adaptations of the 3T3-L1 adipocyte lipidome to defective ether lipid catabolism upon Agmo knockdown
Little is known about the physiological role of alkylglycerol monooxygenase (AGMO), the only enzyme capable of cleaving the 1-O-alkyl ether bond of ether lipids. Expression and enzymatic activity of this enzyme can be detected in a variety of tissues including adipose tissue. This labile lipolytic m...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Sabrina Sailer [verfasserIn] Katharina Lackner [verfasserIn] Mia L. Pras-Raves [verfasserIn] Eric J.M. Wever [verfasserIn] Jan B. van Klinken [verfasserIn] Adriaan D. Dane [verfasserIn] Stephan Geley [verfasserIn] Jakob Koch [verfasserIn] Georg Golderer [verfasserIn] Gabriele Werner-Felmayer [verfasserIn] Markus A. Keller [verfasserIn] Werner Zwerschke [verfasserIn] Frédéric M. Vaz [verfasserIn] Ernst R. Werner [verfasserIn] Katrin Watschinger [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Journal of Lipid Research - Elsevier, 2021, 63(2022), 6, Seite 100222- |
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| Übergeordnetes Werk: |
volume:63 ; year:2022 ; number:6 ; pages:100222- |
| Links: |
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| DOI / URN: |
10.1016/j.jlr.2022.100222 |
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DOAJ043943853 |
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| 520 | |a Little is known about the physiological role of alkylglycerol monooxygenase (AGMO), the only enzyme capable of cleaving the 1-O-alkyl ether bond of ether lipids. Expression and enzymatic activity of this enzyme can be detected in a variety of tissues including adipose tissue. This labile lipolytic membrane-bound protein uses tetrahydrobiopterin as a cofactor, and mice with reduced tetrahydrobiopterin levels have alterations in body fat distribution and blood lipid concentrations. In addition, manipulation of AGMO in macrophages led to significant changes in the cellular lipidome, and alkylglycerolipids, the preferred substrates of AGMO, were shown to accumulate in mature adipocytes. Here, we investigated the roles of AGMO in lipid metabolism by studying 3T3-L1 adipogenesis. AGMO activity was induced over 11 days using an adipocyte differentiation protocol. We show that RNA interference-mediated knockdown of AGMO did not interfere with adipocyte differentiation or affect lipid droplet formation. Furthermore, lipidomics revealed that plasmalogen phospholipids were preferentially accumulated upon Agmo knockdown, and a significant shift toward longer and more polyunsaturated acyl side chains of diacylglycerols and triacylglycerols could be detected by mass spectrometry. Our results indicate that alkylglycerol catabolism has an influence not only on ether-linked species but also on the degree of unsaturation in the massive amounts of triacylglycerols formed during in vitro 3T3-L1 adipocyte differentiation. | ||
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10.1016/j.jlr.2022.100222 doi (DE-627)DOAJ043943853 (DE-599)DOAJ2dea3320485f4a99830874c9c9ea55f9 DE-627 ger DE-627 rakwb eng QD415-436 Sabrina Sailer verfasserin aut Adaptations of the 3T3-L1 adipocyte lipidome to defective ether lipid catabolism upon Agmo knockdown 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Little is known about the physiological role of alkylglycerol monooxygenase (AGMO), the only enzyme capable of cleaving the 1-O-alkyl ether bond of ether lipids. Expression and enzymatic activity of this enzyme can be detected in a variety of tissues including adipose tissue. This labile lipolytic membrane-bound protein uses tetrahydrobiopterin as a cofactor, and mice with reduced tetrahydrobiopterin levels have alterations in body fat distribution and blood lipid concentrations. In addition, manipulation of AGMO in macrophages led to significant changes in the cellular lipidome, and alkylglycerolipids, the preferred substrates of AGMO, were shown to accumulate in mature adipocytes. Here, we investigated the roles of AGMO in lipid metabolism by studying 3T3-L1 adipogenesis. AGMO activity was induced over 11 days using an adipocyte differentiation protocol. We show that RNA interference-mediated knockdown of AGMO did not interfere with adipocyte differentiation or affect lipid droplet formation. Furthermore, lipidomics revealed that plasmalogen phospholipids were preferentially accumulated upon Agmo knockdown, and a significant shift toward longer and more polyunsaturated acyl side chains of diacylglycerols and triacylglycerols could be detected by mass spectrometry. Our results indicate that alkylglycerol catabolism has an influence not only on ether-linked species but also on the degree of unsaturation in the massive amounts of triacylglycerols formed during in vitro 3T3-L1 adipocyte differentiation. alkylglycerol monooxygenase ether lipids 3T3-L1 adipocyte differentiation lipid metabolism lipidomics Biochemistry Katharina Lackner verfasserin aut Mia L. Pras-Raves verfasserin aut Eric J.M. Wever verfasserin aut Jan B. van Klinken verfasserin aut Adriaan D. Dane verfasserin aut Stephan Geley verfasserin aut Jakob Koch verfasserin aut Georg Golderer verfasserin aut Gabriele Werner-Felmayer verfasserin aut Markus A. Keller verfasserin aut Werner Zwerschke verfasserin aut Frédéric M. Vaz verfasserin aut Ernst R. Werner verfasserin aut Katrin Watschinger verfasserin aut In Journal of Lipid Research Elsevier, 2021 63(2022), 6, Seite 100222- (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:63 year:2022 number:6 pages:100222- https://doi.org/10.1016/j.jlr.2022.100222 kostenfrei https://doaj.org/article/2dea3320485f4a99830874c9c9ea55f9 kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227522000554 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 63 2022 6 100222- |
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10.1016/j.jlr.2022.100222 doi (DE-627)DOAJ043943853 (DE-599)DOAJ2dea3320485f4a99830874c9c9ea55f9 DE-627 ger DE-627 rakwb eng QD415-436 Sabrina Sailer verfasserin aut Adaptations of the 3T3-L1 adipocyte lipidome to defective ether lipid catabolism upon Agmo knockdown 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Little is known about the physiological role of alkylglycerol monooxygenase (AGMO), the only enzyme capable of cleaving the 1-O-alkyl ether bond of ether lipids. Expression and enzymatic activity of this enzyme can be detected in a variety of tissues including adipose tissue. This labile lipolytic membrane-bound protein uses tetrahydrobiopterin as a cofactor, and mice with reduced tetrahydrobiopterin levels have alterations in body fat distribution and blood lipid concentrations. In addition, manipulation of AGMO in macrophages led to significant changes in the cellular lipidome, and alkylglycerolipids, the preferred substrates of AGMO, were shown to accumulate in mature adipocytes. Here, we investigated the roles of AGMO in lipid metabolism by studying 3T3-L1 adipogenesis. AGMO activity was induced over 11 days using an adipocyte differentiation protocol. We show that RNA interference-mediated knockdown of AGMO did not interfere with adipocyte differentiation or affect lipid droplet formation. Furthermore, lipidomics revealed that plasmalogen phospholipids were preferentially accumulated upon Agmo knockdown, and a significant shift toward longer and more polyunsaturated acyl side chains of diacylglycerols and triacylglycerols could be detected by mass spectrometry. Our results indicate that alkylglycerol catabolism has an influence not only on ether-linked species but also on the degree of unsaturation in the massive amounts of triacylglycerols formed during in vitro 3T3-L1 adipocyte differentiation. alkylglycerol monooxygenase ether lipids 3T3-L1 adipocyte differentiation lipid metabolism lipidomics Biochemistry Katharina Lackner verfasserin aut Mia L. Pras-Raves verfasserin aut Eric J.M. Wever verfasserin aut Jan B. van Klinken verfasserin aut Adriaan D. Dane verfasserin aut Stephan Geley verfasserin aut Jakob Koch verfasserin aut Georg Golderer verfasserin aut Gabriele Werner-Felmayer verfasserin aut Markus A. Keller verfasserin aut Werner Zwerschke verfasserin aut Frédéric M. Vaz verfasserin aut Ernst R. Werner verfasserin aut Katrin Watschinger verfasserin aut In Journal of Lipid Research Elsevier, 2021 63(2022), 6, Seite 100222- (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:63 year:2022 number:6 pages:100222- https://doi.org/10.1016/j.jlr.2022.100222 kostenfrei https://doaj.org/article/2dea3320485f4a99830874c9c9ea55f9 kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227522000554 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 63 2022 6 100222- |
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10.1016/j.jlr.2022.100222 doi (DE-627)DOAJ043943853 (DE-599)DOAJ2dea3320485f4a99830874c9c9ea55f9 DE-627 ger DE-627 rakwb eng QD415-436 Sabrina Sailer verfasserin aut Adaptations of the 3T3-L1 adipocyte lipidome to defective ether lipid catabolism upon Agmo knockdown 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Little is known about the physiological role of alkylglycerol monooxygenase (AGMO), the only enzyme capable of cleaving the 1-O-alkyl ether bond of ether lipids. Expression and enzymatic activity of this enzyme can be detected in a variety of tissues including adipose tissue. This labile lipolytic membrane-bound protein uses tetrahydrobiopterin as a cofactor, and mice with reduced tetrahydrobiopterin levels have alterations in body fat distribution and blood lipid concentrations. In addition, manipulation of AGMO in macrophages led to significant changes in the cellular lipidome, and alkylglycerolipids, the preferred substrates of AGMO, were shown to accumulate in mature adipocytes. Here, we investigated the roles of AGMO in lipid metabolism by studying 3T3-L1 adipogenesis. AGMO activity was induced over 11 days using an adipocyte differentiation protocol. We show that RNA interference-mediated knockdown of AGMO did not interfere with adipocyte differentiation or affect lipid droplet formation. Furthermore, lipidomics revealed that plasmalogen phospholipids were preferentially accumulated upon Agmo knockdown, and a significant shift toward longer and more polyunsaturated acyl side chains of diacylglycerols and triacylglycerols could be detected by mass spectrometry. Our results indicate that alkylglycerol catabolism has an influence not only on ether-linked species but also on the degree of unsaturation in the massive amounts of triacylglycerols formed during in vitro 3T3-L1 adipocyte differentiation. alkylglycerol monooxygenase ether lipids 3T3-L1 adipocyte differentiation lipid metabolism lipidomics Biochemistry Katharina Lackner verfasserin aut Mia L. Pras-Raves verfasserin aut Eric J.M. Wever verfasserin aut Jan B. van Klinken verfasserin aut Adriaan D. Dane verfasserin aut Stephan Geley verfasserin aut Jakob Koch verfasserin aut Georg Golderer verfasserin aut Gabriele Werner-Felmayer verfasserin aut Markus A. Keller verfasserin aut Werner Zwerschke verfasserin aut Frédéric M. Vaz verfasserin aut Ernst R. Werner verfasserin aut Katrin Watschinger verfasserin aut In Journal of Lipid Research Elsevier, 2021 63(2022), 6, Seite 100222- (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:63 year:2022 number:6 pages:100222- https://doi.org/10.1016/j.jlr.2022.100222 kostenfrei https://doaj.org/article/2dea3320485f4a99830874c9c9ea55f9 kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227522000554 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 63 2022 6 100222- |
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10.1016/j.jlr.2022.100222 doi (DE-627)DOAJ043943853 (DE-599)DOAJ2dea3320485f4a99830874c9c9ea55f9 DE-627 ger DE-627 rakwb eng QD415-436 Sabrina Sailer verfasserin aut Adaptations of the 3T3-L1 adipocyte lipidome to defective ether lipid catabolism upon Agmo knockdown 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Little is known about the physiological role of alkylglycerol monooxygenase (AGMO), the only enzyme capable of cleaving the 1-O-alkyl ether bond of ether lipids. Expression and enzymatic activity of this enzyme can be detected in a variety of tissues including adipose tissue. This labile lipolytic membrane-bound protein uses tetrahydrobiopterin as a cofactor, and mice with reduced tetrahydrobiopterin levels have alterations in body fat distribution and blood lipid concentrations. In addition, manipulation of AGMO in macrophages led to significant changes in the cellular lipidome, and alkylglycerolipids, the preferred substrates of AGMO, were shown to accumulate in mature adipocytes. Here, we investigated the roles of AGMO in lipid metabolism by studying 3T3-L1 adipogenesis. AGMO activity was induced over 11 days using an adipocyte differentiation protocol. We show that RNA interference-mediated knockdown of AGMO did not interfere with adipocyte differentiation or affect lipid droplet formation. Furthermore, lipidomics revealed that plasmalogen phospholipids were preferentially accumulated upon Agmo knockdown, and a significant shift toward longer and more polyunsaturated acyl side chains of diacylglycerols and triacylglycerols could be detected by mass spectrometry. Our results indicate that alkylglycerol catabolism has an influence not only on ether-linked species but also on the degree of unsaturation in the massive amounts of triacylglycerols formed during in vitro 3T3-L1 adipocyte differentiation. alkylglycerol monooxygenase ether lipids 3T3-L1 adipocyte differentiation lipid metabolism lipidomics Biochemistry Katharina Lackner verfasserin aut Mia L. Pras-Raves verfasserin aut Eric J.M. Wever verfasserin aut Jan B. van Klinken verfasserin aut Adriaan D. Dane verfasserin aut Stephan Geley verfasserin aut Jakob Koch verfasserin aut Georg Golderer verfasserin aut Gabriele Werner-Felmayer verfasserin aut Markus A. Keller verfasserin aut Werner Zwerschke verfasserin aut Frédéric M. Vaz verfasserin aut Ernst R. Werner verfasserin aut Katrin Watschinger verfasserin aut In Journal of Lipid Research Elsevier, 2021 63(2022), 6, Seite 100222- (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:63 year:2022 number:6 pages:100222- https://doi.org/10.1016/j.jlr.2022.100222 kostenfrei https://doaj.org/article/2dea3320485f4a99830874c9c9ea55f9 kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227522000554 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 63 2022 6 100222- |
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adaptations of the 3t3-l1 adipocyte lipidome to defective ether lipid catabolism upon agmo knockdown |
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QD415-436 |
| title_auth |
Adaptations of the 3T3-L1 adipocyte lipidome to defective ether lipid catabolism upon Agmo knockdown |
| abstract |
Little is known about the physiological role of alkylglycerol monooxygenase (AGMO), the only enzyme capable of cleaving the 1-O-alkyl ether bond of ether lipids. Expression and enzymatic activity of this enzyme can be detected in a variety of tissues including adipose tissue. This labile lipolytic membrane-bound protein uses tetrahydrobiopterin as a cofactor, and mice with reduced tetrahydrobiopterin levels have alterations in body fat distribution and blood lipid concentrations. In addition, manipulation of AGMO in macrophages led to significant changes in the cellular lipidome, and alkylglycerolipids, the preferred substrates of AGMO, were shown to accumulate in mature adipocytes. Here, we investigated the roles of AGMO in lipid metabolism by studying 3T3-L1 adipogenesis. AGMO activity was induced over 11 days using an adipocyte differentiation protocol. We show that RNA interference-mediated knockdown of AGMO did not interfere with adipocyte differentiation or affect lipid droplet formation. Furthermore, lipidomics revealed that plasmalogen phospholipids were preferentially accumulated upon Agmo knockdown, and a significant shift toward longer and more polyunsaturated acyl side chains of diacylglycerols and triacylglycerols could be detected by mass spectrometry. Our results indicate that alkylglycerol catabolism has an influence not only on ether-linked species but also on the degree of unsaturation in the massive amounts of triacylglycerols formed during in vitro 3T3-L1 adipocyte differentiation. |
| abstractGer |
Little is known about the physiological role of alkylglycerol monooxygenase (AGMO), the only enzyme capable of cleaving the 1-O-alkyl ether bond of ether lipids. Expression and enzymatic activity of this enzyme can be detected in a variety of tissues including adipose tissue. This labile lipolytic membrane-bound protein uses tetrahydrobiopterin as a cofactor, and mice with reduced tetrahydrobiopterin levels have alterations in body fat distribution and blood lipid concentrations. In addition, manipulation of AGMO in macrophages led to significant changes in the cellular lipidome, and alkylglycerolipids, the preferred substrates of AGMO, were shown to accumulate in mature adipocytes. Here, we investigated the roles of AGMO in lipid metabolism by studying 3T3-L1 adipogenesis. AGMO activity was induced over 11 days using an adipocyte differentiation protocol. We show that RNA interference-mediated knockdown of AGMO did not interfere with adipocyte differentiation or affect lipid droplet formation. Furthermore, lipidomics revealed that plasmalogen phospholipids were preferentially accumulated upon Agmo knockdown, and a significant shift toward longer and more polyunsaturated acyl side chains of diacylglycerols and triacylglycerols could be detected by mass spectrometry. Our results indicate that alkylglycerol catabolism has an influence not only on ether-linked species but also on the degree of unsaturation in the massive amounts of triacylglycerols formed during in vitro 3T3-L1 adipocyte differentiation. |
| abstract_unstemmed |
Little is known about the physiological role of alkylglycerol monooxygenase (AGMO), the only enzyme capable of cleaving the 1-O-alkyl ether bond of ether lipids. Expression and enzymatic activity of this enzyme can be detected in a variety of tissues including adipose tissue. This labile lipolytic membrane-bound protein uses tetrahydrobiopterin as a cofactor, and mice with reduced tetrahydrobiopterin levels have alterations in body fat distribution and blood lipid concentrations. In addition, manipulation of AGMO in macrophages led to significant changes in the cellular lipidome, and alkylglycerolipids, the preferred substrates of AGMO, were shown to accumulate in mature adipocytes. Here, we investigated the roles of AGMO in lipid metabolism by studying 3T3-L1 adipogenesis. AGMO activity was induced over 11 days using an adipocyte differentiation protocol. We show that RNA interference-mediated knockdown of AGMO did not interfere with adipocyte differentiation or affect lipid droplet formation. Furthermore, lipidomics revealed that plasmalogen phospholipids were preferentially accumulated upon Agmo knockdown, and a significant shift toward longer and more polyunsaturated acyl side chains of diacylglycerols and triacylglycerols could be detected by mass spectrometry. Our results indicate that alkylglycerol catabolism has an influence not only on ether-linked species but also on the degree of unsaturation in the massive amounts of triacylglycerols formed during in vitro 3T3-L1 adipocyte differentiation. |
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| title_short |
Adaptations of the 3T3-L1 adipocyte lipidome to defective ether lipid catabolism upon Agmo knockdown |
| url |
https://doi.org/10.1016/j.jlr.2022.100222 https://doaj.org/article/2dea3320485f4a99830874c9c9ea55f9 http://www.sciencedirect.com/science/article/pii/S0022227522000554 https://doaj.org/toc/0022-2275 |
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Katharina Lackner Mia L. Pras-Raves Eric J.M. Wever Jan B. van Klinken Adriaan D. Dane Stephan Geley Jakob Koch Georg Golderer Gabriele Werner-Felmayer Markus A. Keller Werner Zwerschke Frédéric M. Vaz Ernst R. Werner Katrin Watschinger |
| author2Str |
Katharina Lackner Mia L. Pras-Raves Eric J.M. Wever Jan B. van Klinken Adriaan D. Dane Stephan Geley Jakob Koch Georg Golderer Gabriele Werner-Felmayer Markus A. Keller Werner Zwerschke Frédéric M. Vaz Ernst R. Werner Katrin Watschinger |
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| doi_str |
10.1016/j.jlr.2022.100222 |
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| up_date |
2024-07-03T20:19:51.188Z |
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