Third Cranial Nerve Palsy after Monoclonal Antibody Therapy for Lung Cancer: A Case Report

Immune checkpoint inhibitors (ICIs) have shown promise in treating cancer patients, and pembrolizumab is a monoclonal IgG4 antibody that targets a human cell surface protein (receptor) called PD-1. Among the side effects, a rare cranial nerve palsy unrelated to the surgical treatment may occur. We r...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Paolo Missori [verfasserIn] Angela Ambrosone [verfasserIn] Leonardo Cristofani [verfasserIn] Francesco Fattapposta [verfasserIn] Antonio Currà [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	cancer cranial nerve lung metastasis pembrolizumab side effects

Übergeordnetes Werk:	In: Case Reports in Ophthalmology - Karger Publishers, 2010, 13(2022), 1, Seite 282-285
Übergeordnetes Werk:	volume:13 ; year:2022 ; number:1 ; pages:282-285

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1159/000524114

Katalog-ID:	DOAJ044048165

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language	English
source	In Case Reports in Ophthalmology 13(2022), 1, Seite 282-285 volume:13 year:2022 number:1 pages:282-285
sourceStr	In Case Reports in Ophthalmology 13(2022), 1, Seite 282-285 volume:13 year:2022 number:1 pages:282-285
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	cancer cranial nerve lung metastasis pembrolizumab side effects Ophthalmology
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authorswithroles_txt_mv	Paolo Missori @@aut@@ Angela Ambrosone @@aut@@ Leonardo Cristofani @@aut@@ Francesco Fattapposta @@aut@@ Antonio Currà @@aut@@
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callnumber-first	R - Medicine
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topic_title	RE1-994 Third Cranial Nerve Palsy after Monoclonal Antibody Therapy for Lung Cancer: A Case Report cancer cranial nerve lung metastasis pembrolizumab side effects
topic	misc RE1-994 misc cancer misc cranial nerve misc lung misc metastasis misc pembrolizumab misc side effects misc Ophthalmology
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title_sort	third cranial nerve palsy after monoclonal antibody therapy for lung cancer: a case report
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title_auth	Third Cranial Nerve Palsy after Monoclonal Antibody Therapy for Lung Cancer: A Case Report
abstract	Immune checkpoint inhibitors (ICIs) have shown promise in treating cancer patients, and pembrolizumab is a monoclonal IgG4 antibody that targets a human cell surface protein (receptor) called PD-1. Among the side effects, a rare cranial nerve palsy unrelated to the surgical treatment may occur. We report a case of a woman, which after neurosurgical treatment for cerebellar metastasis presented painless third cranial nerve palsy. The benefits of ICIs have been ascertained, but side effects also take place. Neurological symptoms should be recognized early to avoid substantial morbidity, and if necessary, the oncologic treatment should be changed.
abstractGer	Immune checkpoint inhibitors (ICIs) have shown promise in treating cancer patients, and pembrolizumab is a monoclonal IgG4 antibody that targets a human cell surface protein (receptor) called PD-1. Among the side effects, a rare cranial nerve palsy unrelated to the surgical treatment may occur. We report a case of a woman, which after neurosurgical treatment for cerebellar metastasis presented painless third cranial nerve palsy. The benefits of ICIs have been ascertained, but side effects also take place. Neurological symptoms should be recognized early to avoid substantial morbidity, and if necessary, the oncologic treatment should be changed.
abstract_unstemmed	Immune checkpoint inhibitors (ICIs) have shown promise in treating cancer patients, and pembrolizumab is a monoclonal IgG4 antibody that targets a human cell surface protein (receptor) called PD-1. Among the side effects, a rare cranial nerve palsy unrelated to the surgical treatment may occur. We report a case of a woman, which after neurosurgical treatment for cerebellar metastasis presented painless third cranial nerve palsy. The benefits of ICIs have been ascertained, but side effects also take place. Neurological symptoms should be recognized early to avoid substantial morbidity, and if necessary, the oncologic treatment should be changed.
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title_short	Third Cranial Nerve Palsy after Monoclonal Antibody Therapy for Lung Cancer: A Case Report
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