World Health Organization estimates of the global and regional disease burden of four foodborne chemical toxins, 2010: a data synthesis [version 1; referees: 2 approved, 1 approved with reservations]

Background Chemical exposures have been associated with a variety of health effects; however, little is known about the global disease burden from foodborne chemicals. Food can be a major pathway for the general population’s exposure to chemicals, and for some chemicals, it accounts for almost 100%...
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Autor*in:	Herman Gibb [verfasserIn] Brecht Devleesschauwer [verfasserIn] P. Michael Bolger [verfasserIn] Felicia Wu [verfasserIn] Janine Ezendam [verfasserIn] Julie Cliff [verfasserIn] Marco Zeilmaker [verfasserIn] Philippe Verger [verfasserIn] John Pitt [verfasserIn] Janis Baines [verfasserIn] Gabriel Adegoke [verfasserIn] Reza Afshari [verfasserIn] Yan Liu [verfasserIn] Bas Bokkers [verfasserIn] Henk van Loveren [verfasserIn] Marcel Mengelers [verfasserIn] Esther Brandon [verfasserIn] Arie H. Havelaar [verfasserIn] David Bellinger [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Epidemiology Global Health

Übergeordnetes Werk:	In: F1000Research - F1000 Research Ltd, 2013, 4(2015)
Übergeordnetes Werk:	volume:4 ; year:2015

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.12688/f1000research.7340.1

Katalog-ID:	DOAJ044054408

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520			\|a Background Chemical exposures have been associated with a variety of health effects; however, little is known about the global disease burden from foodborne chemicals. Food can be a major pathway for the general population’s exposure to chemicals, and for some chemicals, it accounts for almost 100% of exposure. Methods and Findings Groups of foodborne chemicals, both natural and anthropogenic, were evaluated for their ability to contribute to the burden of disease. The results of the analyses on four chemicals are presented here - cyanide in cassava, peanut allergen, aflatoxin, and dioxin. Systematic reviews of the literature were conducted to develop age- and sex-specific disease incidence and mortality estimates due to these chemicals. From these estimates, the numbers of cases, deaths and disability adjusted life years (DALYs) were calculated. For these four chemicals combined, the total number of illnesses, deaths, and DALYs in 2010 is estimated to be 339,000 (95% uncertainty interval [UI]: 186,000-1,239,000); 20,000 (95% UI: 8,000-52,000); and 1,012,000 (95% UI: 562,000-2,822,000), respectively. Both cyanide in cassava and aflatoxin are associated with diseases with high case-fatality ratios. Virtually all human exposure to these four chemicals is through the food supply. Conclusion Chemicals in the food supply, as evidenced by the results for only four chemicals, can have a significant impact on the global burden of disease. The case-fatality rates for these four chemicals range from low (e.g., peanut allergen) to extremely high (aflatoxin and liver cancer). The effects associated with these four chemicals are neurologic (cyanide in cassava), cancer (aflatoxin), allergic response (peanut allergen), endocrine (dioxin), and reproductive (dioxin).
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allfields	10.12688/f1000research.7340.1 doi (DE-627)DOAJ044054408 (DE-599)DOAJfa9c270f6eed4ca685aca765df691286 DE-627 ger DE-627 rakwb eng Herman Gibb verfasserin aut World Health Organization estimates of the global and regional disease burden of four foodborne chemical toxins, 2010: a data synthesis [version 1; referees: 2 approved, 1 approved with reservations] 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Chemical exposures have been associated with a variety of health effects; however, little is known about the global disease burden from foodborne chemicals. Food can be a major pathway for the general population’s exposure to chemicals, and for some chemicals, it accounts for almost 100% of exposure. Methods and Findings Groups of foodborne chemicals, both natural and anthropogenic, were evaluated for their ability to contribute to the burden of disease. The results of the analyses on four chemicals are presented here - cyanide in cassava, peanut allergen, aflatoxin, and dioxin. Systematic reviews of the literature were conducted to develop age- and sex-specific disease incidence and mortality estimates due to these chemicals. From these estimates, the numbers of cases, deaths and disability adjusted life years (DALYs) were calculated. For these four chemicals combined, the total number of illnesses, deaths, and DALYs in 2010 is estimated to be 339,000 (95% uncertainty interval [UI]: 186,000-1,239,000); 20,000 (95% UI: 8,000-52,000); and 1,012,000 (95% UI: 562,000-2,822,000), respectively. Both cyanide in cassava and aflatoxin are associated with diseases with high case-fatality ratios. Virtually all human exposure to these four chemicals is through the food supply. Conclusion Chemicals in the food supply, as evidenced by the results for only four chemicals, can have a significant impact on the global burden of disease. The case-fatality rates for these four chemicals range from low (e.g., peanut allergen) to extremely high (aflatoxin and liver cancer). The effects associated with these four chemicals are neurologic (cyanide in cassava), cancer (aflatoxin), allergic response (peanut allergen), endocrine (dioxin), and reproductive (dioxin). Epidemiology Global Health Medicine R Science Q Brecht Devleesschauwer verfasserin aut P. Michael Bolger verfasserin aut Felicia Wu verfasserin aut Janine Ezendam verfasserin aut Julie Cliff verfasserin aut Marco Zeilmaker verfasserin aut Philippe Verger verfasserin aut John Pitt verfasserin aut Janis Baines verfasserin aut Gabriel Adegoke verfasserin aut Reza Afshari verfasserin aut Yan Liu verfasserin aut Bas Bokkers verfasserin aut Henk van Loveren verfasserin aut Marcel Mengelers verfasserin aut Esther Brandon verfasserin aut Arie H. Havelaar verfasserin aut David Bellinger verfasserin aut In F1000Research F1000 Research Ltd, 2013 4(2015) (DE-627)735133581 (DE-600)2699932-8 20461402 nnns volume:4 year:2015 https://doi.org/10.12688/f1000research.7340.1 kostenfrei https://doaj.org/article/fa9c270f6eed4ca685aca765df691286 kostenfrei http://f1000research.com/articles/4-1393/v1 kostenfrei https://doaj.org/toc/2046-1402 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2015
spelling	10.12688/f1000research.7340.1 doi (DE-627)DOAJ044054408 (DE-599)DOAJfa9c270f6eed4ca685aca765df691286 DE-627 ger DE-627 rakwb eng Herman Gibb verfasserin aut World Health Organization estimates of the global and regional disease burden of four foodborne chemical toxins, 2010: a data synthesis [version 1; referees: 2 approved, 1 approved with reservations] 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Chemical exposures have been associated with a variety of health effects; however, little is known about the global disease burden from foodborne chemicals. Food can be a major pathway for the general population’s exposure to chemicals, and for some chemicals, it accounts for almost 100% of exposure. Methods and Findings Groups of foodborne chemicals, both natural and anthropogenic, were evaluated for their ability to contribute to the burden of disease. The results of the analyses on four chemicals are presented here - cyanide in cassava, peanut allergen, aflatoxin, and dioxin. Systematic reviews of the literature were conducted to develop age- and sex-specific disease incidence and mortality estimates due to these chemicals. From these estimates, the numbers of cases, deaths and disability adjusted life years (DALYs) were calculated. For these four chemicals combined, the total number of illnesses, deaths, and DALYs in 2010 is estimated to be 339,000 (95% uncertainty interval [UI]: 186,000-1,239,000); 20,000 (95% UI: 8,000-52,000); and 1,012,000 (95% UI: 562,000-2,822,000), respectively. Both cyanide in cassava and aflatoxin are associated with diseases with high case-fatality ratios. Virtually all human exposure to these four chemicals is through the food supply. Conclusion Chemicals in the food supply, as evidenced by the results for only four chemicals, can have a significant impact on the global burden of disease. The case-fatality rates for these four chemicals range from low (e.g., peanut allergen) to extremely high (aflatoxin and liver cancer). The effects associated with these four chemicals are neurologic (cyanide in cassava), cancer (aflatoxin), allergic response (peanut allergen), endocrine (dioxin), and reproductive (dioxin). Epidemiology Global Health Medicine R Science Q Brecht Devleesschauwer verfasserin aut P. Michael Bolger verfasserin aut Felicia Wu verfasserin aut Janine Ezendam verfasserin aut Julie Cliff verfasserin aut Marco Zeilmaker verfasserin aut Philippe Verger verfasserin aut John Pitt verfasserin aut Janis Baines verfasserin aut Gabriel Adegoke verfasserin aut Reza Afshari verfasserin aut Yan Liu verfasserin aut Bas Bokkers verfasserin aut Henk van Loveren verfasserin aut Marcel Mengelers verfasserin aut Esther Brandon verfasserin aut Arie H. Havelaar verfasserin aut David Bellinger verfasserin aut In F1000Research F1000 Research Ltd, 2013 4(2015) (DE-627)735133581 (DE-600)2699932-8 20461402 nnns volume:4 year:2015 https://doi.org/10.12688/f1000research.7340.1 kostenfrei https://doaj.org/article/fa9c270f6eed4ca685aca765df691286 kostenfrei http://f1000research.com/articles/4-1393/v1 kostenfrei https://doaj.org/toc/2046-1402 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2015
allfields_unstemmed	10.12688/f1000research.7340.1 doi (DE-627)DOAJ044054408 (DE-599)DOAJfa9c270f6eed4ca685aca765df691286 DE-627 ger DE-627 rakwb eng Herman Gibb verfasserin aut World Health Organization estimates of the global and regional disease burden of four foodborne chemical toxins, 2010: a data synthesis [version 1; referees: 2 approved, 1 approved with reservations] 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Chemical exposures have been associated with a variety of health effects; however, little is known about the global disease burden from foodborne chemicals. Food can be a major pathway for the general population’s exposure to chemicals, and for some chemicals, it accounts for almost 100% of exposure. Methods and Findings Groups of foodborne chemicals, both natural and anthropogenic, were evaluated for their ability to contribute to the burden of disease. The results of the analyses on four chemicals are presented here - cyanide in cassava, peanut allergen, aflatoxin, and dioxin. Systematic reviews of the literature were conducted to develop age- and sex-specific disease incidence and mortality estimates due to these chemicals. From these estimates, the numbers of cases, deaths and disability adjusted life years (DALYs) were calculated. For these four chemicals combined, the total number of illnesses, deaths, and DALYs in 2010 is estimated to be 339,000 (95% uncertainty interval [UI]: 186,000-1,239,000); 20,000 (95% UI: 8,000-52,000); and 1,012,000 (95% UI: 562,000-2,822,000), respectively. Both cyanide in cassava and aflatoxin are associated with diseases with high case-fatality ratios. Virtually all human exposure to these four chemicals is through the food supply. Conclusion Chemicals in the food supply, as evidenced by the results for only four chemicals, can have a significant impact on the global burden of disease. The case-fatality rates for these four chemicals range from low (e.g., peanut allergen) to extremely high (aflatoxin and liver cancer). The effects associated with these four chemicals are neurologic (cyanide in cassava), cancer (aflatoxin), allergic response (peanut allergen), endocrine (dioxin), and reproductive (dioxin). Epidemiology Global Health Medicine R Science Q Brecht Devleesschauwer verfasserin aut P. Michael Bolger verfasserin aut Felicia Wu verfasserin aut Janine Ezendam verfasserin aut Julie Cliff verfasserin aut Marco Zeilmaker verfasserin aut Philippe Verger verfasserin aut John Pitt verfasserin aut Janis Baines verfasserin aut Gabriel Adegoke verfasserin aut Reza Afshari verfasserin aut Yan Liu verfasserin aut Bas Bokkers verfasserin aut Henk van Loveren verfasserin aut Marcel Mengelers verfasserin aut Esther Brandon verfasserin aut Arie H. Havelaar verfasserin aut David Bellinger verfasserin aut In F1000Research F1000 Research Ltd, 2013 4(2015) (DE-627)735133581 (DE-600)2699932-8 20461402 nnns volume:4 year:2015 https://doi.org/10.12688/f1000research.7340.1 kostenfrei https://doaj.org/article/fa9c270f6eed4ca685aca765df691286 kostenfrei http://f1000research.com/articles/4-1393/v1 kostenfrei https://doaj.org/toc/2046-1402 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2015
allfieldsGer	10.12688/f1000research.7340.1 doi (DE-627)DOAJ044054408 (DE-599)DOAJfa9c270f6eed4ca685aca765df691286 DE-627 ger DE-627 rakwb eng Herman Gibb verfasserin aut World Health Organization estimates of the global and regional disease burden of four foodborne chemical toxins, 2010: a data synthesis [version 1; referees: 2 approved, 1 approved with reservations] 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Chemical exposures have been associated with a variety of health effects; however, little is known about the global disease burden from foodborne chemicals. Food can be a major pathway for the general population’s exposure to chemicals, and for some chemicals, it accounts for almost 100% of exposure. Methods and Findings Groups of foodborne chemicals, both natural and anthropogenic, were evaluated for their ability to contribute to the burden of disease. The results of the analyses on four chemicals are presented here - cyanide in cassava, peanut allergen, aflatoxin, and dioxin. Systematic reviews of the literature were conducted to develop age- and sex-specific disease incidence and mortality estimates due to these chemicals. From these estimates, the numbers of cases, deaths and disability adjusted life years (DALYs) were calculated. For these four chemicals combined, the total number of illnesses, deaths, and DALYs in 2010 is estimated to be 339,000 (95% uncertainty interval [UI]: 186,000-1,239,000); 20,000 (95% UI: 8,000-52,000); and 1,012,000 (95% UI: 562,000-2,822,000), respectively. Both cyanide in cassava and aflatoxin are associated with diseases with high case-fatality ratios. Virtually all human exposure to these four chemicals is through the food supply. Conclusion Chemicals in the food supply, as evidenced by the results for only four chemicals, can have a significant impact on the global burden of disease. The case-fatality rates for these four chemicals range from low (e.g., peanut allergen) to extremely high (aflatoxin and liver cancer). The effects associated with these four chemicals are neurologic (cyanide in cassava), cancer (aflatoxin), allergic response (peanut allergen), endocrine (dioxin), and reproductive (dioxin). Epidemiology Global Health Medicine R Science Q Brecht Devleesschauwer verfasserin aut P. Michael Bolger verfasserin aut Felicia Wu verfasserin aut Janine Ezendam verfasserin aut Julie Cliff verfasserin aut Marco Zeilmaker verfasserin aut Philippe Verger verfasserin aut John Pitt verfasserin aut Janis Baines verfasserin aut Gabriel Adegoke verfasserin aut Reza Afshari verfasserin aut Yan Liu verfasserin aut Bas Bokkers verfasserin aut Henk van Loveren verfasserin aut Marcel Mengelers verfasserin aut Esther Brandon verfasserin aut Arie H. Havelaar verfasserin aut David Bellinger verfasserin aut In F1000Research F1000 Research Ltd, 2013 4(2015) (DE-627)735133581 (DE-600)2699932-8 20461402 nnns volume:4 year:2015 https://doi.org/10.12688/f1000research.7340.1 kostenfrei https://doaj.org/article/fa9c270f6eed4ca685aca765df691286 kostenfrei http://f1000research.com/articles/4-1393/v1 kostenfrei https://doaj.org/toc/2046-1402 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2015
allfieldsSound	10.12688/f1000research.7340.1 doi (DE-627)DOAJ044054408 (DE-599)DOAJfa9c270f6eed4ca685aca765df691286 DE-627 ger DE-627 rakwb eng Herman Gibb verfasserin aut World Health Organization estimates of the global and regional disease burden of four foodborne chemical toxins, 2010: a data synthesis [version 1; referees: 2 approved, 1 approved with reservations] 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Chemical exposures have been associated with a variety of health effects; however, little is known about the global disease burden from foodborne chemicals. Food can be a major pathway for the general population’s exposure to chemicals, and for some chemicals, it accounts for almost 100% of exposure. Methods and Findings Groups of foodborne chemicals, both natural and anthropogenic, were evaluated for their ability to contribute to the burden of disease. The results of the analyses on four chemicals are presented here - cyanide in cassava, peanut allergen, aflatoxin, and dioxin. Systematic reviews of the literature were conducted to develop age- and sex-specific disease incidence and mortality estimates due to these chemicals. From these estimates, the numbers of cases, deaths and disability adjusted life years (DALYs) were calculated. For these four chemicals combined, the total number of illnesses, deaths, and DALYs in 2010 is estimated to be 339,000 (95% uncertainty interval [UI]: 186,000-1,239,000); 20,000 (95% UI: 8,000-52,000); and 1,012,000 (95% UI: 562,000-2,822,000), respectively. Both cyanide in cassava and aflatoxin are associated with diseases with high case-fatality ratios. Virtually all human exposure to these four chemicals is through the food supply. Conclusion Chemicals in the food supply, as evidenced by the results for only four chemicals, can have a significant impact on the global burden of disease. The case-fatality rates for these four chemicals range from low (e.g., peanut allergen) to extremely high (aflatoxin and liver cancer). The effects associated with these four chemicals are neurologic (cyanide in cassava), cancer (aflatoxin), allergic response (peanut allergen), endocrine (dioxin), and reproductive (dioxin). Epidemiology Global Health Medicine R Science Q Brecht Devleesschauwer verfasserin aut P. Michael Bolger verfasserin aut Felicia Wu verfasserin aut Janine Ezendam verfasserin aut Julie Cliff verfasserin aut Marco Zeilmaker verfasserin aut Philippe Verger verfasserin aut John Pitt verfasserin aut Janis Baines verfasserin aut Gabriel Adegoke verfasserin aut Reza Afshari verfasserin aut Yan Liu verfasserin aut Bas Bokkers verfasserin aut Henk van Loveren verfasserin aut Marcel Mengelers verfasserin aut Esther Brandon verfasserin aut Arie H. Havelaar verfasserin aut David Bellinger verfasserin aut In F1000Research F1000 Research Ltd, 2013 4(2015) (DE-627)735133581 (DE-600)2699932-8 20461402 nnns volume:4 year:2015 https://doi.org/10.12688/f1000research.7340.1 kostenfrei https://doaj.org/article/fa9c270f6eed4ca685aca765df691286 kostenfrei http://f1000research.com/articles/4-1393/v1 kostenfrei https://doaj.org/toc/2046-1402 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2015
language	English
source	In F1000Research 4(2015) volume:4 year:2015
sourceStr	In F1000Research 4(2015) volume:4 year:2015
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Epidemiology Global Health Medicine R Science Q
isfreeaccess_bool	true
container_title	F1000Research
authorswithroles_txt_mv	Herman Gibb @@aut@@ Brecht Devleesschauwer @@aut@@ P. Michael Bolger @@aut@@ Felicia Wu @@aut@@ Janine Ezendam @@aut@@ Julie Cliff @@aut@@ Marco Zeilmaker @@aut@@ Philippe Verger @@aut@@ John Pitt @@aut@@ Janis Baines @@aut@@ Gabriel Adegoke @@aut@@ Reza Afshari @@aut@@ Yan Liu @@aut@@ Bas Bokkers @@aut@@ Henk van Loveren @@aut@@ Marcel Mengelers @@aut@@ Esther Brandon @@aut@@ Arie H. Havelaar @@aut@@ David Bellinger @@aut@@
publishDateDaySort_date	2015-01-01T00:00:00Z
hierarchy_top_id	735133581
id	DOAJ044054408
language_de	englisch
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author	Herman Gibb
spellingShingle	Herman Gibb misc Epidemiology misc Global Health misc Medicine misc R misc Science misc Q World Health Organization estimates of the global and regional disease burden of four foodborne chemical toxins, 2010: a data synthesis [version 1; referees: 2 approved, 1 approved with reservations]
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topic_title	World Health Organization estimates of the global and regional disease burden of four foodborne chemical toxins, 2010: a data synthesis [version 1; referees: 2 approved, 1 approved with reservations] Epidemiology Global Health
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title	World Health Organization estimates of the global and regional disease burden of four foodborne chemical toxins, 2010: a data synthesis [version 1; referees: 2 approved, 1 approved with reservations]
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title_full	World Health Organization estimates of the global and regional disease burden of four foodborne chemical toxins, 2010: a data synthesis [version 1; referees: 2 approved, 1 approved with reservations]
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author_browse	Herman Gibb Brecht Devleesschauwer P. Michael Bolger Felicia Wu Janine Ezendam Julie Cliff Marco Zeilmaker Philippe Verger John Pitt Janis Baines Gabriel Adegoke Reza Afshari Yan Liu Bas Bokkers Henk van Loveren Marcel Mengelers Esther Brandon Arie H. Havelaar David Bellinger
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title_sort	world health organization estimates of the global and regional disease burden of four foodborne chemical toxins, 2010: a data synthesis [version 1; referees: 2 approved, 1 approved with reservations]
title_auth	World Health Organization estimates of the global and regional disease burden of four foodborne chemical toxins, 2010: a data synthesis [version 1; referees: 2 approved, 1 approved with reservations]
abstract	Background Chemical exposures have been associated with a variety of health effects; however, little is known about the global disease burden from foodborne chemicals. Food can be a major pathway for the general population’s exposure to chemicals, and for some chemicals, it accounts for almost 100% of exposure. Methods and Findings Groups of foodborne chemicals, both natural and anthropogenic, were evaluated for their ability to contribute to the burden of disease. The results of the analyses on four chemicals are presented here - cyanide in cassava, peanut allergen, aflatoxin, and dioxin. Systematic reviews of the literature were conducted to develop age- and sex-specific disease incidence and mortality estimates due to these chemicals. From these estimates, the numbers of cases, deaths and disability adjusted life years (DALYs) were calculated. For these four chemicals combined, the total number of illnesses, deaths, and DALYs in 2010 is estimated to be 339,000 (95% uncertainty interval [UI]: 186,000-1,239,000); 20,000 (95% UI: 8,000-52,000); and 1,012,000 (95% UI: 562,000-2,822,000), respectively. Both cyanide in cassava and aflatoxin are associated with diseases with high case-fatality ratios. Virtually all human exposure to these four chemicals is through the food supply. Conclusion Chemicals in the food supply, as evidenced by the results for only four chemicals, can have a significant impact on the global burden of disease. The case-fatality rates for these four chemicals range from low (e.g., peanut allergen) to extremely high (aflatoxin and liver cancer). The effects associated with these four chemicals are neurologic (cyanide in cassava), cancer (aflatoxin), allergic response (peanut allergen), endocrine (dioxin), and reproductive (dioxin).
abstractGer	Background Chemical exposures have been associated with a variety of health effects; however, little is known about the global disease burden from foodborne chemicals. Food can be a major pathway for the general population’s exposure to chemicals, and for some chemicals, it accounts for almost 100% of exposure. Methods and Findings Groups of foodborne chemicals, both natural and anthropogenic, were evaluated for their ability to contribute to the burden of disease. The results of the analyses on four chemicals are presented here - cyanide in cassava, peanut allergen, aflatoxin, and dioxin. Systematic reviews of the literature were conducted to develop age- and sex-specific disease incidence and mortality estimates due to these chemicals. From these estimates, the numbers of cases, deaths and disability adjusted life years (DALYs) were calculated. For these four chemicals combined, the total number of illnesses, deaths, and DALYs in 2010 is estimated to be 339,000 (95% uncertainty interval [UI]: 186,000-1,239,000); 20,000 (95% UI: 8,000-52,000); and 1,012,000 (95% UI: 562,000-2,822,000), respectively. Both cyanide in cassava and aflatoxin are associated with diseases with high case-fatality ratios. Virtually all human exposure to these four chemicals is through the food supply. Conclusion Chemicals in the food supply, as evidenced by the results for only four chemicals, can have a significant impact on the global burden of disease. The case-fatality rates for these four chemicals range from low (e.g., peanut allergen) to extremely high (aflatoxin and liver cancer). The effects associated with these four chemicals are neurologic (cyanide in cassava), cancer (aflatoxin), allergic response (peanut allergen), endocrine (dioxin), and reproductive (dioxin).
abstract_unstemmed	Background Chemical exposures have been associated with a variety of health effects; however, little is known about the global disease burden from foodborne chemicals. Food can be a major pathway for the general population’s exposure to chemicals, and for some chemicals, it accounts for almost 100% of exposure. Methods and Findings Groups of foodborne chemicals, both natural and anthropogenic, were evaluated for their ability to contribute to the burden of disease. The results of the analyses on four chemicals are presented here - cyanide in cassava, peanut allergen, aflatoxin, and dioxin. Systematic reviews of the literature were conducted to develop age- and sex-specific disease incidence and mortality estimates due to these chemicals. From these estimates, the numbers of cases, deaths and disability adjusted life years (DALYs) were calculated. For these four chemicals combined, the total number of illnesses, deaths, and DALYs in 2010 is estimated to be 339,000 (95% uncertainty interval [UI]: 186,000-1,239,000); 20,000 (95% UI: 8,000-52,000); and 1,012,000 (95% UI: 562,000-2,822,000), respectively. Both cyanide in cassava and aflatoxin are associated with diseases with high case-fatality ratios. Virtually all human exposure to these four chemicals is through the food supply. Conclusion Chemicals in the food supply, as evidenced by the results for only four chemicals, can have a significant impact on the global burden of disease. The case-fatality rates for these four chemicals range from low (e.g., peanut allergen) to extremely high (aflatoxin and liver cancer). The effects associated with these four chemicals are neurologic (cyanide in cassava), cancer (aflatoxin), allergic response (peanut allergen), endocrine (dioxin), and reproductive (dioxin).
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title_short	World Health Organization estimates of the global and regional disease burden of four foodborne chemical toxins, 2010: a data synthesis [version 1; referees: 2 approved, 1 approved with reservations]
url	https://doi.org/10.12688/f1000research.7340.1 https://doaj.org/article/fa9c270f6eed4ca685aca765df691286 http://f1000research.com/articles/4-1393/v1 https://doaj.org/toc/2046-1402
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author2	Brecht Devleesschauwer P. Michael Bolger Felicia Wu Janine Ezendam Julie Cliff Marco Zeilmaker Philippe Verger John Pitt Janis Baines Gabriel Adegoke Reza Afshari Yan Liu Bas Bokkers Henk van Loveren Marcel Mengelers Esther Brandon Arie H. Havelaar David Bellinger
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World Health Organization estimates of the global and regional disease burden of four foodborne chemical toxins, 2010: a data synthesis [version 1; referees: 2 approved, 1 approved with reservations]

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