Cystatin-C and TGF-β levels in patients with diabetic nephropathy

Objective: To evaluate renal impairment in type 2 diabetic patients with normoalbuminuria or microalbuminuria by detection of serum cystatin C and serum and urinary TGF-β levels. Methods: Cross-sectional study conducted at the Department of Endocrinology in Baskent University School of Medicine. Pat...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Mumtaz Takir [verfasserIn] Aslı Dogruk Unal [verfasserIn] Osman Kostek [verfasserIn] Nilufer Bayraktar [verfasserIn] Nilgun Guvener Demirag [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Diabetic nephropathy Cystatin C TGF-β1 Microalbuminuria Normoalbuminuria

Übergeordnetes Werk:	In: Nefrología (English Edition) - Elsevier, 2017, 36(2016), 6, Seite 653-659
Übergeordnetes Werk:	volume:36 ; year:2016 ; number:6 ; pages:653-659

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.nefroe.2016.12.002

Katalog-ID:	DOAJ044303963

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520			\|a Objective: To evaluate renal impairment in type 2 diabetic patients with normoalbuminuria or microalbuminuria by detection of serum cystatin C and serum and urinary TGF-β levels. Methods: Cross-sectional study conducted at the Department of Endocrinology in Baskent University School of Medicine. Patients with type 2 diabetes mellitus without known overt diabetic nephropathy were included in the study. Recruited patients were stratified into four groups, matched in terms of age, gender, microalbuminuria level and estimated GFR calculated with MDRD. Results: 78 patients were enrolled. They were categorized into four groups depending on their urinary albumin excretion and estimated glomerular filtration rate. Macrovascular complication was found to be higher in patients with microalbuminuria than in other patients (p < 0.01), but there were no differences in terms of other diabetic complications. Serum cystatin C level was significantly higher in normoalbuminuric group one patients, while serum and urinary TGF-β1 levels were higher in microalbuminuric group two patients. The serum level of cystatin C was found to negatively correlate with eGFR in group two patients (r = −0.892, p < 0.001). Finally, there was a negative correlation between eGFR and cystatin C in all the patient groups (r = −0.726, p = 0.001). Conclusions: Although urinary albumin excretion is recommended for the detection of type two diabetic nephropathy, there is a group of patients with decreased eGFR but without increased urinary albumin excretion, in which serum cystatin C level was indicated to be used as an early biomarker of diabetic nephropathy.
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allfields	10.1016/j.nefroe.2016.12.002 doi (DE-627)DOAJ044303963 (DE-599)DOAJ6bac3003f28b45a1b70484c59c4a55ba DE-627 ger DE-627 rakwb eng RC870-923 Mumtaz Takir verfasserin aut Cystatin-C and TGF-β levels in patients with diabetic nephropathy 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To evaluate renal impairment in type 2 diabetic patients with normoalbuminuria or microalbuminuria by detection of serum cystatin C and serum and urinary TGF-β levels. Methods: Cross-sectional study conducted at the Department of Endocrinology in Baskent University School of Medicine. Patients with type 2 diabetes mellitus without known overt diabetic nephropathy were included in the study. Recruited patients were stratified into four groups, matched in terms of age, gender, microalbuminuria level and estimated GFR calculated with MDRD. Results: 78 patients were enrolled. They were categorized into four groups depending on their urinary albumin excretion and estimated glomerular filtration rate. Macrovascular complication was found to be higher in patients with microalbuminuria than in other patients (p < 0.01), but there were no differences in terms of other diabetic complications. Serum cystatin C level was significantly higher in normoalbuminuric group one patients, while serum and urinary TGF-β1 levels were higher in microalbuminuric group two patients. The serum level of cystatin C was found to negatively correlate with eGFR in group two patients (r = −0.892, p < 0.001). Finally, there was a negative correlation between eGFR and cystatin C in all the patient groups (r = −0.726, p = 0.001). Conclusions: Although urinary albumin excretion is recommended for the detection of type two diabetic nephropathy, there is a group of patients with decreased eGFR but without increased urinary albumin excretion, in which serum cystatin C level was indicated to be used as an early biomarker of diabetic nephropathy. Diabetic nephropathy Cystatin C TGF-β1 Microalbuminuria Normoalbuminuria Diseases of the genitourinary system. Urology Aslı Dogruk Unal verfasserin aut Osman Kostek verfasserin aut Nilufer Bayraktar verfasserin aut Nilgun Guvener Demirag verfasserin aut In Nefrología (English Edition) Elsevier, 2017 36(2016), 6, Seite 653-659 (DE-627)837956323 (DE-600)2837917-2 20132514 nnns volume:36 year:2016 number:6 pages:653-659 https://doi.org/10.1016/j.nefroe.2016.12.002 kostenfrei https://doaj.org/article/6bac3003f28b45a1b70484c59c4a55ba kostenfrei http://www.sciencedirect.com/science/article/pii/S2013251416301286 kostenfrei https://doaj.org/toc/2013-2514 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 36 2016 6 653-659
spelling	10.1016/j.nefroe.2016.12.002 doi (DE-627)DOAJ044303963 (DE-599)DOAJ6bac3003f28b45a1b70484c59c4a55ba DE-627 ger DE-627 rakwb eng RC870-923 Mumtaz Takir verfasserin aut Cystatin-C and TGF-β levels in patients with diabetic nephropathy 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To evaluate renal impairment in type 2 diabetic patients with normoalbuminuria or microalbuminuria by detection of serum cystatin C and serum and urinary TGF-β levels. Methods: Cross-sectional study conducted at the Department of Endocrinology in Baskent University School of Medicine. Patients with type 2 diabetes mellitus without known overt diabetic nephropathy were included in the study. Recruited patients were stratified into four groups, matched in terms of age, gender, microalbuminuria level and estimated GFR calculated with MDRD. Results: 78 patients were enrolled. They were categorized into four groups depending on their urinary albumin excretion and estimated glomerular filtration rate. Macrovascular complication was found to be higher in patients with microalbuminuria than in other patients (p < 0.01), but there were no differences in terms of other diabetic complications. Serum cystatin C level was significantly higher in normoalbuminuric group one patients, while serum and urinary TGF-β1 levels were higher in microalbuminuric group two patients. The serum level of cystatin C was found to negatively correlate with eGFR in group two patients (r = −0.892, p < 0.001). Finally, there was a negative correlation between eGFR and cystatin C in all the patient groups (r = −0.726, p = 0.001). Conclusions: Although urinary albumin excretion is recommended for the detection of type two diabetic nephropathy, there is a group of patients with decreased eGFR but without increased urinary albumin excretion, in which serum cystatin C level was indicated to be used as an early biomarker of diabetic nephropathy. Diabetic nephropathy Cystatin C TGF-β1 Microalbuminuria Normoalbuminuria Diseases of the genitourinary system. Urology Aslı Dogruk Unal verfasserin aut Osman Kostek verfasserin aut Nilufer Bayraktar verfasserin aut Nilgun Guvener Demirag verfasserin aut In Nefrología (English Edition) Elsevier, 2017 36(2016), 6, Seite 653-659 (DE-627)837956323 (DE-600)2837917-2 20132514 nnns volume:36 year:2016 number:6 pages:653-659 https://doi.org/10.1016/j.nefroe.2016.12.002 kostenfrei https://doaj.org/article/6bac3003f28b45a1b70484c59c4a55ba kostenfrei http://www.sciencedirect.com/science/article/pii/S2013251416301286 kostenfrei https://doaj.org/toc/2013-2514 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 36 2016 6 653-659
allfields_unstemmed	10.1016/j.nefroe.2016.12.002 doi (DE-627)DOAJ044303963 (DE-599)DOAJ6bac3003f28b45a1b70484c59c4a55ba DE-627 ger DE-627 rakwb eng RC870-923 Mumtaz Takir verfasserin aut Cystatin-C and TGF-β levels in patients with diabetic nephropathy 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To evaluate renal impairment in type 2 diabetic patients with normoalbuminuria or microalbuminuria by detection of serum cystatin C and serum and urinary TGF-β levels. Methods: Cross-sectional study conducted at the Department of Endocrinology in Baskent University School of Medicine. Patients with type 2 diabetes mellitus without known overt diabetic nephropathy were included in the study. Recruited patients were stratified into four groups, matched in terms of age, gender, microalbuminuria level and estimated GFR calculated with MDRD. Results: 78 patients were enrolled. They were categorized into four groups depending on their urinary albumin excretion and estimated glomerular filtration rate. Macrovascular complication was found to be higher in patients with microalbuminuria than in other patients (p < 0.01), but there were no differences in terms of other diabetic complications. Serum cystatin C level was significantly higher in normoalbuminuric group one patients, while serum and urinary TGF-β1 levels were higher in microalbuminuric group two patients. The serum level of cystatin C was found to negatively correlate with eGFR in group two patients (r = −0.892, p < 0.001). Finally, there was a negative correlation between eGFR and cystatin C in all the patient groups (r = −0.726, p = 0.001). Conclusions: Although urinary albumin excretion is recommended for the detection of type two diabetic nephropathy, there is a group of patients with decreased eGFR but without increased urinary albumin excretion, in which serum cystatin C level was indicated to be used as an early biomarker of diabetic nephropathy. Diabetic nephropathy Cystatin C TGF-β1 Microalbuminuria Normoalbuminuria Diseases of the genitourinary system. Urology Aslı Dogruk Unal verfasserin aut Osman Kostek verfasserin aut Nilufer Bayraktar verfasserin aut Nilgun Guvener Demirag verfasserin aut In Nefrología (English Edition) Elsevier, 2017 36(2016), 6, Seite 653-659 (DE-627)837956323 (DE-600)2837917-2 20132514 nnns volume:36 year:2016 number:6 pages:653-659 https://doi.org/10.1016/j.nefroe.2016.12.002 kostenfrei https://doaj.org/article/6bac3003f28b45a1b70484c59c4a55ba kostenfrei http://www.sciencedirect.com/science/article/pii/S2013251416301286 kostenfrei https://doaj.org/toc/2013-2514 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 36 2016 6 653-659
allfieldsGer	10.1016/j.nefroe.2016.12.002 doi (DE-627)DOAJ044303963 (DE-599)DOAJ6bac3003f28b45a1b70484c59c4a55ba DE-627 ger DE-627 rakwb eng RC870-923 Mumtaz Takir verfasserin aut Cystatin-C and TGF-β levels in patients with diabetic nephropathy 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To evaluate renal impairment in type 2 diabetic patients with normoalbuminuria or microalbuminuria by detection of serum cystatin C and serum and urinary TGF-β levels. Methods: Cross-sectional study conducted at the Department of Endocrinology in Baskent University School of Medicine. Patients with type 2 diabetes mellitus without known overt diabetic nephropathy were included in the study. Recruited patients were stratified into four groups, matched in terms of age, gender, microalbuminuria level and estimated GFR calculated with MDRD. Results: 78 patients were enrolled. They were categorized into four groups depending on their urinary albumin excretion and estimated glomerular filtration rate. Macrovascular complication was found to be higher in patients with microalbuminuria than in other patients (p < 0.01), but there were no differences in terms of other diabetic complications. Serum cystatin C level was significantly higher in normoalbuminuric group one patients, while serum and urinary TGF-β1 levels were higher in microalbuminuric group two patients. The serum level of cystatin C was found to negatively correlate with eGFR in group two patients (r = −0.892, p < 0.001). Finally, there was a negative correlation between eGFR and cystatin C in all the patient groups (r = −0.726, p = 0.001). Conclusions: Although urinary albumin excretion is recommended for the detection of type two diabetic nephropathy, there is a group of patients with decreased eGFR but without increased urinary albumin excretion, in which serum cystatin C level was indicated to be used as an early biomarker of diabetic nephropathy. Diabetic nephropathy Cystatin C TGF-β1 Microalbuminuria Normoalbuminuria Diseases of the genitourinary system. Urology Aslı Dogruk Unal verfasserin aut Osman Kostek verfasserin aut Nilufer Bayraktar verfasserin aut Nilgun Guvener Demirag verfasserin aut In Nefrología (English Edition) Elsevier, 2017 36(2016), 6, Seite 653-659 (DE-627)837956323 (DE-600)2837917-2 20132514 nnns volume:36 year:2016 number:6 pages:653-659 https://doi.org/10.1016/j.nefroe.2016.12.002 kostenfrei https://doaj.org/article/6bac3003f28b45a1b70484c59c4a55ba kostenfrei http://www.sciencedirect.com/science/article/pii/S2013251416301286 kostenfrei https://doaj.org/toc/2013-2514 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 36 2016 6 653-659
allfieldsSound	10.1016/j.nefroe.2016.12.002 doi (DE-627)DOAJ044303963 (DE-599)DOAJ6bac3003f28b45a1b70484c59c4a55ba DE-627 ger DE-627 rakwb eng RC870-923 Mumtaz Takir verfasserin aut Cystatin-C and TGF-β levels in patients with diabetic nephropathy 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To evaluate renal impairment in type 2 diabetic patients with normoalbuminuria or microalbuminuria by detection of serum cystatin C and serum and urinary TGF-β levels. Methods: Cross-sectional study conducted at the Department of Endocrinology in Baskent University School of Medicine. Patients with type 2 diabetes mellitus without known overt diabetic nephropathy were included in the study. Recruited patients were stratified into four groups, matched in terms of age, gender, microalbuminuria level and estimated GFR calculated with MDRD. Results: 78 patients were enrolled. They were categorized into four groups depending on their urinary albumin excretion and estimated glomerular filtration rate. Macrovascular complication was found to be higher in patients with microalbuminuria than in other patients (p < 0.01), but there were no differences in terms of other diabetic complications. Serum cystatin C level was significantly higher in normoalbuminuric group one patients, while serum and urinary TGF-β1 levels were higher in microalbuminuric group two patients. The serum level of cystatin C was found to negatively correlate with eGFR in group two patients (r = −0.892, p < 0.001). Finally, there was a negative correlation between eGFR and cystatin C in all the patient groups (r = −0.726, p = 0.001). Conclusions: Although urinary albumin excretion is recommended for the detection of type two diabetic nephropathy, there is a group of patients with decreased eGFR but without increased urinary albumin excretion, in which serum cystatin C level was indicated to be used as an early biomarker of diabetic nephropathy. Diabetic nephropathy Cystatin C TGF-β1 Microalbuminuria Normoalbuminuria Diseases of the genitourinary system. Urology Aslı Dogruk Unal verfasserin aut Osman Kostek verfasserin aut Nilufer Bayraktar verfasserin aut Nilgun Guvener Demirag verfasserin aut In Nefrología (English Edition) Elsevier, 2017 36(2016), 6, Seite 653-659 (DE-627)837956323 (DE-600)2837917-2 20132514 nnns volume:36 year:2016 number:6 pages:653-659 https://doi.org/10.1016/j.nefroe.2016.12.002 kostenfrei https://doaj.org/article/6bac3003f28b45a1b70484c59c4a55ba kostenfrei http://www.sciencedirect.com/science/article/pii/S2013251416301286 kostenfrei https://doaj.org/toc/2013-2514 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 36 2016 6 653-659
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callnumber-first	R - Medicine
author	Mumtaz Takir
spellingShingle	Mumtaz Takir misc RC870-923 misc Diabetic nephropathy misc Cystatin C misc TGF-β1 misc Microalbuminuria misc Normoalbuminuria misc Diseases of the genitourinary system. Urology Cystatin-C and TGF-β levels in patients with diabetic nephropathy
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topic_title	RC870-923 Cystatin-C and TGF-β levels in patients with diabetic nephropathy Diabetic nephropathy Cystatin C TGF-β1 Microalbuminuria Normoalbuminuria
topic	misc RC870-923 misc Diabetic nephropathy misc Cystatin C misc TGF-β1 misc Microalbuminuria misc Normoalbuminuria misc Diseases of the genitourinary system. Urology
topic_unstemmed	misc RC870-923 misc Diabetic nephropathy misc Cystatin C misc TGF-β1 misc Microalbuminuria misc Normoalbuminuria misc Diseases of the genitourinary system. Urology
topic_browse	misc RC870-923 misc Diabetic nephropathy misc Cystatin C misc TGF-β1 misc Microalbuminuria misc Normoalbuminuria misc Diseases of the genitourinary system. Urology
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title	Cystatin-C and TGF-β levels in patients with diabetic nephropathy
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title_full	Cystatin-C and TGF-β levels in patients with diabetic nephropathy
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title_sort	cystatin-c and tgf-β levels in patients with diabetic nephropathy
callnumber	RC870-923
title_auth	Cystatin-C and TGF-β levels in patients with diabetic nephropathy
abstract	Objective: To evaluate renal impairment in type 2 diabetic patients with normoalbuminuria or microalbuminuria by detection of serum cystatin C and serum and urinary TGF-β levels. Methods: Cross-sectional study conducted at the Department of Endocrinology in Baskent University School of Medicine. Patients with type 2 diabetes mellitus without known overt diabetic nephropathy were included in the study. Recruited patients were stratified into four groups, matched in terms of age, gender, microalbuminuria level and estimated GFR calculated with MDRD. Results: 78 patients were enrolled. They were categorized into four groups depending on their urinary albumin excretion and estimated glomerular filtration rate. Macrovascular complication was found to be higher in patients with microalbuminuria than in other patients (p < 0.01), but there were no differences in terms of other diabetic complications. Serum cystatin C level was significantly higher in normoalbuminuric group one patients, while serum and urinary TGF-β1 levels were higher in microalbuminuric group two patients. The serum level of cystatin C was found to negatively correlate with eGFR in group two patients (r = −0.892, p < 0.001). Finally, there was a negative correlation between eGFR and cystatin C in all the patient groups (r = −0.726, p = 0.001). Conclusions: Although urinary albumin excretion is recommended for the detection of type two diabetic nephropathy, there is a group of patients with decreased eGFR but without increased urinary albumin excretion, in which serum cystatin C level was indicated to be used as an early biomarker of diabetic nephropathy.
abstractGer	Objective: To evaluate renal impairment in type 2 diabetic patients with normoalbuminuria or microalbuminuria by detection of serum cystatin C and serum and urinary TGF-β levels. Methods: Cross-sectional study conducted at the Department of Endocrinology in Baskent University School of Medicine. Patients with type 2 diabetes mellitus without known overt diabetic nephropathy were included in the study. Recruited patients were stratified into four groups, matched in terms of age, gender, microalbuminuria level and estimated GFR calculated with MDRD. Results: 78 patients were enrolled. They were categorized into four groups depending on their urinary albumin excretion and estimated glomerular filtration rate. Macrovascular complication was found to be higher in patients with microalbuminuria than in other patients (p < 0.01), but there were no differences in terms of other diabetic complications. Serum cystatin C level was significantly higher in normoalbuminuric group one patients, while serum and urinary TGF-β1 levels were higher in microalbuminuric group two patients. The serum level of cystatin C was found to negatively correlate with eGFR in group two patients (r = −0.892, p < 0.001). Finally, there was a negative correlation between eGFR and cystatin C in all the patient groups (r = −0.726, p = 0.001). Conclusions: Although urinary albumin excretion is recommended for the detection of type two diabetic nephropathy, there is a group of patients with decreased eGFR but without increased urinary albumin excretion, in which serum cystatin C level was indicated to be used as an early biomarker of diabetic nephropathy.
abstract_unstemmed	Objective: To evaluate renal impairment in type 2 diabetic patients with normoalbuminuria or microalbuminuria by detection of serum cystatin C and serum and urinary TGF-β levels. Methods: Cross-sectional study conducted at the Department of Endocrinology in Baskent University School of Medicine. Patients with type 2 diabetes mellitus without known overt diabetic nephropathy were included in the study. Recruited patients were stratified into four groups, matched in terms of age, gender, microalbuminuria level and estimated GFR calculated with MDRD. Results: 78 patients were enrolled. They were categorized into four groups depending on their urinary albumin excretion and estimated glomerular filtration rate. Macrovascular complication was found to be higher in patients with microalbuminuria than in other patients (p < 0.01), but there were no differences in terms of other diabetic complications. Serum cystatin C level was significantly higher in normoalbuminuric group one patients, while serum and urinary TGF-β1 levels were higher in microalbuminuric group two patients. The serum level of cystatin C was found to negatively correlate with eGFR in group two patients (r = −0.892, p < 0.001). Finally, there was a negative correlation between eGFR and cystatin C in all the patient groups (r = −0.726, p = 0.001). Conclusions: Although urinary albumin excretion is recommended for the detection of type two diabetic nephropathy, there is a group of patients with decreased eGFR but without increased urinary albumin excretion, in which serum cystatin C level was indicated to be used as an early biomarker of diabetic nephropathy.
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title_short	Cystatin-C and TGF-β levels in patients with diabetic nephropathy
url	https://doi.org/10.1016/j.nefroe.2016.12.002 https://doaj.org/article/6bac3003f28b45a1b70484c59c4a55ba http://www.sciencedirect.com/science/article/pii/S2013251416301286 https://doaj.org/toc/2013-2514
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up_date	2024-07-03T22:19:49.407Z
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Cystatin-C and TGF-β levels in patients with diabetic nephropathy

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