Relatively low sex hormone‐binding globulin concentration is a risk factor for hyperuricemia in middle‐aged Japanese men

Summary Objective Low testosterone and hyperuricemia are associated with metabolic syndrome (MetS). However, little is known about the nature of the relationships between serum testosterone and sex hormone‐binding globulin (SHBG) concentrations, and hyperuricemia. Methods We evaluated the relationsh...
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Autor*in:	Yuya Fujihara [verfasserIn] Nobuya Hamanoue [verfasserIn] Yuko Akehi [verfasserIn] Ryoko Motonaga [verfasserIn] Tomoko Tanaka [verfasserIn] Chikayo Iwaya [verfasserIn] Hiromi Yano [verfasserIn] Makito Tanabe [verfasserIn] Takashi Nomiyama [verfasserIn] Toshihiko Yanase [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Adiponectin sex‐hormone‐binding globulin testosterone uric acid

Übergeordnetes Werk:	In: Obesity Science & Practice - Wiley, 2015, 6(2020), 4, Seite 425-433
Übergeordnetes Werk:	volume:6 ; year:2020 ; number:4 ; pages:425-433

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1002/osp4.413

Katalog-ID:	DOAJ04435343X

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520			\|a Summary Objective Low testosterone and hyperuricemia are associated with metabolic syndrome (MetS). However, little is known about the nature of the relationships between serum testosterone and sex hormone‐binding globulin (SHBG) concentrations, and hyperuricemia. Methods We evaluated the relationships between serum testosterone (calculated bioavailable testosterone [cbT], calculated free testosterone [cFT], SHBG, and total testosterone [TT]) and metabolic indices, including serum uric acid, in 363 Japanese males (mean age 51.1 ± 8.7 years) at routine health examinations. Results Participants with hyperuricemia (≥7.0 mg/dL) demonstrated lower adiponectin, cbT, cFT, SHBG, and TT, but a higher MetS prevalence and higher values of various MetS‐related parameters than those without hyperuricemia (<7.0 mg/dL). Binary regression analysis revealed that less than 52 nmol/L SHBG, less than 5.0 μg/mL serum adiponectin, greater than or equal to 7.0 g/dL total protein, and greater than or equal to 1.0 mg/dL creatinine were statistically significant risk factors for hyperuricemia. Receiver operating characteristic analysis confirmed that less than 46.5 nmol/L (area under the curve [AUC] = 0.645) SHBG and less than 3.68 μg/mL (AUC = 0.691) adiponectin concentrations were significant risk factors for hyperuricemia. Conclusions We provide evidence that low SHBG provides an important marker for hyperuricemia in middle‐aged Japanese men. This finding provides clinical evidence that low SHBG is closely associated with MetS, which is often accompanied with hyperuricemia.
650		4	\|a Adiponectin
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700	0		\|a Makito Tanabe \|e verfasserin \|4 aut
700	0		\|a Takashi Nomiyama \|e verfasserin \|4 aut
700	0		\|a Toshihiko Yanase \|e verfasserin \|4 aut
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allfields	10.1002/osp4.413 doi (DE-627)DOAJ04435343X (DE-599)DOAJ5f1aac06f59241c289713bb18268eb0e DE-627 ger DE-627 rakwb eng RC31-1245 Yuya Fujihara verfasserin aut Relatively low sex hormone‐binding globulin concentration is a risk factor for hyperuricemia in middle‐aged Japanese men 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary Objective Low testosterone and hyperuricemia are associated with metabolic syndrome (MetS). However, little is known about the nature of the relationships between serum testosterone and sex hormone‐binding globulin (SHBG) concentrations, and hyperuricemia. Methods We evaluated the relationships between serum testosterone (calculated bioavailable testosterone [cbT], calculated free testosterone [cFT], SHBG, and total testosterone [TT]) and metabolic indices, including serum uric acid, in 363 Japanese males (mean age 51.1 ± 8.7 years) at routine health examinations. Results Participants with hyperuricemia (≥7.0 mg/dL) demonstrated lower adiponectin, cbT, cFT, SHBG, and TT, but a higher MetS prevalence and higher values of various MetS‐related parameters than those without hyperuricemia (<7.0 mg/dL). Binary regression analysis revealed that less than 52 nmol/L SHBG, less than 5.0 μg/mL serum adiponectin, greater than or equal to 7.0 g/dL total protein, and greater than or equal to 1.0 mg/dL creatinine were statistically significant risk factors for hyperuricemia. Receiver operating characteristic analysis confirmed that less than 46.5 nmol/L (area under the curve [AUC] = 0.645) SHBG and less than 3.68 μg/mL (AUC = 0.691) adiponectin concentrations were significant risk factors for hyperuricemia. Conclusions We provide evidence that low SHBG provides an important marker for hyperuricemia in middle‐aged Japanese men. This finding provides clinical evidence that low SHBG is closely associated with MetS, which is often accompanied with hyperuricemia. Adiponectin sex‐hormone‐binding globulin testosterone uric acid Internal medicine Nobuya Hamanoue verfasserin aut Yuko Akehi verfasserin aut Ryoko Motonaga verfasserin aut Tomoko Tanaka verfasserin aut Chikayo Iwaya verfasserin aut Hiromi Yano verfasserin aut Makito Tanabe verfasserin aut Takashi Nomiyama verfasserin aut Toshihiko Yanase verfasserin aut In Obesity Science & Practice Wiley, 2015 6(2020), 4, Seite 425-433 (DE-627)837398037 (DE-600)2836381-4 20552238 nnns volume:6 year:2020 number:4 pages:425-433 https://doi.org/10.1002/osp4.413 kostenfrei https://doaj.org/article/5f1aac06f59241c289713bb18268eb0e kostenfrei https://doi.org/10.1002/osp4.413 kostenfrei https://doaj.org/toc/2055-2238 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2020 4 425-433
spelling	10.1002/osp4.413 doi (DE-627)DOAJ04435343X (DE-599)DOAJ5f1aac06f59241c289713bb18268eb0e DE-627 ger DE-627 rakwb eng RC31-1245 Yuya Fujihara verfasserin aut Relatively low sex hormone‐binding globulin concentration is a risk factor for hyperuricemia in middle‐aged Japanese men 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary Objective Low testosterone and hyperuricemia are associated with metabolic syndrome (MetS). However, little is known about the nature of the relationships between serum testosterone and sex hormone‐binding globulin (SHBG) concentrations, and hyperuricemia. Methods We evaluated the relationships between serum testosterone (calculated bioavailable testosterone [cbT], calculated free testosterone [cFT], SHBG, and total testosterone [TT]) and metabolic indices, including serum uric acid, in 363 Japanese males (mean age 51.1 ± 8.7 years) at routine health examinations. Results Participants with hyperuricemia (≥7.0 mg/dL) demonstrated lower adiponectin, cbT, cFT, SHBG, and TT, but a higher MetS prevalence and higher values of various MetS‐related parameters than those without hyperuricemia (<7.0 mg/dL). Binary regression analysis revealed that less than 52 nmol/L SHBG, less than 5.0 μg/mL serum adiponectin, greater than or equal to 7.0 g/dL total protein, and greater than or equal to 1.0 mg/dL creatinine were statistically significant risk factors for hyperuricemia. Receiver operating characteristic analysis confirmed that less than 46.5 nmol/L (area under the curve [AUC] = 0.645) SHBG and less than 3.68 μg/mL (AUC = 0.691) adiponectin concentrations were significant risk factors for hyperuricemia. Conclusions We provide evidence that low SHBG provides an important marker for hyperuricemia in middle‐aged Japanese men. This finding provides clinical evidence that low SHBG is closely associated with MetS, which is often accompanied with hyperuricemia. Adiponectin sex‐hormone‐binding globulin testosterone uric acid Internal medicine Nobuya Hamanoue verfasserin aut Yuko Akehi verfasserin aut Ryoko Motonaga verfasserin aut Tomoko Tanaka verfasserin aut Chikayo Iwaya verfasserin aut Hiromi Yano verfasserin aut Makito Tanabe verfasserin aut Takashi Nomiyama verfasserin aut Toshihiko Yanase verfasserin aut In Obesity Science & Practice Wiley, 2015 6(2020), 4, Seite 425-433 (DE-627)837398037 (DE-600)2836381-4 20552238 nnns volume:6 year:2020 number:4 pages:425-433 https://doi.org/10.1002/osp4.413 kostenfrei https://doaj.org/article/5f1aac06f59241c289713bb18268eb0e kostenfrei https://doi.org/10.1002/osp4.413 kostenfrei https://doaj.org/toc/2055-2238 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2020 4 425-433
allfields_unstemmed	10.1002/osp4.413 doi (DE-627)DOAJ04435343X (DE-599)DOAJ5f1aac06f59241c289713bb18268eb0e DE-627 ger DE-627 rakwb eng RC31-1245 Yuya Fujihara verfasserin aut Relatively low sex hormone‐binding globulin concentration is a risk factor for hyperuricemia in middle‐aged Japanese men 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary Objective Low testosterone and hyperuricemia are associated with metabolic syndrome (MetS). However, little is known about the nature of the relationships between serum testosterone and sex hormone‐binding globulin (SHBG) concentrations, and hyperuricemia. Methods We evaluated the relationships between serum testosterone (calculated bioavailable testosterone [cbT], calculated free testosterone [cFT], SHBG, and total testosterone [TT]) and metabolic indices, including serum uric acid, in 363 Japanese males (mean age 51.1 ± 8.7 years) at routine health examinations. Results Participants with hyperuricemia (≥7.0 mg/dL) demonstrated lower adiponectin, cbT, cFT, SHBG, and TT, but a higher MetS prevalence and higher values of various MetS‐related parameters than those without hyperuricemia (<7.0 mg/dL). Binary regression analysis revealed that less than 52 nmol/L SHBG, less than 5.0 μg/mL serum adiponectin, greater than or equal to 7.0 g/dL total protein, and greater than or equal to 1.0 mg/dL creatinine were statistically significant risk factors for hyperuricemia. Receiver operating characteristic analysis confirmed that less than 46.5 nmol/L (area under the curve [AUC] = 0.645) SHBG and less than 3.68 μg/mL (AUC = 0.691) adiponectin concentrations were significant risk factors for hyperuricemia. Conclusions We provide evidence that low SHBG provides an important marker for hyperuricemia in middle‐aged Japanese men. This finding provides clinical evidence that low SHBG is closely associated with MetS, which is often accompanied with hyperuricemia. Adiponectin sex‐hormone‐binding globulin testosterone uric acid Internal medicine Nobuya Hamanoue verfasserin aut Yuko Akehi verfasserin aut Ryoko Motonaga verfasserin aut Tomoko Tanaka verfasserin aut Chikayo Iwaya verfasserin aut Hiromi Yano verfasserin aut Makito Tanabe verfasserin aut Takashi Nomiyama verfasserin aut Toshihiko Yanase verfasserin aut In Obesity Science & Practice Wiley, 2015 6(2020), 4, Seite 425-433 (DE-627)837398037 (DE-600)2836381-4 20552238 nnns volume:6 year:2020 number:4 pages:425-433 https://doi.org/10.1002/osp4.413 kostenfrei https://doaj.org/article/5f1aac06f59241c289713bb18268eb0e kostenfrei https://doi.org/10.1002/osp4.413 kostenfrei https://doaj.org/toc/2055-2238 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2020 4 425-433
allfieldsGer	10.1002/osp4.413 doi (DE-627)DOAJ04435343X (DE-599)DOAJ5f1aac06f59241c289713bb18268eb0e DE-627 ger DE-627 rakwb eng RC31-1245 Yuya Fujihara verfasserin aut Relatively low sex hormone‐binding globulin concentration is a risk factor for hyperuricemia in middle‐aged Japanese men 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary Objective Low testosterone and hyperuricemia are associated with metabolic syndrome (MetS). However, little is known about the nature of the relationships between serum testosterone and sex hormone‐binding globulin (SHBG) concentrations, and hyperuricemia. Methods We evaluated the relationships between serum testosterone (calculated bioavailable testosterone [cbT], calculated free testosterone [cFT], SHBG, and total testosterone [TT]) and metabolic indices, including serum uric acid, in 363 Japanese males (mean age 51.1 ± 8.7 years) at routine health examinations. Results Participants with hyperuricemia (≥7.0 mg/dL) demonstrated lower adiponectin, cbT, cFT, SHBG, and TT, but a higher MetS prevalence and higher values of various MetS‐related parameters than those without hyperuricemia (<7.0 mg/dL). Binary regression analysis revealed that less than 52 nmol/L SHBG, less than 5.0 μg/mL serum adiponectin, greater than or equal to 7.0 g/dL total protein, and greater than or equal to 1.0 mg/dL creatinine were statistically significant risk factors for hyperuricemia. Receiver operating characteristic analysis confirmed that less than 46.5 nmol/L (area under the curve [AUC] = 0.645) SHBG and less than 3.68 μg/mL (AUC = 0.691) adiponectin concentrations were significant risk factors for hyperuricemia. Conclusions We provide evidence that low SHBG provides an important marker for hyperuricemia in middle‐aged Japanese men. This finding provides clinical evidence that low SHBG is closely associated with MetS, which is often accompanied with hyperuricemia. Adiponectin sex‐hormone‐binding globulin testosterone uric acid Internal medicine Nobuya Hamanoue verfasserin aut Yuko Akehi verfasserin aut Ryoko Motonaga verfasserin aut Tomoko Tanaka verfasserin aut Chikayo Iwaya verfasserin aut Hiromi Yano verfasserin aut Makito Tanabe verfasserin aut Takashi Nomiyama verfasserin aut Toshihiko Yanase verfasserin aut In Obesity Science & Practice Wiley, 2015 6(2020), 4, Seite 425-433 (DE-627)837398037 (DE-600)2836381-4 20552238 nnns volume:6 year:2020 number:4 pages:425-433 https://doi.org/10.1002/osp4.413 kostenfrei https://doaj.org/article/5f1aac06f59241c289713bb18268eb0e kostenfrei https://doi.org/10.1002/osp4.413 kostenfrei https://doaj.org/toc/2055-2238 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2020 4 425-433
allfieldsSound	10.1002/osp4.413 doi (DE-627)DOAJ04435343X (DE-599)DOAJ5f1aac06f59241c289713bb18268eb0e DE-627 ger DE-627 rakwb eng RC31-1245 Yuya Fujihara verfasserin aut Relatively low sex hormone‐binding globulin concentration is a risk factor for hyperuricemia in middle‐aged Japanese men 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary Objective Low testosterone and hyperuricemia are associated with metabolic syndrome (MetS). However, little is known about the nature of the relationships between serum testosterone and sex hormone‐binding globulin (SHBG) concentrations, and hyperuricemia. Methods We evaluated the relationships between serum testosterone (calculated bioavailable testosterone [cbT], calculated free testosterone [cFT], SHBG, and total testosterone [TT]) and metabolic indices, including serum uric acid, in 363 Japanese males (mean age 51.1 ± 8.7 years) at routine health examinations. Results Participants with hyperuricemia (≥7.0 mg/dL) demonstrated lower adiponectin, cbT, cFT, SHBG, and TT, but a higher MetS prevalence and higher values of various MetS‐related parameters than those without hyperuricemia (<7.0 mg/dL). Binary regression analysis revealed that less than 52 nmol/L SHBG, less than 5.0 μg/mL serum adiponectin, greater than or equal to 7.0 g/dL total protein, and greater than or equal to 1.0 mg/dL creatinine were statistically significant risk factors for hyperuricemia. Receiver operating characteristic analysis confirmed that less than 46.5 nmol/L (area under the curve [AUC] = 0.645) SHBG and less than 3.68 μg/mL (AUC = 0.691) adiponectin concentrations were significant risk factors for hyperuricemia. Conclusions We provide evidence that low SHBG provides an important marker for hyperuricemia in middle‐aged Japanese men. This finding provides clinical evidence that low SHBG is closely associated with MetS, which is often accompanied with hyperuricemia. Adiponectin sex‐hormone‐binding globulin testosterone uric acid Internal medicine Nobuya Hamanoue verfasserin aut Yuko Akehi verfasserin aut Ryoko Motonaga verfasserin aut Tomoko Tanaka verfasserin aut Chikayo Iwaya verfasserin aut Hiromi Yano verfasserin aut Makito Tanabe verfasserin aut Takashi Nomiyama verfasserin aut Toshihiko Yanase verfasserin aut In Obesity Science & Practice Wiley, 2015 6(2020), 4, Seite 425-433 (DE-627)837398037 (DE-600)2836381-4 20552238 nnns volume:6 year:2020 number:4 pages:425-433 https://doi.org/10.1002/osp4.413 kostenfrei https://doaj.org/article/5f1aac06f59241c289713bb18268eb0e kostenfrei https://doi.org/10.1002/osp4.413 kostenfrei https://doaj.org/toc/2055-2238 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2020 4 425-433
language	English
source	In Obesity Science & Practice 6(2020), 4, Seite 425-433 volume:6 year:2020 number:4 pages:425-433
sourceStr	In Obesity Science & Practice 6(2020), 4, Seite 425-433 volume:6 year:2020 number:4 pages:425-433
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Adiponectin sex‐hormone‐binding globulin testosterone uric acid Internal medicine
isfreeaccess_bool	true
container_title	Obesity Science & Practice
authorswithroles_txt_mv	Yuya Fujihara @@aut@@ Nobuya Hamanoue @@aut@@ Yuko Akehi @@aut@@ Ryoko Motonaga @@aut@@ Tomoko Tanaka @@aut@@ Chikayo Iwaya @@aut@@ Hiromi Yano @@aut@@ Makito Tanabe @@aut@@ Takashi Nomiyama @@aut@@ Toshihiko Yanase @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	837398037
id	DOAJ04435343X
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ04435343X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230503002954.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2020 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1002/osp4.413</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ04435343X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ5f1aac06f59241c289713bb18268eb0e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC31-1245</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Yuya Fujihara</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Relatively low sex hormone‐binding globulin concentration is a risk factor for hyperuricemia in middle‐aged Japanese men</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Summary Objective Low testosterone and hyperuricemia are associated with metabolic syndrome (MetS). However, little is known about the nature of the relationships between serum testosterone and sex hormone‐binding globulin (SHBG) concentrations, and hyperuricemia. Methods We evaluated the relationships between serum testosterone (calculated bioavailable testosterone [cbT], calculated free testosterone [cFT], SHBG, and total testosterone [TT]) and metabolic indices, including serum uric acid, in 363 Japanese males (mean age 51.1 ± 8.7 years) at routine health examinations. Results Participants with hyperuricemia (≥7.0 mg/dL) demonstrated lower adiponectin, cbT, cFT, SHBG, and TT, but a higher MetS prevalence and higher values of various MetS‐related parameters than those without hyperuricemia (<7.0 mg/dL). Binary regression analysis revealed that less than 52 nmol/L SHBG, less than 5.0 μg/mL serum adiponectin, greater than or equal to 7.0 g/dL total protein, and greater than or equal to 1.0 mg/dL creatinine were statistically significant risk factors for hyperuricemia. Receiver operating characteristic analysis confirmed that less than 46.5 nmol/L (area under the curve [AUC] = 0.645) SHBG and less than 3.68 μg/mL (AUC = 0.691) adiponectin concentrations were significant risk factors for hyperuricemia. Conclusions We provide evidence that low SHBG provides an important marker for hyperuricemia in middle‐aged Japanese men. 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callnumber-first	R - Medicine
author	Yuya Fujihara
spellingShingle	Yuya Fujihara misc RC31-1245 misc Adiponectin misc sex‐hormone‐binding globulin misc testosterone misc uric acid misc Internal medicine Relatively low sex hormone‐binding globulin concentration is a risk factor for hyperuricemia in middle‐aged Japanese men
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topic_title	RC31-1245 Relatively low sex hormone‐binding globulin concentration is a risk factor for hyperuricemia in middle‐aged Japanese men Adiponectin sex‐hormone‐binding globulin testosterone uric acid
topic	misc RC31-1245 misc Adiponectin misc sex‐hormone‐binding globulin misc testosterone misc uric acid misc Internal medicine
topic_unstemmed	misc RC31-1245 misc Adiponectin misc sex‐hormone‐binding globulin misc testosterone misc uric acid misc Internal medicine
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title	Relatively low sex hormone‐binding globulin concentration is a risk factor for hyperuricemia in middle‐aged Japanese men
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title_full	Relatively low sex hormone‐binding globulin concentration is a risk factor for hyperuricemia in middle‐aged Japanese men
author_sort	Yuya Fujihara
journal	Obesity Science & Practice
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author_browse	Yuya Fujihara Nobuya Hamanoue Yuko Akehi Ryoko Motonaga Tomoko Tanaka Chikayo Iwaya Hiromi Yano Makito Tanabe Takashi Nomiyama Toshihiko Yanase
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title_sort	relatively low sex hormone‐binding globulin concentration is a risk factor for hyperuricemia in middle‐aged japanese men
callnumber	RC31-1245
title_auth	Relatively low sex hormone‐binding globulin concentration is a risk factor for hyperuricemia in middle‐aged Japanese men
abstract	Summary Objective Low testosterone and hyperuricemia are associated with metabolic syndrome (MetS). However, little is known about the nature of the relationships between serum testosterone and sex hormone‐binding globulin (SHBG) concentrations, and hyperuricemia. Methods We evaluated the relationships between serum testosterone (calculated bioavailable testosterone [cbT], calculated free testosterone [cFT], SHBG, and total testosterone [TT]) and metabolic indices, including serum uric acid, in 363 Japanese males (mean age 51.1 ± 8.7 years) at routine health examinations. Results Participants with hyperuricemia (≥7.0 mg/dL) demonstrated lower adiponectin, cbT, cFT, SHBG, and TT, but a higher MetS prevalence and higher values of various MetS‐related parameters than those without hyperuricemia (<7.0 mg/dL). Binary regression analysis revealed that less than 52 nmol/L SHBG, less than 5.0 μg/mL serum adiponectin, greater than or equal to 7.0 g/dL total protein, and greater than or equal to 1.0 mg/dL creatinine were statistically significant risk factors for hyperuricemia. Receiver operating characteristic analysis confirmed that less than 46.5 nmol/L (area under the curve [AUC] = 0.645) SHBG and less than 3.68 μg/mL (AUC = 0.691) adiponectin concentrations were significant risk factors for hyperuricemia. Conclusions We provide evidence that low SHBG provides an important marker for hyperuricemia in middle‐aged Japanese men. This finding provides clinical evidence that low SHBG is closely associated with MetS, which is often accompanied with hyperuricemia.
abstractGer	Summary Objective Low testosterone and hyperuricemia are associated with metabolic syndrome (MetS). However, little is known about the nature of the relationships between serum testosterone and sex hormone‐binding globulin (SHBG) concentrations, and hyperuricemia. Methods We evaluated the relationships between serum testosterone (calculated bioavailable testosterone [cbT], calculated free testosterone [cFT], SHBG, and total testosterone [TT]) and metabolic indices, including serum uric acid, in 363 Japanese males (mean age 51.1 ± 8.7 years) at routine health examinations. Results Participants with hyperuricemia (≥7.0 mg/dL) demonstrated lower adiponectin, cbT, cFT, SHBG, and TT, but a higher MetS prevalence and higher values of various MetS‐related parameters than those without hyperuricemia (<7.0 mg/dL). Binary regression analysis revealed that less than 52 nmol/L SHBG, less than 5.0 μg/mL serum adiponectin, greater than or equal to 7.0 g/dL total protein, and greater than or equal to 1.0 mg/dL creatinine were statistically significant risk factors for hyperuricemia. Receiver operating characteristic analysis confirmed that less than 46.5 nmol/L (area under the curve [AUC] = 0.645) SHBG and less than 3.68 μg/mL (AUC = 0.691) adiponectin concentrations were significant risk factors for hyperuricemia. Conclusions We provide evidence that low SHBG provides an important marker for hyperuricemia in middle‐aged Japanese men. This finding provides clinical evidence that low SHBG is closely associated with MetS, which is often accompanied with hyperuricemia.
abstract_unstemmed	Summary Objective Low testosterone and hyperuricemia are associated with metabolic syndrome (MetS). However, little is known about the nature of the relationships between serum testosterone and sex hormone‐binding globulin (SHBG) concentrations, and hyperuricemia. Methods We evaluated the relationships between serum testosterone (calculated bioavailable testosterone [cbT], calculated free testosterone [cFT], SHBG, and total testosterone [TT]) and metabolic indices, including serum uric acid, in 363 Japanese males (mean age 51.1 ± 8.7 years) at routine health examinations. Results Participants with hyperuricemia (≥7.0 mg/dL) demonstrated lower adiponectin, cbT, cFT, SHBG, and TT, but a higher MetS prevalence and higher values of various MetS‐related parameters than those without hyperuricemia (<7.0 mg/dL). Binary regression analysis revealed that less than 52 nmol/L SHBG, less than 5.0 μg/mL serum adiponectin, greater than or equal to 7.0 g/dL total protein, and greater than or equal to 1.0 mg/dL creatinine were statistically significant risk factors for hyperuricemia. Receiver operating characteristic analysis confirmed that less than 46.5 nmol/L (area under the curve [AUC] = 0.645) SHBG and less than 3.68 μg/mL (AUC = 0.691) adiponectin concentrations were significant risk factors for hyperuricemia. Conclusions We provide evidence that low SHBG provides an important marker for hyperuricemia in middle‐aged Japanese men. This finding provides clinical evidence that low SHBG is closely associated with MetS, which is often accompanied with hyperuricemia.
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title_short	Relatively low sex hormone‐binding globulin concentration is a risk factor for hyperuricemia in middle‐aged Japanese men
url	https://doi.org/10.1002/osp4.413 https://doaj.org/article/5f1aac06f59241c289713bb18268eb0e https://doaj.org/toc/2055-2238
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up_date	2024-07-03T22:34:48.138Z
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However, little is known about the nature of the relationships between serum testosterone and sex hormone‐binding globulin (SHBG) concentrations, and hyperuricemia. Methods We evaluated the relationships between serum testosterone (calculated bioavailable testosterone [cbT], calculated free testosterone [cFT], SHBG, and total testosterone [TT]) and metabolic indices, including serum uric acid, in 363 Japanese males (mean age 51.1 ± 8.7 years) at routine health examinations. Results Participants with hyperuricemia (≥7.0 mg/dL) demonstrated lower adiponectin, cbT, cFT, SHBG, and TT, but a higher MetS prevalence and higher values of various MetS‐related parameters than those without hyperuricemia (<7.0 mg/dL). Binary regression analysis revealed that less than 52 nmol/L SHBG, less than 5.0 μg/mL serum adiponectin, greater than or equal to 7.0 g/dL total protein, and greater than or equal to 1.0 mg/dL creatinine were statistically significant risk factors for hyperuricemia. Receiver operating characteristic analysis confirmed that less than 46.5 nmol/L (area under the curve [AUC] = 0.645) SHBG and less than 3.68 μg/mL (AUC = 0.691) adiponectin concentrations were significant risk factors for hyperuricemia. Conclusions We provide evidence that low SHBG provides an important marker for hyperuricemia in middle‐aged Japanese men. 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Relatively low sex hormone‐binding globulin concentration is a risk factor for hyperuricemia in middle‐aged Japanese men

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